Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3)

Identity

Alias (NCBI)ATP6N1C
ATP6V0A3
Atp6i
OC-116kDa
OC116
OPTB1
Stv1
TIRC7
Vph1
a3
HGNC (Hugo) TCIRG1
HGNC Alias symbTIRC7
OC-116
OC116
ATP6N1C
Atp6i
a3
ATP6V0A3
HGNC Alias nameT-cell immune response cDNA 7
 V-ATPase subunit a3
HGNC Previous nameT-cell, immune regulator 1
 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a isoform 3
 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
 T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3
LocusID (NCBI) 10312
Atlas_Id 53799
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 68042980 and ends at 68050899 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALKBH3 (11p11.2) / TCIRG1 (11q13.2)TCIRG1 (11q13.2) / CNIH1 (14q22.2)WWP2 (16q22.1) / TCIRG1 (11q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TCIRG1   11647
LRG (Locus Reference Genomic)LRG_115
Cards
Entrez_Gene (NCBI)TCIRG1    T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
AliasesATP6N1C; ATP6V0A3; Atp6i; OC-116kDa; 
OC116; OPTB1; Stv1; TIRC7; Vph1; a3
GeneCards (Weizmann)TCIRG1
Ensembl hg19 (Hinxton)ENSG00000110719 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110719 [Gene_View]  ENSG00000110719 [Sequence]  chr11:68042980-68050899 [Contig_View]  TCIRG1 [Vega]
ICGC DataPortalENSG00000110719
TCGA cBioPortalTCIRG1
AceView (NCBI)TCIRG1
Genatlas (Paris)TCIRG1
SOURCE (Princeton)TCIRG1
Genetics Home Reference (NIH)TCIRG1
Genomic and cartography
GoldenPath hg38 (UCSC)TCIRG1  -     chr11:68042980-68050899 +  11q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TCIRG1  -     11q13.2   [Description]    (hg19-Feb_2009)
GoldenPathTCIRG1 - 11q13.2 [CytoView hg19]  TCIRG1 - 11q13.2 [CytoView hg38]
ImmunoBaseENSG00000110719
Genome Data Viewer NCBITCIRG1 [Mapview hg19]  
OMIM259700   604592   
Gene and transcription
Genbank (Entrez)AA625923 AF025374 AF497545 AK057093 AW083897
RefSeq transcript (Entrez)NM_001351059 NM_006019 NM_006053
Consensus coding sequences : CCDS (NCBI)TCIRG1
Gene ExpressionTCIRG1 [ NCBI-GEO ]   TCIRG1 [ EBI - ARRAY_EXPRESS ]   TCIRG1 [ SEEK ]   TCIRG1 [ MEM ]
Gene Expression Viewer (FireBrowse)TCIRG1 [ Firebrowse - Broad ]
GenevisibleExpression of TCIRG1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10312
GTEX Portal (Tissue expression)TCIRG1
Human Protein AtlasENSG00000110719-TCIRG1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13488   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13488  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13488
PhosPhoSitePlusQ13488
Domains : Interpro (EBI)V-ATPase_116kDa_su    V-type_ATPase_116kDa_su_euka   
Domain families : Pfam (Sanger)V_ATPase_I (PF01496)   
Domain families : Pfam (NCBI)pfam01496   
Conserved Domain (NCBI)TCIRG1
SuperfamilyQ13488
AlphaFold pdb e-kbQ13488   
Human Protein Atlas [tissue]ENSG00000110719-TCIRG1 [tissue]
HPRD05207
Protein Interaction databases
DIP (DOE-UCLA)Q13488
IntAct (EBI)Q13488
BioGRIDTCIRG1
STRING (EMBL)TCIRG1
ZODIACTCIRG1
Ontologies - Pathways
QuickGOQ13488
Ontology : AmiGOautophagosome assembly  vacuolar proton-transporting V-type ATPase, V0 domain  ossification  osteoclast proliferation  transporter activity  protein binding  nucleus  lysosomal membrane  lysosomal membrane  late endosome  plasma membrane  plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  apoptotic process  inflammatory response  cellular defense response  vacuolar acidification  protein catabolic process in the vacuole  positive regulation of cell population proliferation  insulin receptor signaling pathway  endosome membrane  regulation of proton transport  response to silver ion  gene expression  regulation of gene expression  immunoglobulin mediated immune response  macroautophagy  apical plasma membrane  vacuolar proton-transporting V-type ATPase complex  optic nerve development  establishment of cell polarity  B cell differentiation  T cell differentiation  osteoclast differentiation  phagocytic vesicle membrane  ruffle organization  protein localization to organelle  transferrin transport  cellular response to amino acid starvation  ion transmembrane transport  memory T cell activation  T-helper 1 cell activation  T cell homeostasis  neutrophil degranulation  tooth eruption  bone resorption  regulation of osteoblast differentiation  proton-transporting ATPase activity, rotational mechanism  regulation of insulin secretion  ATPase binding  establishment of vesicle localization  retina development in camera-type eye  hematopoietic stem cell homeostasis  enamel mineralization  cellular response to cytokine stimulus  phagosome acidification  dentin mineralization  ficolin-1-rich granule membrane  proton transmembrane transport  
Ontology : EGO-EBIautophagosome assembly  vacuolar proton-transporting V-type ATPase, V0 domain  ossification  osteoclast proliferation  transporter activity  protein binding  nucleus  lysosomal membrane  lysosomal membrane  late endosome  plasma membrane  plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  apoptotic process  inflammatory response  cellular defense response  vacuolar acidification  protein catabolic process in the vacuole  positive regulation of cell population proliferation  insulin receptor signaling pathway  endosome membrane  regulation of proton transport  response to silver ion  gene expression  regulation of gene expression  immunoglobulin mediated immune response  macroautophagy  apical plasma membrane  vacuolar proton-transporting V-type ATPase complex  optic nerve development  establishment of cell polarity  B cell differentiation  T cell differentiation  osteoclast differentiation  phagocytic vesicle membrane  ruffle organization  protein localization to organelle  transferrin transport  cellular response to amino acid starvation  ion transmembrane transport  memory T cell activation  T-helper 1 cell activation  T cell homeostasis  neutrophil degranulation  tooth eruption  bone resorption  regulation of osteoblast differentiation  proton-transporting ATPase activity, rotational mechanism  regulation of insulin secretion  ATPase binding  establishment of vesicle localization  retina development in camera-type eye  hematopoietic stem cell homeostasis  enamel mineralization  cellular response to cytokine stimulus  phagosome acidification  dentin mineralization  ficolin-1-rich granule membrane  proton transmembrane transport  
Pathways : KEGGOxidative phosphorylation    Lysosome    Phagosome    Synaptic vesicle cycle    Collecting duct acid secretion    Vibrio cholerae infection    Epithelial cell signaling in Helicobacter pylori infection    Tuberculosis    Rheumatoid arthritis   
NDEx NetworkTCIRG1
Atlas of Cancer Signalling NetworkTCIRG1
Wikipedia pathwaysTCIRG1
Orthology - Evolution
OrthoDB10312
GeneTree (enSembl)ENSG00000110719
Phylogenetic Trees/Animal Genes : TreeFamTCIRG1
Homologs : HomoloGeneTCIRG1
Homology/Alignments : Family Browser (UCSC)TCIRG1
Gene fusions - Rearrangements
Fusion : QuiverTCIRG1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCIRG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCIRG1
dbVarTCIRG1
ClinVarTCIRG1
MonarchTCIRG1
1000_GenomesTCIRG1 
Exome Variant ServerTCIRG1
GNOMAD BrowserENSG00000110719
Varsome BrowserTCIRG1
ACMGTCIRG1 variants
VarityQ13488
Genomic Variants (DGV)TCIRG1 [DGVbeta]
DECIPHERTCIRG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTCIRG1 
Mutations
ICGC Data PortalTCIRG1 
TCGA Data PortalTCIRG1 
Broad Tumor PortalTCIRG1
OASIS PortalTCIRG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCIRG1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTCIRG1
Mutations and Diseases : HGMDTCIRG1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTCIRG1
DgiDB (Drug Gene Interaction Database)TCIRG1
DoCM (Curated mutations)TCIRG1
CIViC (Clinical Interpretations of Variants in Cancer)TCIRG1
Cancer3DTCIRG1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM259700    604592   
Orphanet822    2530   
DisGeNETTCIRG1
MedgenTCIRG1
Genetic Testing Registry TCIRG1
NextProtQ13488 [Medical]
GENETestsTCIRG1
Target ValidationTCIRG1
Huge Navigator TCIRG1 [HugePedia]
ClinGenTCIRG1
Clinical trials, drugs, therapy
MyCancerGenomeTCIRG1
Protein Interactions : CTDTCIRG1
Pharm GKB GenePA36399
PharosQ13488
Clinical trialTCIRG1
Miscellaneous
canSAR (ICR)TCIRG1
HarmonizomeTCIRG1
DataMed IndexTCIRG1
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTCIRG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:34:36 CEST 2021

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