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TCF15 (transcription factor 15)

Identity

Alias (NCBI)EC2
PARAXIS
bHLHa40
HGNC (Hugo) TCF15
HGNC Alias symbEC2
PARAXIS
bHLHa40
HGNC Previous nametranscription factor 15 (basic helix-loop-helix)
LocusID (NCBI) 6939
Atlas_Id 50541
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 603993 and ends at 610266 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TCF15   11627
Cards
Entrez_Gene (NCBI)TCF15    transcription factor 15
AliasesEC2; PARAXIS; bHLHa40
GeneCards (Weizmann)TCF15
Ensembl hg19 (Hinxton)ENSG00000125878 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125878 [Gene_View]  ENSG00000125878 [Sequence]  chr20:603993-610266 [Contig_View]  TCF15 [Vega]
ICGC DataPortalENSG00000125878
TCGA cBioPortalTCF15
AceView (NCBI)TCF15
Genatlas (Paris)TCF15
SOURCE (Princeton)TCF15
Genetics Home Reference (NIH)TCF15
Genomic and cartography
GoldenPath hg38 (UCSC)TCF15  -     chr20:603993-610266 -  20p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TCF15  -     20p13   [Description]    (hg19-Feb_2009)
GoldenPathTCF15 - 20p13 [CytoView hg19]  TCF15 - 20p13 [CytoView hg38]
ImmunoBaseENSG00000125878
Genome Data Viewer NCBITCF15 [Mapview hg19]  
OMIM601010   
Gene and transcription
Genbank (Entrez)AI218364 AW290965 BC067836 U08336
RefSeq transcript (Entrez)NM_004609
Consensus coding sequences : CCDS (NCBI)TCF15
Gene ExpressionTCF15 [ NCBI-GEO ]   TCF15 [ EBI - ARRAY_EXPRESS ]   TCF15 [ SEEK ]   TCF15 [ MEM ]
Gene Expression Viewer (FireBrowse)TCF15 [ Firebrowse - Broad ]
GenevisibleExpression of TCF15 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6939
GTEX Portal (Tissue expression)TCF15
Human Protein AtlasENSG00000125878-TCF15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12870   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12870  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12870
PhosPhoSitePlusQ12870
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom    HLH_DNA-bd_sf   
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)TCF15
SuperfamilyQ12870
AlphaFold pdb e-kbQ12870   
Human Protein Atlas [tissue]ENSG00000125878-TCF15 [tissue]
HPRD03003
Protein Interaction databases
DIP (DOE-UCLA)Q12870
IntAct (EBI)Q12870
BioGRIDTCF15
STRING (EMBL)TCF15
ZODIACTCF15
Ontologies - Pathways
QuickGOQ12870
Ontology : AmiGOchromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  somitogenesis  respiratory system process  DNA-binding transcription factor activity  nucleus  regulation of transcription by RNA polymerase II  mesoderm development  stem cell population maintenance  developmental process  post-anal tail morphogenesis  eating behavior  bHLH transcription factor binding  ear development  skin development  establishment of epithelial cell apical/basal polarity  positive regulation of transcription by RNA polymerase II  protein dimerization activity  paraxial mesoderm development  muscle organ morphogenesis  skeletal system morphogenesis  neuromuscular process controlling posture  mesenchymal to epithelial transition  E-box binding  RNA polymerase II transcription regulator complex  negative regulation of hematopoietic stem cell differentiation  regulation of extracellular matrix organization  positive regulation of stem cell differentiation  
Ontology : EGO-EBIchromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  somitogenesis  respiratory system process  DNA-binding transcription factor activity  nucleus  regulation of transcription by RNA polymerase II  mesoderm development  stem cell population maintenance  developmental process  post-anal tail morphogenesis  eating behavior  bHLH transcription factor binding  ear development  skin development  establishment of epithelial cell apical/basal polarity  positive regulation of transcription by RNA polymerase II  protein dimerization activity  paraxial mesoderm development  muscle organ morphogenesis  skeletal system morphogenesis  neuromuscular process controlling posture  mesenchymal to epithelial transition  E-box binding  RNA polymerase II transcription regulator complex  negative regulation of hematopoietic stem cell differentiation  regulation of extracellular matrix organization  positive regulation of stem cell differentiation  
NDEx NetworkTCF15
Atlas of Cancer Signalling NetworkTCF15
Wikipedia pathwaysTCF15
Orthology - Evolution
OrthoDB6939
GeneTree (enSembl)ENSG00000125878
Phylogenetic Trees/Animal Genes : TreeFamTCF15
Homologs : HomoloGeneTCF15
Homology/Alignments : Family Browser (UCSC)TCF15
Gene fusions - Rearrangements
Fusion : QuiverTCF15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCF15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCF15
dbVarTCF15
ClinVarTCF15
MonarchTCF15
1000_GenomesTCF15 
Exome Variant ServerTCF15
GNOMAD BrowserENSG00000125878
Varsome BrowserTCF15
ACMGTCF15 variants
VarityQ12870
Genomic Variants (DGV)TCF15 [DGVbeta]
DECIPHERTCF15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTCF15 
Mutations
ICGC Data PortalTCF15 
TCGA Data PortalTCF15 
Broad Tumor PortalTCF15
OASIS PortalTCF15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCF15  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTCF15
Mutations and Diseases : HGMDTCF15
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTCF15
DgiDB (Drug Gene Interaction Database)TCF15
DoCM (Curated mutations)TCF15
CIViC (Clinical Interpretations of Variants in Cancer)TCF15
Cancer3DTCF15
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601010   
Orphanet
DisGeNETTCF15
MedgenTCF15
Genetic Testing Registry TCF15
NextProtQ12870 [Medical]
GENETestsTCF15
Target ValidationTCF15
Huge Navigator TCF15 [HugePedia]
ClinGenTCF15
Clinical trials, drugs, therapy
MyCancerGenomeTCF15
Protein Interactions : CTDTCF15
Pharm GKB GenePA36382
PharosQ12870
Clinical trialTCF15
Miscellaneous
canSAR (ICR)TCF15
HarmonizomeTCF15
DataMed IndexTCF15
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTCF15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:34:34 CEST 2021

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