Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TCF7L2 (transcription factor 7-like 2 (T-cell specific, HMG-box))

Identity

Other namesTCF-4
TCF4
HGNC (Hugo) TCF7L2
LocusID (NCBI) 6934
Location 10q25.2
Location_base_pair Starts at 114710009 and ends at 114927436 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TCF7L2   11641
Cards
Entrez_Gene (NCBI)TCF7L2  6934  transcription factor 7-like 2 (T-cell specific, HMG-box)
GeneCards (Weizmann)TCF7L2
Ensembl (Hinxton)ENSG00000148737 [Gene_View]  chr10:114710009-114927436 [Contig_View]  TCF7L2 [Vega]
AceView (NCBI)TCF7L2
Genatlas (Paris)TCF7L2
WikiGenes6934
SOURCE (Princeton)NM_001146274 NM_001146283 NM_001146284 NM_001146285 NM_001146286 NM_001198525 NM_001198526 NM_001198527 NM_001198528 NM_001198529 NM_001198530 NM_001198531 NM_030756
Genomic and cartography
GoldenPath (UCSC)TCF7L2  -  10q25.2   chr10:114710009-114927436 +  10q25.2   [Description]    (hg19-Feb_2009)
EnsemblTCF7L2 - 10q25.2 [CytoView]
Mapping of homologs : NCBITCF7L2 [Mapview]
OMIM125853   602228   
Gene and transcription
Genbank (Entrez)AB034691 AB440195 AB451266 AK074705 AK225809
RefSeq transcript (Entrez)NM_001146274 NM_001146283 NM_001146284 NM_001146285 NM_001146286 NM_001198525 NM_001198526 NM_001198527 NM_001198528 NM_001198529 NM_001198530 NM_001198531 NM_030756
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_012631 NT_030059 NW_001838006 NW_004929376
Consensus coding sequences : CCDS (NCBI)TCF7L2
Cluster EST : UnigeneHs.593995 [ NCBI ]
CGAP (NCI)Hs.593995
Alternative Splicing : Fast-db (Paris)GSHG0003692
Alternative Splicing GalleryENSG00000148737
Gene ExpressionTCF7L2 [ NCBI-GEO ]     TCF7L2 [ SEEK ]   TCF7L2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQB0 (Uniprot)
NextProtQ9NQB0  [Medical]
With graphics : InterProQ9NQB0
Splice isoforms : SwissVarQ9NQB0 (Swissvar)
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)Catenin_binding_dom    CTNNB1-bd_N    HMG_box_dom    TCF/LEF   
Related proteins : CluSTrQ9NQB0
Domain families : Pfam (Sanger)CTNNB1_binding (PF08347)    HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam08347    pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
DMDM Disease mutations6934
Blocks (Seattle)Q9NQB0
PDB (SRS)1JDH    1JPW    2GL7   
PDB (PDBSum)1JDH    1JPW    2GL7   
PDB (IMB)1JDH    1JPW    2GL7   
PDB (RSDB)1JDH    1JPW    2GL7   
Human Protein AtlasENSG00000148737
Peptide AtlasQ9NQB0
HPRD03751
IPIIPI00164708   IPI00335587   IPI00221004   IPI00221005   IPI00221006   IPI00221007   IPI00221008   IPI00221009   IPI00221010   IPI00221011   IPI01014645   IPI00479483   IPI00937155   IPI00641691   IPI00975648   IPI00983769   IPI00944473   IPI00479038   IPI00552531   IPI01011684   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQB0
IntAct (EBI)Q9NQB0
FunCoupENSG00000148737
BioGRIDTCF7L2
InParanoidQ9NQB0
Interologous Interaction database Q9NQB0
IntegromeDBTCF7L2
STRING (EMBL)TCF7L2
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II repressing transcription factor binding  blood vessel development  chromatin binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  nucleoplasm  transcription factor complex  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  cell cycle arrest  brain development  beta-catenin binding  beta-catenin binding  transcription factor binding  cell proliferation  response to glucose  positive regulation of heparan sulfate proteoglycan biosynthetic process  oligodendrocyte development  PML body  protein kinase binding  neural tube development  pituitary gland development  bone mineralization  negative regulation of BMP signaling pathway  embryonic genitalia morphogenesis  pancreas development  regulation of myelination  positive regulation of insulin secretion  positive regulation of insulin secretion  positive regulation of protein binding  secretory granule localization  regulation of hormone metabolic process  protein-DNA complex  somatic stem cell maintenance  nuclear hormone receptor binding  catenin import into nucleus  negative regulation of fibroblast growth factor receptor signaling pathway  odontogenesis of dentin-containing tooth  glucose homeostasis  positive regulation of apoptotic process  negative regulation of sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding  sequence-specific DNA binding  maintenance of DNA repeat elements  skin development  transcription regulatory region DNA binding  canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition  gamma-catenin binding  fat cell differentiation  negative regulation of fat cell differentiation  negative regulation of transcription, DNA-dependent  negative regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  negative regulation of organ growth  positive regulation of protein export from nucleus  embryonic digestive tract morphogenesis  embryonic hindgut morphogenesis  myoblast fate commitment  regulation of skeletal muscle tissue development  regulation of smooth muscle cell proliferation  generation of neurons  regulation of oligodendrocyte differentiation  positive regulation of epithelial cell proliferation  positive regulation of protein kinase B signaling cascade  canonical Wnt receptor signaling pathway  face morphogenesis  regulation of insulin secretion involved in cellular response to glucose stimulus  armadillo repeat domain binding  beta-catenin-TCF7L2 complex  negative regulation of canonical Wnt receptor signaling pathway  negative regulation of type B pancreatic cell apoptotic process  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II repressing transcription factor binding  blood vessel development  chromatin binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  nucleoplasm  transcription factor complex  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  cell cycle arrest  brain development  beta-catenin binding  beta-catenin binding  transcription factor binding  cell proliferation  response to glucose  positive regulation of heparan sulfate proteoglycan biosynthetic process  oligodendrocyte development  PML body  protein kinase binding  neural tube development  pituitary gland development  bone mineralization  negative regulation of BMP signaling pathway  embryonic genitalia morphogenesis  pancreas development  regulation of myelination  positive regulation of insulin secretion  positive regulation of insulin secretion  positive regulation of protein binding  secretory granule localization  regulation of hormone metabolic process  protein-DNA complex  somatic stem cell maintenance  nuclear hormone receptor binding  catenin import into nucleus  negative regulation of fibroblast growth factor receptor signaling pathway  odontogenesis of dentin-containing tooth  glucose homeostasis  positive regulation of apoptotic process  negative regulation of sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding  sequence-specific DNA binding  maintenance of DNA repeat elements  skin development  transcription regulatory region DNA binding  canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition  gamma-catenin binding  fat cell differentiation  negative regulation of fat cell differentiation  negative regulation of transcription, DNA-dependent  negative regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  negative regulation of organ growth  positive regulation of protein export from nucleus  embryonic digestive tract morphogenesis  embryonic hindgut morphogenesis  myoblast fate commitment  regulation of skeletal muscle tissue development  regulation of smooth muscle cell proliferation  generation of neurons  regulation of oligodendrocyte differentiation  positive regulation of epithelial cell proliferation  positive regulation of protein kinase B signaling cascade  canonical Wnt receptor signaling pathway  face morphogenesis  regulation of insulin secretion involved in cellular response to glucose stimulus  armadillo repeat domain binding  beta-catenin-TCF7L2 complex  negative regulation of canonical Wnt receptor signaling pathway  negative regulation of type B pancreatic cell apoptotic process  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Adherens junction    Melanogenesis    Pathways in cancer    Colorectal cancer    Endometrial cancer    Prostate cancer    Thyroid cancer    Basal cell carcinoma    Acute myeloid leukemia    Arrhythmogenic right ventricular cardiomyopathy (ARVC)   
REACTOMETCF7L2
Protein Interaction DatabaseTCF7L2
Wikipedia pathwaysTCF7L2
Gene fusion - rearrangments
Rearrangement : COSMICVTI1A [10q25.2]  -  TCF7L2 [10q25.2]
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TCF7L2
SNP (GeneSNP Utah)TCF7L2
SNP : HGBaseTCF7L2
Genetic variants : HAPMAPTCF7L2
1000_GenomesTCF7L2 
ICGC programENSG00000148737 
Cancer Gene: CensusTCF7L2 
Somatic Mutations in Cancer : COSMICTCF7L2 
CONAN: Copy Number AnalysisTCF7L2 
Mutations and Diseases : HGMDTCF7L2
OMIM125853    602228   
GENETestsTCF7L2
Disease Genetic AssociationTCF7L2
Huge Navigator TCF7L2 [HugePedia]  TCF7L2 [HugeCancerGEM]
Genomic VariantsTCF7L2  TCF7L2 [DGVbeta]
Exome VariantTCF7L2
dbVarTCF7L2
ClinVarTCF7L2
snp3D : Map Gene to Disease6934
General knowledge
Homologs : HomoloGeneTCF7L2
Homology/Alignments : Family Browser (UCSC)TCF7L2
Phylogenetic Trees/Animal Genes : TreeFamTCF7L2
Chemical/Protein Interactions : CTD6934
Chemical/Pharm GKB GenePA36394
Clinical trialTCF7L2
Cancer Resource (Charite)ENSG00000148737
Other databases
Probes
Litterature
PubMed464 Pubmed reference(s) in Entrez
CoreMineTCF7L2
iHOPTCF7L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:44:47 CEST 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.