Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TCF7L2 (transcription factor 7 like 2)

Identity

Alias_namesTCF4
transcription factor 7-like 2 (T-cell specific
Alias_symbol (synonym)TCF-4
Other alias
HGNC (Hugo) TCF7L2
LocusID (NCBI) 6934
Atlas_Id 42496
Location 10q25.2  [Link to chromosome band 10q25]
Location_base_pair Starts at 112950250 and ends at 113167677 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		FAM168B (2q21.1) / TCF7L2 (10q25.2)TCF7L2 (10q25.2) / ATP5G3 (2q31.1)TCF7L2 (10q25.2) / CHD6 (20q12)
TCF7L2 (10q25.2) / KIAA0391 (14q13.2)TCF7L2 (10q25.2) / PTPRC (1q31.3)TCF7L2 (10q25.2) / TACC2 (10q26.13)
TCF7L2 (10q25.2) / VTI1A (10q25.2)VTI1A (10q25.2) / TCF7L2 (10q25.2)VTI1A 10q25.2 / TCF7L2 10q25.2
TCF7L2 10q25.2 / TACC2 10q26.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Colon: Colorectal adenocarcinoma

External links

Nomenclature
HGNC (Hugo)TCF7L2   11641
Cards
Entrez_Gene (NCBI)TCF7L2  6934  transcription factor 7 like 2
AliasesTCF-4; TCF4
GeneCards (Weizmann)TCF7L2
Ensembl hg19 (Hinxton)ENSG00000148737 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148737 [Gene_View]  chr10:112950250-113167677 [Contig_View]  TCF7L2 [Vega]
ICGC DataPortalENSG00000148737
TCGA cBioPortalTCF7L2
AceView (NCBI)TCF7L2
Genatlas (Paris)TCF7L2
WikiGenes6934
SOURCE (Princeton)TCF7L2
Genetics Home Reference (NIH)TCF7L2
Genomic and cartography
GoldenPath hg38 (UCSC)TCF7L2  -     chr10:112950250-113167677 +  10q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TCF7L2  -     10q25.2   [Description]    (hg19-Feb_2009)
EnsemblTCF7L2 - 10q25.2 [CytoView hg19]  TCF7L2 - 10q25.2 [CytoView hg38]
Mapping of homologs : NCBITCF7L2 [Mapview hg19]  TCF7L2 [Mapview hg38]
OMIM125853   602228   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001146274 NM_001146283 NM_001146284 NM_001146285 NM_001146286 NM_001198525 NM_001198526 NM_001198527 NM_001198528 NM_001198529 NM_001198530 NM_001198531 NM_001349870 NM_001349871 NM_030756
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TCF7L2
Cluster EST : UnigeneHs.593995 [ NCBI ]
CGAP (NCI)Hs.593995
Alternative Splicing GalleryENSG00000148737
Gene ExpressionTCF7L2 [ NCBI-GEO ]   TCF7L2 [ EBI - ARRAY_EXPRESS ]   TCF7L2 [ SEEK ]   TCF7L2 [ MEM ]
Gene Expression Viewer (FireBrowse)TCF7L2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6934
GTEX Portal (Tissue expression)TCF7L2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQB0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NQB0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NQB0
Splice isoforms : SwissVarQ9NQB0
PhosPhoSitePlusQ9NQB0
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)Catenin_binding_dom    CTNNB1-bd_N    HMG_box_dom    TCF/LEF    TCF7L2   
Domain families : Pfam (Sanger)CTNNB1_binding (PF08347)    HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam08347    pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)TCF7L2
DMDM Disease mutations6934
Blocks (Seattle)TCF7L2
PDB (SRS)1JDH    1JPW    2GL7   
PDB (PDBSum)1JDH    1JPW    2GL7   
PDB (IMB)1JDH    1JPW    2GL7   
PDB (RSDB)1JDH    1JPW    2GL7   
Structural Biology KnowledgeBase1JDH    1JPW    2GL7   
SCOP (Structural Classification of Proteins)1JDH    1JPW    2GL7   
CATH (Classification of proteins structures)1JDH    1JPW    2GL7   
SuperfamilyQ9NQB0
Human Protein AtlasENSG00000148737
Peptide AtlasQ9NQB0
HPRD03751
IPIIPI00164708   IPI00335587   IPI00221004   IPI00221005   IPI00221006   IPI00221007   IPI00221008   IPI00221009   IPI00221010   IPI00221011   IPI01014645   IPI00479483   IPI00937155   IPI00641691   IPI00975648   IPI00983769   IPI00944473   IPI00479038   IPI00552531   IPI01011684   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQB0
IntAct (EBI)Q9NQB0
FunCoupENSG00000148737
BioGRIDTCF7L2
STRING (EMBL)TCF7L2
ZODIACTCF7L2
Ontologies - Pathways
QuickGOQ9NQB0
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II repressing transcription factor binding  blood vessel development  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  cell cycle arrest  Wnt signaling pathway, calcium modulating pathway  beta-catenin binding  beta-catenin binding  transcription factor binding  cell proliferation  response to glucose  positive regulation of heparan sulfate proteoglycan biosynthetic process  PML body  protein kinase binding  pancreas development  positive regulation of insulin secretion  positive regulation of insulin secretion  positive regulation of protein binding  regulation of hormone metabolic process  protein-DNA complex  nuclear hormone receptor binding  glucose homeostasis  negative regulation of sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding  sequence-specific DNA binding  maintenance of DNA repeat elements  transcription regulatory region DNA binding  canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition  gamma-catenin binding  fat cell differentiation  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of protein export from nucleus  myoblast fate commitment  regulation of smooth muscle cell proliferation  positive regulation of protein kinase B signaling  canonical Wnt signaling pathway  armadillo repeat domain binding  beta-catenin-TCF7L2 complex  negative regulation of canonical Wnt signaling pathway  beta-catenin-TCF complex assembly  negative regulation of type B pancreatic cell apoptotic process  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II repressing transcription factor binding  blood vessel development  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  cell cycle arrest  Wnt signaling pathway, calcium modulating pathway  beta-catenin binding  beta-catenin binding  transcription factor binding  cell proliferation  response to glucose  positive regulation of heparan sulfate proteoglycan biosynthetic process  PML body  protein kinase binding  pancreas development  positive regulation of insulin secretion  positive regulation of insulin secretion  positive regulation of protein binding  regulation of hormone metabolic process  protein-DNA complex  nuclear hormone receptor binding  glucose homeostasis  negative regulation of sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding  sequence-specific DNA binding  maintenance of DNA repeat elements  transcription regulatory region DNA binding  canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition  gamma-catenin binding  fat cell differentiation  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of protein export from nucleus  myoblast fate commitment  regulation of smooth muscle cell proliferation  positive regulation of protein kinase B signaling  canonical Wnt signaling pathway  armadillo repeat domain binding  beta-catenin-TCF7L2 complex  negative regulation of canonical Wnt signaling pathway  beta-catenin-TCF complex assembly  negative regulation of type B pancreatic cell apoptotic process  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGG   
NDEx NetworkTCF7L2
Atlas of Cancer Signalling NetworkTCF7L2
Wikipedia pathwaysTCF7L2
Orthology - Evolution
OrthoDB6934
GeneTree (enSembl)ENSG00000148737
Phylogenetic Trees/Animal Genes : TreeFamTCF7L2
HOVERGENQ9NQB0
HOGENOMQ9NQB0
Homologs : HomoloGeneTCF7L2
Homology/Alignments : Family Browser (UCSC)TCF7L2
Gene fusions - Rearrangements
Fusion : MitelmanTCF7L2/- [10q25.2/]  
Fusion : MitelmanTCF7L2/TACC2 [10q25.2/10q26.13]  [t(10;10)(q25;q26)]  
Fusion : MitelmanVTI1A/TCF7L2 [10q25.2/10q25.2]  [del(10)(q25q25)]  
Fusion: TCGATCF7L2 10q25.2 TACC2 10q26.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCF7L2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCF7L2
dbVarTCF7L2
ClinVarTCF7L2
1000_GenomesTCF7L2 
Exome Variant ServerTCF7L2
ExAC (Exome Aggregation Consortium)TCF7L2 (select the gene name)
Genetic variants : HAPMAP6934
Genomic Variants (DGV)TCF7L2 [DGVbeta]
DECIPHERTCF7L2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTCF7L2 
Mutations
ICGC Data PortalTCF7L2 
TCGA Data PortalTCF7L2 
Broad Tumor PortalTCF7L2
OASIS PortalTCF7L2 [ Somatic mutations - Copy number]
Cancer Gene: CensusTCF7L2 
Somatic Mutations in Cancer : COSMICTCF7L2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTCF7L2
intOGen PortalTCF7L2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TCF7L2
DgiDB (Drug Gene Interaction Database)TCF7L2
DoCM (Curated mutations)TCF7L2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TCF7L2 (select a term)
intoGenTCF7L2
Cancer3DTCF7L2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM125853    602228   
Orphanet
MedgenTCF7L2
Genetic Testing Registry TCF7L2
NextProtQ9NQB0 [Medical]
TSGene6934
GENETestsTCF7L2
Target ValidationTCF7L2
Huge Navigator TCF7L2 [HugePedia]
snp3D : Map Gene to Disease6934
BioCentury BCIQTCF7L2
ClinGenTCF7L2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6934
Chemical/Pharm GKB GenePA36394
Clinical trialTCF7L2
Miscellaneous
canSAR (ICR)TCF7L2 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTCF7L2
EVEXTCF7L2
GoPubMedTCF7L2
iHOPTCF7L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:34:32 CEST 2017
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