TBP (TATA-box binding protein)

2003-06-01 Affiliation

Identity

HGNC

TBP

LOCATION

6q27

LOCUSID

6908

ALIAS

GTF2D,GTF2D1,HDL4,SCA17,TFIID

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6908
MIM: 600075
HGNC: 11588
Ensembl: ENSG00000112592

Variants:

dbSNP: 6908
ClinVar: 6908
TCGA: ENSG00000112592
COSMIC: TBP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112592	ENST00000230354	P20226
ENSG00000112592	ENST00000392092	P20226
ENSG00000112592	ENST00000421512	Q7Z6S5
ENSG00000112592	ENST00000423353	Q7Z6S4
ENSG00000112592	ENST00000446829	H0Y6D8
ENSG00000112592	ENST00000540980	P20226
ENSG00000112592	ENST00000616883	Q32MN6
ENSG00000112592	ENST00000636632	A0A1B0GVC6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Basal transcription factors	KEGG	ko03022
Huntington's disease	KEGG	ko05016
Basal transcription factors	KEGG	hsa03022
Huntington's disease	KEGG	hsa05016
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Transcription of the HIV genome	REACTOME	R-HSA-167172
HIV Transcription Initiation	REACTOME	R-HSA-167161
RNA Polymerase II HIV Promoter Escape	REACTOME	R-HSA-167162
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	REACTOME	R-HSA-504046
RNA Polymerase I Transcription	REACTOME	R-HSA-73864
RNA Polymerase I Promoter Clearance	REACTOME	R-HSA-73854
RNA Polymerase I Transcription Initiation	REACTOME	R-HSA-73762
RNA Polymerase I Promoter Escape	REACTOME	R-HSA-73772
RNA Polymerase I Chain Elongation	REACTOME	R-HSA-73777
RNA Polymerase I Transcription Termination	REACTOME	R-HSA-73863
RNA Polymerase III Transcription	REACTOME	R-HSA-74158
RNA Polymerase III Abortive And Retractive Initiation	REACTOME	R-HSA-749476
RNA Polymerase III Transcription Initiation	REACTOME	R-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 Promoter	REACTOME	R-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 Promoter	REACTOME	R-HSA-76066
RNA Polymerase III Transcription Initiation From Type 3 Promoter	REACTOME	R-HSA-76071
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Pre-transcription Events	REACTOME	R-HSA-674695
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	REACTOME	R-HSA-73779
RNA Polymerase II Transcription Initiation And Promoter Clearance	REACTOME	R-HSA-76042
RNA Polymerase II Transcription Initiation	REACTOME	R-HSA-75953
RNA Polymerase II Promoter Escape	REACTOME	R-HSA-73776
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
Negative epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250941
SIRT1 negatively regulates rRNA Expression	REACTOME	R-HSA-427359
NoRC negatively regulates rRNA expression	REACTOME	R-HSA-427413
Positive epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250913
B-WICH complex positively regulates rRNA expression	REACTOME	R-HSA-5250924
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756
RNA polymerase II transcribes snRNA genes	REACTOME	R-HSA-6807505

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17499043	2007	Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.	64
23332750	2013	Human TFIID binds to core promoter DNA in a reorganized structural state.	62
11809839	2002	TBP dynamics in living human cells: constitutive association of TBP with mitotic chromosomes.	61
18931662	2008	The TBP-PP2A mitotic complex bookmarks genes by preventing condensin action.	44
18765812	2008	Regulation of TATA-binding protein dynamics in living yeast cells.	41
12972251	2003	Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes.	35
21450820	2011	Herpes simplex virus 1 ICP4 forms complexes with TFIID and mediator in virus-infected cells.	30
12697807	2003	Increased expression of TATA-binding protein, the central transcription factor, can contribute to oncogenesis.	29
15545613	2004	TATA box binding protein induces structure in the recombinant glucocorticoid receptor AF1 domain.	29
17074809	2007	TBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation.	29

Citation

Dessen P

TBP (TATA-box binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42481/tbp