| Nomenclature |
|---|
| HGNC (Hugo) | TDG 11700 |
| Cards |
|---|
| Entrez_Gene (NCBI) | TDG 6996 thymine DNA glycosylase |
| Aliases | hTDG |
| GeneCards (Weizmann) | TDG |
| Ensembl hg19 (Hinxton) | ENSG00000139372 [Gene_View] chr12:104359593-104382656 [Contig_View] TDG [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000139372 [Gene_View] chr12:104359593-104382656 [Contig_View] TDG [Vega] |
| ICGC DataPortal | ENSG00000139372 |
| TCGA cBioPortal | TDG |
| AceView (NCBI) | TDG |
| Genatlas (Paris) | TDG |
| WikiGenes | 6996 |
| SOURCE (Princeton) | TDG |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | TDG - chr12:104359593-104382656 + 12q23.3 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | TDG - 12q23.3 [Description] (hg38-Dec_2013) |
| Ensembl | TDG - 12q23.3 [CytoView hg19] TDG - 12q23.3 [CytoView hg38] |
| Mapping of homologs : NCBI | TDG [Mapview hg19] TDG [Mapview hg38] |
| OMIM | 601423 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AI004247 AI452763 AK295387 AK299832 AK303631 |
| RefSeq transcript (Entrez) | NM_001008411 NM_003211 |
| RefSeq genomic (Entrez) | NC_000012 NC_018923 NT_029419 NW_004929384 |
| Consensus coding sequences : CCDS (NCBI) | TDG |
| Cluster EST : Unigene | Hs.584809 [ NCBI ] |
| CGAP (NCI) | Hs.584809 |
| Alternative Splicing Gallery | ENSG00000139372 |
| Gene Expression | TDG [ NCBI-GEO ] TDG [ EBI - ARRAY_EXPRESS ]
TDG [ SEEK ] TDG [ MEM ] |
| Gene Expression Viewer (FireBrowse) | TDG [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 6996 |
| GTEX Portal (Tissue expression) | TDG |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q13569 (Uniprot) |
| NextProt | Q13569 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q13569 |
| Splice isoforms : SwissVar | Q13569 (Swissvar) |
| Catalytic activity : Enzyme | 3.2.2.29 [ Enzyme-Expasy ] 3.2.2.293.2.2.29 [ IntEnz-EBI ] 3.2.2.29 [ BRENDA ] 3.2.2.29 [ KEGG ] |
| PhosPhoSitePlus | Q13569 |
| Domains : Interpro (EBI) | DNA_glycosylase_G/T-mismatch Thymine-DNA_glycosylase Uracil-DNA_glycosylase-like |
| Domain families : Pfam (Sanger) | UDG (PF03167) |
| Domain families : Pfam (NCBI) | pfam03167 |
| Domain families : Smart (EMBL) | UDG (SM00986) |
| DMDM Disease mutations | 6996 |
| Blocks (Seattle) | TDG |
| PDB (SRS) | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS |
| PDB (PDBSum) | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS |
| PDB (IMB) | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS |
| PDB (RSDB) | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS |
| Structural Biology KnowledgeBase | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS |
| SCOP (Structural Classification of Proteins) | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS |
| CATH (Classification of proteins structures) | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS |
| Superfamily | Q13569 |
| Human Protein Atlas | ENSG00000139372 |
| Peptide Atlas | Q13569 |
| HPRD | 03251 |
| IPI | IPI00333201 IPI00909580 IPI00909826 IPI00976977 IPI01011249 IPI01009111 IPI01011228 IPI01015010 IPI01014539 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q13569 |
| IntAct (EBI) | Q13569 |
| FunCoup | ENSG00000139372 |
| BioGRID | TDG |
| STRING (EMBL) | TDG |
| ZODIAC | TDG |
| Ontologies - Pathways |
|---|
| QuickGO | Q13569 |
| Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription cofactor activity damaged DNA binding double-stranded DNA binding uracil DNA N-glycosylase activity protein kinase C binding protein binding nucleus nucleoplasm nucleoplasm plasma membrane base-excision repair base-excision repair, AP site formation mismatch repair transcription, DNA-templated pyrimidine-specific mismatch base pair DNA N-glycosylase activity embryo development chromatin modification PML body protein sumoylation DNA N-glycosylase activity DNA N-glycosylase activity mismatched DNA binding negative regulation of protein binding SUMO binding oxidative DNA demethylation negative regulation of chromatin binding regulation of gene expression, epigenetic protein homodimerization activity structure-specific DNA binding depyrimidination DNA demethylation |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription cofactor activity damaged DNA binding double-stranded DNA binding uracil DNA N-glycosylase activity protein kinase C binding protein binding nucleus nucleoplasm nucleoplasm plasma membrane base-excision repair base-excision repair, AP site formation mismatch repair transcription, DNA-templated pyrimidine-specific mismatch base pair DNA N-glycosylase activity embryo development chromatin modification PML body protein sumoylation DNA N-glycosylase activity DNA N-glycosylase activity mismatched DNA binding negative regulation of protein binding SUMO binding oxidative DNA demethylation negative regulation of chromatin binding regulation of gene expression, epigenetic protein homodimerization activity structure-specific DNA binding depyrimidination DNA demethylation |
| Pathways : KEGG | Base excision repair |
| NDEx Network | TDG |
| Atlas of Cancer Signalling Network | TDG |
| Wikipedia pathways | TDG |
| Orthology - Evolution |
|---|
| OrthoDB | 6996 |
| GeneTree (enSembl) | ENSG00000139372 |
| Phylogenetic Trees/Animal Genes : TreeFam | TDG |
| Homologs : HomoloGene | TDG |
| Homology/Alignments : Family Browser (UCSC) | TDG |
| Gene fusions - Rearrangements |
|---|
| Fusion: TCGA | TDG 12q23.3 STAB2 12q23.3 BRCA |
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | TDG [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | TDG |
| dbVar | TDG |
| ClinVar | TDG |
| 1000_Genomes | TDG |
| Exome Variant Server | TDG |
| ExAC (Exome Aggregation Consortium) | TDG (select the gene name) |
| Genetic variants : HAPMAP | 6996 |
| Genomic Variants (DGV) | TDG [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | TDG |
| TCGA Data Portal | TDG |
| Broad Tumor Portal | TDG |
| OASIS Portal | TDG [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | TDG |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search TDG |
| DgiDB (Drug Gene Interaction Database) | TDG |
| DoCM (Curated mutations) | TDG (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | TDG (select a term) |
| intoGen | TDG |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | 12:104359593-104382656 ENSG00000139372 |
| CONAN: Copy Number Analysis | TDG |
| Mutations and Diseases : HGMD | TDG |
| OMIM | 601423 |
| Medgen | TDG |
| Genetic Testing Registry | TDG
|
| NextProt | Q13569 [Medical] |
| TSGene | 6996 |
| GENETests | TDG |
| Huge Navigator |
TDG [HugePedia] |
| snp3D : Map Gene to Disease | 6996 |
| BioCentury BCIQ | TDG |
| ClinGen | TDG |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 6996 |
| Chemical/Pharm GKB Gene | PA36419 |
| Clinical trial | TDG |
| Miscellaneous |
|---|
| canSAR (ICR) | TDG (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 87 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | TDG |
| EVEX | TDG |
| GoPubMed | TDG |
| iHOP | TDG |
