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TCP1 (t-complex 1)

Identity

Alias (NCBI)CCT-alpha
CCT1
CCTa
D6S230E
TCP-1-alpha
HGNC (Hugo) TCP1
HGNC Alias symbD6S230E
CCT1
Ccta
LocusID (NCBI) 6950
Atlas_Id 54963
Location 6q25.3  [Link to chromosome band 6q25]
Location_base_pair Starts at 159778498 and ends at 159789602 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TCP1 (6q25.3) / ACAT2 (6q25.3)TCP1 (6q25.3) / GMDS (6p25.3)TMEM230 (20p13) / TCP1 (6q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TCP1   11655
Cards
Entrez_Gene (NCBI)TCP1  6950  t-complex 1
AliasesCCT-alpha; CCT1; CCTa; D6S230E; 
TCP-1-alpha
GeneCards (Weizmann)TCP1
Ensembl hg19 (Hinxton)ENSG00000120438 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120438 [Gene_View]  ENSG00000120438 [Sequence]  chr6:159778498-159789602 [Contig_View]  TCP1 [Vega]
ICGC DataPortalENSG00000120438
TCGA cBioPortalTCP1
AceView (NCBI)TCP1
Genatlas (Paris)TCP1
WikiGenes6950
SOURCE (Princeton)TCP1
Genetics Home Reference (NIH)TCP1
Genomic and cartography
GoldenPath hg38 (UCSC)TCP1  -     chr6:159778498-159789602 -  6q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TCP1  -     6q25.3   [Description]    (hg19-Feb_2009)
GoldenPathTCP1 - 6q25.3 [CytoView hg19]  TCP1 - 6q25.3 [CytoView hg38]
ImmunoBaseENSG00000120438
genome Data Viewer NCBITCP1 [Mapview hg19]  
OMIM186980   
Gene and transcription
Genbank (Entrez)AA810047 AK308551 AK312604 BC000665 BM697304
RefSeq transcript (Entrez)NM_001008897 NM_030752
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TCP1
Alternative Splicing GalleryENSG00000120438
Gene ExpressionTCP1 [ NCBI-GEO ]   TCP1 [ EBI - ARRAY_EXPRESS ]   TCP1 [ SEEK ]   TCP1 [ MEM ]
Gene Expression Viewer (FireBrowse)TCP1 [ Firebrowse - Broad ]
GenevisibleExpression of TCP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6950
GTEX Portal (Tissue expression)TCP1
Human Protein AtlasENSG00000120438-TCP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17987   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17987  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17987
Splice isoforms : SwissVarP17987
PhosPhoSitePlusP17987
Domaine pattern : Prosite (Expaxy)TCP1_1 (PS00750)    TCP1_2 (PS00751)    TCP1_3 (PS00995)   
Domains : Interpro (EBI)Chap_CCT_alpha    Chaperone_TCP-1    Chaperonin_TCP-1_CS    Cpn60/TCP-1    GroEL-like_apical_dom_sf    GROEL-like_equatorial_sf    TCP-1-like_intermed_sf   
Domain families : Pfam (Sanger)Cpn60_TCP1 (PF00118)   
Domain families : Pfam (NCBI)pfam00118   
Conserved Domain (NCBI)TCP1
DMDM Disease mutations6950
Blocks (Seattle)TCP1
PDB (RSDB)6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
PDB Europe6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
PDB (PDBSum)6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
PDB (IMB)6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
Structural Biology KnowledgeBase6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
SCOP (Structural Classification of Proteins)6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
CATH (Classification of proteins structures)6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
SuperfamilyP17987
Human Protein Atlas [tissue]ENSG00000120438-TCP1 [tissue]
Peptide AtlasP17987
HPRD01748
IPIIPI00290566   IPI00550591   IPI01014211   IPI01013751   IPI01015459   IPI01014996   IPI01013914   IPI01013508   IPI01014629   IPI01014342   IPI01011863   
Protein Interaction databases
DIP (DOE-UCLA)P17987
IntAct (EBI)P17987
FunCoupENSG00000120438
BioGRIDTCP1
STRING (EMBL)TCP1
ZODIACTCP1
Ontologies - Pathways
QuickGOP17987
Ontology : AmiGOpericentriolar material  acrosomal vesicle  zona pellucida receptor complex  RNA binding  protein binding  ATP binding  nuclear heterochromatin  Golgi apparatus  centrosome  cytosol  chaperonin-containing T-complex  chaperonin-containing T-complex  microtubule  protein folding  tubulin complex assembly  binding of sperm to zona pellucida  ubiquitin protein ligase binding  positive regulation of telomere maintenance via telomerase  interleukin-12-mediated signaling pathway  translocation of peptides or proteins into host cell cytoplasm  cell body  protein stabilization  unfolded protein binding  positive regulation of telomerase activity  extracellular exosome  scaRNA localization to Cajal body  toxin transport  positive regulation of establishment of protein localization to telomere  positive regulation of protein localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  regulation of macrophage apoptotic process  
Ontology : EGO-EBIpericentriolar material  acrosomal vesicle  zona pellucida receptor complex  RNA binding  protein binding  ATP binding  nuclear heterochromatin  Golgi apparatus  centrosome  cytosol  chaperonin-containing T-complex  chaperonin-containing T-complex  microtubule  protein folding  tubulin complex assembly  binding of sperm to zona pellucida  ubiquitin protein ligase binding  positive regulation of telomere maintenance via telomerase  interleukin-12-mediated signaling pathway  translocation of peptides or proteins into host cell cytoplasm  cell body  protein stabilization  unfolded protein binding  positive regulation of telomerase activity  extracellular exosome  scaRNA localization to Cajal body  toxin transport  positive regulation of establishment of protein localization to telomere  positive regulation of protein localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  regulation of macrophage apoptotic process  
NDEx NetworkTCP1
Atlas of Cancer Signalling NetworkTCP1
Wikipedia pathwaysTCP1
Orthology - Evolution
OrthoDB6950
GeneTree (enSembl)ENSG00000120438
Phylogenetic Trees/Animal Genes : TreeFamTCP1
HOGENOMP17987
Homologs : HomoloGeneTCP1
Homology/Alignments : Family Browser (UCSC)TCP1
Gene fusions - Rearrangements
Fusion : QuiverTCP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCP1
dbVarTCP1
ClinVarTCP1
MonarchTCP1
1000_GenomesTCP1 
Exome Variant ServerTCP1
GNOMAD BrowserENSG00000120438
Varsome BrowserTCP1
Genetic variants : HAPMAP6950
Genomic Variants (DGV)TCP1 [DGVbeta]
DECIPHERTCP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTCP1 
Mutations
ICGC Data PortalTCP1 
TCGA Data PortalTCP1 
Broad Tumor PortalTCP1
OASIS PortalTCP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTCP1
Mutations and Diseases : HGMDTCP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TCP1
DgiDB (Drug Gene Interaction Database)TCP1
DoCM (Curated mutations)TCP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TCP1 (select a term)
intoGenTCP1
Cancer3DTCP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186980   
Orphanet
DisGeNETTCP1
MedgenTCP1
Genetic Testing Registry TCP1
NextProtP17987 [Medical]
TSGene6950
GENETestsTCP1
Target ValidationTCP1
Huge Navigator TCP1 [HugePedia]
snp3D : Map Gene to Disease6950
BioCentury BCIQTCP1
ClinGenTCP1
Clinical trials, drugs, therapy
Protein Interactions : CTD6950
Pharm GKB GenePA36406
Clinical trialTCP1
Miscellaneous
canSAR (ICR)TCP1 (select the gene name)
HarmonizomeTCP1
DataMed IndexTCP1
Probes
Litterature
PubMed233 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTCP1
EVEXTCP1
GoPubMedTCP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:35:41 CEST 2020
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