Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TCN2 (transcobalamin 2)

Identity

Alias (NCBI)D22S676
D22S750
II
TC
TC II
TC-2
TC2
TCII
HGNC (Hugo) TCN2
HGNC Alias symbD22S676
D22S750
TC2
HGNC Alias namemacrocytic anemia
HGNC Previous nametranscobalamin II; macrocytic anemia
 transcobalamin II
LocusID (NCBI) 6948
Atlas_Id 51539
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 30607083 and ends at 30627060 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TCN2 (22q12.2) / TGFB1 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TCN2   11653
LRG (Locus Reference Genomic)LRG_116
Cards
Entrez_Gene (NCBI)TCN2    transcobalamin 2
AliasesD22S676; D22S750; II; TC; 
TC; TC-2; TC2; TCII
GeneCards (Weizmann)TCN2
Ensembl hg19 (Hinxton)ENSG00000185339 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185339 [Gene_View]  ENSG00000185339 [Sequence]  chr22:30607083-30627060 [Contig_View]  TCN2 [Vega]
ICGC DataPortalENSG00000185339
TCGA cBioPortalTCN2
AceView (NCBI)TCN2
Genatlas (Paris)TCN2
SOURCE (Princeton)TCN2
Genetics Home Reference (NIH)TCN2
Genomic and cartography
GoldenPath hg38 (UCSC)TCN2  -     chr22:30607083-30627060 +  22q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TCN2  -     22q12.2   [Description]    (hg19-Feb_2009)
GoldenPathTCN2 - 22q12.2 [CytoView hg19]  TCN2 - 22q12.2 [CytoView hg38]
ImmunoBaseENSG00000185339
Genome Data Viewer NCBITCN2 [Mapview hg19]  
OMIM275350   613441   
Gene and transcription
Genbank (Entrez)AK225445 AK313711 BC001176 BC011239 CR456591
RefSeq transcript (Entrez)NM_000355 NM_001184726 NM_001190420
Consensus coding sequences : CCDS (NCBI)TCN2
Gene ExpressionTCN2 [ NCBI-GEO ]   TCN2 [ EBI - ARRAY_EXPRESS ]   TCN2 [ SEEK ]   TCN2 [ MEM ]
Gene Expression Viewer (FireBrowse)TCN2 [ Firebrowse - Broad ]
GenevisibleExpression of TCN2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6948
GTEX Portal (Tissue expression)TCN2
Human Protein AtlasENSG00000185339-TCN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20062   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20062  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20062
PhosPhoSitePlusP20062
Domaine pattern : Prosite (Expaxy)COBALAMIN_BINDING (PS00468)   
Domains : Interpro (EBI)Cbl-bd_prot    DUF4430    Terpenoid_cyclase/PrenylTrfase   
Domain families : Pfam (Sanger)Cobalamin_bind (PF01122)    DUF4430 (PF14478)   
Domain families : Pfam (NCBI)pfam01122    pfam14478   
Conserved Domain (NCBI)TCN2
PDB (RSDB)2BB5    4ZRP    4ZRQ    5NO0    5NP4    5NRP    5NSA   
PDB Europe2BB5    4ZRP    4ZRQ    5NO0    5NP4    5NRP    5NSA   
PDB (PDBSum)2BB5    4ZRP    4ZRQ    5NO0    5NP4    5NRP    5NSA   
PDB (IMB)2BB5    4ZRP    4ZRQ    5NO0    5NP4    5NRP    5NSA   
Structural Biology KnowledgeBase2BB5    4ZRP    4ZRQ    5NO0    5NP4    5NRP    5NSA   
SCOP (Structural Classification of Proteins)2BB5    4ZRP    4ZRQ    5NO0    5NP4    5NRP    5NSA   
CATH (Classification of proteins structures)2BB5    4ZRP    4ZRQ    5NO0    5NP4    5NRP    5NSA   
SuperfamilyP20062
AlphaFold pdb e-kbP20062   
Human Protein Atlas [tissue]ENSG00000185339-TCN2 [tissue]
HPRD02037
Protein Interaction databases
DIP (DOE-UCLA)P20062
IntAct (EBI)P20062
BioGRIDTCN2
STRING (EMBL)TCN2
ZODIACTCN2
Ontologies - Pathways
QuickGOP20062
Ontology : AmiGOprotein binding  extracellular region  extracellular space  extracellular space  endosome  cobalt ion transport  cobalamin metabolic process  cobalamin transport  cobalamin transport  cobalamin binding  cobalamin binding  lysosomal lumen  metal ion binding  
Ontology : EGO-EBIprotein binding  extracellular region  extracellular space  extracellular space  endosome  cobalt ion transport  cobalamin metabolic process  cobalamin transport  cobalamin transport  cobalamin binding  cobalamin binding  lysosomal lumen  metal ion binding  
Pathways : KEGGVitamin digestion and absorption   
NDEx NetworkTCN2
Atlas of Cancer Signalling NetworkTCN2
Wikipedia pathwaysTCN2
Orthology - Evolution
OrthoDB6948
GeneTree (enSembl)ENSG00000185339
Phylogenetic Trees/Animal Genes : TreeFamTCN2
Homologs : HomoloGeneTCN2
Homology/Alignments : Family Browser (UCSC)TCN2
Gene fusions - Rearrangements
Fusion : QuiverTCN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCN2
dbVarTCN2
ClinVarTCN2
MonarchTCN2
1000_GenomesTCN2 
Exome Variant ServerTCN2
GNOMAD BrowserENSG00000185339
Varsome BrowserTCN2
ACMGTCN2 variants
VarityP20062
Genomic Variants (DGV)TCN2 [DGVbeta]
DECIPHERTCN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTCN2 
Mutations
ICGC Data PortalTCN2 
TCGA Data PortalTCN2 
Broad Tumor PortalTCN2
OASIS PortalTCN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTCN2
Mutations and Diseases : HGMDTCN2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTCN2
DgiDB (Drug Gene Interaction Database)TCN2
DoCM (Curated mutations)TCN2
CIViC (Clinical Interpretations of Variants in Cancer)TCN2
Cancer3DTCN2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM275350    613441   
Orphanet1729   
DisGeNETTCN2
MedgenTCN2
Genetic Testing Registry TCN2
NextProtP20062 [Medical]
GENETestsTCN2
Target ValidationTCN2
Huge Navigator TCN2 [HugePedia]
ClinGenTCN2
Clinical trials, drugs, therapy
MyCancerGenomeTCN2
Protein Interactions : CTDTCN2
Pharm GKB GenePA36404
PharosP20062
Clinical trialTCN2
Miscellaneous
canSAR (ICR)TCN2
HarmonizomeTCN2
DataMed IndexTCN2
Probes
Litterature
PubMed136 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTCN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:34:37 CEST 2021

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