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TEAD2 (TEA domain transcription factor 2)

Identity

Alias_namesTEA domain family member 2
Alias_symbol (synonym)TEF-4
ETF
TEF4
Other aliasTEAD-2
HGNC (Hugo) TEAD2
LocusID (NCBI) 8463
Atlas_Id 74607
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 49340596 and ends at 49362457 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PHLDB1 (11q23.3) / TEAD2 (19q13.33)TEAD2 (19q13.33) / PPY (17q21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TEAD2   11715
Cards
Entrez_Gene (NCBI)TEAD2  8463  TEA domain transcription factor 2
AliasesETF; TEAD-2; TEF-4; TEF4
GeneCards (Weizmann)TEAD2
Ensembl hg19 (Hinxton)ENSG00000074219 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074219 [Gene_View]  chr19:49340596-49362457 [Contig_View]  TEAD2 [Vega]
ICGC DataPortalENSG00000074219
TCGA cBioPortalTEAD2
AceView (NCBI)TEAD2
Genatlas (Paris)TEAD2
WikiGenes8463
SOURCE (Princeton)TEAD2
Genetics Home Reference (NIH)TEAD2
Genomic and cartography
GoldenPath hg38 (UCSC)TEAD2  -     chr19:49340596-49362457 -  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TEAD2  -     19q13.33   [Description]    (hg19-Feb_2009)
EnsemblTEAD2 - 19q13.33 [CytoView hg19]  TEAD2 - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBITEAD2 [Mapview hg19]  TEAD2 [Mapview hg38]
OMIM601729   
Gene and transcription
Genbank (Entrez)AK093236 AK290736 AK300241 AL832240 BC007556
RefSeq transcript (Entrez)NM_001256658 NM_001256659 NM_001256660 NM_001256661 NM_001256662 NM_003598
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TEAD2
Cluster EST : UnigeneHs.515534 [ NCBI ]
CGAP (NCI)Hs.515534
Alternative Splicing GalleryENSG00000074219
Gene ExpressionTEAD2 [ NCBI-GEO ]   TEAD2 [ EBI - ARRAY_EXPRESS ]   TEAD2 [ SEEK ]   TEAD2 [ MEM ]
Gene Expression Viewer (FireBrowse)TEAD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8463
GTEX Portal (Tissue expression)TEAD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15562   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15562  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15562
Splice isoforms : SwissVarQ15562
PhosPhoSitePlusQ15562
Domaine pattern : Prosite (Expaxy)TEA_1 (PS00554)    TEA_2 (PS51088)   
Domains : Interpro (EBI)TEA/ATTS_dom    TEF_metazoa   
Domain families : Pfam (Sanger)TEA (PF01285)   
Domain families : Pfam (NCBI)pfam01285   
Domain families : Smart (EMBL)TEA (SM00426)  
Conserved Domain (NCBI)TEAD2
DMDM Disease mutations8463
Blocks (Seattle)TEAD2
PDB (SRS)3L15    5DQ8    5DQE    5EMV    5HGU   
PDB (PDBSum)3L15    5DQ8    5DQE    5EMV    5HGU   
PDB (IMB)3L15    5DQ8    5DQE    5EMV    5HGU   
PDB (RSDB)3L15    5DQ8    5DQE    5EMV    5HGU   
Structural Biology KnowledgeBase3L15    5DQ8    5DQE    5EMV    5HGU   
SCOP (Structural Classification of Proteins)3L15    5DQ8    5DQE    5EMV    5HGU   
CATH (Classification of proteins structures)3L15    5DQ8    5DQE    5EMV    5HGU   
SuperfamilyQ15562
Human Protein AtlasENSG00000074219
Peptide AtlasQ15562
IPIIPI00018174   IPI01014442   IPI00550685   
Protein Interaction databases
DIP (DOE-UCLA)Q15562
IntAct (EBI)Q15562
FunCoupENSG00000074219
BioGRIDTEAD2
STRING (EMBL)TEAD2
ZODIACTEAD2
Ontologies - Pathways
QuickGOQ15562
Ontology : AmiGORNA polymerase II transcription factor binding  transcription factor activity, transcription factor recruiting  transcription coactivator binding  vasculogenesis  neural tube closure  embryonic heart tube morphogenesis  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytosol  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  protein complex assembly  notochord development  hippo signaling  intracellular membrane-bounded organelle  sequence-specific DNA binding  transcription regulatory region DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  paraxial mesoderm development  lateral mesoderm development  embryonic organ development  negative regulation of cell death  TEAD-2-YAP complex  cellular response to retinoic acid  disordered domain specific binding  regulation of stem cell differentiation  
Ontology : EGO-EBIRNA polymerase II transcription factor binding  transcription factor activity, transcription factor recruiting  transcription coactivator binding  vasculogenesis  neural tube closure  embryonic heart tube morphogenesis  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytosol  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  protein complex assembly  notochord development  hippo signaling  intracellular membrane-bounded organelle  sequence-specific DNA binding  transcription regulatory region DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  paraxial mesoderm development  lateral mesoderm development  embryonic organ development  negative regulation of cell death  TEAD-2-YAP complex  cellular response to retinoic acid  disordered domain specific binding  regulation of stem cell differentiation  
Pathways : KEGGHippo signaling pathway   
NDEx NetworkTEAD2
Atlas of Cancer Signalling NetworkTEAD2
Wikipedia pathwaysTEAD2
Orthology - Evolution
OrthoDB8463
GeneTree (enSembl)ENSG00000074219
Phylogenetic Trees/Animal Genes : TreeFamTEAD2
HOVERGENQ15562
HOGENOMQ15562
Homologs : HomoloGeneTEAD2
Homology/Alignments : Family Browser (UCSC)TEAD2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTEAD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TEAD2
dbVarTEAD2
ClinVarTEAD2
1000_GenomesTEAD2 
Exome Variant ServerTEAD2
ExAC (Exome Aggregation Consortium)TEAD2 (select the gene name)
Genetic variants : HAPMAP8463
Genomic Variants (DGV)TEAD2 [DGVbeta]
DECIPHERTEAD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTEAD2 
Mutations
ICGC Data PortalTEAD2 
TCGA Data PortalTEAD2 
Broad Tumor PortalTEAD2
OASIS PortalTEAD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTEAD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTEAD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TEAD2
DgiDB (Drug Gene Interaction Database)TEAD2
DoCM (Curated mutations)TEAD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TEAD2 (select a term)
intoGenTEAD2
Cancer3DTEAD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601729   
Orphanet
MedgenTEAD2
Genetic Testing Registry TEAD2
NextProtQ15562 [Medical]
TSGene8463
GENETestsTEAD2
Target ValidationTEAD2
Huge Navigator TEAD2 [HugePedia]
snp3D : Map Gene to Disease8463
BioCentury BCIQTEAD2
ClinGenTEAD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8463
Chemical/Pharm GKB GenePA36433
Clinical trialTEAD2
Miscellaneous
canSAR (ICR)TEAD2 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTEAD2
EVEXTEAD2
GoPubMedTEAD2
iHOPTEAD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:45:11 CEST 2017

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