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TCN1 (transcobalamin 1)

Identity

Alias_namestranscobalamin I (vitamin B12 binding protein, R binder family)
transcobalamin I
Alias_symbol (synonym)TCI
TC1
Other aliasHC
TC-1
HGNC (Hugo) TCN1
LocusID (NCBI) 6947
Atlas_Id 52729
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 59620281 and ends at 59634041 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MYL12A (18p11.31) / TCN1 (11q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TCN1   11652
Cards
Entrez_Gene (NCBI)TCN1  6947  transcobalamin 1
AliasesHC; TC-1; TC1; TCI
GeneCards (Weizmann)TCN1
Ensembl hg19 (Hinxton)ENSG00000134827 [Gene_View]  chr11:59620281-59634041 [Contig_View]  TCN1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000134827 [Gene_View]  chr11:59620281-59634041 [Contig_View]  TCN1 [Vega]
ICGC DataPortalENSG00000134827
TCGA cBioPortalTCN1
AceView (NCBI)TCN1
Genatlas (Paris)TCN1
WikiGenes6947
SOURCE (Princeton)TCN1
Genetics Home Reference (NIH)TCN1
Genomic and cartography
GoldenPath hg19 (UCSC)TCN1  -     chr11:59620281-59634041 -  11q12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TCN1  -     11q12.1   [Description]    (hg38-Dec_2013)
EnsemblTCN1 - 11q12.1 [CytoView hg19]  TCN1 - 11q12.1 [CytoView hg38]
Mapping of homologs : NCBITCN1 [Mapview hg19]  TCN1 [Mapview hg38]
OMIM189905   
Gene and transcription
Genbank (Entrez)AK292990 BC018632 BC156607 BM769693 BM818792
RefSeq transcript (Entrez)NM_001062
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)TCN1
Cluster EST : UnigeneHs.2012 [ NCBI ]
CGAP (NCI)Hs.2012
Alternative Splicing GalleryENSG00000134827
Gene ExpressionTCN1 [ NCBI-GEO ]   TCN1 [ EBI - ARRAY_EXPRESS ]   TCN1 [ SEEK ]   TCN1 [ MEM ]
Gene Expression Viewer (FireBrowse)TCN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6947
GTEX Portal (Tissue expression)TCN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20061   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20061  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20061
Splice isoforms : SwissVarP20061
PhosPhoSitePlusP20061
Domaine pattern : Prosite (Expaxy)COBALAMIN_BINDING (PS00468)   
Domains : Interpro (EBI)Cbl-bd_transpt_euk    DUF4430   
Domain families : Pfam (Sanger)Cobalamin_bind (PF01122)    DUF4430 (PF14478)   
Domain families : Pfam (NCBI)pfam01122    pfam14478   
Conserved Domain (NCBI)TCN1
DMDM Disease mutations6947
Blocks (Seattle)TCN1
PDB (SRS)2CKV    4KKI    4KKJ   
PDB (PDBSum)2CKV    4KKI    4KKJ   
PDB (IMB)2CKV    4KKI    4KKJ   
PDB (RSDB)2CKV    4KKI    4KKJ   
Structural Biology KnowledgeBase2CKV    4KKI    4KKJ   
SCOP (Structural Classification of Proteins)2CKV    4KKI    4KKJ   
CATH (Classification of proteins structures)2CKV    4KKI    4KKJ   
SuperfamilyP20061
Human Protein AtlasENSG00000134827
Peptide AtlasP20061
HPRD01795
IPIIPI00299729   
Protein Interaction databases
DIP (DOE-UCLA)P20061
IntAct (EBI)P20061
FunCoupENSG00000134827
BioGRIDTCN1
STRING (EMBL)TCN1
ZODIACTCN1
Ontologies - Pathways
QuickGOP20061
Ontology : AmiGOextracellular region  extracellular space  cobalt ion transport  cobalamin metabolic process  cobalamin transport  cobalamin binding  
Ontology : EGO-EBIextracellular region  extracellular space  cobalt ion transport  cobalamin metabolic process  cobalamin transport  cobalamin binding  
NDEx NetworkTCN1
Atlas of Cancer Signalling NetworkTCN1
Wikipedia pathwaysTCN1
Orthology - Evolution
OrthoDB6947
GeneTree (enSembl)ENSG00000134827
Phylogenetic Trees/Animal Genes : TreeFamTCN1
HOVERGENP20061
HOGENOMP20061
Homologs : HomoloGeneTCN1
Homology/Alignments : Family Browser (UCSC)TCN1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCN1
dbVarTCN1
ClinVarTCN1
1000_GenomesTCN1 
Exome Variant ServerTCN1
ExAC (Exome Aggregation Consortium)TCN1 (select the gene name)
Genetic variants : HAPMAP6947
Genomic Variants (DGV)TCN1 [DGVbeta]
DECIPHER (Syndromes)11:59620281-59634041  ENSG00000134827
CONAN: Copy Number AnalysisTCN1 
Mutations
ICGC Data PortalTCN1 
TCGA Data PortalTCN1 
Broad Tumor PortalTCN1
OASIS PortalTCN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTCN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TCN1
DgiDB (Drug Gene Interaction Database)TCN1
DoCM (Curated mutations)TCN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TCN1 (select a term)
intoGenTCN1
Cancer3DTCN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM189905   
Orphanet
MedgenTCN1
Genetic Testing Registry TCN1
NextProtP20061 [Medical]
TSGene6947
GENETestsTCN1
Huge Navigator TCN1 [HugePedia]
snp3D : Map Gene to Disease6947
BioCentury BCIQTCN1
ClinGenTCN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6947
Chemical/Pharm GKB GenePA36403
Clinical trialTCN1
Miscellaneous
canSAR (ICR)TCN1 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTCN1
EVEXTCN1
GoPubMedTCN1
iHOPTCN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:22:04 CEST 2017

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