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TBP (TATA-box binding protein)

Identity

Alias (NCBI)GTF2D
GTF2D1
HDL4
SCA17
TFIID
HGNC (Hugo) TBP
HGNC Alias symbTFIID
HGNC Previous nameGTF2D1
 SCA17
LocusID (NCBI) 6908
Atlas_Id 42481
Location 6q27  [Link to chromosome band 6q27]
Location_base_pair Starts at 170554369 and ends at 170572859 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TBP   11588
Cards
Entrez_Gene (NCBI)TBP    TATA-box binding protein
AliasesGTF2D; GTF2D1; HDL4; SCA17; 
TFIID
GeneCards (Weizmann)TBP
Ensembl hg19 (Hinxton)ENSG00000112592 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112592 [Gene_View]  ENSG00000112592 [Sequence]  chr6:170554369-170572859 [Contig_View]  TBP [Vega]
ICGC DataPortalENSG00000112592
TCGA cBioPortalTBP
AceView (NCBI)TBP
Genatlas (Paris)TBP
SOURCE (Princeton)TBP
Genetics Home Reference (NIH)TBP
Genomic and cartography
GoldenPath hg38 (UCSC)TBP  -     chr6:170554369-170572859 +  6q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBP  -     6q27   [Description]    (hg19-Feb_2009)
GoldenPathTBP - 6q27 [CytoView hg19]  TBP - 6q27 [CytoView hg38]
ImmunoBaseENSG00000112592
Genome Data Viewer NCBITBP [Mapview hg19]  
OMIM168600   600075   607136   
Gene and transcription
Genbank (Entrez)AK298272 AK304648 AK315222 BC109053 BC109054
RefSeq transcript (Entrez)NM_001172085 NM_003194
Consensus coding sequences : CCDS (NCBI)TBP
Gene ExpressionTBP [ NCBI-GEO ]   TBP [ EBI - ARRAY_EXPRESS ]   TBP [ SEEK ]   TBP [ MEM ]
Gene Expression Viewer (FireBrowse)TBP [ Firebrowse - Broad ]
GenevisibleExpression of TBP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6908
GTEX Portal (Tissue expression)TBP
Human Protein AtlasENSG00000112592-TBP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20226   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20226  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20226
PhosPhoSitePlusP20226
Domaine pattern : Prosite (Expaxy)TFIID (PS00351)   
Domains : Interpro (EBI)TBP    TBP_CS    TBP_dom_sf    TBP_eukaryotic   
Domain families : Pfam (Sanger)TBP (PF00352)   
Domain families : Pfam (NCBI)pfam00352   
Conserved Domain (NCBI)TBP
PDB (RSDB)1C9B    1CDW    1JFI    1NVP    1TGH    4ROC    4ROD    4ROE    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5N9G    6MZD    6MZL    6MZM    6O9L   
PDB Europe1C9B    1CDW    1JFI    1NVP    1TGH    4ROC    4ROD    4ROE    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5N9G    6MZD    6MZL    6MZM    6O9L   
PDB (PDBSum)1C9B    1CDW    1JFI    1NVP    1TGH    4ROC    4ROD    4ROE    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5N9G    6MZD    6MZL    6MZM    6O9L   
PDB (IMB)1C9B    1CDW    1JFI    1NVP    1TGH    4ROC    4ROD    4ROE    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5N9G    6MZD    6MZL    6MZM    6O9L   
Structural Biology KnowledgeBase1C9B    1CDW    1JFI    1NVP    1TGH    4ROC    4ROD    4ROE    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5N9G    6MZD    6MZL    6MZM    6O9L   
SCOP (Structural Classification of Proteins)1C9B    1CDW    1JFI    1NVP    1TGH    4ROC    4ROD    4ROE    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5N9G    6MZD    6MZL    6MZM    6O9L   
CATH (Classification of proteins structures)1C9B    1CDW    1JFI    1NVP    1TGH    4ROC    4ROD    4ROE    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5N9G    6MZD    6MZL    6MZM    6O9L   
SuperfamilyP20226
AlphaFold pdb e-kbP20226   
Human Protein Atlas [tissue]ENSG00000112592-TBP [tissue]
HPRD02511
Protein Interaction databases
DIP (DOE-UCLA)P20226
IntAct (EBI)P20226
BioGRIDTBP
STRING (EMBL)TBP
ZODIACTBP
Ontologies - Pathways
QuickGOP20226
Ontology : AmiGOchromatin  euchromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  RNA polymerase III general transcription initiation factor activity  core promoter sequence-specific DNA binding  RNA polymerase II general transcription initiation factor binding  TFIIB-class transcription factor binding  female pronucleus  male pronucleus  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor TFIID complex  transcription factor TFIIA complex  cytoplasm  DNA-templated transcription, initiation  transcription initiation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription by RNA polymerase III  transcription by RNA polymerase III  spermatogenesis  transcription factor binding  RNA polymerase II general transcription initiation factor activity  RNA polymerase II general transcription initiation factor activity  aryl hydrocarbon receptor binding  enzyme binding  protein-containing complex  snRNA transcription by RNA polymerase II  positive regulation of gene expression, epigenetic  positive regulation of transcription, DNA-templated  RNA polymerase II preinitiation complex assembly  transcription preinitiation complex  general transcription initiation factor activity  DNA-binding transcription factor binding  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIchromatin  euchromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  RNA polymerase III general transcription initiation factor activity  core promoter sequence-specific DNA binding  RNA polymerase II general transcription initiation factor binding  TFIIB-class transcription factor binding  female pronucleus  male pronucleus  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor TFIID complex  transcription factor TFIIA complex  cytoplasm  DNA-templated transcription, initiation  transcription initiation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription by RNA polymerase III  transcription by RNA polymerase III  spermatogenesis  transcription factor binding  RNA polymerase II general transcription initiation factor activity  RNA polymerase II general transcription initiation factor activity  aryl hydrocarbon receptor binding  enzyme binding  protein-containing complex  snRNA transcription by RNA polymerase II  positive regulation of gene expression, epigenetic  positive regulation of transcription, DNA-templated  RNA polymerase II preinitiation complex assembly  transcription preinitiation complex  general transcription initiation factor activity  DNA-binding transcription factor binding  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTARNA polymerase III transcription [Genes]    Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells [Genes]    CARM1 and Regulation of the Estrogen Receptor [Genes]    Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes [Genes]   
Pathways : KEGGBasal transcription factors    Huntington's disease    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Viral carcinogenesis   
NDEx NetworkTBP
Atlas of Cancer Signalling NetworkTBP
Wikipedia pathwaysTBP
Orthology - Evolution
OrthoDB6908
GeneTree (enSembl)ENSG00000112592
Phylogenetic Trees/Animal Genes : TreeFamTBP
Homologs : HomoloGeneTBP
Homology/Alignments : Family Browser (UCSC)TBP
Gene fusions - Rearrangements
Fusion : QuiverTBP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBP
dbVarTBP
ClinVarTBP
MonarchTBP
1000_GenomesTBP 
Exome Variant ServerTBP
GNOMAD BrowserENSG00000112592
Varsome BrowserTBP
ACMGTBP variants
VarityP20226
Genomic Variants (DGV)TBP [DGVbeta]
DECIPHERTBP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBP 
Mutations
ICGC Data PortalTBP 
TCGA Data PortalTBP 
Broad Tumor PortalTBP
OASIS PortalTBP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTBP
Mutations and Diseases : HGMDTBP
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTBP
DgiDB (Drug Gene Interaction Database)TBP
DoCM (Curated mutations)TBP
CIViC (Clinical Interpretations of Variants in Cancer)TBP
Cancer3DTBP
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM168600    600075    607136   
Orphanet13776   
DisGeNETTBP
MedgenTBP
Genetic Testing Registry TBP
NextProtP20226 [Medical]
GENETestsTBP
Target ValidationTBP
Huge Navigator TBP [HugePedia]
ClinGenTBP
Clinical trials, drugs, therapy
MyCancerGenomeTBP
Protein Interactions : CTDTBP
Pharm GKB GenePA36352
PharosP20226
Clinical trialTBP
Miscellaneous
canSAR (ICR)TBP
HarmonizomeTBP
DataMed IndexTBP
Probes
Litterature
PubMed389 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTBP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:34:29 CEST 2021

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