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TCF7 (transcription factor 7 (T-cell specific, HMG-box))

Identity

Alias_symbol (synonym)TCF-1
Other alias
HGNC (Hugo) TCF7
LocusID (NCBI) 6932
Atlas_Id 42494
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 133451298 and ends at 133483920 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TCF7 (5q31.1) / MPHOSPH9 (12q24.31)TCF7 (5q31.1) / MTPAP (10p11.23)TCF7 (5q31.1) / S100A14 (1q21.3)
TCF7 (5q31.1) / TOR1AIP2 (1q25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TCF7   11639
Cards
Entrez_Gene (NCBI)TCF7  6932  transcription factor 7 (T-cell specific, HMG-box)
AliasesTCF-1
GeneCards (Weizmann)TCF7
Ensembl hg19 (Hinxton)ENSG00000081059 [Gene_View]  chr5:133451298-133483920 [Contig_View]  TCF7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000081059 [Gene_View]  chr5:133451298-133483920 [Contig_View]  TCF7 [Vega]
ICGC DataPortalENSG00000081059
TCGA cBioPortalTCF7
AceView (NCBI)TCF7
Genatlas (Paris)TCF7
WikiGenes6932
SOURCE (Princeton)TCF7
Genetics Home Reference (NIH)TCF7
Genomic and cartography
GoldenPath hg19 (UCSC)TCF7  -     chr5:133451298-133483920 +  5q31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TCF7  -     5q31.1   [Description]    (hg38-Dec_2013)
EnsemblTCF7 - 5q31.1 [CytoView hg19]  TCF7 - 5q31.1 [CytoView hg38]
Mapping of homologs : NCBITCF7 [Mapview hg19]  TCF7 [Mapview hg38]
OMIM189908   
Gene and transcription
Genbank (Entrez)AK057580 AK093530 AK093683 AK131428 AK310591
RefSeq transcript (Entrez)NM_001134851 NM_001134852 NM_003202 NM_201632 NM_201634 NM_213648
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_030367 NT_034772 NW_004929323
Consensus coding sequences : CCDS (NCBI)TCF7
Cluster EST : UnigeneHs.573153 [ NCBI ]
CGAP (NCI)Hs.573153
Alternative Splicing GalleryENSG00000081059
Gene ExpressionTCF7 [ NCBI-GEO ]   TCF7 [ EBI - ARRAY_EXPRESS ]   TCF7 [ SEEK ]   TCF7 [ MEM ]
Gene Expression Viewer (FireBrowse)TCF7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6932
GTEX Portal (Tissue expression)TCF7
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36402   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36402  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36402
Splice isoforms : SwissVarP36402
PhosPhoSitePlusP36402
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)Catenin_binding_dom    CTNNB1-bd_N    HMG_box_dom    TCF/LEF   
Domain families : Pfam (Sanger)CTNNB1_binding (PF08347)    HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam08347    pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)TCF7
DMDM Disease mutations6932
Blocks (Seattle)TCF7
SuperfamilyP36402
Human Protein AtlasENSG00000081059
Peptide AtlasP36402
HPRD01797
IPIIPI00003325   IPI00477635   IPI00479759   IPI00477092   IPI00478950   IPI00479370   IPI00478219   IPI00334125   IPI00385101   IPI00219960   IPI00219961   IPI00219962   IPI00402002   IPI00219964   IPI00219965   IPI00478992   IPI00976178   IPI00976158   IPI00973771   IPI00978938   IPI00980238   IPI00974251   IPI00978840   IPI00978134   IPI00981575   IPI00979543   
Protein Interaction databases
DIP (DOE-UCLA)P36402
IntAct (EBI)P36402
FunCoupENSG00000081059
BioGRIDTCF7
STRING (EMBL)TCF7
ZODIACTCF7
Ontologies - Pathways
QuickGOP36402
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  core promoter binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  protein binding  nucleus  nucleoplasm  transcription factor complex  nuclear euchromatin  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  immune response  beta-catenin binding  neural tube development  embryonic genitalia morphogenesis  T cell receptor V(D)J recombination  regulation of cell proliferation  sequence-specific DNA binding  transcription regulatory region DNA binding  canonical Wnt signaling pathway involved in negative regulation of apoptotic process  alpha-beta T cell differentiation  embryonic digestive tract morphogenesis  embryonic hindgut morphogenesis  canonical Wnt signaling pathway  cellular response to interleukin-4  beta-catenin-TCF complex assembly  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  core promoter binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  protein binding  nucleus  nucleoplasm  transcription factor complex  nuclear euchromatin  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  immune response  beta-catenin binding  neural tube development  embryonic genitalia morphogenesis  T cell receptor V(D)J recombination  regulation of cell proliferation  sequence-specific DNA binding  transcription regulatory region DNA binding  canonical Wnt signaling pathway involved in negative regulation of apoptotic process  alpha-beta T cell differentiation  embryonic digestive tract morphogenesis  embryonic hindgut morphogenesis  canonical Wnt signaling pathway  cellular response to interleukin-4  beta-catenin-TCF complex assembly  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Adherens junction    Melanogenesis    Pathways in cancer    Colorectal cancer    Endometrial cancer    Prostate cancer    Thyroid cancer    Basal cell carcinoma    Acute myeloid leukemia    Arrhythmogenic right ventricular cardiomyopathy (ARVC)   
NDEx NetworkTCF7
Atlas of Cancer Signalling NetworkTCF7
Wikipedia pathwaysTCF7
Orthology - Evolution
OrthoDB6932
GeneTree (enSembl)ENSG00000081059
Phylogenetic Trees/Animal Genes : TreeFamTCF7
HOVERGENP36402
HOGENOMP36402
Homologs : HomoloGeneTCF7
Homology/Alignments : Family Browser (UCSC)TCF7
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCF7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCF7
dbVarTCF7
ClinVarTCF7
1000_GenomesTCF7 
Exome Variant ServerTCF7
ExAC (Exome Aggregation Consortium)TCF7 (select the gene name)
Genetic variants : HAPMAP6932
Genomic Variants (DGV)TCF7 [DGVbeta]
DECIPHER (Syndromes)5:133451298-133483920  ENSG00000081059
CONAN: Copy Number AnalysisTCF7 
Mutations
ICGC Data PortalTCF7 
TCGA Data PortalTCF7 
Broad Tumor PortalTCF7
OASIS PortalTCF7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCF7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTCF7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TCF7
DgiDB (Drug Gene Interaction Database)TCF7
DoCM (Curated mutations)TCF7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TCF7 (select a term)
intoGenTCF7
Cancer3DTCF7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM189908   
Orphanet
MedgenTCF7
Genetic Testing Registry TCF7
NextProtP36402 [Medical]
TSGene6932
GENETestsTCF7
Huge Navigator TCF7 [HugePedia]
snp3D : Map Gene to Disease6932
BioCentury BCIQTCF7
ClinGenTCF7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6932
Chemical/Pharm GKB GenePA36392
Clinical trialTCF7
Miscellaneous
canSAR (ICR)TCF7 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTCF7
EVEXTCF7
GoPubMedTCF7
iHOPTCF7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:30:37 CET 2017

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