Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TBXA2R (thromboxane A2 receptor)

Identity

Other aliasBDPLT13
TXA2-R
HGNC (Hugo) TBXA2R
LocusID (NCBI) 6915
Atlas_Id 43842
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 3594506 and ends at 3606833 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ERN1 (17q23.3) / TBXA2R (19p13.3)TBXA2R (19p13.3) / GIT2 (12q24.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TBXA2R   11608
LRG (Locus Reference Genomic)LRG_578
Cards
Entrez_Gene (NCBI)TBXA2R  6915  thromboxane A2 receptor
AliasesBDPLT13; TXA2-R
GeneCards (Weizmann)TBXA2R
Ensembl hg19 (Hinxton)ENSG00000006638 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006638 [Gene_View]  chr19:3594506-3606833 [Contig_View]  TBXA2R [Vega]
ICGC DataPortalENSG00000006638
TCGA cBioPortalTBXA2R
AceView (NCBI)TBXA2R
Genatlas (Paris)TBXA2R
WikiGenes6915
SOURCE (Princeton)TBXA2R
Genetics Home Reference (NIH)TBXA2R
Genomic and cartography
GoldenPath hg38 (UCSC)TBXA2R  -     chr19:3594506-3606833 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBXA2R  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblTBXA2R - 19p13.3 [CytoView hg19]  TBXA2R - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBITBXA2R [Mapview hg19]  TBXA2R [Mapview hg38]
OMIM188070   614009   
Gene and transcription
Genbank (Entrez)AY429110 BC028027 BC074749 BC074750 BC121148
RefSeq transcript (Entrez)NM_001060 NM_201636
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TBXA2R
Cluster EST : UnigeneHs.442530 [ NCBI ]
CGAP (NCI)Hs.442530
Alternative Splicing GalleryENSG00000006638
Gene ExpressionTBXA2R [ NCBI-GEO ]   TBXA2R [ EBI - ARRAY_EXPRESS ]   TBXA2R [ SEEK ]   TBXA2R [ MEM ]
Gene Expression Viewer (FireBrowse)TBXA2R [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6915
GTEX Portal (Tissue expression)TBXA2R
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21731   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21731  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21731
Splice isoforms : SwissVarP21731
PhosPhoSitePlusP21731
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Prostanoid_rcpt    Thbox_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)TBXA2R
DMDM Disease mutations6915
Blocks (Seattle)TBXA2R
PDB (SRS)1LBN   
PDB (PDBSum)1LBN   
PDB (IMB)1LBN   
PDB (RSDB)1LBN   
Structural Biology KnowledgeBase1LBN   
SCOP (Structural Classification of Proteins)1LBN   
CATH (Classification of proteins structures)1LBN   
SuperfamilyP21731
Human Protein AtlasENSG00000006638
Peptide AtlasP21731
HPRD01768
IPIIPI00745939   IPI00941797   IPI00896367   
Protein Interaction databases
DIP (DOE-UCLA)P21731
IntAct (EBI)P21731
FunCoupENSG00000006638
BioGRIDTBXA2R
STRING (EMBL)TBXA2R
ZODIACTBXA2R
Ontologies - Pathways
QuickGOP21731
Ontology : AmiGOacrosomal vesicle  thromboxane A2 receptor activity  guanyl-nucleotide exchange factor activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  response to nutrient  nuclear speck  positive regulation of blood coagulation  response to testosterone  thromboxane A2 signaling pathway  response to drug  positive regulation of GTPase activity  response to ethanol  positive regulation of angiogenesis  positive regulation of blood pressure  positive regulation of vasoconstriction  cellular response to lipopolysaccharide  
Ontology : EGO-EBIacrosomal vesicle  thromboxane A2 receptor activity  guanyl-nucleotide exchange factor activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  response to nutrient  nuclear speck  positive regulation of blood coagulation  response to testosterone  thromboxane A2 signaling pathway  response to drug  positive regulation of GTPase activity  response to ethanol  positive regulation of angiogenesis  positive regulation of blood pressure  positive regulation of vasoconstriction  cellular response to lipopolysaccharide  
Pathways : BIOCARTAEicosanoid Metabolism [Genes]   
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction   
NDEx NetworkTBXA2R
Atlas of Cancer Signalling NetworkTBXA2R
Wikipedia pathwaysTBXA2R
Orthology - Evolution
OrthoDB6915
GeneTree (enSembl)ENSG00000006638
Phylogenetic Trees/Animal Genes : TreeFamTBXA2R
HOVERGENP21731
HOGENOMP21731
Homologs : HomoloGeneTBXA2R
Homology/Alignments : Family Browser (UCSC)TBXA2R
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBXA2R [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBXA2R
dbVarTBXA2R
ClinVarTBXA2R
1000_GenomesTBXA2R 
Exome Variant ServerTBXA2R
ExAC (Exome Aggregation Consortium)TBXA2R (select the gene name)
Genetic variants : HAPMAP6915
Genomic Variants (DGV)TBXA2R [DGVbeta]
DECIPHERTBXA2R [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBXA2R 
Mutations
ICGC Data PortalTBXA2R 
TCGA Data PortalTBXA2R 
Broad Tumor PortalTBXA2R
OASIS PortalTBXA2R [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBXA2R  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTBXA2R
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TBXA2R
DgiDB (Drug Gene Interaction Database)TBXA2R
DoCM (Curated mutations)TBXA2R (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBXA2R (select a term)
intoGenTBXA2R
Cancer3DTBXA2R(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM188070    614009   
Orphanet18909   
MedgenTBXA2R
Genetic Testing Registry TBXA2R
NextProtP21731 [Medical]
TSGene6915
GENETestsTBXA2R
Target ValidationTBXA2R
Huge Navigator TBXA2R [HugePedia]
snp3D : Map Gene to Disease6915
BioCentury BCIQTBXA2R
ClinGenTBXA2R
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6915
Chemical/Pharm GKB GenePA348
Clinical trialTBXA2R
Miscellaneous
canSAR (ICR)TBXA2R (select the gene name)
Probes
Litterature
PubMed140 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTBXA2R
EVEXTBXA2R
GoPubMedTBXA2R
iHOPTBXA2R
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:58:49 CEST 2017

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