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TENM4 (teneurin transmembrane protein 4)

Identity

Alias_namesODZ4
odz
Alias_symbol (synonym)KIAA1302
Ten-M4
Other aliasDoc4
ETM5
TNM4
ten-4
HGNC (Hugo) TENM4
LocusID (NCBI) 26011
Atlas_Id 41605
Location 11q14.1  [Link to chromosome band 11q14]
Location_base_pair Starts at 78653283 and ends at 79440651 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C2CD3 (11q13.4) / TENM4 (11q14.1)DLEC1 (3p22.2) / TENM4 (11q14.1)ELL3 (15q15.3) / TENM4 (11q14.1)
GAB2 (11q14.1) / TENM4 (11q14.1)KIF13B (8p12) / TENM4 (11q14.1)MTCH2 (11p11.2) / TENM4 (11q14.1)
POLD3 (11q13.4) / TENM4 (11q14.1)RSF1 (11q14.1) / TENM4 (11q14.1)TENM4 (11q14.1) / CADM1 (11q23.3)
TENM4 (11q14.1) / CALR (19p13.2)TENM4 (11q14.1) / DLEC1 (3p22.2)TENM4 (11q14.1) / GRIK4 (11q23.3)
TENM4 (11q14.1) / INTS4 (11q14.1)TENM4 (11q14.1) / NRG1 (8p12)TENM4 (11q14.1) / RBM4 (11q13.2)
TENM4 (11q14.1) / TMTC2 (12q21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)TENM4   29945
Cards
Entrez_Gene (NCBI)TENM4  26011  teneurin transmembrane protein 4
AliasesDoc4; ETM5; ODZ4; TNM4; 
Ten-M4; ten-4
GeneCards (Weizmann)TENM4
Ensembl hg19 (Hinxton)ENSG00000149256 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149256 [Gene_View]  chr11:78653283-79440651 [Contig_View]  TENM4 [Vega]
ICGC DataPortalENSG00000149256
TCGA cBioPortalTENM4
AceView (NCBI)TENM4
Genatlas (Paris)TENM4
WikiGenes26011
SOURCE (Princeton)TENM4
Genetics Home Reference (NIH)TENM4
Genomic and cartography
GoldenPath hg38 (UCSC)TENM4  -     chr11:78653283-79440651 -  11q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TENM4  -     11q14.1   [Description]    (hg19-Feb_2009)
EnsemblTENM4 - 11q14.1 [CytoView hg19]  TENM4 - 11q14.1 [CytoView hg38]
Mapping of homologs : NCBITENM4 [Mapview hg19]  TENM4 [Mapview hg38]
OMIM610084   616736   
Gene and transcription
Genbank (Entrez)AB037723 AK023935 AK056531 AK127101 AK127705
RefSeq transcript (Entrez)NM_001098816
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TENM4
Cluster EST : UnigeneHs.213087 [ NCBI ]
CGAP (NCI)Hs.213087
Alternative Splicing GalleryENSG00000149256
Gene ExpressionTENM4 [ NCBI-GEO ]   TENM4 [ EBI - ARRAY_EXPRESS ]   TENM4 [ SEEK ]   TENM4 [ MEM ]
Gene Expression Viewer (FireBrowse)TENM4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26011
GTEX Portal (Tissue expression)TENM4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6N022   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6N022  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6N022
Splice isoforms : SwissVarQ6N022
PhosPhoSitePlusQ6N022
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    TENEURIN_N (PS51361)   
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like    CarboxyPept-like_regulatory    EGF-like_CS    EGF-like_dom    EGF_extracell    Rhs_assc_core    Ten-4    Ten_N    Tox-GHH_dom    YD   
Domain families : Pfam (Sanger)EGF_2 (PF07974)    Ten_N (PF06484)    Tox-GHH (PF15636)   
Domain families : Pfam (NCBI)pfam07974    pfam06484    pfam15636   
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)TENM4
DMDM Disease mutations26011
Blocks (Seattle)TENM4
SuperfamilyQ6N022
Human Protein AtlasENSG00000149256
Peptide AtlasQ6N022
IPIIPI00737429   IPI00985392   IPI00983352   IPI00984270   
Protein Interaction databases
DIP (DOE-UCLA)Q6N022
IntAct (EBI)Q6N022
FunCoupENSG00000149256
BioGRIDTENM4
STRING (EMBL)TENM4
ZODIACTENM4
Ontologies - Pathways
QuickGOQ6N022
Ontology : AmiGOgastrulation with mouth forming second  nucleus  cytoplasm  plasma membrane  integral component of plasma membrane  signal transduction  regulation of myelination  positive regulation of myelination  central nervous system myelin formation  central nervous system myelin formation  protein homodimerization activity  neuron projection  neuron development  positive regulation of oligodendrocyte differentiation  cardiac muscle cell proliferation  cardiac cell fate specification  self proteolysis  positive regulation of gastrulation  
Ontology : EGO-EBIgastrulation with mouth forming second  nucleus  cytoplasm  plasma membrane  integral component of plasma membrane  signal transduction  regulation of myelination  positive regulation of myelination  central nervous system myelin formation  central nervous system myelin formation  protein homodimerization activity  neuron projection  neuron development  positive regulation of oligodendrocyte differentiation  cardiac muscle cell proliferation  cardiac cell fate specification  self proteolysis  positive regulation of gastrulation  
NDEx NetworkTENM4
Atlas of Cancer Signalling NetworkTENM4
Wikipedia pathwaysTENM4
Orthology - Evolution
OrthoDB26011
GeneTree (enSembl)ENSG00000149256
Phylogenetic Trees/Animal Genes : TreeFamTENM4
HOVERGENQ6N022
HOGENOMQ6N022
Homologs : HomoloGeneTENM4
Homology/Alignments : Family Browser (UCSC)TENM4
Gene fusions - Rearrangements
Fusion : MitelmanC2CD3/TENM4 [11q13.4/11q14.1]  [t(11;11)(q13;q14)]  
Fusion : MitelmanDLEC1/TENM4 [3p22.2/11q14.1]  [t(3;11)(p22;q14)]  
Fusion : MitelmanGAB2/TENM4 [11q14.1/11q14.1]  [t(11;11)(q14;q14)]  
Fusion : MitelmanKIF13B/TENM4 [8p12/11q14.1]  [t(8;11)(p12;q14)]  
Fusion : MitelmanPOLD3/TENM4 [11q13.4/11q14.1]  [t(11;11)(q13;q14)]  
Fusion : MitelmanRSF1/TENM4 [11q14.1/11q14.1]  [t(11;11)(q14;q14)]  
Fusion : MitelmanTENM4/GRIK4 [11q14.1/11q23.3]  [t(11;11)(q14;q23)]  
Fusion : MitelmanTENM4/INTS4 [11q14.1/11q14.1]  [t(11;11)(q14;q14)]  
Fusion : MitelmanTENM4/NRG1 [11q14.1/8p12]  [dic(8;11)(p12;q14)]  [t(8;11)(p12;q14)]  
Fusion : MitelmanTENM4/RBM4 [11q14.1/11q13.2]  [t(11;11)(q13;q14)]  
Fusion : MitelmanTENM4/TMTC2 [11q14.1/12q21.31]  [t(11;12)(q14;q21)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTENM4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TENM4
dbVarTENM4
ClinVarTENM4
1000_GenomesTENM4 
Exome Variant ServerTENM4
ExAC (Exome Aggregation Consortium)TENM4 (select the gene name)
Genetic variants : HAPMAP26011
Genomic Variants (DGV)TENM4 [DGVbeta]
DECIPHERTENM4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTENM4 
Mutations
ICGC Data PortalTENM4 
TCGA Data PortalTENM4 
Broad Tumor PortalTENM4
OASIS PortalTENM4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTENM4
BioMutasearch TENM4
DgiDB (Drug Gene Interaction Database)TENM4
DoCM (Curated mutations)TENM4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TENM4 (select a term)
intoGenTENM4
Cancer3DTENM4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610084    616736   
Orphanet
MedgenTENM4
Genetic Testing Registry TENM4
NextProtQ6N022 [Medical]
TSGene26011
GENETestsTENM4
Target ValidationTENM4
Huge Navigator TENM4 [HugePedia]
snp3D : Map Gene to Disease26011
BioCentury BCIQTENM4
ClinGenTENM4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26011
Chemical/Pharm GKB GenePA134896466
Clinical trialTENM4
Miscellaneous
canSAR (ICR)TENM4 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTENM4
EVEXTENM4
GoPubMedTENM4
iHOPTENM4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:16:41 CEST 2017

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