TBXA2R (thromboxane A2 receptor)

2007-02-01 Affiliation

Identity

HGNC

TBXA2R

LOCATION

19p13.3

LOCUSID

6915

ALIAS

BDPLT13,TXA2-R

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6915
MIM: 188070
HGNC: 11608
Ensembl: ENSG00000006638

Variants:

dbSNP: 6915
ClinVar: 6915
TCGA: ENSG00000006638
COSMIC: TBXA2R

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000006638	ENST00000375190	P21731
ENSG00000006638	ENST00000411851	P21731
ENSG00000006638	ENST00000589966	K7ER80

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Platelet activation	KEGG	hsa04611
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Signal amplification	REACTOME	R-HSA-392518
Thromboxane signalling through TP receptor	REACTOME	R-HSA-428930
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Eicosanoid ligand-binding receptors	REACTOME	R-HSA-391903
Prostanoid ligand receptors	REACTOME	R-HSA-391908
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
G alpha (12/13) signalling events	REACTOME	R-HSA-416482
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA174	GNAQ	Gene	Pathway	associated		20938371
PA176	GNB3	Gene	Pathway	associated		20938371
PA28764	GNA11	Gene	Pathway	associated		20938371
PA28765	GNA12	Gene	Pathway	associated		20938371
PA28766	GNA13	Gene	Pathway	associated		20938371
PA28768	GNA15	Gene	Pathway	associated		20938371
PA443450	Asthma	Disease	ClinicalAnnotation	associated	PD	15898979
PA443890	Diabetes Mellitus, Type 2	Disease	ClinicalAnnotation	associated	PD
PA448497	aspirin	Chemical	ClinicalAnnotation	associated	PD	15898979, 17245331, 23688183

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
12796499	2003	Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases.	48
18063812	2008	Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide.	40
19247692	2009	Analyses of associations with asthma in four asthma population samples from Canada and Australia.	39
15471868	2004	Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation.	37
19264973	2009	Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.	36
16126723	2005	The intracellular trafficking of the G protein-coupled receptor TPbeta depends on a direct interaction with Rab11.	30
18802021	2008	Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis.	29
15242977	2004	Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration.	28
19570744	2009	Activation of thromboxane A(2) receptors induces orphan nuclear receptor Nurr1 expression and stimulates cell proliferation in human lung cancer cells.	24

Citation

Dessen P

TBXA2R (thromboxane A2 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43842/tbxa2r