TEAD4 (TEA domain transcription factor 4)

2014-06-01  

Identity

HGNC
TEAD4
LOCATION
12p13.33
LOCUSID
7004
ALIAS
EFTR-2,RTEF1,TCF13L1,TEF-3,TEF3,TEFR-1,hRTEF-1B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7004
MIM: 601714
HGNC: 11717
Ensembl: ENSG00000197905

Variants:

dbSNP: 7004
ClinVar: 7004
TCGA: ENSG00000197905
COSMIC: TEAD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197905ENST00000358409A0A0A0MRF3
ENSG00000197905ENST00000359864Q53GI4
ENSG00000197905ENST00000397122Q15561
ENSG00000197905ENST00000443986H0Y7B0
ENSG00000197905ENST00000536826H0YFF9
ENSG00000197905ENST00000540314H0YFK0
ENSG00000197905ENST00000543035H0YGS2
ENSG00000197905ENST00000544666H0YG62

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Hippo signalingKEGGhsa_M00683
Hippo signalingKEGGM00683
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
268324112016Tead and AP1 Coordinate Transcription and Motility.56
235765522013YAP/TEAD-mediated transcription controls cellular senescence.43
87029741996A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain.37
287528532017Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation.37
243259162014Integrative genomics analysis reveals the multilevel dysregulation and oncogenic characteristics of TEAD4 in gastric cancer.32
263875382016Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial-mesenchymal transition and metastasis in a YAP-independent manner.31
280510672017VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer.28
259707722015The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1.23
256281252015Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival.22
237809152013The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences.19

Citation

Dessen P

TEAD4 (TEA domain transcription factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/54031/tead4