Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TBX21 (T-box transcription factor 21)

Identity

Alias (NCBI)T-PET
T-bet
TBET
TBLYM
HGNC (Hugo) TBX21
HGNC Alias symbTBLYM
T-bet
HGNC Previous nameT-box 21
LocusID (NCBI) 30009
Atlas_Id 46077
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 47733236 and ends at 47746122 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)TBX21   11599
Cards
Entrez_Gene (NCBI)TBX21    T-box transcription factor 21
AliasesT-PET; T-bet; TBET; TBLYM
GeneCards (Weizmann)TBX21
Ensembl hg19 (Hinxton)ENSG00000073861 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073861 [Gene_View]  ENSG00000073861 [Sequence]  chr17:47733236-47746122 [Contig_View]  TBX21 [Vega]
ICGC DataPortalENSG00000073861
TCGA cBioPortalTBX21
AceView (NCBI)TBX21
Genatlas (Paris)TBX21
SOURCE (Princeton)TBX21
Genetics Home Reference (NIH)TBX21
Genomic and cartography
GoldenPath hg38 (UCSC)TBX21  -     chr17:47733236-47746122 +  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBX21  -     17q21.32   [Description]    (hg19-Feb_2009)
GoldenPathTBX21 - 17q21.32 [CytoView hg19]  TBX21 - 17q21.32 [CytoView hg38]
ImmunoBaseENSG00000073861
genome Data Viewer NCBITBX21 [Mapview hg19]  
OMIM208550   604895   
Gene and transcription
Genbank (Entrez)AF093098 AF241243 AK223634 BC039739
RefSeq transcript (Entrez)NM_013351
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TBX21
Alternative Splicing GalleryENSG00000073861
Gene ExpressionTBX21 [ NCBI-GEO ]   TBX21 [ EBI - ARRAY_EXPRESS ]   TBX21 [ SEEK ]   TBX21 [ MEM ]
Gene Expression Viewer (FireBrowse)TBX21 [ Firebrowse - Broad ]
GenevisibleExpression of TBX21 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)30009
GTEX Portal (Tissue expression)TBX21
Human Protein AtlasENSG00000073861-TBX21 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UL17   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UL17  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UL17
Splice isoforms : SwissVarQ9UL17
PhosPhoSitePlusQ9UL17
Domaine pattern : Prosite (Expaxy)TBOX_1 (PS01283)    TBOX_2 (PS01264)    TBOX_3 (PS50252)   
Domains : Interpro (EBI)p53-like_TF_DNA-bd    T-box_sf    TF_T-box    TF_T-box_CS   
Domain families : Pfam (Sanger)T-box (PF00907)   
Domain families : Pfam (NCBI)pfam00907   
Domain families : Smart (EMBL)TBOX (SM00425)  
Conserved Domain (NCBI)TBX21
Blocks (Seattle)TBX21
SuperfamilyQ9UL17
Human Protein Atlas [tissue]ENSG00000073861-TBX21 [tissue]
Peptide AtlasQ9UL17
HPRD05355
IPIIPI00007732   
Protein Interaction databases
DIP (DOE-UCLA)Q9UL17
IntAct (EBI)Q9UL17
BioGRIDTBX21
STRING (EMBL)TBX21
ZODIACTBX21
Ontologies - Pathways
QuickGOQ9UL17
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  transcription regulatory region sequence-specific DNA binding  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II activating transcription factor binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  cell fate specification  heart looping  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  regulation of transcription, DNA-templated  multicellular organism development  response to virus  T cell differentiation  negative regulation of interleukin-2 production  neuronal cell body  proteasome-mediated ubiquitin-dependent protein catabolic process  sequence-specific DNA binding  regulation of T cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of isotype switching to IgG isotypes  cellular response to organic substance  lymphocyte migration  lymphocyte migration  negative regulation of T-helper 17 cell differentiation  negative regulation of T-helper 17 cell lineage commitment  negative regulation of T-helper 2 cell cytokine production  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  transcription regulatory region sequence-specific DNA binding  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II activating transcription factor binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  cell fate specification  heart looping  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  regulation of transcription, DNA-templated  multicellular organism development  response to virus  T cell differentiation  negative regulation of interleukin-2 production  neuronal cell body  proteasome-mediated ubiquitin-dependent protein catabolic process  sequence-specific DNA binding  regulation of T cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of isotype switching to IgG isotypes  cellular response to organic substance  lymphocyte migration  lymphocyte migration  negative regulation of T-helper 17 cell differentiation  negative regulation of T-helper 17 cell lineage commitment  negative regulation of T-helper 2 cell cytokine production  
Pathways : KEGGInflammatory bowel disease (IBD)   
NDEx NetworkTBX21
Atlas of Cancer Signalling NetworkTBX21
Wikipedia pathwaysTBX21
Orthology - Evolution
OrthoDB30009
GeneTree (enSembl)ENSG00000073861
Phylogenetic Trees/Animal Genes : TreeFamTBX21
HOGENOMQ9UL17
Homologs : HomoloGeneTBX21
Homology/Alignments : Family Browser (UCSC)TBX21
Gene fusions - Rearrangements
Fusion : QuiverTBX21
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBX21 [hg38]
dbVarTBX21
ClinVarTBX21
MonarchTBX21
1000_GenomesTBX21 
Exome Variant ServerTBX21
GNOMAD BrowserENSG00000073861
Varsome BrowserTBX21
Genomic Variants (DGV)TBX21 [DGVbeta]
DECIPHERTBX21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBX21 
Mutations
ICGC Data PortalTBX21 
TCGA Data PortalTBX21 
Broad Tumor PortalTBX21
OASIS PortalTBX21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBX21  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTBX21
Mutations and Diseases : HGMDTBX21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TBX21
DgiDB (Drug Gene Interaction Database)TBX21
DoCM (Curated mutations)TBX21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBX21 (select a term)
intoGenTBX21
Cancer3DTBX21(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM208550    604895   
Orphanet
DisGeNETTBX21
MedgenTBX21
Genetic Testing Registry TBX21
NextProtQ9UL17 [Medical]
GENETestsTBX21
Target ValidationTBX21
Huge Navigator TBX21 [HugePedia]
ClinGenTBX21
Clinical trials, drugs, therapy
MyCancerGenomeTBX21
Protein Interactions : CTD
Pharm GKB GenePA36362
PharosQ9UL17
Clinical trialTBX21
Miscellaneous
canSAR (ICR)TBX21 (select the gene name)
HarmonizomeTBX21
DataMed IndexTBX21
Probes
Litterature
PubMed205 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTBX21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jan 1 18:40:36 CET 2021

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