Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TDG (thymine-DNA glycosylase)

Identity

Other nameshTDG
HGNC (Hugo) TDG
LocusID (NCBI) 6996
Location 12q23.3
Location_base_pair Starts at 104359593 and ends at 104382656 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TDG   11700
Cards
Entrez_Gene (NCBI)TDG  6996  thymine-DNA glycosylase
GeneCards (Weizmann)TDG
Ensembl hg19 (Hinxton)ENSG00000139372 [Gene_View]  chr12:104359593-104382656 [Contig_View]  TDG [Vega]
Ensembl hg38 (Hinxton)ENSG00000139372 [Gene_View]  chr12:104359593-104382656 [Contig_View]  TDG [Vega]
ICGC DataPortalENSG00000139372
cBioPortalTDG
AceView (NCBI)TDG
Genatlas (Paris)TDG
WikiGenes6996
SOURCE (Princeton)TDG
Genomic and cartography
GoldenPath hg19 (UCSC)TDG  -     chr12:104359593-104382656 +  12q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TDG  -     12q23.3   [Description]    (hg38-Dec_2013)
EnsemblTDG - 12q23.3 [CytoView hg19]  TDG - 12q23.3 [CytoView hg38]
Mapping of homologs : NCBITDG [Mapview hg19]  TDG [Mapview hg38]
OMIM601423   
Gene and transcription
Genbank (Entrez)AI004247 AI452763 AK295387 AK299832 AK303631
RefSeq transcript (Entrez)NM_001008411 NM_003211
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NT_029419 NW_001838061 NW_004929384
Consensus coding sequences : CCDS (NCBI)TDG
Cluster EST : UnigeneHs.584809 [ NCBI ]
CGAP (NCI)Hs.584809
Alternative Splicing : Fast-db (Paris)GSHG0006951
Alternative Splicing GalleryENSG00000139372
Gene ExpressionTDG [ NCBI-GEO ]     TDG [ SEEK ]   TDG [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13569 (Uniprot)
NextProtQ13569  [Medical]
With graphics : InterProQ13569
Splice isoforms : SwissVarQ13569 (Swissvar)
Catalytic activity : Enzyme3.2.2.29 [ Enzyme-Expasy ]   3.2.2.293.2.2.29 [ IntEnz-EBI ]   3.2.2.29 [ BRENDA ]   3.2.2.29 [ KEGG ]   
Domains : Interpro (EBI)DNA_glycosylase_G/T-mismatch    Thymine-DNA_glycosylase    Uracil-DNA_glycosylase-like   
Related proteins : CluSTrQ13569
Domain families : Pfam (Sanger)UDG (PF03167)   
Domain families : Pfam (NCBI)pfam03167   
Domain families : Smart (EMBL)UDG (SM00986)  
DMDM Disease mutations6996
Blocks (Seattle)Q13569
PDB (SRS)1WYW    2D07    2RBA    3UFJ    3UO7    3UOB    4FNC    4JGC   
PDB (PDBSum)1WYW    2D07    2RBA    3UFJ    3UO7    3UOB    4FNC    4JGC   
PDB (IMB)1WYW    2D07    2RBA    3UFJ    3UO7    3UOB    4FNC    4JGC   
PDB (RSDB)1WYW    2D07    2RBA    3UFJ    3UO7    3UOB    4FNC    4JGC   
Human Protein AtlasENSG00000139372
Peptide AtlasQ13569
HPRD03251
IPIIPI00333201   IPI00909580   IPI00909826   IPI00976977   IPI01011249   IPI01009111   IPI01011228   IPI01015010   IPI01014539   
Protein Interaction databases
DIP (DOE-UCLA)Q13569
IntAct (EBI)Q13569
FunCoupENSG00000139372
BioGRIDTDG
IntegromeDBTDG
STRING (EMBL)TDG
Ontologies - Pathways
QuickGOQ13569
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription cofactor activity  damaged DNA binding  double-stranded DNA binding  protein kinase C binding  protein binding  nucleus  nucleoplasm  nucleolus  plasma membrane  DNA repair  base-excision repair  base-excision repair  base-excision repair, AP site formation  mismatch repair  transcription from RNA polymerase II promoter  pyrimidine-specific mismatch base pair DNA N-glycosylase activity  embryo development  chromatin modification  PML body  DNA N-glycosylase activity  mismatched DNA binding  negative regulation of protein binding  SUMO binding  negative regulation of chromatin binding  regulation of gene expression, epigenetic  protein homodimerization activity  structure-specific DNA binding  depyrimidination  DNA demethylation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription cofactor activity  damaged DNA binding  double-stranded DNA binding  protein kinase C binding  protein binding  nucleus  nucleoplasm  nucleolus  plasma membrane  DNA repair  base-excision repair  base-excision repair  base-excision repair, AP site formation  mismatch repair  transcription from RNA polymerase II promoter  pyrimidine-specific mismatch base pair DNA N-glycosylase activity  embryo development  chromatin modification  PML body  DNA N-glycosylase activity  mismatched DNA binding  negative regulation of protein binding  SUMO binding  negative regulation of chromatin binding  regulation of gene expression, epigenetic  protein homodimerization activity  structure-specific DNA binding  depyrimidination  DNA demethylation  
Pathways : KEGGBase excision repair   
Protein Interaction DatabaseTDG
DoCM (Curated mutations)TDG
Wikipedia pathwaysTDG
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTDG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TDG
dbVarTDG
ClinVarTDG
1000_GenomesTDG 
Exome Variant ServerTDG
SNP (GeneSNP Utah)TDG
SNP : HGBaseTDG
Genetic variants : HAPMAPTDG
Genomic VariantsTDG  TDG [DGVbeta]
Mutations
ICGC Data PortalENSG00000139372 
Somatic Mutations in Cancer : COSMICTDG 
CONAN: Copy Number AnalysisTDG 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:104359593-104382656
Mutations and Diseases : HGMDTDG
OMIM601423   
MedgenTDG
NextProtQ13569 [Medical]
GENETestsTDG
Disease Genetic AssociationTDG
Huge Navigator TDG [HugePedia]  TDG [HugeCancerGEM]
snp3D : Map Gene to Disease6996
DGIdb (Drug Gene Interaction db)TDG
General knowledge
Homologs : HomoloGeneTDG
Homology/Alignments : Family Browser (UCSC)TDG
Phylogenetic Trees/Animal Genes : TreeFamTDG
Chemical/Protein Interactions : CTD6996
Chemical/Pharm GKB GenePA36419
Clinical trialTDG
Cancer Resource (Charite)ENSG00000139372
Other databases
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
CoreMineTDG
GoPubMedTDG
iHOPTDG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 01:52:31 CET 2014
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