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TEAD2 (TEA domain transcription factor 2)

Identity

Alias (NCBI)ETF
TEAD-2
TEF-4
TEF4
HGNC (Hugo) TEAD2
HGNC Alias symbTEF-4
ETF
TEF4
HGNC Previous nameTEA domain family member 2
LocusID (NCBI) 8463
Atlas_Id 74607
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 49340596 and ends at 49362416 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PHLDB1 (11q23.3) / TEAD2 (19q13.33)TEAD2 (19q13.33) / PPY (17q21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TEAD2   11715
Cards
Entrez_Gene (NCBI)TEAD2    TEA domain transcription factor 2
AliasesETF; TEAD-2; TEF-4; TEF4
GeneCards (Weizmann)TEAD2
Ensembl hg19 (Hinxton)ENSG00000074219 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074219 [Gene_View]  ENSG00000074219 [Sequence]  chr19:49340596-49362416 [Contig_View]  TEAD2 [Vega]
ICGC DataPortalENSG00000074219
TCGA cBioPortalTEAD2
AceView (NCBI)TEAD2
Genatlas (Paris)TEAD2
SOURCE (Princeton)TEAD2
Genetics Home Reference (NIH)TEAD2
Genomic and cartography
GoldenPath hg38 (UCSC)TEAD2  -     chr19:49340596-49362416 -  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TEAD2  -     19q13.33   [Description]    (hg19-Feb_2009)
GoldenPathTEAD2 - 19q13.33 [CytoView hg19]  TEAD2 - 19q13.33 [CytoView hg38]
ImmunoBaseENSG00000074219
Genome Data Viewer NCBITEAD2 [Mapview hg19]  
OMIM601729   
Gene and transcription
Genbank (Entrez)AK093236 AK290736 AK300241 AL832240 BC007556
RefSeq transcript (Entrez)NM_001256658 NM_001256659 NM_001256660 NM_001256661 NM_001256662 NM_003598
Consensus coding sequences : CCDS (NCBI)TEAD2
Gene ExpressionTEAD2 [ NCBI-GEO ]   TEAD2 [ EBI - ARRAY_EXPRESS ]   TEAD2 [ SEEK ]   TEAD2 [ MEM ]
Gene Expression Viewer (FireBrowse)TEAD2 [ Firebrowse - Broad ]
GenevisibleExpression of TEAD2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8463
GTEX Portal (Tissue expression)TEAD2
Human Protein AtlasENSG00000074219-TEAD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15562   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15562  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15562
PhosPhoSitePlusQ15562
Domaine pattern : Prosite (Expaxy)TEA_1 (PS00554)    TEA_2 (PS51088)   
Domains : Interpro (EBI)TEA/ATTS_dom    TEA/ATTS_sf    TEF_metazoa    YBD   
Domain families : Pfam (Sanger)TEA (PF01285)    YBD (PF17725)   
Domain families : Pfam (NCBI)pfam01285    pfam17725   
Domain families : Smart (EMBL)TEA (SM00426)  
Conserved Domain (NCBI)TEAD2
PDB (RSDB)3L15    5DQ8    5DQE    5EMV    5HGU    6CDY    6E5G    6S60    6S64    6S66    6S69    6S6J    6UYB    6UYC    6VAH   
PDB Europe3L15    5DQ8    5DQE    5EMV    5HGU    6CDY    6E5G    6S60    6S64    6S66    6S69    6S6J    6UYB    6UYC    6VAH   
PDB (PDBSum)3L15    5DQ8    5DQE    5EMV    5HGU    6CDY    6E5G    6S60    6S64    6S66    6S69    6S6J    6UYB    6UYC    6VAH   
PDB (IMB)3L15    5DQ8    5DQE    5EMV    5HGU    6CDY    6E5G    6S60    6S64    6S66    6S69    6S6J    6UYB    6UYC    6VAH   
Structural Biology KnowledgeBase3L15    5DQ8    5DQE    5EMV    5HGU    6CDY    6E5G    6S60    6S64    6S66    6S69    6S6J    6UYB    6UYC    6VAH   
SCOP (Structural Classification of Proteins)3L15    5DQ8    5DQE    5EMV    5HGU    6CDY    6E5G    6S60    6S64    6S66    6S69    6S6J    6UYB    6UYC    6VAH   
CATH (Classification of proteins structures)3L15    5DQ8    5DQE    5EMV    5HGU    6CDY    6E5G    6S60    6S64    6S66    6S69    6S6J    6UYB    6UYC    6VAH   
SuperfamilyQ15562
AlphaFold pdb e-kbQ15562   
Human Protein Atlas [tissue]ENSG00000074219-TEAD2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q15562
IntAct (EBI)Q15562
BioGRIDTEAD2
STRING (EMBL)TEAD2
ZODIACTEAD2
Ontologies - Pathways
QuickGOQ15562
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription coactivator binding  vasculogenesis  neural tube closure  embryonic heart tube morphogenesis  DNA-binding transcription factor activity  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  cytosol  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  notochord development  hippo signaling  hippo signaling  intracellular membrane-bounded organelle  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  paraxial mesoderm development  lateral mesoderm development  embryonic organ development  negative regulation of cell death  protein-containing complex assembly  cellular response to retinoic acid  disordered domain specific binding  TEAD-YAP complex  sequence-specific double-stranded DNA binding  regulation of stem cell differentiation  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription coactivator binding  vasculogenesis  neural tube closure  embryonic heart tube morphogenesis  DNA-binding transcription factor activity  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  cytosol  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  notochord development  hippo signaling  hippo signaling  intracellular membrane-bounded organelle  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  paraxial mesoderm development  lateral mesoderm development  embryonic organ development  negative regulation of cell death  protein-containing complex assembly  cellular response to retinoic acid  disordered domain specific binding  TEAD-YAP complex  sequence-specific double-stranded DNA binding  regulation of stem cell differentiation  
NDEx NetworkTEAD2
Atlas of Cancer Signalling NetworkTEAD2
Wikipedia pathwaysTEAD2
Orthology - Evolution
OrthoDB8463
GeneTree (enSembl)ENSG00000074219
Phylogenetic Trees/Animal Genes : TreeFamTEAD2
Homologs : HomoloGeneTEAD2
Homology/Alignments : Family Browser (UCSC)TEAD2
Gene fusions - Rearrangements
Fusion : QuiverTEAD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTEAD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TEAD2
dbVarTEAD2
ClinVarTEAD2
MonarchTEAD2
1000_GenomesTEAD2 
Exome Variant ServerTEAD2
GNOMAD BrowserENSG00000074219
Varsome BrowserTEAD2
ACMGTEAD2 variants
VarityQ15562
Genomic Variants (DGV)TEAD2 [DGVbeta]
DECIPHERTEAD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTEAD2 
Mutations
ICGC Data PortalTEAD2 
TCGA Data PortalTEAD2 
Broad Tumor PortalTEAD2
OASIS PortalTEAD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTEAD2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTEAD2
Mutations and Diseases : HGMDTEAD2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTEAD2
DgiDB (Drug Gene Interaction Database)TEAD2
DoCM (Curated mutations)TEAD2
CIViC (Clinical Interpretations of Variants in Cancer)TEAD2
Cancer3DTEAD2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601729   
Orphanet
DisGeNETTEAD2
MedgenTEAD2
Genetic Testing Registry TEAD2
NextProtQ15562 [Medical]
GENETestsTEAD2
Target ValidationTEAD2
Huge Navigator TEAD2 [HugePedia]
ClinGenTEAD2
Clinical trials, drugs, therapy
MyCancerGenomeTEAD2
Protein Interactions : CTDTEAD2
Pharm GKB GenePA36433
PharosQ15562
Clinical trialTEAD2
Miscellaneous
canSAR (ICR)TEAD2
HarmonizomeTEAD2
DataMed IndexTEAD2
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTEAD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:25:08 CEST 2021

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