Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TELO2 (telomere maintenance 2)

Identity

Other aliasCLK2
TEL2
YHFS
HGNC (Hugo) TELO2
LocusID (NCBI) 9894
Atlas_Id 57266
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 1493351 and ends at 1510459 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GJA1 (6q22.31) / TELO2 (16p13.3)MAPK8IP3 (16p13.3) / TELO2 (16p13.3)TELO2 (16p13.3) / SMYD5 (2p13.2)
TELO2 (16p13.3) / TELO2 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  MAPK8IP3/TELO2 (16p13)

External links

Nomenclature
HGNC (Hugo)TELO2   29099
Cards
Entrez_Gene (NCBI)TELO2  9894  telomere maintenance 2
AliasesCLK2; TEL2; YHFS
GeneCards (Weizmann)TELO2
Ensembl hg19 (Hinxton)ENSG00000100726 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100726 [Gene_View]  ENSG00000100726 [Sequence]  chr16:1493351-1510459 [Contig_View]  TELO2 [Vega]
ICGC DataPortalENSG00000100726
TCGA cBioPortalTELO2
AceView (NCBI)TELO2
Genatlas (Paris)TELO2
WikiGenes9894
SOURCE (Princeton)TELO2
Genetics Home Reference (NIH)TELO2
Genomic and cartography
GoldenPath hg38 (UCSC)TELO2  -     chr16:1493351-1510459 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TELO2  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblTELO2 - 16p13.3 [CytoView hg19]  TELO2 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBITELO2 [Mapview hg19]  TELO2 [Mapview hg38]
OMIM611140   616954   
Gene and transcription
Genbank (Entrez)AB014583 AK001786 AK302103 AL080126 AL137394
RefSeq transcript (Entrez)NM_001351846 NM_016111
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TELO2
Cluster EST : UnigeneHs.271044 [ NCBI ]
CGAP (NCI)Hs.271044
Alternative Splicing GalleryENSG00000100726
Gene ExpressionTELO2 [ NCBI-GEO ]   TELO2 [ EBI - ARRAY_EXPRESS ]   TELO2 [ SEEK ]   TELO2 [ MEM ]
Gene Expression Viewer (FireBrowse)TELO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9894
GTEX Portal (Tissue expression)TELO2
Human Protein AtlasENSG00000100726-TELO2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4R8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4R8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4R8
Splice isoforms : SwissVarQ9Y4R8
PhosPhoSitePlusQ9Y4R8
Domains : Interpro (EBI)ARM-type_fold    TEL2_sf    Telomere_length_regulation_dom   
Domain families : Pfam (Sanger)Telomere_reg-2 (PF10193)   
Domain families : Pfam (NCBI)pfam10193   
Conserved Domain (NCBI)TELO2
DMDM Disease mutations9894
Blocks (Seattle)TELO2
PDB (RSDB)4PSI   
PDB Europe4PSI   
PDB (PDBSum)4PSI   
PDB (IMB)4PSI   
Structural Biology KnowledgeBase4PSI   
SCOP (Structural Classification of Proteins)4PSI   
CATH (Classification of proteins structures)4PSI   
SuperfamilyQ9Y4R8
Human Protein Atlas [tissue]ENSG00000100726-TELO2 [tissue]
Peptide AtlasQ9Y4R8
IPIIPI00016868   IPI00903289   IPI01026249   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4R8
IntAct (EBI)Q9Y4R8
FunCoupENSG00000100726
BioGRIDTELO2
STRING (EMBL)TELO2
ZODIACTELO2
Ontologies - Pathways
QuickGOQ9Y4R8
Ontology : AmiGOtelomere maintenance  nuclear chromosome, telomeric region  protein binding  nucleus  cytoplasm  cytosol  cytosol  membrane  nuclear body  protein kinase binding  TORC1 complex  TORC2 complex  regulation of TOR signaling  protein-containing complex scaffold activity  nuclear periphery  telomeric DNA binding  protein-containing complex binding  protein stabilization  Hsp90 protein binding  ASTRA complex  positive regulation of protein serine/threonine kinase activity  positive regulation of TORC1 signaling  positive regulation of TORC2 signaling  
Ontology : EGO-EBItelomere maintenance  nuclear chromosome, telomeric region  protein binding  nucleus  cytoplasm  cytosol  cytosol  membrane  nuclear body  protein kinase binding  TORC1 complex  TORC2 complex  regulation of TOR signaling  protein-containing complex scaffold activity  nuclear periphery  telomeric DNA binding  protein-containing complex binding  protein stabilization  Hsp90 protein binding  ASTRA complex  positive regulation of protein serine/threonine kinase activity  positive regulation of TORC1 signaling  positive regulation of TORC2 signaling  
Pathways : KEGGFanconi anemia pathway   
NDEx NetworkTELO2
Atlas of Cancer Signalling NetworkTELO2
Wikipedia pathwaysTELO2
Orthology - Evolution
OrthoDB9894
GeneTree (enSembl)ENSG00000100726
Phylogenetic Trees/Animal Genes : TreeFamTELO2
HOGENOMQ9Y4R8
Homologs : HomoloGeneTELO2
Homology/Alignments : Family Browser (UCSC)TELO2
Gene fusions - Rearrangements
Fusion : QuiverTELO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTELO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TELO2
dbVarTELO2
ClinVarTELO2
1000_GenomesTELO2 
Exome Variant ServerTELO2
ExAC (Exome Aggregation Consortium)ENSG00000100726
GNOMAD BrowserENSG00000100726
Varsome BrowserTELO2
Genetic variants : HAPMAP9894
Genomic Variants (DGV)TELO2 [DGVbeta]
DECIPHERTELO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTELO2 
Mutations
ICGC Data PortalTELO2 
TCGA Data PortalTELO2 
Broad Tumor PortalTELO2
OASIS PortalTELO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTELO2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTELO2
BioMutasearch TELO2
DgiDB (Drug Gene Interaction Database)TELO2
DoCM (Curated mutations)TELO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TELO2 (select a term)
intoGenTELO2
Cancer3DTELO2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611140    616954   
Orphanet
DisGeNETTELO2
MedgenTELO2
Genetic Testing Registry TELO2
NextProtQ9Y4R8 [Medical]
TSGene9894
GENETestsTELO2
Target ValidationTELO2
Huge Navigator TELO2 [HugePedia]
snp3D : Map Gene to Disease9894
BioCentury BCIQTELO2
ClinGenTELO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9894
Chemical/Pharm GKB GenePA162405604
Clinical trialTELO2
Miscellaneous
canSAR (ICR)TELO2 (select the gene name)
DataMed IndexTELO2
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTELO2
EVEXTELO2
GoPubMedTELO2
iHOPTELO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Feb 14 17:01:26 CET 2019
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