Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TBX21 (T-box 21)

Identity

Alias_symbol (synonym)TBLYM
T-bet
Other aliasT-PET
TBET
HGNC (Hugo) TBX21
LocusID (NCBI) 30009
Atlas_Id 46077
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 47733244 and ends at 47746119 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TBX21   11599
Cards
Entrez_Gene (NCBI)TBX21  30009  T-box 21
AliasesT-PET; T-bet; TBET; TBLYM
GeneCards (Weizmann)TBX21
Ensembl hg19 (Hinxton)ENSG00000073861 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073861 [Gene_View]  chr17:47733244-47746119 [Contig_View]  TBX21 [Vega]
ICGC DataPortalENSG00000073861
TCGA cBioPortalTBX21
AceView (NCBI)TBX21
Genatlas (Paris)TBX21
WikiGenes30009
SOURCE (Princeton)TBX21
Genetics Home Reference (NIH)TBX21
Genomic and cartography
GoldenPath hg38 (UCSC)TBX21  -     chr17:47733244-47746119 +  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBX21  -     17q21.32   [Description]    (hg19-Feb_2009)
EnsemblTBX21 - 17q21.32 [CytoView hg19]  TBX21 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBITBX21 [Mapview hg19]  TBX21 [Mapview hg38]
OMIM208550   604895   
Gene and transcription
Genbank (Entrez)AF093098 AF241243 AK223634 BC039739
RefSeq transcript (Entrez)NM_013351
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TBX21
Cluster EST : UnigeneHs.272409 [ NCBI ]
CGAP (NCI)Hs.272409
Alternative Splicing GalleryENSG00000073861
Gene ExpressionTBX21 [ NCBI-GEO ]   TBX21 [ EBI - ARRAY_EXPRESS ]   TBX21 [ SEEK ]   TBX21 [ MEM ]
Gene Expression Viewer (FireBrowse)TBX21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)30009
GTEX Portal (Tissue expression)TBX21
Human Protein AtlasENSG00000073861-TBX21 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UL17   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UL17  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UL17
Splice isoforms : SwissVarQ9UL17
PhosPhoSitePlusQ9UL17
Domaine pattern : Prosite (Expaxy)TBOX_1 (PS01283)    TBOX_2 (PS01264)    TBOX_3 (PS50252)   
Domains : Interpro (EBI)p53-like_TF_DNA-bd    TF_T-box    TF_T-box_CS   
Domain families : Pfam (Sanger)T-box (PF00907)   
Domain families : Pfam (NCBI)pfam00907   
Domain families : Smart (EMBL)TBOX (SM00425)  
Conserved Domain (NCBI)TBX21
DMDM Disease mutations30009
Blocks (Seattle)TBX21
SuperfamilyQ9UL17
Human Protein Atlas [tissue]ENSG00000073861-TBX21 [tissue]
Peptide AtlasQ9UL17
HPRD05355
IPIIPI00007732   
Protein Interaction databases
DIP (DOE-UCLA)Q9UL17
IntAct (EBI)Q9UL17
FunCoupENSG00000073861
BioGRIDTBX21
STRING (EMBL)TBX21
ZODIACTBX21
Ontologies - Pathways
QuickGOQ9UL17
Ontology : AmiGOtranscription factor activity, sequence-specific DNA binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  multicellular organism development  response to virus  T cell differentiation  neuronal cell body  transcription regulatory region DNA binding  positive regulation of transcription, DNA-templated  positive regulation of isotype switching to IgG isotypes  cellular response to organic substance  lymphocyte migration  
Ontology : EGO-EBItranscription factor activity, sequence-specific DNA binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  multicellular organism development  response to virus  T cell differentiation  neuronal cell body  transcription regulatory region DNA binding  positive regulation of transcription, DNA-templated  positive regulation of isotype switching to IgG isotypes  cellular response to organic substance  lymphocyte migration  
Pathways : KEGGInflammatory bowel disease (IBD)   
NDEx NetworkTBX21
Atlas of Cancer Signalling NetworkTBX21
Wikipedia pathwaysTBX21
Orthology - Evolution
OrthoDB30009
GeneTree (enSembl)ENSG00000073861
Phylogenetic Trees/Animal Genes : TreeFamTBX21
HOVERGENQ9UL17
HOGENOMQ9UL17
Homologs : HomoloGeneTBX21
Homology/Alignments : Family Browser (UCSC)TBX21
Gene fusions - Rearrangements
Tumor Fusion PortalTBX21
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBX21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBX21
dbVarTBX21
ClinVarTBX21
1000_GenomesTBX21 
Exome Variant ServerTBX21
ExAC (Exome Aggregation Consortium)ENSG00000073861
GNOMAD BrowserENSG00000073861
Genetic variants : HAPMAP30009
Genomic Variants (DGV)TBX21 [DGVbeta]
DECIPHERTBX21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBX21 
Mutations
ICGC Data PortalTBX21 
TCGA Data PortalTBX21 
Broad Tumor PortalTBX21
OASIS PortalTBX21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBX21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTBX21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TBX21
DgiDB (Drug Gene Interaction Database)TBX21
DoCM (Curated mutations)TBX21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBX21 (select a term)
intoGenTBX21
Cancer3DTBX21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM208550    604895   
Orphanet
DisGeNETTBX21
MedgenTBX21
Genetic Testing Registry TBX21
NextProtQ9UL17 [Medical]
TSGene30009
GENETestsTBX21
Target ValidationTBX21
Huge Navigator TBX21 [HugePedia]
snp3D : Map Gene to Disease30009
BioCentury BCIQTBX21
ClinGenTBX21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD30009
Chemical/Pharm GKB GenePA36362
Clinical trialTBX21
Miscellaneous
canSAR (ICR)TBX21 (select the gene name)
Probes
Litterature
PubMed166 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTBX21
EVEXTBX21
GoPubMedTBX21
iHOPTBX21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:37:54 CET 2017

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