| Nomenclature | | HGNC (Hugo) | TCF7L2 11641 |
| Cards | | Entrez_Gene (NCBI) | TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box) |
| GeneCards (Weizmann) | TCF7L2 |
| Ensembl (Hinxton) | ENSG00000148737 [Gene_View] chr10:114710009-114927436 [Contig_View] TCF7L2 [Vega] |
| ICGC DataPortal | ENSG00000148737 |
| cBioPortal | TCF7L2 |
| AceView (NCBI) | TCF7L2 |
| Genatlas (Paris) | TCF7L2 |
| WikiGenes | 6934 |
| SOURCE (Princeton) | NM_001146274 NM_001146283 NM_001146284 NM_001146285 NM_001146286 NM_001198525 NM_001198526 NM_001198527 NM_001198528 NM_001198529 NM_001198530 NM_001198531 NM_030756 |
| Genomic and cartography | | GoldenPath (UCSC) | TCF7L2 - 10q25.2 chr10:114710009-114927436 + 10q25.2 [Description] (hg19-Feb_2009) |
| Ensembl | TCF7L2 - 10q25.2 [CytoView] |
| Mapping of homologs : NCBI | TCF7L2 [Mapview] |
| OMIM | 125853 602228 |
| Gene and transcription |
| Genbank (Entrez) | AB034691 AB440195 AB451266 AK074705 AK225809 |
| RefSeq transcript (Entrez) | NM_001146274 NM_001146283 NM_001146284 NM_001146285 NM_001146286 NM_001198525 NM_001198526 NM_001198527 NM_001198528 NM_001198529 NM_001198530 NM_001198531 NM_030756 |
| RefSeq genomic (Entrez) | AC_000142 NC_000010 NC_018921 NG_012631 NT_030059 NW_001838006 NW_004929376 |
| Consensus coding sequences : CCDS (NCBI) | TCF7L2 |
| Cluster EST : Unigene | Hs.593995 [ NCBI ] |
| CGAP (NCI) | Hs.593995 |
| Alternative Splicing : Fast-db (Paris) | GSHG0003692 |
| Alternative Splicing Gallery | ENSG00000148737 |
| Gene Expression | TCF7L2 [ NCBI-GEO ] TCF7L2 [ SEEK ] TCF7L2 [ MEM ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9NQB0 (Uniprot) |
| NextProt | Q9NQB0 [Medical] |
| With graphics : InterPro | Q9NQB0 |
| Splice isoforms : SwissVar | Q9NQB0 (Swissvar) |
| Domaine pattern : Prosite (Expaxy) | HMG_BOX_2 (PS50118) |
| Domains : Interpro (EBI) | Catenin_binding_dom [organisation] CTNNB1-bd_N [organisation] HMG_box_dom [organisation] TCF/LEF [organisation] TCF7L2 [organisation] |
| Related proteins : CluSTr | Q9NQB0 |
| Domain families : Pfam (Sanger) | CTNNB1_binding (PF08347) HMG_box (PF00505) |
| Domain families : Pfam (NCBI) | pfam08347 pfam00505 |
| Domain families : Smart (EMBL) | HMG (SM00398) |
| DMDM Disease mutations | 6934 |
| Blocks (Seattle) | Q9NQB0 |
| PDB (SRS) | 1JDH 1JPW 2GL7 |
| PDB (PDBSum) | 1JDH 1JPW 2GL7 |
| PDB (IMB) | 1JDH 1JPW 2GL7 |
| PDB (RSDB) | 1JDH 1JPW 2GL7 |
| Human Protein Atlas | ENSG00000148737 [gene] [tissue] [antibody] [cell] [cancer] |
| Peptide Atlas | Q9NQB0 |
| HPRD | 03751 |
| IPI | IPI00164708 IPI00335587 IPI00221004 IPI00221005 IPI00221006 IPI00221007 IPI00221008 IPI00221009 IPI00221010 IPI00221011 IPI01014645 IPI00479483 IPI00937155 IPI00641691 IPI00975648 IPI00983769 IPI00944473 IPI00479038 IPI00552531 IPI01011684 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9NQB0 |
| IntAct (EBI) | Q9NQB0 |
| FunCoup | ENSG00000148737 |
| BioGRID | TCF7L2 |
| InParanoid | Q9NQB0 |
| Interologous Interaction database | Q9NQB0 |
| IntegromeDB | TCF7L2 |
| STRING (EMBL) | TCF7L2 |
| Ontologies - Pathways | | Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II repressing transcription factor binding blood vessel development chromatin binding sequence-specific DNA binding transcription factor activity protein binding nucleus nucleoplasm nucleoplasm transcription factor complex nucleolus cytoplasm transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell cycle arrest brain development beta-catenin binding beta-catenin binding transcription factor binding cell proliferation response to glucose positive regulation of heparan sulfate proteoglycan biosynthetic process oligodendrocyte development PML body protein kinase binding neural tube development pituitary gland development bone mineralization negative regulation of BMP signaling pathway embryonic genitalia morphogenesis pancreas development regulation of myelination positive regulation of insulin secretion positive regulation of insulin secretion positive regulation of protein binding secretory granule localization regulation of hormone metabolic process protein-DNA complex somatic stem cell maintenance nuclear hormone receptor binding catenin import into nucleus negative regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth glucose homeostasis positive regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding sequence-specific DNA binding maintenance of DNA repeat elements skin development transcription regulatory region DNA binding canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition gamma-catenin binding fat cell differentiation negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of organ growth positive regulation of protein export from nucleus embryonic digestive tract morphogenesis embryonic hindgut morphogenesis myoblast fate commitment regulation of skeletal muscle tissue development regulation of smooth muscle cell proliferation generation of neurons regulation of oligodendrocyte differentiation positive regulation of epithelial cell proliferation positive regulation of protein kinase B signaling canonical Wnt signaling pathway face morphogenesis regulation of insulin secretion involved in cellular response to glucose stimulus armadillo repeat domain binding beta-catenin-TCF7L2 complex negative regulation of canonical Wnt signaling pathway negative regulation of type B pancreatic cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II repressing transcription factor binding blood vessel development chromatin binding sequence-specific DNA binding transcription factor activity protein binding nucleus nucleoplasm nucleoplasm transcription factor complex nucleolus cytoplasm transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell cycle arrest brain development beta-catenin binding beta-catenin binding transcription factor binding cell proliferation response to glucose positive regulation of heparan sulfate proteoglycan biosynthetic process oligodendrocyte development PML body protein kinase binding neural tube development pituitary gland development bone mineralization negative regulation of BMP signaling pathway embryonic genitalia morphogenesis pancreas development regulation of myelination positive regulation of insulin secretion positive regulation of insulin secretion positive regulation of protein binding secretory granule localization regulation of hormone metabolic process protein-DNA complex somatic stem cell maintenance nuclear hormone receptor binding catenin import into nucleus negative regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth glucose homeostasis positive regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding sequence-specific DNA binding maintenance of DNA repeat elements skin development transcription regulatory region DNA binding canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition gamma-catenin binding fat cell differentiation negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of organ growth positive regulation of protein export from nucleus embryonic digestive tract morphogenesis embryonic hindgut morphogenesis myoblast fate commitment regulation of skeletal muscle tissue development regulation of smooth muscle cell proliferation generation of neurons regulation of oligodendrocyte differentiation positive regulation of epithelial cell proliferation positive regulation of protein kinase B signaling canonical Wnt signaling pathway face morphogenesis regulation of insulin secretion involved in cellular response to glucose stimulus armadillo repeat domain binding beta-catenin-TCF7L2 complex negative regulation of canonical Wnt signaling pathway negative regulation of type B pancreatic cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway |
| Pathways : KEGG | Wnt signaling pathway Hippo signaling pathway Adherens junction Melanogenesis Pathways in cancer Colorectal cancer Endometrial cancer Prostate cancer Thyroid cancer Basal cell carcinoma Acute myeloid leukemia Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| Protein Interaction Database | TCF7L2 |
| Wikipedia pathways | TCF7L2 |
| Gene fusion - rearrangments | | Rearrangement : COSMIC | VTI1A [10q25.2] - TCF7L2 [10q25.2] |
| |
[COSF1147] [COSF1148] [COSF1149] [COSF1150] [COSF1151] [COSF1152] [COSF1153] [COSF1154] |
| Polymorphisms : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | TCF7L2 |
| snp3D : Map Gene to Disease | 6934 |
| SNP (GeneSNP Utah) | TCF7L2 |
| SNP : HGBase | TCF7L2 |
| Genetic variants : HAPMAP | TCF7L2 |
| Exome Variant | TCF7L2 |
| 1000_Genomes | TCF7L2 |
| ICGC program | ENSG00000148737 |
| Cancer Gene: Census | TCF7L2 |
| Somatic Mutations in Cancer : COSMIC | TCF7L2 |
| CONAN: Copy Number Analysis | TCF7L2 |
| Mutations and Diseases : HGMD | TCF7L2 |
| Genomic Variants | TCF7L2 TCF7L2 [DGVbeta] |
| dbVar | TCF7L2 |
| ClinVar | TCF7L2 |
| Pred. of missenses | PolyPhen-2 SIFT(SG) SIFT(JCVI) Align-GVGD MutAssessor Mutanalyser |
| Pred. splices | GeneSplicer Human Splicing Finder MaxEntScan |
| Diseases | | OMIM | 125853 602228 |
| Medgen | TCF7L2 |
| GENETests | TCF7L2 |
| Disease Genetic Association | TCF7L2 |
| Huge Navigator |
TCF7L2 [HugePedia] TCF7L2 [HugeCancerGEM] |
| General knowledge |
|---|
| Homologs : HomoloGene | TCF7L2 |
| Homology/Alignments : Family Browser (UCSC) | TCF7L2 |
| Phylogenetic Trees/Animal Genes : TreeFam | TCF7L2 |
| Chemical/Protein Interactions : CTD | 6934 |
| Chemical/Pharm GKB Gene | PA36394 |
| Clinical trial | TCF7L2 |
| Cancer Resource (Charite) | ENSG00000148737 |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 482 Pubmed reference(s) in Entrez |
| CoreMine | TCF7L2 |
| iHOP | TCF7L2 |
| OncoSearch | TCF7L2 |
