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TENM2 (teneurin transmembrane protein 2)

Identity

Alias_namesODZ2
odz
Alias_symbol (synonym)KIAA1127
Ten-M2
Other aliasTEN-M2
TNM2
ten-2
HGNC (Hugo) TENM2
LocusID (NCBI) 57451
Atlas_Id 50560
Location 5q34  [Link to chromosome band 5q34]
Location_base_pair Starts at 167181941 and ends at 167691162 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANKH (5p15.2) / TENM2 (5q34)IGH (14q32.33) / TENM2 (5q34)IGHG1 (14q32.33) / TENM2 (5q34)
TBC1D9B (5q35.3) / TENM2 (5q34)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TENM2   29943
Cards
Entrez_Gene (NCBI)TENM2  57451  teneurin transmembrane protein 2
AliasesODZ2; TEN-M2; TNM2; ten-2
GeneCards (Weizmann)TENM2
Ensembl hg19 (Hinxton)ENSG00000145934 [Gene_View]  chr5:167181941-167691162 [Contig_View]  TENM2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000145934 [Gene_View]  chr5:167181941-167691162 [Contig_View]  TENM2 [Vega]
ICGC DataPortalENSG00000145934
TCGA cBioPortalTENM2
AceView (NCBI)TENM2
Genatlas (Paris)TENM2
WikiGenes57451
SOURCE (Princeton)TENM2
Genetics Home Reference (NIH)TENM2
Genomic and cartography
GoldenPath hg19 (UCSC)TENM2  -     chr5:167181941-167691162 +  5q34   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TENM2  -     5q34   [Description]    (hg38-Dec_2013)
EnsemblTENM2 - 5q34 [CytoView hg19]  TENM2 - 5q34 [CytoView hg38]
Mapping of homologs : NCBITENM2 [Mapview hg19]  TENM2 [Mapview hg38]
OMIM610119   
Gene and transcription
Genbank (Entrez)AB032953 AK056053 AK293262 AK302302 AL137500
RefSeq transcript (Entrez)NM_001080428 NM_001122679
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_023133 NW_004929325
Consensus coding sequences : CCDS (NCBI)TENM2
Cluster EST : UnigeneHs.631957 [ NCBI ]
CGAP (NCI)Hs.631957
Alternative Splicing GalleryENSG00000145934
Gene ExpressionTENM2 [ NCBI-GEO ]   TENM2 [ EBI - ARRAY_EXPRESS ]   TENM2 [ SEEK ]   TENM2 [ MEM ]
Gene Expression Viewer (FireBrowse)TENM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57451
GTEX Portal (Tissue expression)TENM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NT68   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NT68  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NT68
Splice isoforms : SwissVarQ9NT68
PhosPhoSitePlusQ9NT68
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    TENEURIN_N (PS51361)   
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like    CarboxyPept-like_regulatory    EGF-like_CS    EGF-like_dom    Quino_amine_DH_bsu    Rhs_assc_core    Ten2    Ten_N    Tox-GHH_dom    YD   
Domain families : Pfam (Sanger)Ten_N (PF06484)    Tox-GHH (PF15636)   
Domain families : Pfam (NCBI)pfam06484    pfam15636   
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)TENM2
DMDM Disease mutations57451
Blocks (Seattle)TENM2
SuperfamilyQ9NT68
Human Protein AtlasENSG00000145934
Peptide AtlasQ9NT68
IPIIPI00182194   IPI00984227   IPI00981922   
Protein Interaction databases
DIP (DOE-UCLA)Q9NT68
IntAct (EBI)Q9NT68
FunCoupENSG00000145934
BioGRIDTENM2
STRING (EMBL)TENM2
ZODIACTENM2
Ontologies - Pathways
QuickGOQ9NT68
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  receptor binding  receptor binding  calcium ion binding  protein binding  intracellular  nucleus  endoplasmic reticulum  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  cell-cell junction  transcription, DNA-templated  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  signal transduction  axon guidance  single organismal cell-cell adhesion  PML body  cell junction  filopodium  dendrite  growth cone  calcium-mediated signaling using intracellular calcium source  protein homodimerization activity  neuron projection  dendritic spine  synapse  postsynaptic membrane  protein heterodimerization activity  cell adhesion molecule binding  positive regulation of filopodium assembly  self proteolysis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  receptor binding  receptor binding  calcium ion binding  protein binding  intracellular  nucleus  endoplasmic reticulum  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  cell-cell junction  transcription, DNA-templated  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  signal transduction  axon guidance  single organismal cell-cell adhesion  PML body  cell junction  filopodium  dendrite  growth cone  calcium-mediated signaling using intracellular calcium source  protein homodimerization activity  neuron projection  dendritic spine  synapse  postsynaptic membrane  protein heterodimerization activity  cell adhesion molecule binding  positive regulation of filopodium assembly  self proteolysis  
NDEx NetworkTENM2
Atlas of Cancer Signalling NetworkTENM2
Wikipedia pathwaysTENM2
Orthology - Evolution
OrthoDB57451
GeneTree (enSembl)ENSG00000145934
Phylogenetic Trees/Animal Genes : TreeFamTENM2
HOVERGENQ9NT68
HOGENOMQ9NT68
Homologs : HomoloGeneTENM2
Homology/Alignments : Family Browser (UCSC)TENM2
Gene fusions - Rearrangements
Fusion : MitelmanANKH/TENM2 [5p15.2/5q34]  [t(5;5)(p15;q34)]  
Fusion : MitelmanIGH/TENM2 [14q32.33/5q34]  [t(5;14)(q34;q32)]  
Fusion : MitelmanTBC1D9B/TENM2 [5q35.3/5q34]  [t(5;5)(q34;q35)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTENM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TENM2
dbVarTENM2
ClinVarTENM2
1000_GenomesTENM2 
Exome Variant ServerTENM2
ExAC (Exome Aggregation Consortium)TENM2 (select the gene name)
Genetic variants : HAPMAP57451
Genomic Variants (DGV)TENM2 [DGVbeta]
DECIPHER (Syndromes)5:167181941-167691162  ENSG00000145934
CONAN: Copy Number AnalysisTENM2 
Mutations
ICGC Data PortalTENM2 
TCGA Data PortalTENM2 
Broad Tumor PortalTENM2
OASIS PortalTENM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTENM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTENM2
BioMutasearch TENM2
DgiDB (Drug Gene Interaction Database)TENM2
DoCM (Curated mutations)TENM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TENM2 (select a term)
intoGenTENM2
Cancer3DTENM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610119   
Orphanet
MedgenTENM2
Genetic Testing Registry TENM2
NextProtQ9NT68 [Medical]
TSGene57451
GENETestsTENM2
Huge Navigator TENM2 [HugePedia]
snp3D : Map Gene to Disease57451
BioCentury BCIQTENM2
ClinGenTENM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57451
Chemical/Pharm GKB GenePA134909677
Clinical trialTENM2
Miscellaneous
canSAR (ICR)TENM2 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTENM2
EVEXTENM2
GoPubMedTENM2
iHOPTENM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:30:47 CET 2017

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