TDG (thymine DNA glycosylase)

2003-02-01  

Identity

HGNC
LOCATION
12q23.3
LOCUSID
ALIAS
hTDG
FUSION GENES

Other Information

Locus ID:

NCBI: 6996
MIM: 601423
HGNC: 11700
Ensembl: ENSG00000139372

Variants:

dbSNP: 6996
ClinVar: 6996
TCGA: ENSG00000139372
COSMIC: TDG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139372ENST00000266775G8JL98
ENSG00000139372ENST00000392872Q13569
ENSG00000139372ENST00000436021F5H539
ENSG00000139372ENST00000537100F5H0I7
ENSG00000139372ENST00000540956H0YH18
ENSG00000139372ENST00000544861B4E127

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Base excision repairKEGGhsa03410
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
TET1,2,3 and TDG demethylate DNAREACTOMER-HSA-5221030
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Base-Excision Repair, AP Site FormationREACTOMER-HSA-73929
DepyrimidinationREACTOMER-HSA-73928
Recognition and association of DNA glycosylase with site containing an affected pyrimidineREACTOMER-HSA-110328
Cleavage of the damaged pyrimidineREACTOMER-HSA-110329
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Displacement of DNA glycosylase by APEX1REACTOMER-HSA-110357

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
218628362011Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.314
223274022012Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.141
159595182005Crystal structure of thymine DNA glycosylase conjugated to SUMO-1.85
250878722014Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.81
158235332005Functionality of human thymine DNA glycosylase requires SUMO-regulated changes in protein conformation.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
194027492009Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil.61
185870512008Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition.58
229623652012Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.57
128742882003T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha.53

Citation

Dessen P

TDG (thymine DNA glycosylase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42506/tdg