TCHP (trichoplein keratin filament binding)

2010-02-01  

Identity

HGNC
TCHP
LOCATION
12q24.11
LOCUSID
84260
ALIAS
TpMs
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84260
MIM: 612654
HGNC: 28135
Ensembl: ENSG00000139437

Variants:

dbSNP: 84260
ClinVar: 84260
TCGA: ENSG00000139437
COSMIC: TCHP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139437ENST00000312777Q9BT92
ENSG00000139437ENST00000312777A0A024RBM9
ENSG00000139437ENST00000405876Q9BT92
ENSG00000139437ENST00000405876A0A024RBM9
ENSG00000139437ENST00000536408F5GWH6
ENSG00000139437ENST00000544838Q9BT92
ENSG00000139437ENST00000544838A0A024RBM9

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
209308472010Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition.45
213250312011Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.35
244030672014Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin.32
157310132005Identification of trichoplein, a novel keratin filament-binding protein.25
268802002016Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.21
189317012009MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer.20
290808402019Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy.6

Citation

Dessen P

TCHP (trichoplein keratin filament binding)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51319/tchp