TCP1 (t-complex 1)

2015-02-01  

Identity

HGNC
LOCATION
6q25.3
LOCUSID
ALIAS
CCT-alpha,CCT1,CCTa,D6S230E,TCP-1-alpha
FUSION GENES

Other Information

Locus ID:

NCBI: 6950
MIM: 186980
HGNC: 11655
Ensembl: ENSG00000120438

Variants:

dbSNP: 6950
ClinVar: 6950
TCGA: ENSG00000120438
COSMIC: TCP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120438ENST00000321394P17987
ENSG00000120438ENST00000392168E7EQR6
ENSG00000120438ENST00000420894E7ERF2
ENSG00000120438ENST00000536394F5H726
ENSG00000120438ENST00000537390F5H676
ENSG00000120438ENST00000538128F5H7Y1
ENSG00000120438ENST00000538530F5GYL4
ENSG00000120438ENST00000539756F5GZ03
ENSG00000120438ENST00000539948F5H136
ENSG00000120438ENST00000543517F5GZI8
ENSG00000120438ENST00000544255F5H282

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Folding of actin by CCT/TriCREACTOMER-HSA-390450
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
BBSome-mediated cargo-targeting to ciliumREACTOMER-HSA-5620922
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
16304911992TCP1 complex is a molecular chaperone in tubulin biogenesis.115
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
191320872009A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease.84
87186791996gamma-Tubulin in mammalian cells: the centrosomal and the cytosolic forms.83
86332461996Principles of chaperone-assisted protein folding: differences between in vitro and in vivo mechanisms.60
19019441991The yeast homolog to mouse Tcp-1 affects microtubule-mediated processes.52
79164601994Two yeast genes with similarity to TCP-1 are required for microtubule and actin function in vivo.48
279291172016CCT complex restricts neuropathogenic protein aggregation via autophagy.32
257047582015Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes.31
159236172005CCT chaperonin complex is required for the biogenesis of functional Plk1.24

Citation

Dessen P

TCP1 (t-complex 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54963/tcp1