Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TDG (thymine DNA glycosylase)

Identity

Other aliashTDG
HGNC (Hugo) TDG
LocusID (NCBI) 6996
Atlas_Id 42506
Location 12q23.3  [Link to chromosome band 12q23]
Location_base_pair Starts at 103965815 and ends at 103988878 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TDG (12q23.3) / STAB2 (12q23.3)YWHAQ (2p25.1) / TDG (12q23.3)TDG 12q23.3 / STAB2 12q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(q23;q23) TDG/STAB2

External links

Nomenclature
HGNC (Hugo)TDG   11700
Cards
Entrez_Gene (NCBI)TDG  6996  thymine DNA glycosylase
AliaseshTDG
GeneCards (Weizmann)TDG
Ensembl hg19 (Hinxton)ENSG00000139372 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139372 [Gene_View]  chr12:103965815-103988878 [Contig_View]  TDG [Vega]
ICGC DataPortalENSG00000139372
TCGA cBioPortalTDG
AceView (NCBI)TDG
Genatlas (Paris)TDG
WikiGenes6996
SOURCE (Princeton)TDG
Genetics Home Reference (NIH)TDG
Genomic and cartography
GoldenPath hg38 (UCSC)TDG  -     chr12:103965815-103988878 +  12q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TDG  -     12q23.3   [Description]    (hg19-Feb_2009)
EnsemblTDG - 12q23.3 [CytoView hg19]  TDG - 12q23.3 [CytoView hg38]
Mapping of homologs : NCBITDG [Mapview hg19]  TDG [Mapview hg38]
OMIM601423   
Gene and transcription
Genbank (Entrez)AI004247 AI452763 AK295387 AK299832 AK303631
RefSeq transcript (Entrez)NM_001008411 NM_003211
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TDG
Cluster EST : UnigeneHs.584809 [ NCBI ]
CGAP (NCI)Hs.584809
Alternative Splicing GalleryENSG00000139372
Gene ExpressionTDG [ NCBI-GEO ]   TDG [ EBI - ARRAY_EXPRESS ]   TDG [ SEEK ]   TDG [ MEM ]
Gene Expression Viewer (FireBrowse)TDG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6996
GTEX Portal (Tissue expression)TDG
Human Protein AtlasENSG00000139372-TDG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13569   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13569  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13569
Splice isoforms : SwissVarQ13569
Catalytic activity : Enzyme3.2.2.29 [ Enzyme-Expasy ]   3.2.2.293.2.2.29 [ IntEnz-EBI ]   3.2.2.29 [ BRENDA ]   3.2.2.29 [ KEGG ]   
PhosPhoSitePlusQ13569
Domains : Interpro (EBI)MUG/TDG    TDG    Uracil-DNA_glycosylase-like   
Domain families : Pfam (Sanger)UDG (PF03167)   
Domain families : Pfam (NCBI)pfam03167   
Conserved Domain (NCBI)TDG
DMDM Disease mutations6996
Blocks (Seattle)TDG
PDB (SRS)1WYW    2D07    2RBA    3UFJ    3UO7    3UOB    4FNC    4JGC    4XEG    4Z3A    4Z47    4Z7B    4Z7Z    5CYS    5FF8    5HF7    5JXY    5T2W   
PDB (PDBSum)1WYW    2D07    2RBA    3UFJ    3UO7    3UOB    4FNC    4JGC    4XEG    4Z3A    4Z47    4Z7B    4Z7Z    5CYS    5FF8    5HF7    5JXY    5T2W   
PDB (IMB)1WYW    2D07    2RBA    3UFJ    3UO7    3UOB    4FNC    4JGC    4XEG    4Z3A    4Z47    4Z7B    4Z7Z    5CYS    5FF8    5HF7    5JXY    5T2W   
PDB (RSDB)1WYW    2D07    2RBA    3UFJ    3UO7    3UOB    4FNC    4JGC    4XEG    4Z3A    4Z47    4Z7B    4Z7Z    5CYS    5FF8    5HF7    5JXY    5T2W   
Structural Biology KnowledgeBase1WYW    2D07    2RBA    3UFJ    3UO7    3UOB    4FNC    4JGC    4XEG    4Z3A    4Z47    4Z7B    4Z7Z    5CYS    5FF8    5HF7    5JXY    5T2W   
SCOP (Structural Classification of Proteins)1WYW    2D07    2RBA    3UFJ    3UO7    3UOB    4FNC    4JGC    4XEG    4Z3A    4Z47    4Z7B    4Z7Z    5CYS    5FF8    5HF7    5JXY    5T2W   
CATH (Classification of proteins structures)1WYW    2D07    2RBA    3UFJ    3UO7    3UOB    4FNC    4JGC    4XEG    4Z3A    4Z47    4Z7B    4Z7Z    5CYS    5FF8    5HF7    5JXY    5T2W   
SuperfamilyQ13569
Human Protein Atlas [tissue]ENSG00000139372-TDG [tissue]
Peptide AtlasQ13569
HPRD03251
IPIIPI00333201   IPI00909580   IPI00909826   IPI00976977   IPI01011249   IPI01009111   IPI01011228   IPI01015010   IPI01014539   
Protein Interaction databases
DIP (DOE-UCLA)Q13569
IntAct (EBI)Q13569
FunCoupENSG00000139372
BioGRIDTDG
STRING (EMBL)TDG
ZODIACTDG
Ontologies - Pathways
QuickGOQ13569
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  magnesium ion binding  RNA polymerase II transcription cofactor activity  DNA binding  damaged DNA binding  double-stranded DNA binding  uracil DNA N-glycosylase activity  protein kinase C binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  plasma membrane  base-excision repair  base-excision repair, AP site formation  base-excision repair, AP site formation  mismatch repair  transcription, DNA-templated  transcription factor binding  pyrimidine-specific mismatch base pair DNA N-glycosylase activity  pyrimidine-specific mismatch base pair DNA N-glycosylase activity  embryo development  covalent chromatin modification  PML body  DNA N-glycosylase activity  DNA N-glycosylase activity  protein domain specific binding  mismatched DNA binding  sodium ion binding  chloride ion binding  negative regulation of protein binding  SUMO binding  oxidative DNA demethylation  negative regulation of chromatin binding  regulation of gene expression, epigenetic  protein homodimerization activity  protein self-association  G/U mismatch-specific uracil-DNA glycosylase activity  depyrimidination  DNA demethylation  regulation of DNA N-glycosylase activity  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  magnesium ion binding  RNA polymerase II transcription cofactor activity  DNA binding  damaged DNA binding  double-stranded DNA binding  uracil DNA N-glycosylase activity  protein kinase C binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  plasma membrane  base-excision repair  base-excision repair, AP site formation  base-excision repair, AP site formation  mismatch repair  transcription, DNA-templated  transcription factor binding  pyrimidine-specific mismatch base pair DNA N-glycosylase activity  pyrimidine-specific mismatch base pair DNA N-glycosylase activity  embryo development  covalent chromatin modification  PML body  DNA N-glycosylase activity  DNA N-glycosylase activity  protein domain specific binding  mismatched DNA binding  sodium ion binding  chloride ion binding  negative regulation of protein binding  SUMO binding  oxidative DNA demethylation  negative regulation of chromatin binding  regulation of gene expression, epigenetic  protein homodimerization activity  protein self-association  G/U mismatch-specific uracil-DNA glycosylase activity  depyrimidination  DNA demethylation  regulation of DNA N-glycosylase activity  
NDEx NetworkTDG
Atlas of Cancer Signalling NetworkTDG
Wikipedia pathwaysTDG
Orthology - Evolution
OrthoDB6996
GeneTree (enSembl)ENSG00000139372
Phylogenetic Trees/Animal Genes : TreeFamTDG
HOVERGENQ13569
HOGENOMQ13569
Homologs : HomoloGeneTDG
Homology/Alignments : Family Browser (UCSC)TDG
Gene fusions - Rearrangements
Fusion : MitelmanTDG/STAB2 [12q23.3/12q23.3]  
Fusion: TCGA_MDACCTDG 12q23.3 STAB2 12q23.3 BRCA
Fusion PortalTDG 12q23.3 STAB2 12q23.3 BRCA
Fusion : QuiverTDG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTDG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TDG
dbVarTDG
ClinVarTDG
1000_GenomesTDG 
Exome Variant ServerTDG
ExAC (Exome Aggregation Consortium)ENSG00000139372
GNOMAD BrowserENSG00000139372
Genetic variants : HAPMAP6996
Genomic Variants (DGV)TDG [DGVbeta]
DECIPHERTDG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTDG 
Mutations
ICGC Data PortalTDG 
TCGA Data PortalTDG 
Broad Tumor PortalTDG
OASIS PortalTDG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTDG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTDG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TDG
DgiDB (Drug Gene Interaction Database)TDG
DoCM (Curated mutations)TDG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TDG (select a term)
intoGenTDG
Cancer3DTDG(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601423   
Orphanet
DisGeNETTDG
MedgenTDG
Genetic Testing Registry TDG
NextProtQ13569 [Medical]
TSGene6996
GENETestsTDG
Target ValidationTDG
Huge Navigator TDG [HugePedia]
snp3D : Map Gene to Disease6996
BioCentury BCIQTDG
ClinGenTDG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6996
Chemical/Pharm GKB GenePA36419
Clinical trialTDG
Miscellaneous
canSAR (ICR)TDG (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTDG
EVEXTDG
GoPubMedTDG
iHOPTDG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon May 14 12:23:12 CEST 2018
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