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TCF7 (transcription factor 7)

Identity

Alias (NCBI)TCF-1
HGNC (Hugo) TCF7
HGNC Alias symbTCF-1
HGNC Alias nameT-cell-factor-7
HGNC Previous nametranscription factor 7 (T-cell specific, HMG-box)
LocusID (NCBI) 6932
Atlas_Id 42494
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 134115613 and ends at 134148210 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TCF7 (5q31.1) / MPHOSPH9 (12q24.31)TCF7 (5q31.1) / MTPAP (10p11.23)TCF7 (5q31.1) / S100A14 (1q21.3)
TCF7 (5q31.1) / TOR1AIP2 (1q25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  del(5q) in acute lymphoblastic leukemia (ALL)
t(5;11)(q31;p11) TCF7/SPI1


External links

 

Nomenclature
HGNC (Hugo)TCF7   11639
Cards
Entrez_Gene (NCBI)TCF7    transcription factor 7
AliasesTCF-1
GeneCards (Weizmann)TCF7
Ensembl hg19 (Hinxton)ENSG00000081059 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000081059 [Gene_View]  ENSG00000081059 [Sequence]  chr5:134115613-134148210 [Contig_View]  TCF7 [Vega]
ICGC DataPortalENSG00000081059
TCGA cBioPortalTCF7
AceView (NCBI)TCF7
Genatlas (Paris)TCF7
SOURCE (Princeton)TCF7
Genetics Home Reference (NIH)TCF7
Genomic and cartography
GoldenPath hg38 (UCSC)TCF7  -     chr5:134115613-134148210 +  5q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TCF7  -     5q31.1   [Description]    (hg19-Feb_2009)
GoldenPathTCF7 - 5q31.1 [CytoView hg19]  TCF7 - 5q31.1 [CytoView hg38]
ImmunoBaseENSG00000081059
Genome Data Viewer NCBITCF7 [Mapview hg19]  
OMIM189908   
Gene and transcription
Genbank (Entrez)AK057580 AK093530 AK093683 AK131428 AK310591
RefSeq transcript (Entrez)NM_001134851 NM_001134852 NM_001346425 NM_001346450 NM_001366502 NM_003202 NM_201632 NM_201634 NM_213648
Consensus coding sequences : CCDS (NCBI)TCF7
Gene ExpressionTCF7 [ NCBI-GEO ]   TCF7 [ EBI - ARRAY_EXPRESS ]   TCF7 [ SEEK ]   TCF7 [ MEM ]
Gene Expression Viewer (FireBrowse)TCF7 [ Firebrowse - Broad ]
GenevisibleExpression of TCF7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6932
GTEX Portal (Tissue expression)TCF7
Human Protein AtlasENSG00000081059-TCF7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36402   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36402  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36402
PhosPhoSitePlusP36402
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)Catenin-bd_sf    CTNNB1-bd_N    HMG_box_dom    HMG_box_dom_sf    TCF/LEF    Tcf7   
Domain families : Pfam (Sanger)CTNNB1_binding (PF08347)    HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam08347    pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)TCF7
SuperfamilyP36402
AlphaFold pdb e-kbP36402   
Human Protein Atlas [tissue]ENSG00000081059-TCF7 [tissue]
HPRD01797
Protein Interaction databases
DIP (DOE-UCLA)P36402
IntAct (EBI)P36402
BioGRIDTCF7
STRING (EMBL)TCF7
ZODIACTCF7
Ontologies - Pathways
QuickGOP36402
Ontology : AmiGOtranscription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  immune response  beta-catenin binding  nuclear body  T cell receptor V(D)J recombination  gamma-delta T cell differentiation  regulation of gamma-delta T cell differentiation  negative regulation of transcription, DNA-templated  canonical Wnt signaling pathway  cellular response to interleukin-4  beta-catenin-TCF complex assembly  sequence-specific double-stranded DNA binding  beta-catenin-TCF complex  
Ontology : EGO-EBItranscription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  immune response  beta-catenin binding  nuclear body  T cell receptor V(D)J recombination  gamma-delta T cell differentiation  regulation of gamma-delta T cell differentiation  negative regulation of transcription, DNA-templated  canonical Wnt signaling pathway  cellular response to interleukin-4  beta-catenin-TCF complex assembly  sequence-specific double-stranded DNA binding  beta-catenin-TCF complex  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Adherens junction    Melanogenesis    Pathways in cancer    Colorectal cancer    Endometrial cancer    Prostate cancer    Thyroid cancer    Basal cell carcinoma    Acute myeloid leukemia    Arrhythmogenic right ventricular cardiomyopathy (ARVC)   
NDEx NetworkTCF7
Atlas of Cancer Signalling NetworkTCF7
Wikipedia pathwaysTCF7
Orthology - Evolution
OrthoDB6932
GeneTree (enSembl)ENSG00000081059
Phylogenetic Trees/Animal Genes : TreeFamTCF7
Homologs : HomoloGeneTCF7
Homology/Alignments : Family Browser (UCSC)TCF7
Gene fusions - Rearrangements
Fusion : QuiverTCF7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCF7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCF7
dbVarTCF7
ClinVarTCF7
MonarchTCF7
1000_GenomesTCF7 
Exome Variant ServerTCF7
GNOMAD BrowserENSG00000081059
Varsome BrowserTCF7
ACMGTCF7 variants
VarityP36402
Genomic Variants (DGV)TCF7 [DGVbeta]
DECIPHERTCF7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTCF7 
Mutations
ICGC Data PortalTCF7 
TCGA Data PortalTCF7 
Broad Tumor PortalTCF7
OASIS PortalTCF7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCF7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTCF7
Mutations and Diseases : HGMDTCF7
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTCF7
DgiDB (Drug Gene Interaction Database)TCF7
DoCM (Curated mutations)TCF7
CIViC (Clinical Interpretations of Variants in Cancer)TCF7
Cancer3DTCF7
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM189908   
Orphanet
DisGeNETTCF7
MedgenTCF7
Genetic Testing Registry TCF7
NextProtP36402 [Medical]
GENETestsTCF7
Target ValidationTCF7
Huge Navigator TCF7 [HugePedia]
ClinGenTCF7
Clinical trials, drugs, therapy
MyCancerGenomeTCF7
Protein Interactions : CTDTCF7
Pharm GKB GenePA36392
PharosP36402
Clinical trialTCF7
Miscellaneous
canSAR (ICR)TCF7
HarmonizomeTCF7
DataMed IndexTCF7
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTCF7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:34:35 CEST 2021

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