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TCF7L1 (transcription factor 7 like 1)

Identity

Alias_namesTCF3
transcription factor 7-like 1 (T-cell specific
Other aliasTCF-3
HGNC (Hugo) TCF7L1
LocusID (NCBI) 83439
Atlas_Id 42495
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 85133460 and ends at 85310388 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELMOD3 (2p11.2) / TCF7L1 (2p11.2)EPAS1 (2p21) / TCF7L1 (2p11.2)KCNAB1 (3q25.31) / TCF7L1 (2p11.2)
NAV2 (11p15.1) / TCF7L1 (2p11.2)NOP2 (12p13.31) / TCF7L1 (2p11.2)PBX1 (1q23.3) / TCF7L1 (2p11.2)
SLC4A1 (17q21.31) / TCF7L1 (2p11.2)TCF7L1 (2p11.2) / DAZAP1 (19p13.3)TCF7L1 (2p11.2) / DNAH6 (2p11.2)
TCF7L1 (2p11.2) / EPAS1 (2p21)TCF7L1 (2p11.2) / PBX1 (1q23.3)TCF7L1 (2p11.2) / TCF7L1 (2p11.2)
TCF7L1 (2p11.2) / TFPT (19q13.42)TCF7L1 (2p11.2) / WIF1 (12q14.3)TFPT (19q13.42) / TCF7L1 (2p11.2)
ELMOD3 2p11.2 / TCF7L1 2p11.2TCF7L1 2p11.2 / DNAH6 2p11.2TCF7L1 2p11.2 / WIF1 12q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TCF7L1   11640
Cards
Entrez_Gene (NCBI)TCF7L1  83439  transcription factor 7 like 1
AliasesTCF-3; TCF3
GeneCards (Weizmann)TCF7L1
Ensembl hg19 (Hinxton)ENSG00000152284 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152284 [Gene_View]  chr2:85133460-85310388 [Contig_View]  TCF7L1 [Vega]
ICGC DataPortalENSG00000152284
TCGA cBioPortalTCF7L1
AceView (NCBI)TCF7L1
Genatlas (Paris)TCF7L1
WikiGenes83439
SOURCE (Princeton)TCF7L1
Genetics Home Reference (NIH)TCF7L1
Genomic and cartography
GoldenPath hg38 (UCSC)TCF7L1  -     chr2:85133460-85310388 +  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TCF7L1  -     2p11.2   [Description]    (hg19-Feb_2009)
EnsemblTCF7L1 - 2p11.2 [CytoView hg19]  TCF7L1 - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBITCF7L1 [Mapview hg19]  TCF7L1 [Mapview hg38]
OMIM604652   
Gene and transcription
Genbank (Entrez)AB031046 BC058894 BF434361
RefSeq transcript (Entrez)NM_031283
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TCF7L1
Cluster EST : UnigeneHs.516297 [ NCBI ]
CGAP (NCI)Hs.516297
Alternative Splicing GalleryENSG00000152284
Gene ExpressionTCF7L1 [ NCBI-GEO ]   TCF7L1 [ EBI - ARRAY_EXPRESS ]   TCF7L1 [ SEEK ]   TCF7L1 [ MEM ]
Gene Expression Viewer (FireBrowse)TCF7L1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83439
GTEX Portal (Tissue expression)TCF7L1
Human Protein AtlasENSG00000152284-TCF7L1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCS4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCS4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCS4
Splice isoforms : SwissVarQ9HCS4
PhosPhoSitePlusQ9HCS4
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)Catenin_binding_dom    CTNNB1-bd_N    HMG_box_dom    TCF/LEF    Tcf7l1   
Domain families : Pfam (Sanger)CTNNB1_binding (PF08347)    HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam08347    pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)TCF7L1
DMDM Disease mutations83439
Blocks (Seattle)TCF7L1
SuperfamilyQ9HCS4
Human Protein Atlas [tissue]ENSG00000152284-TCF7L1 [tissue]
Peptide AtlasQ9HCS4
HPRD06874
IPIIPI00010396   IPI00926801   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCS4
IntAct (EBI)Q9HCS4
FunCoupENSG00000152284
BioGRIDTCF7L1
STRING (EMBL)TCF7L1
ZODIACTCF7L1
Ontologies - Pathways
QuickGOQ9HCS4
Ontology : AmiGODNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytosol  chromatin organization  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  beta-catenin binding  regulation of Wnt signaling pathway  sequence-specific DNA binding  transcription regulatory region DNA binding  canonical Wnt signaling pathway  beta-catenin-TCF complex assembly  
Ontology : EGO-EBIDNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytosol  chromatin organization  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  beta-catenin binding  regulation of Wnt signaling pathway  sequence-specific DNA binding  transcription regulatory region DNA binding  canonical Wnt signaling pathway  beta-catenin-TCF complex assembly  
Pathways : KEGG   
NDEx NetworkTCF7L1
Atlas of Cancer Signalling NetworkTCF7L1
Wikipedia pathwaysTCF7L1
Orthology - Evolution
OrthoDB83439
GeneTree (enSembl)ENSG00000152284
Phylogenetic Trees/Animal Genes : TreeFamTCF7L1
HOVERGENQ9HCS4
HOGENOMQ9HCS4
Homologs : HomoloGeneTCF7L1
Homology/Alignments : Family Browser (UCSC)TCF7L1
Gene fusions - Rearrangements
Fusion : MitelmanELMOD3/TCF7L1 [2p11.2/2p11.2]  [t(2;2)(p11;p11)]  
Fusion : MitelmanNAV2/TCF7L1 [11p15.1/2p11.2]  [t(2;11)(p11;p15)]  
Fusion : MitelmanTCF7L1/DNAH6 [2p11.2/2p11.2]  [t(2;2)(p11;p11)]  
Fusion : MitelmanTCF7L1/WIF1 [2p11.2/12q14.3]  [t(2;12)(p11;q14)]  
Fusion: TCGA_MDACCELMOD3 2p11.2 TCF7L1 2p11.2 BRCA
Fusion: TCGA_MDACCTCF7L1 2p11.2 DNAH6 2p11.2 LUAD
Fusion: TCGA_MDACCTCF7L1 2p11.2 WIF1 12q14.3 BRCA
Tumor Fusion PortalTCF7L1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCF7L1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCF7L1
dbVarTCF7L1
ClinVarTCF7L1
1000_GenomesTCF7L1 
Exome Variant ServerTCF7L1
ExAC (Exome Aggregation Consortium)ENSG00000152284
GNOMAD BrowserENSG00000152284
Genetic variants : HAPMAP83439
Genomic Variants (DGV)TCF7L1 [DGVbeta]
DECIPHERTCF7L1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTCF7L1 
Mutations
ICGC Data PortalTCF7L1 
TCGA Data PortalTCF7L1 
Broad Tumor PortalTCF7L1
OASIS PortalTCF7L1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCF7L1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTCF7L1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TCF7L1
DgiDB (Drug Gene Interaction Database)TCF7L1
DoCM (Curated mutations)TCF7L1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TCF7L1 (select a term)
intoGenTCF7L1
Cancer3DTCF7L1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604652   
Orphanet
DisGeNETTCF7L1
MedgenTCF7L1
Genetic Testing Registry TCF7L1
NextProtQ9HCS4 [Medical]
TSGene83439
GENETestsTCF7L1
Target ValidationTCF7L1
Huge Navigator TCF7L1 [HugePedia]
snp3D : Map Gene to Disease83439
BioCentury BCIQTCF7L1
ClinGenTCF7L1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83439
Chemical/Pharm GKB GenePA36393
Clinical trialTCF7L1
Miscellaneous
canSAR (ICR)TCF7L1 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTCF7L1
EVEXTCF7L1
GoPubMedTCF7L1
iHOPTCF7L1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:37:58 CET 2017

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