| FAM168B (2q21.1) / TCF7L2 (10q25.2) | TCF7L2 (10q25.2) / ATP5G3 (2q31.1) | TCF7L2 (10q25.2) / CHD6 (20q12) |
|
TCF7L2 (10q25.2) / KIAA0391 (14q13.2) | TCF7L2 (10q25.2) / PTPRC (1q31.3) | TCF7L2 (10q25.2) / TACC2 (10q26.13) |
|
TCF7L2 (10q25.2) / VTI1A (10q25.2) | VTI1A (10q25.2) / TCF7L2 (10q25.2) | VTI1A TCF7L2 10q25.2 |
|
TCF7L2 10q25.2 / TACC2 10q26.13 |
| Nomenclature |
HGNC (Hugo) | TCF7L2 11641 |
| Cards |
Entrez_Gene (NCBI) | TCF7L2 transcription factor 7 like 2 |
Aliases | TCF-4; TCF4 |
GeneCards (Weizmann) | TCF7L2 |
Ensembl hg19 (Hinxton) | ENSG00000148737 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000148737 [Gene_View]  ENSG00000148737 [Sequence] chr10:112950247-113167677 [Contig_View] TCF7L2 [Vega] |
ICGC DataPortal | ENSG00000148737 |
TCGA cBioPortal | TCF7L2 |
AceView (NCBI) | TCF7L2 |
Genatlas (Paris) | TCF7L2 |
SOURCE (Princeton) | TCF7L2 |
Genetics Home Reference (NIH) | TCF7L2 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | TCF7L2 - chr10:112950247-113167677 + 10q25.2 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | TCF7L2 - 10q25.2 [Description] (hg19-Feb_2009) |
GoldenPath | TCF7L2 - 10q25.2 [CytoView hg19] TCF7L2 - 10q25.2 [CytoView hg38] |
ImmunoBase | ENSG00000148737 |
genome Data Viewer NCBI | TCF7L2 [Mapview hg19] |
OMIM | 125853 602228 |
| Gene and transcription |
Genbank (Entrez) | AB034691 AB440195 AB451266 AK074705 AK225809 |
RefSeq transcript (Entrez) | NM_001146274 NM_001146283 NM_001146284 NM_001146285 NM_001146286 NM_001198525 NM_001198526 NM_001198527 NM_001198528 NM_001198529 NM_001198530 NM_001198531 NM_001349870 NM_001349871 NM_001363501 NM_001367943 NM_030756 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | TCF7L2 |
Alternative Splicing Gallery | ENSG00000148737 |
Gene Expression | TCF7L2 [ NCBI-GEO ] TCF7L2 [ EBI - ARRAY_EXPRESS ]
TCF7L2 [ SEEK ] TCF7L2 [ MEM ] |
Gene Expression Viewer (FireBrowse) | TCF7L2 [ Firebrowse - Broad ] |
Genevisible | Expression of TCF7L2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 6934 |
GTEX Portal (Tissue expression) | TCF7L2 |
Human Protein Atlas | ENSG00000148737-TCF7L2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | Q9NQB0 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | Q9NQB0 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | Q9NQB0 |
Splice isoforms : SwissVar | Q9NQB0 |
PhosPhoSitePlus | Q9NQB0 |
Domaine pattern : Prosite (Expaxy) | HMG_BOX_2 (PS50118) |
Domains : Interpro (EBI) | Catenin_binding_dom_sf CTNNB1-bd_N HMG_box_dom HMG_box_dom_sf TCF/LEF |
Domain families : Pfam (Sanger) | CTNNB1_binding (PF08347) HMG_box (PF00505) |
Domain families : Pfam (NCBI) | pfam08347 pfam00505 |
Domain families : Smart (EMBL) | HMG (SM00398) |
Conserved Domain (NCBI) | TCF7L2 |
Blocks (Seattle) | TCF7L2 |
PDB (RSDB) | 1JDH 1JPW 2GL7 |
PDB Europe | 1JDH 1JPW 2GL7 |
PDB (PDBSum) | 1JDH 1JPW 2GL7 |
PDB (IMB) | 1JDH 1JPW 2GL7 |
Structural Biology KnowledgeBase | 1JDH 1JPW 2GL7 |
SCOP (Structural Classification of Proteins) | 1JDH 1JPW 2GL7 |
CATH (Classification of proteins structures) | 1JDH 1JPW 2GL7 |
Superfamily | Q9NQB0 |
Human Protein Atlas [tissue] | ENSG00000148737-TCF7L2 [tissue] |
Peptide Atlas | Q9NQB0 |
HPRD | 03751 |
IPI | IPI00164708 IPI00335587 IPI00221004 IPI00221005 IPI00221006 IPI00221007 IPI00221008 IPI00221009 IPI00221010 IPI00221011 IPI01014645 IPI00479483 IPI00937155 IPI00641691 IPI00975648 IPI00983769 IPI00944473 IPI00479038 IPI00552531 IPI01011684 |
| Protein Interaction databases |
DIP (DOE-UCLA) | Q9NQB0 |
IntAct (EBI) | Q9NQB0 |
BioGRID | TCF7L2 |
STRING (EMBL) | TCF7L2 |
ZODIAC | TCF7L2 |
| Ontologies - Pathways |
QuickGO | Q9NQB0 |
Ontology : AmiGO | negative regulation of transcription by RNA polymerase II nuclear chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II repressing transcription factor binding DNA-binding transcription activator activity, RNA polymerase II-specific blood vessel development chromatin binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription factor complex regulation of transcription by RNA polymerase II cell cycle arrest Wnt signaling pathway, calcium modulating pathway beta-catenin binding beta-catenin binding beta-catenin binding transcription factor binding response to glucose positive regulation of heparan sulfate proteoglycan biosynthetic process Wnt signaling pathway PML body protein kinase binding pancreas development positive regulation of insulin secretion positive regulation of protein binding regulation of hormone metabolic process protein-DNA complex nuclear hormone receptor binding glucose homeostasis negative regulation of DNA-binding transcription factor activity sequence-specific DNA binding sequence-specific DNA binding maintenance of DNA repeat elements canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition gamma-catenin binding fat cell differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of protein export from nucleus myoblast fate commitment regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation positive regulation of protein kinase B signaling canonical Wnt signaling pathway canonical Wnt signaling pathway armadillo repeat domain binding beta-catenin-TCF7L2 complex negative regulation of canonical Wnt signaling pathway beta-catenin-TCF complex assembly negative regulation of type B pancreatic cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway |
Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II nuclear chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II repressing transcription factor binding DNA-binding transcription activator activity, RNA polymerase II-specific blood vessel development chromatin binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription factor complex regulation of transcription by RNA polymerase II cell cycle arrest Wnt signaling pathway, calcium modulating pathway beta-catenin binding beta-catenin binding beta-catenin binding transcription factor binding response to glucose positive regulation of heparan sulfate proteoglycan biosynthetic process Wnt signaling pathway PML body protein kinase binding pancreas development positive regulation of insulin secretion positive regulation of protein binding regulation of hormone metabolic process protein-DNA complex nuclear hormone receptor binding glucose homeostasis negative regulation of DNA-binding transcription factor activity sequence-specific DNA binding sequence-specific DNA binding maintenance of DNA repeat elements canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition gamma-catenin binding fat cell differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of protein export from nucleus myoblast fate commitment regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation positive regulation of protein kinase B signaling canonical Wnt signaling pathway canonical Wnt signaling pathway armadillo repeat domain binding beta-catenin-TCF7L2 complex negative regulation of canonical Wnt signaling pathway beta-catenin-TCF complex assembly negative regulation of type B pancreatic cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway |
Pathways : KEGG | Wnt signaling pathway Hippo signaling pathway Adherens junction Melanogenesis Pathways in cancer Colorectal cancer Endometrial cancer Prostate cancer Thyroid cancer Basal cell carcinoma Acute myeloid leukemia Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
NDEx Network | TCF7L2 |
Atlas of Cancer Signalling Network | TCF7L2 |
Wikipedia pathways | TCF7L2 |
| Orthology - Evolution |
OrthoDB | 6934 |
GeneTree (enSembl) | ENSG00000148737 |
Phylogenetic Trees/Animal Genes : TreeFam | TCF7L2 |
HOGENOM | Q9NQB0 |
Homologs : HomoloGene | TCF7L2 |
Homology/Alignments : Family Browser (UCSC) | TCF7L2 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | TCF7L2/- [10q25.2/]   |
Fusion : Mitelman | TCF7L2/TACC2 [10q25.2/10q26.13]   |
Fusion : Mitelman | VTI1A/TCF7L2 [10q25.2/10q25.2]   |
Fusion Portal | TCF7L2 10q25.2 TACC2 10q26.13 BRCA |
Fusion : Quiver | TCF7L2 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | TCF7L2 [hg38] |
dbVar | TCF7L2 |
ClinVar | TCF7L2 |
Monarch | TCF7L2 |
1000_Genomes | TCF7L2 |
Exome Variant Server | TCF7L2 |
GNOMAD Browser | ENSG00000148737 |
Varsome Browser | TCF7L2 |
Genomic Variants (DGV) | TCF7L2 [DGVbeta] |
DECIPHER | TCF7L2 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | TCF7L2 |
| Mutations |
ICGC Data Portal | TCF7L2 |
TCGA Data Portal | TCF7L2 |
Broad Tumor Portal | TCF7L2 |
OASIS Portal | TCF7L2 [ Somatic mutations - Copy number] |
Cancer Gene: Census | TCF7L2 |
Somatic Mutations in Cancer : COSMIC | TCF7L2 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | TCF7L2 |
Mutations and Diseases : HGMD | TCF7L2 |
intOGen Portal | TCF7L2 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
LOVD (Leiden Open Variation Database) | MSeqDR-LSDB Mitochondrial Disease Locus Specific Database |
BioMuta | search TCF7L2 |
DgiDB (Drug Gene Interaction Database) | TCF7L2 |
DoCM (Curated mutations) | TCF7L2 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | TCF7L2 (select a term) |
intoGen | TCF7L2 |
Cancer3D | TCF7L2(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
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OMIM | 125853 602228 |
Orphanet | |
DisGeNET | TCF7L2 |
Medgen | TCF7L2 |
Genetic Testing Registry | TCF7L2
|
NextProt | Q9NQB0 [Medical] |
GENETests | TCF7L2 |
Target Validation | TCF7L2 |
Huge Navigator |
TCF7L2 [HugePedia] |
ClinGen | TCF7L2 |
| Clinical trials, drugs, therapy |
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MyCancerGenome | TCF7L2 |
Protein Interactions : CTD | |
Pharm GKB Gene | PA36394 |
Pharos | Q9NQB0 |
Clinical trial | TCF7L2 |
| Miscellaneous |
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canSAR (ICR) | TCF7L2 (select the gene name) |
Harmonizome | TCF7L2 |
DataMed Index | TCF7L2 |
| Probes |
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| Litterature |
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PubMed | 499 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
EVEX | TCF7L2 |