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TEAD4 (TEA domain transcription factor 4)

Identity

Alias_namesTCF13L1
TEA domain family member 4
Alias_symbol (synonym)TEF-3
TEFR-1
EFTR-2
RTEF-1
Other aliasRTEF1
TEF3
hRTEF-1B
HGNC (Hugo) TEAD4
LocusID (NCBI) 7004
Atlas_Id 54031
Location 12p13.33  [Link to chromosome band 12p13]
Location_base_pair Starts at 2959582 and ends at 3040676 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C15orf39 (15q24.2) / TEAD4 (12p13.33)SFPQ (16q24.1) / TEAD4 (12p13.33)TEAD4 (12p13.33) / C2CD5 (12p12.1)
TEAD4 (12p13.33) / ERC1 (12p13.33)TEAD4 (12p13.33) / TEAD4 (12p13.33)TEAD4 (12p13.33) / ZNF207 (17q11.2)
TEAD4 12p13.33 KIAA0528

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(p12;p13) TEAD4/C2CD5


External links

Nomenclature
HGNC (Hugo)TEAD4   11717
Cards
Entrez_Gene (NCBI)TEAD4  7004  TEA domain transcription factor 4
AliasesEFTR-2; RTEF1; TCF13L1; TEF-3; 
TEF3; TEFR-1; hRTEF-1B
GeneCards (Weizmann)TEAD4
Ensembl hg19 (Hinxton)ENSG00000197905 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197905 [Gene_View]  ENSG00000197905 [Sequence]  chr12:2959582-3040676 [Contig_View]  TEAD4 [Vega]
ICGC DataPortalENSG00000197905
TCGA cBioPortalTEAD4
AceView (NCBI)TEAD4
Genatlas (Paris)TEAD4
WikiGenes7004
SOURCE (Princeton)TEAD4
Genetics Home Reference (NIH)TEAD4
Genomic and cartography
GoldenPath hg38 (UCSC)TEAD4  -     chr12:2959582-3040676 +  12p13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TEAD4  -     12p13.33   [Description]    (hg19-Feb_2009)
EnsemblTEAD4 - 12p13.33 [CytoView hg19]  TEAD4 - 12p13.33 [CytoView hg38]
Mapping of homologs : NCBITEAD4 [Mapview hg19]  TEAD4 [Mapview hg38]
OMIM601714   
Gene and transcription
Genbank (Entrez)AK222947 AY101179 BC015497 BM464237 BM555991
RefSeq transcript (Entrez)NM_003213 NM_201441 NM_201443
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TEAD4
Cluster EST : UnigeneHs.94865 [ NCBI ]
CGAP (NCI)Hs.94865
Alternative Splicing GalleryENSG00000197905
Gene ExpressionTEAD4 [ NCBI-GEO ]   TEAD4 [ EBI - ARRAY_EXPRESS ]   TEAD4 [ SEEK ]   TEAD4 [ MEM ]
Gene Expression Viewer (FireBrowse)TEAD4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7004
GTEX Portal (Tissue expression)TEAD4
Human Protein AtlasENSG00000197905-TEAD4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15561   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15561  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15561
Splice isoforms : SwissVarQ15561
PhosPhoSitePlusQ15561
Domaine pattern : Prosite (Expaxy)TEA_1 (PS00554)    TEA_2 (PS51088)   
Domains : Interpro (EBI)TEA/ATTS_dom    TEA/ATTS_sf    TEF-3    TEF_metazoa   
Domain families : Pfam (Sanger)TEA (PF01285)   
Domain families : Pfam (NCBI)pfam01285   
Domain families : Smart (EMBL)TEA (SM00426)  
Conserved Domain (NCBI)TEAD4
DMDM Disease mutations7004
Blocks (Seattle)TEAD4
PDB (SRS)5GZB    5OAQ   
PDB (PDBSum)5GZB    5OAQ   
PDB (IMB)5GZB    5OAQ   
PDB (RSDB)5GZB    5OAQ   
Structural Biology KnowledgeBase5GZB    5OAQ   
SCOP (Structural Classification of Proteins)5GZB    5OAQ   
CATH (Classification of proteins structures)5GZB    5OAQ   
SuperfamilyQ15561
Human Protein Atlas [tissue]ENSG00000197905-TEAD4 [tissue]
Peptide AtlasQ15561
HPRD03421
IPIIPI00216204   IPI00410573   IPI01009318   IPI01009590   IPI01010614   IPI00410574   IPI01014942   IPI01013777   
Protein Interaction databases
DIP (DOE-UCLA)Q15561
IntAct (EBI)Q15561
FunCoupENSG00000197905
BioGRIDTEAD4
STRING (EMBL)TEAD4
ZODIACTEAD4
Ontologies - Pathways
QuickGOQ15561
Ontology : AmiGODNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II transcription factor binding  skeletal system development  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  regulation of transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  muscle organ development  hippo signaling  hippo signaling  sequence-specific DNA binding  transcription regulatory region DNA binding  positive regulation of transcription by RNA polymerase II  
Ontology : EGO-EBIDNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II transcription factor binding  skeletal system development  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  regulation of transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  muscle organ development  hippo signaling  hippo signaling  sequence-specific DNA binding  transcription regulatory region DNA binding  positive regulation of transcription by RNA polymerase II  
Pathways : KEGGHippo signaling pathway   
NDEx NetworkTEAD4
Atlas of Cancer Signalling NetworkTEAD4
Wikipedia pathwaysTEAD4
Orthology - Evolution
OrthoDB7004
GeneTree (enSembl)ENSG00000197905
Phylogenetic Trees/Animal Genes : TreeFamTEAD4
HOVERGENQ15561
HOGENOMQ15561
Homologs : HomoloGeneTEAD4
Homology/Alignments : Family Browser (UCSC)TEAD4
Gene fusions - Rearrangements
Fusion : MitelmanTEAD4/C2CD5 [12p13.33/12p12.1]  
Fusion PortalTEAD4 12p13.33 KIAA0528 BRCA
Fusion : QuiverTEAD4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTEAD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TEAD4
dbVarTEAD4
ClinVarTEAD4
1000_GenomesTEAD4 
Exome Variant ServerTEAD4
ExAC (Exome Aggregation Consortium)ENSG00000197905
GNOMAD BrowserENSG00000197905
Varsome BrowserTEAD4
Genetic variants : HAPMAP7004
Genomic Variants (DGV)TEAD4 [DGVbeta]
DECIPHERTEAD4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTEAD4 
Mutations
ICGC Data PortalTEAD4 
TCGA Data PortalTEAD4 
Broad Tumor PortalTEAD4
OASIS PortalTEAD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTEAD4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTEAD4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TEAD4
DgiDB (Drug Gene Interaction Database)TEAD4
DoCM (Curated mutations)TEAD4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TEAD4 (select a term)
intoGenTEAD4
Cancer3DTEAD4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601714   
Orphanet
DisGeNETTEAD4
MedgenTEAD4
Genetic Testing Registry TEAD4
NextProtQ15561 [Medical]
TSGene7004
GENETestsTEAD4
Target ValidationTEAD4
Huge Navigator TEAD4 [HugePedia]
snp3D : Map Gene to Disease7004
BioCentury BCIQTEAD4
ClinGenTEAD4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7004
Chemical/Pharm GKB GenePA36435
Clinical trialTEAD4
Miscellaneous
canSAR (ICR)TEAD4 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTEAD4
EVEXTEAD4
GoPubMedTEAD4
iHOPTEAD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:44:27 CET 2018

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