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TEAD1 (TEA domain transcription factor 1)

Identity

Alias_namesTCF13
AA
atrophia areata, peripapillary chorioretinal degeneration
TEA domain family member 1 (SV40 transcriptional enhancer factor)
Alias_symbol (synonym)TEF-1
Other aliasNTEF-1
REF1
TCF-13
TEAD-1
HGNC (Hugo) TEAD1
LocusID (NCBI) 7003
Atlas_Id 50607
Location 11p15.3  [Link to chromosome band 11p15]
Location_base_pair Starts at 12674422 and ends at 12944737 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARNTL (11p15.2) / TEAD1 (11p15.3)ATP5L (11q23.3) / TEAD1 (11p15.3)C9 (5p13.1) / TEAD1 (11p15.3)
CLPTM1L (5p15.33) / TEAD1 (11p15.3)PARVA (11p15.3) / TEAD1 (11p15.3)PIK3C2A (11p15.1) / TEAD1 (11p15.3)
SEMA6A (5q23.1) / TEAD1 (11p15.3)TEAD1 (11p15.3) / ABCC8 (11p15.1)TEAD1 (11p15.3) / ATP5L (11q23.3)
TEAD1 (11p15.3) / CAP2 (6p22.3)TEAD1 (11p15.3) / MICAL2 (11p15.3)TEAD1 (11p15.3) / NCOA2 (8q13.3)
TEAD1 (11p15.3) / PARVA (11p15.3)TEAD1 (11p15.3) / TEAD1 (11p15.3)TEAD1 (11p15.3) / WDR41 (5q13.3)
UBAP2 (9p13.3) / TEAD1 (11p15.3)ARNTL 11p15.2 / TEAD1 11p15.3TEAD1 11p15.3 / CAP2 6p22.3
TEAD1 11p15.3 / MICAL2 11p15.3TEAD1 11p15.3 / PARVA 11p15.3UBAP2 9p13.3 / TEAD1 11p15.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 13 ]
  Prostate tumors: an overview
Soft Tissues: Rhabdomyosarcoma
Soft tissue tumors: an overview
Lung: Translocations in Small Cell Carcinoma
del(11)(p15p15) PIK3C2A/TEAD1
t(5;11)(p15;p15) CLPTM1L/TEAD1
t(6;11)(p22;p15) TEAD1/CAP2
t(8;11)(q13;p15) TEAD1/NCOA2
t(9;11)(p13;p15) UBAP2/TEAD1
t(11;11)(p15;p15) TEAD1/PARVA
t(11;11)(p15;p15) ARNTL/TEAD1
t(11;11)(p15;p15) TEAD1/MICAL2
t(11;11)(p15;q23) ATP5L/TEAD1

External links

Nomenclature
HGNC (Hugo)TEAD1   11714
Cards
Entrez_Gene (NCBI)TEAD1  7003  TEA domain transcription factor 1
AliasesAA; NTEF-1; REF1; TCF-13; 
TCF13; TEAD-1; TEF-1
GeneCards (Weizmann)TEAD1
Ensembl hg19 (Hinxton)ENSG00000187079 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187079 [Gene_View]  ENSG00000187079 [Sequence]  chr11:12674422-12944737 [Contig_View]  TEAD1 [Vega]
ICGC DataPortalENSG00000187079
TCGA cBioPortalTEAD1
AceView (NCBI)TEAD1
Genatlas (Paris)TEAD1
WikiGenes7003
SOURCE (Princeton)TEAD1
Genetics Home Reference (NIH)TEAD1
Genomic and cartography
GoldenPath hg38 (UCSC)TEAD1  -     chr11:12674422-12944737 +  11p15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TEAD1  -     11p15.3   [Description]    (hg19-Feb_2009)
EnsemblTEAD1 - 11p15.3 [CytoView hg19]  TEAD1 - 11p15.3 [CytoView hg38]
Mapping of homologs : NCBITEAD1 [Mapview hg19]  TEAD1 [Mapview hg38]
OMIM108985   189967   
Gene and transcription
Genbank (Entrez)AB209858 AI189919 AI199443 AK027342 AK075070
RefSeq transcript (Entrez)NM_021961
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TEAD1
Cluster EST : UnigeneHs.655331 [ NCBI ]
CGAP (NCI)Hs.655331
Alternative Splicing GalleryENSG00000187079
Gene ExpressionTEAD1 [ NCBI-GEO ]   TEAD1 [ EBI - ARRAY_EXPRESS ]   TEAD1 [ SEEK ]   TEAD1 [ MEM ]
Gene Expression Viewer (FireBrowse)TEAD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7003
GTEX Portal (Tissue expression)TEAD1
Human Protein AtlasENSG00000187079-TEAD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28347   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28347  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28347
Splice isoforms : SwissVarP28347
PhosPhoSitePlusP28347
Domaine pattern : Prosite (Expaxy)TEA_1 (PS00554)    TEA_2 (PS51088)   
Domains : Interpro (EBI)TEA/ATTS_dom    TEF_metazoa   
Domain families : Pfam (Sanger)TEA (PF01285)   
Domain families : Pfam (NCBI)pfam01285   
Domain families : Smart (EMBL)TEA (SM00426)  
Conserved Domain (NCBI)TEAD1
DMDM Disease mutations7003
Blocks (Seattle)TEAD1
PDB (SRS)2HZD    3KYS    4RE1    4Z8E   
PDB (PDBSum)2HZD    3KYS    4RE1    4Z8E   
PDB (IMB)2HZD    3KYS    4RE1    4Z8E   
PDB (RSDB)2HZD    3KYS    4RE1    4Z8E   
Structural Biology KnowledgeBase2HZD    3KYS    4RE1    4Z8E   
SCOP (Structural Classification of Proteins)2HZD    3KYS    4RE1    4Z8E   
CATH (Classification of proteins structures)2HZD    3KYS    4RE1    4Z8E   
SuperfamilyP28347
Human Protein Atlas [tissue]ENSG00000187079-TEAD1 [tissue]
Peptide AtlasP28347
HPRD01802
IPIIPI00002901   IPI00844019   IPI00978120   IPI00980149   
Protein Interaction databases
DIP (DOE-UCLA)P28347
IntAct (EBI)P28347
FunCoupENSG00000187079
BioGRIDTEAD1
STRING (EMBL)TEAD1
ZODIACTEAD1
Ontologies - Pathways
QuickGOP28347
Ontology : AmiGOtranscription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding  proximal promoter sequence-specific DNA binding  RNA polymerase II transcription factor binding  transcription factor activity, transcription factor recruiting  transcription coactivator binding  DNA binding  DNA binding transcription factor activity  protein binding  nucleoplasm  nucleoplasm  transcription initiation from RNA polymerase II promoter  protein complex assembly  hippo signaling  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  embryonic organ development  TEAD-1-YAP complex  positive regulation of pri-miRNA transcription by RNA polymerase II  
Ontology : EGO-EBItranscription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding  proximal promoter sequence-specific DNA binding  RNA polymerase II transcription factor binding  transcription factor activity, transcription factor recruiting  transcription coactivator binding  DNA binding  DNA binding transcription factor activity  protein binding  nucleoplasm  nucleoplasm  transcription initiation from RNA polymerase II promoter  protein complex assembly  hippo signaling  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  embryonic organ development  TEAD-1-YAP complex  positive regulation of pri-miRNA transcription by RNA polymerase II  
NDEx NetworkTEAD1
Atlas of Cancer Signalling NetworkTEAD1
Wikipedia pathwaysTEAD1
Orthology - Evolution
OrthoDB7003
GeneTree (enSembl)ENSG00000187079
Phylogenetic Trees/Animal Genes : TreeFamTEAD1
HOVERGENP28347
HOGENOMP28347
Homologs : HomoloGeneTEAD1
Homology/Alignments : Family Browser (UCSC)TEAD1
Gene fusions - Rearrangements
Fusion : MitelmanARNTL/TEAD1 [11p15.2/11p15.3]  [t(11;11)(p15;p15)]  
Fusion : MitelmanATP5L/TEAD1 [11q23.3/11p15.3]  [t(11;11)(p15;q23)]  
Fusion : MitelmanCLPTM1L/TEAD1 [5p15.33/11p15.3]  [t(5;11)(p15;p15)]  
Fusion : MitelmanPIK3C2A/TEAD1 [11p15.1/11p15.3]  [del(11)(p15p15)]  
Fusion : MitelmanTEAD1/CAP2 [11p15.3/6p22.3]  [t(6;11)(p22;p15)]  
Fusion : MitelmanTEAD1/MICAL2 [11p15.3/11p15.3]  [t(11;11)(p15;p15)]  
Fusion : MitelmanTEAD1/NCOA2 [11p15.3/8q13.3]  [t(8;11)(q13;p15)]  
Fusion : MitelmanTEAD1/PARVA [11p15.3/11p15.3]  [t(11;11)(p15;p15)]  
Fusion : MitelmanUBAP2/TEAD1 [9p13.3/11p15.3]  [t(9;11)(p13;p15)]  
Fusion PortalARNTL 11p15.2 TEAD1 11p15.3 BRCA HNSC
Fusion PortalTEAD1 11p15.3 CAP2 6p22.3 BRCA
Fusion PortalTEAD1 11p15.3 MICAL2 11p15.3 PRAD
Fusion PortalTEAD1 11p15.3 PARVA 11p15.3 BRCA
Fusion PortalUBAP2 9p13.3 TEAD1 11p15.3 BRCA
Fusion : QuiverTEAD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTEAD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TEAD1
dbVarTEAD1
ClinVarTEAD1
1000_GenomesTEAD1 
Exome Variant ServerTEAD1
ExAC (Exome Aggregation Consortium)ENSG00000187079
GNOMAD BrowserENSG00000187079
Genetic variants : HAPMAP7003
Genomic Variants (DGV)TEAD1 [DGVbeta]
DECIPHERTEAD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTEAD1 
Mutations
ICGC Data PortalTEAD1 
TCGA Data PortalTEAD1 
Broad Tumor PortalTEAD1
OASIS PortalTEAD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTEAD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTEAD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch TEAD1
DgiDB (Drug Gene Interaction Database)TEAD1
DoCM (Curated mutations)TEAD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TEAD1 (select a term)
intoGenTEAD1
Cancer3DTEAD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM108985    189967   
Orphanet11733   
DisGeNETTEAD1
MedgenTEAD1
Genetic Testing Registry TEAD1
NextProtP28347 [Medical]
TSGene7003
GENETestsTEAD1
Target ValidationTEAD1
Huge Navigator TEAD1 [HugePedia]
snp3D : Map Gene to Disease7003
BioCentury BCIQTEAD1
ClinGenTEAD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7003
Chemical/Pharm GKB GenePA36432
Clinical trialTEAD1
Miscellaneous
canSAR (ICR)TEAD1 (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTEAD1
EVEXTEAD1
GoPubMedTEAD1
iHOPTEAD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:53:33 CEST 2018
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