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TBXT (T-box transcription factor T)

Identity

Other aliasSAVA
T
TFT
HGNC (Hugo) TBXT
LocusID (NCBI) 6862
Atlas_Id 57327
Location 6q27  [Link to chromosome band 6q27]
Location_base_pair Starts at 166157656 and ends at 166168669 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)TBXT   11515
Cards
Entrez_Gene (NCBI)TBXT  6862  T-box transcription factor T
AliasesSAVA; T; TFT
GeneCards (Weizmann)TBXT
Ensembl hg19 (Hinxton)ENSG00000164458 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164458 [Gene_View]  ENSG00000164458 [Sequence]  chr6:166157656-166168669 [Contig_View]  TBXT [Vega]
ICGC DataPortalENSG00000164458
TCGA cBioPortalTBXT
AceView (NCBI)TBXT
Genatlas (Paris)TBXT
WikiGenes6862
SOURCE (Princeton)TBXT
Genetics Home Reference (NIH)TBXT
Genomic and cartography
GoldenPath hg38 (UCSC)TBXT  -     chr6:166157656-166168669 -  6q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBXT  -     6q27   [Description]    (hg19-Feb_2009)
EnsemblTBXT - 6q27 [CytoView hg19]  TBXT - 6q27 [CytoView hg38]
Mapping of homologs : NCBITBXT [Mapview hg19]  TBXT [Mapview hg38]
OMIM182940   601397   615709   
Gene and transcription
Genbank (Entrez)AJ001699 BC039877 BC098425 BE785653 BG436736
RefSeq transcript (Entrez)NM_001270484 NM_001366285 NM_001366286 NM_003181
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TBXT
Cluster EST : UnigeneHs.742027 [ NCBI ]
CGAP (NCI)Hs.742027
Alternative Splicing GalleryENSG00000164458
Gene ExpressionTBXT [ NCBI-GEO ]   TBXT [ EBI - ARRAY_EXPRESS ]   TBXT [ SEEK ]   TBXT [ MEM ]
Gene Expression Viewer (FireBrowse)TBXT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6862
GTEX Portal (Tissue expression)TBXT
Human Protein AtlasENSG00000164458-TBXT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15178   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15178  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15178
Splice isoforms : SwissVarO15178
PhosPhoSitePlusO15178
Domaine pattern : Prosite (Expaxy)TBOX_1 (PS01283)    TBOX_2 (PS01264)    TBOX_3 (PS50252)   
Domains : Interpro (EBI)p53-like_TF_DNA-bd    T-box_sf    TF_Brachyury    TF_T-box    TF_T-box_CS   
Domain families : Pfam (Sanger)T-box (PF00907)   
Domain families : Pfam (NCBI)pfam00907   
Domain families : Smart (EMBL)TBOX (SM00425)  
Conserved Domain (NCBI)TBXT
DMDM Disease mutations6862
Blocks (Seattle)TBXT
PDB (SRS)6F58    6F59   
PDB (PDBSum)6F58    6F59   
PDB (IMB)6F58    6F59   
PDB (RSDB)6F58    6F59   
Structural Biology KnowledgeBase6F58    6F59   
SCOP (Structural Classification of Proteins)6F58    6F59   
CATH (Classification of proteins structures)6F58    6F59   
SuperfamilyO15178
Human Protein Atlas [tissue]ENSG00000164458-TBXT [tissue]
Peptide AtlasO15178
IPIIPI00005203   IPI00619896   
Protein Interaction databases
DIP (DOE-UCLA)O15178
IntAct (EBI)O15178
FunCoupENSG00000164458
BioGRIDTBXT
STRING (EMBL)TBXT
ZODIACTBXT
Ontologies - Pathways
QuickGOO15178
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II transcription factor binding  RNA polymerase II activating transcription factor binding  vasculogenesis  somitogenesis  neural plate morphogenesis  neural tube closure  heart morphogenesis  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  DNA-binding transcription factor activity  nucleus  cytoplasm  signal transduction  penetration of zona pellucida  mesoderm development  mesoderm migration involved in gastrulation  positive regulation of cell proliferation  anterior/posterior axis specification, embryo  notochord formation  signal transduction involved in regulation of gene expression  BMP signaling pathway  post-anal tail morphogenesis  negative regulation of DNA-binding transcription factor activity  embryonic skeletal system development  canonical Wnt signaling pathway  bone morphogenesis  SMAD protein signal transduction  determination of heart left/right asymmetry  cellular response to retinoic acid  primitive streak formation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II transcription factor binding  RNA polymerase II activating transcription factor binding  vasculogenesis  somitogenesis  neural plate morphogenesis  neural tube closure  heart morphogenesis  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  DNA-binding transcription factor activity  nucleus  cytoplasm  signal transduction  penetration of zona pellucida  mesoderm development  mesoderm migration involved in gastrulation  positive regulation of cell proliferation  anterior/posterior axis specification, embryo  notochord formation  signal transduction involved in regulation of gene expression  BMP signaling pathway  post-anal tail morphogenesis  negative regulation of DNA-binding transcription factor activity  embryonic skeletal system development  canonical Wnt signaling pathway  bone morphogenesis  SMAD protein signal transduction  determination of heart left/right asymmetry  cellular response to retinoic acid  primitive streak formation  
NDEx NetworkTBXT
Atlas of Cancer Signalling NetworkTBXT
Wikipedia pathwaysTBXT
Orthology - Evolution
OrthoDB6862
GeneTree (enSembl)ENSG00000164458
Phylogenetic Trees/Animal Genes : TreeFamTBXT
HOVERGENO15178
HOGENOMO15178
Homologs : HomoloGeneTBXT
Homology/Alignments : Family Browser (UCSC)TBXT
Gene fusions - Rearrangements
Fusion : QuiverTBXT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBXT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBXT
dbVarTBXT
ClinVarTBXT
1000_GenomesTBXT 
Exome Variant ServerTBXT
ExAC (Exome Aggregation Consortium)ENSG00000164458
GNOMAD BrowserENSG00000164458
Varsome BrowserTBXT
Genetic variants : HAPMAP6862
Genomic Variants (DGV)TBXT [DGVbeta]
DECIPHERTBXT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBXT 
Mutations
ICGC Data PortalTBXT 
TCGA Data PortalTBXT 
Broad Tumor PortalTBXT
OASIS PortalTBXT [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTBXT
BioMutasearch TBXT
DgiDB (Drug Gene Interaction Database)TBXT
DoCM (Curated mutations)TBXT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBXT (select a term)
intoGenTBXT
Cancer3DTBXT(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182940    601397    615709   
Orphanet
DisGeNETTBXT
MedgenTBXT
Genetic Testing Registry TBXT
NextProtO15178 [Medical]
TSGene6862
GENETestsTBXT
Target ValidationTBXT
Huge Navigator TBXT [HugePedia]
snp3D : Map Gene to Disease6862
BioCentury BCIQTBXT
ClinGenTBXT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6862
Chemical/Pharm GKB GenePA36296
Clinical trialTBXT
Miscellaneous
canSAR (ICR)TBXT (select the gene name)
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTBXT
EVEXTBXT
GoPubMedTBXT
iHOPTBXT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:44:08 CET 2018

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