Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TCN2 (transcobalamin 2)

Identity

Alias_namestranscobalamin II; macrocytic anemia
transcobalamin II
Alias_symbol (synonym)D22S676
D22S750
TC2
Other aliasII
TC
TC II
TC-2
TCII
HGNC (Hugo) TCN2
LocusID (NCBI) 6948
Atlas_Id 51539
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 31003070 and ends at 31023047 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TCN2 (22q12.2) / TGFB1 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TCN2   11653
LRG (Locus Reference Genomic)LRG_116
Cards
Entrez_Gene (NCBI)TCN2  6948  transcobalamin 2
AliasesD22S676; D22S750; II; TC; 
TC; TC-2; TC2; TCII
GeneCards (Weizmann)TCN2
Ensembl hg19 (Hinxton)ENSG00000185339 [Gene_View]  chr22:31003070-31023047 [Contig_View]  TCN2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000185339 [Gene_View]  chr22:31003070-31023047 [Contig_View]  TCN2 [Vega]
ICGC DataPortalENSG00000185339
TCGA cBioPortalTCN2
AceView (NCBI)TCN2
Genatlas (Paris)TCN2
WikiGenes6948
SOURCE (Princeton)TCN2
Genetics Home Reference (NIH)TCN2
Genomic and cartography
GoldenPath hg19 (UCSC)TCN2  -     chr22:31003070-31023047 +  22q12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TCN2  -     22q12.2   [Description]    (hg38-Dec_2013)
EnsemblTCN2 - 22q12.2 [CytoView hg19]  TCN2 - 22q12.2 [CytoView hg38]
Mapping of homologs : NCBITCN2 [Mapview hg19]  TCN2 [Mapview hg38]
OMIM275350   613441   
Gene and transcription
Genbank (Entrez)AK225445 AK313711 BC001176 BC011239 CR456591
RefSeq transcript (Entrez)NM_000355 NM_001184726 NM_001190420
RefSeq genomic (Entrez)NC_000022 NC_018933 NG_007263 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)TCN2
Cluster EST : UnigeneHs.417948 [ NCBI ]
CGAP (NCI)Hs.417948
Alternative Splicing GalleryENSG00000185339
Gene ExpressionTCN2 [ NCBI-GEO ]   TCN2 [ EBI - ARRAY_EXPRESS ]   TCN2 [ SEEK ]   TCN2 [ MEM ]
Gene Expression Viewer (FireBrowse)TCN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6948
GTEX Portal (Tissue expression)TCN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20062   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20062  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20062
Splice isoforms : SwissVarP20062
PhosPhoSitePlusP20062
Domaine pattern : Prosite (Expaxy)COBALAMIN_BINDING (PS00468)   
Domains : Interpro (EBI)Cbl-bd_transpt_euk    DUF4430    Terpenoid_cyclase/PrenylTrfase   
Domain families : Pfam (Sanger)Cobalamin_bind (PF01122)    DUF4430 (PF14478)   
Domain families : Pfam (NCBI)pfam01122    pfam14478   
Conserved Domain (NCBI)TCN2
DMDM Disease mutations6948
Blocks (Seattle)TCN2
PDB (SRS)2BB5   
PDB (PDBSum)2BB5   
PDB (IMB)2BB5   
PDB (RSDB)2BB5   
Structural Biology KnowledgeBase2BB5   
SCOP (Structural Classification of Proteins)2BB5   
CATH (Classification of proteins structures)2BB5   
SuperfamilyP20062
Human Protein AtlasENSG00000185339
Peptide AtlasP20062
HPRD02037
IPIIPI00219465   IPI00879436   IPI00386630   IPI00879778   IPI00877901   
Protein Interaction databases
DIP (DOE-UCLA)P20062
IntAct (EBI)P20062
FunCoupENSG00000185339
BioGRIDTCN2
STRING (EMBL)TCN2
ZODIACTCN2
Ontologies - Pathways
QuickGOP20062
Ontology : AmiGOextracellular region  extracellular space  endosome  cobalt ion transport  cobalamin metabolic process  cobalamin transport  cobalamin binding  lysosomal lumen  metal ion binding  extracellular exosome  
Ontology : EGO-EBIextracellular region  extracellular space  endosome  cobalt ion transport  cobalamin metabolic process  cobalamin transport  cobalamin binding  lysosomal lumen  metal ion binding  extracellular exosome  
Pathways : KEGGVitamin digestion and absorption   
NDEx NetworkTCN2
Atlas of Cancer Signalling NetworkTCN2
Wikipedia pathwaysTCN2
Orthology - Evolution
OrthoDB6948
GeneTree (enSembl)ENSG00000185339
Phylogenetic Trees/Animal Genes : TreeFamTCN2
HOVERGENP20062
HOGENOMP20062
Homologs : HomoloGeneTCN2
Homology/Alignments : Family Browser (UCSC)TCN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCN2
dbVarTCN2
ClinVarTCN2
1000_GenomesTCN2 
Exome Variant ServerTCN2
ExAC (Exome Aggregation Consortium)TCN2 (select the gene name)
Genetic variants : HAPMAP6948
Genomic Variants (DGV)TCN2 [DGVbeta]
DECIPHER (Syndromes)22:31003070-31023047  ENSG00000185339
CONAN: Copy Number AnalysisTCN2 
Mutations
ICGC Data PortalTCN2 
TCGA Data PortalTCN2 
Broad Tumor PortalTCN2
OASIS PortalTCN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTCN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TCN2
DgiDB (Drug Gene Interaction Database)TCN2
DoCM (Curated mutations)TCN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TCN2 (select a term)
intoGenTCN2
Cancer3DTCN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM275350    613441   
Orphanet1729   
MedgenTCN2
Genetic Testing Registry TCN2
NextProtP20062 [Medical]
TSGene6948
GENETestsTCN2
Huge Navigator TCN2 [HugePedia]
snp3D : Map Gene to Disease6948
BioCentury BCIQTCN2
ClinGenTCN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6948
Chemical/Pharm GKB GenePA36404
Clinical trialTCN2
Miscellaneous
canSAR (ICR)TCN2 (select the gene name)
Probes
Litterature
PubMed107 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTCN2
EVEXTCN2
GoPubMedTCN2
iHOPTCN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:22:05 CEST 2017

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