Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TCF21 (transcription factor 21)

Identity

Alias (NCBI)POD1
bHLHa23
HGNC (Hugo) TCF21
HGNC Alias symbPOD1
bHLHa23
LocusID (NCBI) 6943
Atlas_Id 45561
Location 6q23.2  [Link to chromosome band 6q23]
Location_base_pair Starts at 133889113 and ends at 133895537 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)TCF21   11632
LRG (Locus Reference Genomic)LRG_446
Cards
Entrez_Gene (NCBI)TCF21  6943  transcription factor 21
AliasesPOD1; bHLHa23
GeneCards (Weizmann)TCF21
Ensembl hg19 (Hinxton)ENSG00000118526 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118526 [Gene_View]  ENSG00000118526 [Sequence]  chr6:133889113-133895537 [Contig_View]  TCF21 [Vega]
ICGC DataPortalENSG00000118526
TCGA cBioPortalTCF21
AceView (NCBI)TCF21
Genatlas (Paris)TCF21
WikiGenes6943
SOURCE (Princeton)TCF21
Genetics Home Reference (NIH)TCF21
Genomic and cartography
GoldenPath hg38 (UCSC)TCF21  -     chr6:133889113-133895537 +  6q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TCF21  -     6q23.2   [Description]    (hg19-Feb_2009)
GoldenPathTCF21 - 6q23.2 [CytoView hg19]  TCF21 - 6q23.2 [CytoView hg38]
ImmunoBaseENSG00000118526
genome Data Viewer NCBITCF21 [Mapview hg19]  
OMIM603306   
Gene and transcription
Genbank (Entrez)AF035718 AF047419 AK091844 AL550251 BC025697
RefSeq transcript (Entrez)NM_003206 NM_198392
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TCF21
Alternative Splicing GalleryENSG00000118526
Gene ExpressionTCF21 [ NCBI-GEO ]   TCF21 [ EBI - ARRAY_EXPRESS ]   TCF21 [ SEEK ]   TCF21 [ MEM ]
Gene Expression Viewer (FireBrowse)TCF21 [ Firebrowse - Broad ]
GenevisibleExpression of TCF21 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6943
GTEX Portal (Tissue expression)TCF21
Human Protein AtlasENSG00000118526-TCF21 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43680   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43680  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43680
Splice isoforms : SwissVarO43680
PhosPhoSitePlusO43680
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom    HLH_DNA-bd_sf   
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)TCF21
DMDM Disease mutations6943
Blocks (Seattle)TCF21
SuperfamilyO43680
Human Protein Atlas [tissue]ENSG00000118526-TCF21 [tissue]
Peptide AtlasO43680
HPRD04493
IPIIPI00306587   
Protein Interaction databases
DIP (DOE-UCLA)O43680
IntAct (EBI)O43680
FunCoupENSG00000118526
BioGRIDTCF21
STRING (EMBL)TCF21
ZODIACTCF21
Ontologies - Pathways
QuickGOO43680
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  ureteric bud development  branching involved in ureteric bud morphogenesis  morphogenesis of a branching structure  kidney development  vasculature development  nucleus  nucleus  regulation of transcription by RNA polymerase II  sex determination  branchiomeric skeletal muscle development  epithelial cell differentiation  developmental process  glomerulus development  histone deacetylase binding  bHLH transcription factor binding  positive regulation of transcription by RNA polymerase II  protein dimerization activity  lung alveolus development  spleen development  embryonic digestive tract morphogenesis  reproductive structure development  gland development  androgen receptor binding  Sertoli cell differentiation  roof of mouth development  lung morphogenesis  lung vasculature development  bronchiole development  diaphragm development  respiratory system development  negative regulation of androgen receptor signaling pathway  E-box binding  metanephric mesenchymal cell differentiation  metanephric glomerular capillary formation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  ureteric bud development  branching involved in ureteric bud morphogenesis  morphogenesis of a branching structure  kidney development  vasculature development  nucleus  nucleus  regulation of transcription by RNA polymerase II  sex determination  branchiomeric skeletal muscle development  epithelial cell differentiation  developmental process  glomerulus development  histone deacetylase binding  bHLH transcription factor binding  positive regulation of transcription by RNA polymerase II  protein dimerization activity  lung alveolus development  spleen development  embryonic digestive tract morphogenesis  reproductive structure development  gland development  androgen receptor binding  Sertoli cell differentiation  roof of mouth development  lung morphogenesis  lung vasculature development  bronchiole development  diaphragm development  respiratory system development  negative regulation of androgen receptor signaling pathway  E-box binding  metanephric mesenchymal cell differentiation  metanephric glomerular capillary formation  
NDEx NetworkTCF21
Atlas of Cancer Signalling NetworkTCF21
Wikipedia pathwaysTCF21
Orthology - Evolution
OrthoDB6943
GeneTree (enSembl)ENSG00000118526
Phylogenetic Trees/Animal Genes : TreeFamTCF21
HOGENOMO43680
Homologs : HomoloGeneTCF21
Homology/Alignments : Family Browser (UCSC)TCF21
Gene fusions - Rearrangements
Fusion : QuiverTCF21
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCF21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCF21
dbVarTCF21
ClinVarTCF21
MonarchTCF21
1000_GenomesTCF21 
Exome Variant ServerTCF21
GNOMAD BrowserENSG00000118526
Varsome BrowserTCF21
Genetic variants : HAPMAP6943
Genomic Variants (DGV)TCF21 [DGVbeta]
DECIPHERTCF21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTCF21 
Mutations
ICGC Data PortalTCF21 
TCGA Data PortalTCF21 
Broad Tumor PortalTCF21
OASIS PortalTCF21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCF21  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTCF21
Mutations and Diseases : HGMDTCF21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TCF21
DgiDB (Drug Gene Interaction Database)TCF21
DoCM (Curated mutations)TCF21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TCF21 (select a term)
intoGenTCF21
Cancer3DTCF21(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603306   
Orphanet
DisGeNETTCF21
MedgenTCF21
Genetic Testing Registry TCF21
NextProtO43680 [Medical]
TSGene6943
GENETestsTCF21
Target ValidationTCF21
Huge Navigator TCF21 [HugePedia]
snp3D : Map Gene to Disease6943
BioCentury BCIQTCF21
ClinGenTCF21
Clinical trials, drugs, therapy
Protein Interactions : CTD6943
Pharm GKB GenePA36387
Clinical trialTCF21
Miscellaneous
canSAR (ICR)TCF21 (select the gene name)
HarmonizomeTCF21
DataMed IndexTCF21
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTCF21
EVEXTCF21
GoPubMedTCF21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:35:37 CEST 2020

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