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TDO2 (tryptophan 2,3-dioxygenase)

Identity

Other aliasTDO
TO
TPH2
TRPO
HGNC (Hugo) TDO2
LocusID (NCBI) 6999
Atlas_Id 56848
Location 4q32.1  [Link to chromosome band 4q32]
Location_base_pair Starts at 155903693 and ends at 155920406 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TDO2 (4q32.1) / GZMB (14q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TDO2   11708
Cards
Entrez_Gene (NCBI)TDO2  6999  tryptophan 2,3-dioxygenase
AliasesTDO; TO; TPH2; TRPO
GeneCards (Weizmann)TDO2
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr4:155903693-155920406 [Contig_View]  TDO2 [Vega]
TCGA cBioPortalTDO2
AceView (NCBI)TDO2
Genatlas (Paris)TDO2
WikiGenes6999
SOURCE (Princeton)TDO2
Genetics Home Reference (NIH)TDO2
Genomic and cartography
GoldenPath hg38 (UCSC)TDO2  -     chr4:155903693-155920406 +  4q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TDO2  -     4q32.1   [Description]    (hg19-Feb_2009)
EnsemblTDO2 - 4q32.1 [CytoView hg19]  TDO2 - 4q32.1 [CytoView hg38]
Mapping of homologs : NCBITDO2 [Mapview hg19]  TDO2 [Mapview hg38]
OMIM191070   
Gene and transcription
Genbank (Entrez)AA705255 AK289418 AK307741 BC005355 BG616664
RefSeq transcript (Entrez)NM_005651
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TDO2
Cluster EST : UnigeneHs.593955 [ NCBI ]
CGAP (NCI)Hs.593955
Gene ExpressionTDO2 [ NCBI-GEO ]   TDO2 [ EBI - ARRAY_EXPRESS ]   TDO2 [ SEEK ]   TDO2 [ MEM ]
Gene Expression Viewer (FireBrowse)TDO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6999
GTEX Portal (Tissue expression)TDO2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48775   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48775  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48775
Splice isoforms : SwissVarP48775
PhosPhoSitePlusP48775
Domains : Interpro (EBI)Trp_2_3_dOase   
Domain families : Pfam (Sanger)Trp_dioxygenase (PF03301)   
Domain families : Pfam (NCBI)pfam03301   
Conserved Domain (NCBI)TDO2
DMDM Disease mutations6999
Blocks (Seattle)TDO2
PDB (SRS)4PW8    5TI9    5TIA   
PDB (PDBSum)4PW8    5TI9    5TIA   
PDB (IMB)4PW8    5TI9    5TIA   
PDB (RSDB)4PW8    5TI9    5TIA   
Structural Biology KnowledgeBase4PW8    5TI9    5TIA   
SCOP (Structural Classification of Proteins)4PW8    5TI9    5TIA   
CATH (Classification of proteins structures)4PW8    5TI9    5TIA   
SuperfamilyP48775
Peptide AtlasP48775
IPIIPI00011206   IPI00966958   IPI00964978   
Protein Interaction databases
DIP (DOE-UCLA)P48775
IntAct (EBI)P48775
BioGRIDTDO2
STRING (EMBL)TDO2
ZODIACTDO2
Ontologies - Pathways
QuickGOP48775
Ontology : AmiGOtryptophan 2,3-dioxygenase activity  tryptophan 2,3-dioxygenase activity  tryptophan 2,3-dioxygenase activity  protein binding  cytosol  tryptophan catabolic process  amino acid binding  tryptophan catabolic process to kynurenine  tryptophan catabolic process to kynurenine  tryptophan catabolic process to acetyl-CoA  oxygen binding  heme binding  heme binding  identical protein binding  metal ion binding  protein homotetramerization  oxidation-reduction process  
Ontology : EGO-EBItryptophan 2,3-dioxygenase activity  tryptophan 2,3-dioxygenase activity  tryptophan 2,3-dioxygenase activity  protein binding  cytosol  tryptophan catabolic process  amino acid binding  tryptophan catabolic process to kynurenine  tryptophan catabolic process to kynurenine  tryptophan catabolic process to acetyl-CoA  oxygen binding  heme binding  heme binding  identical protein binding  metal ion binding  protein homotetramerization  oxidation-reduction process  
Pathways : KEGGTryptophan metabolism   
NDEx NetworkTDO2
Atlas of Cancer Signalling NetworkTDO2
Wikipedia pathwaysTDO2
Orthology - Evolution
OrthoDB6999
Phylogenetic Trees/Animal Genes : TreeFamTDO2
HOVERGENP48775
HOGENOMP48775
Homologs : HomoloGeneTDO2
Homology/Alignments : Family Browser (UCSC)TDO2
Gene fusions - Rearrangements
Tumor Fusion PortalTDO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTDO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TDO2
dbVarTDO2
ClinVarTDO2
1000_GenomesTDO2 
Exome Variant ServerTDO2
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP6999
Genomic Variants (DGV)TDO2 [DGVbeta]
DECIPHERTDO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTDO2 
Mutations
ICGC Data PortalTDO2 
TCGA Data PortalTDO2 
Broad Tumor PortalTDO2
OASIS PortalTDO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTDO2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTDO2
BioMutasearch TDO2
DgiDB (Drug Gene Interaction Database)TDO2
DoCM (Curated mutations)TDO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TDO2 (select a term)
intoGenTDO2
Cancer3DTDO2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191070   
Orphanet
DisGeNETTDO2
MedgenTDO2
Genetic Testing Registry TDO2
NextProtP48775 [Medical]
TSGene6999
GENETestsTDO2
Target ValidationTDO2
Huge Navigator TDO2 [HugePedia]
snp3D : Map Gene to Disease6999
BioCentury BCIQTDO2
ClinGenTDO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6999
Chemical/Pharm GKB GenePA36427
Clinical trialTDO2
Miscellaneous
canSAR (ICR)TDO2 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTDO2
EVEXTDO2
GoPubMedTDO2
iHOPTDO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:38:04 CET 2017

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