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TELO2 (telomere maintenance 2)

Identity

Alias (NCBI)CLK2
TEL2
YHFS
HGNC (Hugo) TELO2
HGNC Alias symbKIAA0683
hCLK2
TEL2
HGNC Previous nameTEL2, telomere maintenance 2, homolog (S. cerevisiae)
LocusID (NCBI) 9894
Atlas_Id 57266
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 1493360 and ends at 1510454 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GJA1 (6q22.31) / TELO2 (16p13.3)MAPK8IP3 (16p13.3) / TELO2 (16p13.3)TELO2 (16p13.3) / SMYD5 (2p13.2)
TELO2 (16p13.3) / TELO2 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)TELO2   29099
Cards
Entrez_Gene (NCBI)TELO2    telomere maintenance 2
AliasesCLK2; TEL2; YHFS
GeneCards (Weizmann)TELO2
Ensembl hg19 (Hinxton)ENSG00000100726 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100726 [Gene_View]  ENSG00000100726 [Sequence]  chr16:1493360-1510454 [Contig_View]  TELO2 [Vega]
ICGC DataPortalENSG00000100726
TCGA cBioPortalTELO2
AceView (NCBI)TELO2
Genatlas (Paris)TELO2
SOURCE (Princeton)TELO2
Genetics Home Reference (NIH)TELO2
Genomic and cartography
GoldenPath hg38 (UCSC)TELO2  -     chr16:1493360-1510454 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TELO2  -     16p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTELO2 - 16p13.3 [CytoView hg19]  TELO2 - 16p13.3 [CytoView hg38]
ImmunoBaseENSG00000100726
Genome Data Viewer NCBITELO2 [Mapview hg19]  
OMIM611140   616954   
Gene and transcription
Genbank (Entrez)AB014583 AK001786 AK302103 AL080126 AL137394
RefSeq transcript (Entrez)NM_001351846 NM_016111
Consensus coding sequences : CCDS (NCBI)TELO2
Gene ExpressionTELO2 [ NCBI-GEO ]   TELO2 [ EBI - ARRAY_EXPRESS ]   TELO2 [ SEEK ]   TELO2 [ MEM ]
Gene Expression Viewer (FireBrowse)TELO2 [ Firebrowse - Broad ]
GenevisibleExpression of TELO2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9894
GTEX Portal (Tissue expression)TELO2
Human Protein AtlasENSG00000100726-TELO2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4R8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4R8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4R8
PhosPhoSitePlusQ9Y4R8
Domains : Interpro (EBI)ARM-type_fold    TEL2_sf    Telomere_length_regulation_dom   
Domain families : Pfam (Sanger)Telomere_reg-2 (PF10193)   
Domain families : Pfam (NCBI)pfam10193   
Conserved Domain (NCBI)TELO2
PDB (RSDB)4PSI   
PDB Europe4PSI   
PDB (PDBSum)4PSI   
PDB (IMB)4PSI   
Structural Biology KnowledgeBase4PSI   
SCOP (Structural Classification of Proteins)4PSI   
CATH (Classification of proteins structures)4PSI   
SuperfamilyQ9Y4R8
AlphaFold pdb e-kbQ9Y4R8   
Human Protein Atlas [tissue]ENSG00000100726-TELO2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4R8
IntAct (EBI)Q9Y4R8
BioGRIDTELO2
STRING (EMBL)TELO2
ZODIACTELO2
Ontologies - Pathways
QuickGOQ9Y4R8
Ontology : AmiGOchromosome, telomeric region  protein binding  nucleus  cytoplasm  cytosol  cytosol  telomere maintenance via telomerase  membrane  nuclear body  protein kinase binding  TORC1 complex  TORC2 complex  regulation of TOR signaling  nuclear periphery  telomeric DNA binding  protein-containing complex binding  protein stabilization  protein stabilization  Hsp90 protein binding  Hsp90 protein binding  molecular adaptor activity  ASTRA complex  positive regulation of protein serine/threonine kinase activity  positive regulation of TORC1 signaling  positive regulation of TORC2 signaling  
Ontology : EGO-EBIchromosome, telomeric region  protein binding  nucleus  cytoplasm  cytosol  cytosol  telomere maintenance via telomerase  membrane  nuclear body  protein kinase binding  TORC1 complex  TORC2 complex  regulation of TOR signaling  nuclear periphery  telomeric DNA binding  protein-containing complex binding  protein stabilization  protein stabilization  Hsp90 protein binding  Hsp90 protein binding  molecular adaptor activity  ASTRA complex  positive regulation of protein serine/threonine kinase activity  positive regulation of TORC1 signaling  positive regulation of TORC2 signaling  
Pathways : KEGGFanconi anemia pathway   
NDEx NetworkTELO2
Atlas of Cancer Signalling NetworkTELO2
Wikipedia pathwaysTELO2
Orthology - Evolution
OrthoDB9894
GeneTree (enSembl)ENSG00000100726
Phylogenetic Trees/Animal Genes : TreeFamTELO2
Homologs : HomoloGeneTELO2
Homology/Alignments : Family Browser (UCSC)TELO2
Gene fusions - Rearrangements
Fusion : QuiverTELO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTELO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TELO2
dbVarTELO2
ClinVarTELO2
MonarchTELO2
1000_GenomesTELO2 
Exome Variant ServerTELO2
GNOMAD BrowserENSG00000100726
Varsome BrowserTELO2
ACMGTELO2 variants
VarityQ9Y4R8
Genomic Variants (DGV)TELO2 [DGVbeta]
DECIPHERTELO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTELO2 
Mutations
ICGC Data PortalTELO2 
TCGA Data PortalTELO2 
Broad Tumor PortalTELO2
OASIS PortalTELO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTELO2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTELO2
Mutations and Diseases : HGMDTELO2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTELO2
DgiDB (Drug Gene Interaction Database)TELO2
DoCM (Curated mutations)TELO2
CIViC (Clinical Interpretations of Variants in Cancer)TELO2
Cancer3DTELO2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611140    616954   
Orphanet
DisGeNETTELO2
MedgenTELO2
Genetic Testing Registry TELO2
NextProtQ9Y4R8 [Medical]
GENETestsTELO2
Target ValidationTELO2
Huge Navigator TELO2 [HugePedia]
ClinGenTELO2
Clinical trials, drugs, therapy
MyCancerGenomeTELO2
Protein Interactions : CTDTELO2
Pharm GKB GenePA162405604
PharosQ9Y4R8
Clinical trialTELO2
Miscellaneous
canSAR (ICR)TELO2
HarmonizomeTELO2
DataMed IndexTELO2
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTELO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:34:44 CEST 2021
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