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TDP2 (tyrosyl-DNA phosphodiesterase 2)

Identity

Alias_namesTTRAP
TRAF and TNF receptor associated protein
Other aliasAD022
EAP2
EAPII
dJ30M3.3
hTDP2
HGNC (Hugo) TDP2
LocusID (NCBI) 51567
Atlas_Id 51498
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 24649977 and ends at 24666887 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GPLD1 (6p22.3) / TDP2 (6p22.3)TDP2 (6p22.3) / TDP2 (6p22.3)GPLD1 6p22.3 / TDP2 6p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p22;p22) GPLD1/TDP2


External links

Nomenclature
HGNC (Hugo)TDP2   17768
Cards
Entrez_Gene (NCBI)TDP2  51567  tyrosyl-DNA phosphodiesterase 2
AliasesAD022; EAP2; EAPII; TTRAP; 
dJ30M3.3; hTDP2
GeneCards (Weizmann)TDP2
Ensembl hg19 (Hinxton)ENSG00000111802 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111802 [Gene_View]  ENSG00000111802 [Sequence]  chr6:24649977-24666887 [Contig_View]  TDP2 [Vega]
ICGC DataPortalENSG00000111802
TCGA cBioPortalTDP2
AceView (NCBI)TDP2
Genatlas (Paris)TDP2
WikiGenes51567
SOURCE (Princeton)TDP2
Genetics Home Reference (NIH)TDP2
Genomic and cartography
GoldenPath hg38 (UCSC)TDP2  -     chr6:24649977-24666887 -  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TDP2  -     6p22.3   [Description]    (hg19-Feb_2009)
EnsemblTDP2 - 6p22.3 [CytoView hg19]  TDP2 - 6p22.3 [CytoView hg38]
Mapping of homologs : NCBITDP2 [Mapview hg19]  TDP2 [Mapview hg38]
OMIM605764   616949   
Gene and transcription
Genbank (Entrez)AF201687 AF223469 AJ269473 AJ420495 AK002168
RefSeq transcript (Entrez)NM_016614
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TDP2
Cluster EST : UnigeneHs.403010 [ NCBI ]
CGAP (NCI)Hs.403010
Alternative Splicing GalleryENSG00000111802
Gene ExpressionTDP2 [ NCBI-GEO ]   TDP2 [ EBI - ARRAY_EXPRESS ]   TDP2 [ SEEK ]   TDP2 [ MEM ]
Gene Expression Viewer (FireBrowse)TDP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51567
GTEX Portal (Tissue expression)TDP2
Human Protein AtlasENSG00000111802-TDP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95551   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95551  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95551
Splice isoforms : SwissVarO95551
Catalytic activity : Enzyme3.1.4.- [ Enzyme-Expasy ]   3.1.4.-3.1.4.- [ IntEnz-EBI ]   3.1.4.- [ BRENDA ]   3.1.4.- [ KEGG ]   
PhosPhoSitePlusO95551
Domains : Interpro (EBI)Endo/exonuclease/phosphatase    UBA-like   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)   
Domain families : Pfam (NCBI)pfam03372   
Conserved Domain (NCBI)TDP2
DMDM Disease mutations51567
Blocks (Seattle)TDP2
PDB (SRS)5INO    5J3P    5J3S   
PDB (PDBSum)5INO    5J3P    5J3S   
PDB (IMB)5INO    5J3P    5J3S   
PDB (RSDB)5INO    5J3P    5J3S   
Structural Biology KnowledgeBase5INO    5J3P    5J3S   
SCOP (Structural Classification of Proteins)5INO    5J3P    5J3S   
CATH (Classification of proteins structures)5INO    5J3P    5J3S   
SuperfamilyO95551
Human Protein Atlas [tissue]ENSG00000111802-TDP2 [tissue]
Peptide AtlasO95551
HPRD05771
IPIIPI00009913   IPI00954485   IPI00954580   IPI01018880   IPI00385454   
Protein Interaction databases
DIP (DOE-UCLA)O95551
IntAct (EBI)O95551
FunCoupENSG00000111802
BioGRIDTDP2
STRING (EMBL)TDP2
ZODIACTDP2
Ontologies - Pathways
QuickGOO95551
Ontology : AmiGOmagnesium ion binding  magnesium ion binding  single-stranded DNA binding  transcription corepressor activity  nuclease activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  double-strand break repair  double-strand break repair  cell surface receptor signaling pathway  aggresome  nuclear body  PML body  manganese ion binding  tyrosyl-RNA phosphodiesterase activity  neuron development  5'-tyrosyl-DNA phosphodiesterase activity  5'-tyrosyl-DNA phosphodiesterase activity  nucleic acid phosphodiester bond hydrolysis  negative regulation of nucleic acid-templated transcription  
Ontology : EGO-EBImagnesium ion binding  magnesium ion binding  single-stranded DNA binding  transcription corepressor activity  nuclease activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  double-strand break repair  double-strand break repair  cell surface receptor signaling pathway  aggresome  nuclear body  PML body  manganese ion binding  tyrosyl-RNA phosphodiesterase activity  neuron development  5'-tyrosyl-DNA phosphodiesterase activity  5'-tyrosyl-DNA phosphodiesterase activity  nucleic acid phosphodiester bond hydrolysis  negative regulation of nucleic acid-templated transcription  
NDEx NetworkTDP2
Atlas of Cancer Signalling NetworkTDP2
Wikipedia pathwaysTDP2
Orthology - Evolution
OrthoDB51567
GeneTree (enSembl)ENSG00000111802
Phylogenetic Trees/Animal Genes : TreeFamTDP2
HOVERGENO95551
HOGENOMO95551
Homologs : HomoloGeneTDP2
Homology/Alignments : Family Browser (UCSC)TDP2
Gene fusions - Rearrangements
Fusion : MitelmanGPLD1/TDP2 [6p22.3/6p22.3]  [t(6;6)(p22;p22)]  
Fusion PortalGPLD1 6p22.3 TDP2 6p22.3 GBM
Fusion : QuiverTDP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTDP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TDP2
dbVarTDP2
ClinVarTDP2
1000_GenomesTDP2 
Exome Variant ServerTDP2
ExAC (Exome Aggregation Consortium)ENSG00000111802
GNOMAD BrowserENSG00000111802
Genetic variants : HAPMAP51567
Genomic Variants (DGV)TDP2 [DGVbeta]
DECIPHERTDP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTDP2 
Mutations
ICGC Data PortalTDP2 
TCGA Data PortalTDP2 
Broad Tumor PortalTDP2
OASIS PortalTDP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTDP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTDP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TDP2
DgiDB (Drug Gene Interaction Database)TDP2
DoCM (Curated mutations)TDP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TDP2 (select a term)
intoGenTDP2
Cancer3DTDP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605764    616949   
Orphanet22930   
DisGeNETTDP2
MedgenTDP2
Genetic Testing Registry TDP2
NextProtO95551 [Medical]
TSGene51567
GENETestsTDP2
Target ValidationTDP2
Huge Navigator TDP2 [HugePedia]
snp3D : Map Gene to Disease51567
BioCentury BCIQTDP2
ClinGenTDP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51567
Chemical/Pharm GKB GenePA165618310
Clinical trialTDP2
Miscellaneous
canSAR (ICR)TDP2 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTDP2
EVEXTDP2
GoPubMedTDP2
iHOPTDP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:53:32 CEST 2018

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