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TBXT (T-box transcription factor T)

Identity

Alias (NCBI)SAVA
T
TFT
HGNC (Hugo) TBXT
HGNC Previous nameT
HGNC Previous nameT, brachyury homolog (mouse)
 T brachyury transcription factor
LocusID (NCBI) 6862
Atlas_Id 57327
Location 6q27  [Link to chromosome band 6q27]
Location_base_pair Starts at 166157656 and ends at 166168669 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)TBXT   11515
Cards
Entrez_Gene (NCBI)TBXT    T-box transcription factor T
AliasesSAVA; T; TFT
GeneCards (Weizmann)TBXT
Ensembl hg19 (Hinxton)ENSG00000164458 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164458 [Gene_View]  ENSG00000164458 [Sequence]  chr6:166157656-166168669 [Contig_View]  TBXT [Vega]
ICGC DataPortalENSG00000164458
TCGA cBioPortalTBXT
AceView (NCBI)TBXT
Genatlas (Paris)TBXT
SOURCE (Princeton)TBXT
Genetics Home Reference (NIH)TBXT
Genomic and cartography
GoldenPath hg38 (UCSC)TBXT  -     chr6:166157656-166168669 -  6q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBXT  -     6q27   [Description]    (hg19-Feb_2009)
GoldenPathTBXT - 6q27 [CytoView hg19]  TBXT - 6q27 [CytoView hg38]
ImmunoBaseENSG00000164458
Genome Data Viewer NCBITBXT [Mapview hg19]  
OMIM182940   601397   615709   
Gene and transcription
Genbank (Entrez)AJ001699 BC039877 BC098425 BE785653 BG436736
RefSeq transcript (Entrez)NM_001270484 NM_001366285 NM_001366286 NM_003181
Consensus coding sequences : CCDS (NCBI)TBXT
Gene ExpressionTBXT [ NCBI-GEO ]   TBXT [ EBI - ARRAY_EXPRESS ]   TBXT [ SEEK ]   TBXT [ MEM ]
Gene Expression Viewer (FireBrowse)TBXT [ Firebrowse - Broad ]
GenevisibleExpression of TBXT in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6862
GTEX Portal (Tissue expression)TBXT
Human Protein AtlasENSG00000164458-TBXT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15178   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15178  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15178
PhosPhoSitePlusO15178
Domaine pattern : Prosite (Expaxy)TBOX_1 (PS01283)    TBOX_2 (PS01264)    TBOX_3 (PS50252)   
Domains : Interpro (EBI)p53-like_TF_DNA-bd    T-box_sf    TF_Brachyury    TF_T-box    TF_T-box_CS   
Domain families : Pfam (Sanger)T-box (PF00907)   
Domain families : Pfam (NCBI)pfam00907   
Domain families : Smart (EMBL)TBOX (SM00425)  
Conserved Domain (NCBI)TBXT
PDB (RSDB)5QRF    5QRG    5QRH    5QRI    5QRJ    5QRK    5QRL    5QRM    5QRN    5QRO    5QRP    5QRQ    5QRR    5QRS    5QRT    5QRU    5QRV    5QRW    5QRX    5QRY    5QRZ    5QS0    5QS1    5QS2    5QS3    5QS4    5QS5    5QS6    5QS7    5QS8    5QS9    5QSA    5QSB    5QSC    5QSD    5QSE    5QSF    5QSG    5QSH    5QSI    5QSJ    5QSK    5QSL    5QT0    6F58    6F59    6ZU8   
PDB Europe5QRF    5QRG    5QRH    5QRI    5QRJ    5QRK    5QRL    5QRM    5QRN    5QRO    5QRP    5QRQ    5QRR    5QRS    5QRT    5QRU    5QRV    5QRW    5QRX    5QRY    5QRZ    5QS0    5QS1    5QS2    5QS3    5QS4    5QS5    5QS6    5QS7    5QS8    5QS9    5QSA    5QSB    5QSC    5QSD    5QSE    5QSF    5QSG    5QSH    5QSI    5QSJ    5QSK    5QSL    5QT0    6F58    6F59    6ZU8   
PDB (PDBSum)5QRF    5QRG    5QRH    5QRI    5QRJ    5QRK    5QRL    5QRM    5QRN    5QRO    5QRP    5QRQ    5QRR    5QRS    5QRT    5QRU    5QRV    5QRW    5QRX    5QRY    5QRZ    5QS0    5QS1    5QS2    5QS3    5QS4    5QS5    5QS6    5QS7    5QS8    5QS9    5QSA    5QSB    5QSC    5QSD    5QSE    5QSF    5QSG    5QSH    5QSI    5QSJ    5QSK    5QSL    5QT0    6F58    6F59    6ZU8   
PDB (IMB)5QRF    5QRG    5QRH    5QRI    5QRJ    5QRK    5QRL    5QRM    5QRN    5QRO    5QRP    5QRQ    5QRR    5QRS    5QRT    5QRU    5QRV    5QRW    5QRX    5QRY    5QRZ    5QS0    5QS1    5QS2    5QS3    5QS4    5QS5    5QS6    5QS7    5QS8    5QS9    5QSA    5QSB    5QSC    5QSD    5QSE    5QSF    5QSG    5QSH    5QSI    5QSJ    5QSK    5QSL    5QT0    6F58    6F59    6ZU8   
Structural Biology KnowledgeBase5QRF    5QRG    5QRH    5QRI    5QRJ    5QRK    5QRL    5QRM    5QRN    5QRO    5QRP    5QRQ    5QRR    5QRS    5QRT    5QRU    5QRV    5QRW    5QRX    5QRY    5QRZ    5QS0    5QS1    5QS2    5QS3    5QS4    5QS5    5QS6    5QS7    5QS8    5QS9    5QSA    5QSB    5QSC    5QSD    5QSE    5QSF    5QSG    5QSH    5QSI    5QSJ    5QSK    5QSL    5QT0    6F58    6F59    6ZU8   
SCOP (Structural Classification of Proteins)5QRF    5QRG    5QRH    5QRI    5QRJ    5QRK    5QRL    5QRM    5QRN    5QRO    5QRP    5QRQ    5QRR    5QRS    5QRT    5QRU    5QRV    5QRW    5QRX    5QRY    5QRZ    5QS0    5QS1    5QS2    5QS3    5QS4    5QS5    5QS6    5QS7    5QS8    5QS9    5QSA    5QSB    5QSC    5QSD    5QSE    5QSF    5QSG    5QSH    5QSI    5QSJ    5QSK    5QSL    5QT0    6F58    6F59    6ZU8   
CATH (Classification of proteins structures)5QRF    5QRG    5QRH    5QRI    5QRJ    5QRK    5QRL    5QRM    5QRN    5QRO    5QRP    5QRQ    5QRR    5QRS    5QRT    5QRU    5QRV    5QRW    5QRX    5QRY    5QRZ    5QS0    5QS1    5QS2    5QS3    5QS4    5QS5    5QS6    5QS7    5QS8    5QS9    5QSA    5QSB    5QSC    5QSD    5QSE    5QSF    5QSG    5QSH    5QSI    5QSJ    5QSK    5QSL    5QT0    6F58    6F59    6ZU8   
SuperfamilyO15178
AlphaFold pdb e-kbO15178   
Human Protein Atlas [tissue]ENSG00000164458-TBXT [tissue]
Protein Interaction databases
DIP (DOE-UCLA)O15178
IntAct (EBI)O15178
BioGRIDTBXT
STRING (EMBL)TBXT
ZODIACTBXT
Ontologies - Pathways
QuickGOO15178
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  mesoderm formation  cell fate specification  somitogenesis  heart morphogenesis  heart morphogenesis  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  DNA-binding transcription factor activity  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  signal transduction  mesoderm development  anterior/posterior axis specification, embryo  negative regulation of DNA-binding transcription factor activity  RNA polymerase II-specific DNA-binding transcription factor binding  RNA polymerase II-specific DNA-binding transcription factor binding  primitive streak formation  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  mesoderm formation  cell fate specification  somitogenesis  heart morphogenesis  heart morphogenesis  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  DNA-binding transcription factor activity  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  signal transduction  mesoderm development  anterior/posterior axis specification, embryo  negative regulation of DNA-binding transcription factor activity  RNA polymerase II-specific DNA-binding transcription factor binding  RNA polymerase II-specific DNA-binding transcription factor binding  primitive streak formation  sequence-specific double-stranded DNA binding  
NDEx NetworkTBXT
Atlas of Cancer Signalling NetworkTBXT
Wikipedia pathwaysTBXT
Orthology - Evolution
OrthoDB6862
GeneTree (enSembl)ENSG00000164458
Phylogenetic Trees/Animal Genes : TreeFamTBXT
Homologs : HomoloGeneTBXT
Homology/Alignments : Family Browser (UCSC)TBXT
Gene fusions - Rearrangements
Fusion : QuiverTBXT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBXT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBXT
dbVarTBXT
ClinVarTBXT
MonarchTBXT
1000_GenomesTBXT 
Exome Variant ServerTBXT
GNOMAD BrowserENSG00000164458
Varsome BrowserTBXT
ACMGTBXT variants
VarityO15178
Genomic Variants (DGV)TBXT [DGVbeta]
DECIPHERTBXT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBXT 
Mutations
ICGC Data PortalTBXT 
TCGA Data PortalTBXT 
Broad Tumor PortalTBXT
OASIS PortalTBXT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBXT  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTBXT
Mutations and Diseases : HGMDTBXT
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTBXT
DgiDB (Drug Gene Interaction Database)TBXT
DoCM (Curated mutations)TBXT
CIViC (Clinical Interpretations of Variants in Cancer)TBXT
Cancer3DTBXT
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182940    601397    615709   
Orphanet
DisGeNETTBXT
MedgenTBXT
Genetic Testing Registry TBXT
NextProtO15178 [Medical]
GENETestsTBXT
Target ValidationTBXT
Huge Navigator TBXT [HugePedia]
ClinGenTBXT
Clinical trials, drugs, therapy
MyCancerGenomeTBXT
Protein Interactions : CTDTBXT
Pharm GKB GenePA36296
PharosO15178
Clinical trialTBXT
Miscellaneous
canSAR (ICR)TBXT
HarmonizomeTBXT
DataMed IndexTBXT
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTBXT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:34:32 CEST 2021

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