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TCF7L1 (transcription factor 7 like 1)

Identity

Alias (NCBI)TCF-3
TCF3
HGNC (Hugo) TCF7L1
HGNC Previous nameTCF3
HGNC Previous nametranscription factor 7-like 1 (T-cell specific, HMG-box)
LocusID (NCBI) 83439
Atlas_Id 42495
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 85133392 and ends at 85310387 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELMOD3 (2p11.2) / TCF7L1 (2p11.2)EPAS1 (2p21) / TCF7L1 (2p11.2)KCNAB1 (3q25.31) / TCF7L1 (2p11.2)
NAV2 (11p15.1) / TCF7L1 (2p11.2)NOP2 (12p13.31) / TCF7L1 (2p11.2)PBX1 (1q23.3) / TCF7L1 (2p11.2)
SLC4A1 (17q21.31) / TCF7L1 (2p11.2)TCF7L1 (2p11.2) / DAZAP1 (19p13.3)TCF7L1 (2p11.2) / DNAH6 (2p11.2)
TCF7L1 (2p11.2) / EPAS1 (2p21)TCF7L1 (2p11.2) / PBX1 (1q23.3)TCF7L1 (2p11.2) / TCF7L1 (2p11.2)
TCF7L1 (2p11.2) / TFPT (19q13.42)TCF7L1 (2p11.2) / WIF1 (12q14.3)TFPT (19q13.42) / TCF7L1 (2p11.2)
ELMOD3 2p11.2 / TCF7L1 2p11.2TCF7L1 2p11.2 / DNAH6 2p11.2TCF7L1 2p11.2 / WIF1 12q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TCF7L1   11640
Cards
Entrez_Gene (NCBI)TCF7L1    transcription factor 7 like 1
AliasesTCF-3; TCF3
GeneCards (Weizmann)TCF7L1
Ensembl hg19 (Hinxton)ENSG00000152284 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152284 [Gene_View]  ENSG00000152284 [Sequence]  chr2:85133392-85310387 [Contig_View]  TCF7L1 [Vega]
ICGC DataPortalENSG00000152284
TCGA cBioPortalTCF7L1
AceView (NCBI)TCF7L1
Genatlas (Paris)TCF7L1
SOURCE (Princeton)TCF7L1
Genetics Home Reference (NIH)TCF7L1
Genomic and cartography
GoldenPath hg38 (UCSC)TCF7L1  -     chr2:85133392-85310387 +  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TCF7L1  -     2p11.2   [Description]    (hg19-Feb_2009)
GoldenPathTCF7L1 - 2p11.2 [CytoView hg19]  TCF7L1 - 2p11.2 [CytoView hg38]
ImmunoBaseENSG00000152284
Genome Data Viewer NCBITCF7L1 [Mapview hg19]  
OMIM604652   
Gene and transcription
Genbank (Entrez)AB031046 BC058894 BF434361
RefSeq transcript (Entrez)NM_031283
Consensus coding sequences : CCDS (NCBI)TCF7L1
Gene ExpressionTCF7L1 [ NCBI-GEO ]   TCF7L1 [ EBI - ARRAY_EXPRESS ]   TCF7L1 [ SEEK ]   TCF7L1 [ MEM ]
Gene Expression Viewer (FireBrowse)TCF7L1 [ Firebrowse - Broad ]
GenevisibleExpression of TCF7L1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83439
GTEX Portal (Tissue expression)TCF7L1
Human Protein AtlasENSG00000152284-TCF7L1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCS4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCS4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCS4
PhosPhoSitePlusQ9HCS4
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)Catenin-bd_sf    CTNNB1-bd_N    HMG_box_dom    HMG_box_dom_sf    TCF/LEF    Tcf7l1   
Domain families : Pfam (Sanger)CTNNB1_binding (PF08347)    HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam08347    pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)TCF7L1
SuperfamilyQ9HCS4
AlphaFold pdb e-kbQ9HCS4   
Human Protein Atlas [tissue]ENSG00000152284-TCF7L1 [tissue]
HPRD06874
Protein Interaction databases
DIP (DOE-UCLA)Q9HCS4
IntAct (EBI)Q9HCS4
BioGRIDTCF7L1
STRING (EMBL)TCF7L1
ZODIACTCF7L1
Ontologies - Pathways
QuickGOQ9HCS4
Ontology : AmiGORNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  DNA-binding transcription factor activity  nucleus  nucleoplasm  nucleoplasm  cytosol  chromatin organization  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  beta-catenin binding  regulation of Wnt signaling pathway  canonical Wnt signaling pathway  beta-catenin-TCF complex assembly  sequence-specific double-stranded DNA binding  beta-catenin-TCF complex  
Ontology : EGO-EBIRNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  DNA-binding transcription factor activity  nucleus  nucleoplasm  nucleoplasm  cytosol  chromatin organization  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  beta-catenin binding  regulation of Wnt signaling pathway  canonical Wnt signaling pathway  beta-catenin-TCF complex assembly  sequence-specific double-stranded DNA binding  beta-catenin-TCF complex  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Adherens junction    Melanogenesis    Pathways in cancer    Colorectal cancer    Endometrial cancer    Prostate cancer    Thyroid cancer    Basal cell carcinoma    Acute myeloid leukemia    Arrhythmogenic right ventricular cardiomyopathy (ARVC)   
NDEx NetworkTCF7L1
Atlas of Cancer Signalling NetworkTCF7L1
Wikipedia pathwaysTCF7L1
Orthology - Evolution
OrthoDB83439
GeneTree (enSembl)ENSG00000152284
Phylogenetic Trees/Animal Genes : TreeFamTCF7L1
Homologs : HomoloGeneTCF7L1
Homology/Alignments : Family Browser (UCSC)TCF7L1
Gene fusions - Rearrangements
Fusion : MitelmanELMOD3/TCF7L1 [2p11.2/2p11.2]  
Fusion : MitelmanNAV2/TCF7L1 [11p15.1/2p11.2]  
Fusion : MitelmanTCF7L1/DNAH6 [2p11.2/2p11.2]  
Fusion : MitelmanTCF7L1/WIF1 [2p11.2/12q14.3]  
Fusion : QuiverTCF7L1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCF7L1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCF7L1
dbVarTCF7L1
ClinVarTCF7L1
MonarchTCF7L1
1000_GenomesTCF7L1 
Exome Variant ServerTCF7L1
GNOMAD BrowserENSG00000152284
Varsome BrowserTCF7L1
ACMGTCF7L1 variants
VarityQ9HCS4
Genomic Variants (DGV)TCF7L1 [DGVbeta]
DECIPHERTCF7L1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTCF7L1 
Mutations
ICGC Data PortalTCF7L1 
TCGA Data PortalTCF7L1 
Broad Tumor PortalTCF7L1
OASIS PortalTCF7L1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCF7L1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTCF7L1
Mutations and Diseases : HGMDTCF7L1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTCF7L1
DgiDB (Drug Gene Interaction Database)TCF7L1
DoCM (Curated mutations)TCF7L1
CIViC (Clinical Interpretations of Variants in Cancer)TCF7L1
Cancer3DTCF7L1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604652   
Orphanet
DisGeNETTCF7L1
MedgenTCF7L1
Genetic Testing Registry TCF7L1
NextProtQ9HCS4 [Medical]
GENETestsTCF7L1
Target ValidationTCF7L1
Huge Navigator TCF7L1 [HugePedia]
ClinGenTCF7L1
Clinical trials, drugs, therapy
MyCancerGenomeTCF7L1
Protein Interactions : CTDTCF7L1
Pharm GKB GenePA36393
PharosQ9HCS4
Clinical trialTCF7L1
Miscellaneous
canSAR (ICR)TCF7L1
HarmonizomeTCF7L1
DataMed IndexTCF7L1
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTCF7L1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:34:35 CEST 2021

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