| Nomenclature |
HGNC (Hugo) | TDG 11700 |
| Cards |
Entrez_Gene (NCBI) | TDG thymine DNA glycosylase |
Aliases | hTDG |
GeneCards (Weizmann) | TDG |
Ensembl hg19 (Hinxton) | ENSG00000139372 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000139372 [Gene_View]  ENSG00000139372 [Sequence] chr12:103965872-103988874 [Contig_View] TDG [Vega] |
ICGC DataPortal | ENSG00000139372 |
TCGA cBioPortal | TDG |
AceView (NCBI) | TDG |
Genatlas (Paris) | TDG |
SOURCE (Princeton) | TDG |
Genetics Home Reference (NIH) | TDG |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | TDG - chr12:103965872-103988874 + 12q23.3 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | TDG - 12q23.3 [Description] (hg19-Feb_2009) |
GoldenPath | TDG - 12q23.3 [CytoView hg19] TDG - 12q23.3 [CytoView hg38] |
ImmunoBase | ENSG00000139372 |
genome Data Viewer NCBI | TDG [Mapview hg19] |
OMIM | 601423 |
| Gene and transcription |
Genbank (Entrez) | AI004247 AI452763 AK295387 AK299832 AK303631 |
RefSeq transcript (Entrez) | NM_001008411 NM_001363612 NM_003211 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | TDG |
Alternative Splicing Gallery | ENSG00000139372 |
Gene Expression | TDG [ NCBI-GEO ] TDG [ EBI - ARRAY_EXPRESS ]
TDG [ SEEK ] TDG [ MEM ] |
Gene Expression Viewer (FireBrowse) | TDG [ Firebrowse - Broad ] |
Genevisible | Expression of TDG in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 6996 |
GTEX Portal (Tissue expression) | TDG |
Human Protein Atlas | ENSG00000139372-TDG [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | Q13569 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | Q13569 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | Q13569 |
Splice isoforms : SwissVar | Q13569 |
Catalytic activity : Enzyme | 3.2.2.29 [ Enzyme-Expasy ] 3.2.2.293.2.2.29 [ IntEnz-EBI ] 3.2.2.29 [ BRENDA ] 3.2.2.29 [ KEGG ] [ MEROPS ] |
PhosPhoSitePlus | Q13569 |
Domains : Interpro (EBI) | MUG/TDG TDG Uracil-DNA_glycosylase-like Uracil-DNA_glycosylase-like_sf |
Domain families : Pfam (Sanger) | UDG (PF03167) |
Domain families : Pfam (NCBI) | pfam03167 |
Conserved Domain (NCBI) | TDG |
Blocks (Seattle) | TDG |
PDB (RSDB) | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17 |
PDB Europe | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17 |
PDB (PDBSum) | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17 |
PDB (IMB) | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17 |
Structural Biology KnowledgeBase | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17 |
SCOP (Structural Classification of Proteins) | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17 |
CATH (Classification of proteins structures) | 1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17 |
Superfamily | Q13569 |
Human Protein Atlas [tissue] | ENSG00000139372-TDG [tissue] |
Peptide Atlas | Q13569 |
HPRD | 03251 |
IPI | IPI00333201 IPI00909580 IPI00909826 IPI00976977 IPI01011249 IPI01009111 IPI01011228 IPI01015010 IPI01014539 |
| Protein Interaction databases |
DIP (DOE-UCLA) | Q13569 |
IntAct (EBI) | Q13569 |
BioGRID | TDG |
STRING (EMBL) | TDG |
ZODIAC | TDG |
| Ontologies - Pathways |
QuickGO | Q13569 |
Ontology : AmiGO | negative regulation of transcription by RNA polymerase II magnesium ion binding DNA binding damaged DNA binding double-stranded DNA binding transcription coregulator activity uracil DNA N-glycosylase activity uracil DNA N-glycosylase activity protein kinase C binding protein binding ATP binding nucleus nucleus nucleoplasm nucleoplasm plasma membrane base-excision repair base-excision repair, AP site formation base-excision repair, AP site formation base-excision repair, AP site formation mismatch repair chromatin organization transcription factor binding pyrimidine-specific mismatch base pair DNA N-glycosylase activity pyrimidine-specific mismatch base pair DNA N-glycosylase activity pyrimidine-specific mismatch base pair DNA N-glycosylase activity PML body DNA N-glycosylase activity DNA N-glycosylase activity protein domain specific binding mismatched DNA binding sodium ion binding chloride ion binding negative regulation of protein binding SUMO binding oxidative DNA demethylation negative regulation of chromatin binding regulation of gene expression, epigenetic protein homodimerization activity protein self-association G/U mismatch-specific uracil-DNA glycosylase activity depyrimidination regulation of embryonic development DNA demethylation regulation of DNA N-glycosylase activity |
Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II magnesium ion binding DNA binding damaged DNA binding double-stranded DNA binding transcription coregulator activity uracil DNA N-glycosylase activity uracil DNA N-glycosylase activity protein kinase C binding protein binding ATP binding nucleus nucleus nucleoplasm nucleoplasm plasma membrane base-excision repair base-excision repair, AP site formation base-excision repair, AP site formation base-excision repair, AP site formation mismatch repair chromatin organization transcription factor binding pyrimidine-specific mismatch base pair DNA N-glycosylase activity pyrimidine-specific mismatch base pair DNA N-glycosylase activity pyrimidine-specific mismatch base pair DNA N-glycosylase activity PML body DNA N-glycosylase activity DNA N-glycosylase activity protein domain specific binding mismatched DNA binding sodium ion binding chloride ion binding negative regulation of protein binding SUMO binding oxidative DNA demethylation negative regulation of chromatin binding regulation of gene expression, epigenetic protein homodimerization activity protein self-association G/U mismatch-specific uracil-DNA glycosylase activity depyrimidination regulation of embryonic development DNA demethylation regulation of DNA N-glycosylase activity |
Pathways : KEGG | Base excision repair |
NDEx Network | TDG |
Atlas of Cancer Signalling Network | TDG |
Wikipedia pathways | TDG |
| Orthology - Evolution |
OrthoDB | 6996 |
GeneTree (enSembl) | ENSG00000139372 |
Phylogenetic Trees/Animal Genes : TreeFam | TDG |
HOGENOM | Q13569 |
Homologs : HomoloGene | TDG |
Homology/Alignments : Family Browser (UCSC) | TDG |
| Gene fusions - Rearrangements |
Fusion : Mitelman | TDG/STAB2 [12q23.3/12q23.3]   |
Fusion Portal | TDG 12q23.3 STAB2 12q23.3 BRCA |
Fusion : Quiver | TDG |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | TDG [hg38] |
dbVar | TDG |
ClinVar | TDG |
Monarch | TDG |
1000_Genomes | TDG |
Exome Variant Server | TDG |
GNOMAD Browser | ENSG00000139372 |
Varsome Browser | TDG |
Genomic Variants (DGV) | TDG [DGVbeta] |
DECIPHER | TDG [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | TDG |
| Mutations |
ICGC Data Portal | TDG |
TCGA Data Portal | TDG |
Broad Tumor Portal | TDG |
OASIS Portal | TDG [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | TDG [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | TDG |
Mutations and Diseases : HGMD | TDG |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search TDG |
DgiDB (Drug Gene Interaction Database) | TDG |
DoCM (Curated mutations) | TDG (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | TDG (select a term) |
intoGen | TDG |
Cancer3D | TDG(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
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OMIM | 601423 |
Orphanet | |
DisGeNET | TDG |
Medgen | TDG |
Genetic Testing Registry | TDG
|
NextProt | Q13569 [Medical] |
GENETests | TDG |
Target Validation | TDG |
Huge Navigator |
TDG [HugePedia] |
ClinGen | TDG |
| Clinical trials, drugs, therapy |
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MyCancerGenome | TDG |
Protein Interactions : CTD | |
Pharm GKB Gene | PA36419 |
Pharos | Q13569 |
Clinical trial | TDG |
| Miscellaneous |
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canSAR (ICR) | TDG (select the gene name) |
Harmonizome | TDG |
DataMed Index | TDG |
| Probes |
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| Litterature |
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PubMed | 108 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
EVEX | TDG |