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TENM4 (teneurin transmembrane protein 4)

Identity

Alias (NCBI)Doc4
ETM5
ODZ4
TEN4
TNM4
Ten-M4
ten-4
HGNC (Hugo) TENM4
HGNC Alias symbKIAA1302
Ten-M4
TEN4
HGNC Previous nameODZ4
HGNC Previous nameodz, odd Oz/ten-m homolog 4 (Drosophila)
LocusID (NCBI) 26011
Atlas_Id 41605
Location 11q14.1  [Link to chromosome band 11q14]
Location_base_pair Starts at 78652829 and ends at 79441030 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C2CD3 (11q13.4) / TENM4 (11q14.1)DLEC1 (3p22.2) / TENM4 (11q14.1)ELL3 (15q15.3) / TENM4 (11q14.1)
GAB2 (11q14.1) / TENM4 (11q14.1)KIF13B (8p12) / TENM4 (11q14.1)MTCH2 (11p11.2) / TENM4 (11q14.1)
POLD3 (11q13.4) / TENM4 (11q14.1)RSF1 (11q14.1) / TENM4 (11q14.1)TENM4 (11q14.1) / CADM1 (11q23.3)
TENM4 (11q14.1) / CALR (19p13.2)TENM4 (11q14.1) / DLEC1 (3p22.2)TENM4 (11q14.1) / GRIK4 (11q23.3)
TENM4 (11q14.1) / INTS4 (11q14.1)TENM4 (11q14.1) / NRG1 (8p12)TENM4 (11q14.1) / RBM4 (11q13.2)
TENM4 (11q14.1) / TMTC2 (12q21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q14;q23) TENM4/CADM1


External links

 

Nomenclature
HGNC (Hugo)TENM4   29945
Cards
Entrez_Gene (NCBI)TENM4    teneurin transmembrane protein 4
AliasesDoc4; ETM5; ODZ4; TEN4; 
TNM4; Ten-M4; ten-4
GeneCards (Weizmann)TENM4
Ensembl hg19 (Hinxton)ENSG00000149256 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149256 [Gene_View]  ENSG00000149256 [Sequence]  chr11:78652829-79441030 [Contig_View]  TENM4 [Vega]
ICGC DataPortalENSG00000149256
TCGA cBioPortalTENM4
AceView (NCBI)TENM4
Genatlas (Paris)TENM4
SOURCE (Princeton)TENM4
Genetics Home Reference (NIH)TENM4
Genomic and cartography
GoldenPath hg38 (UCSC)TENM4  -     chr11:78652829-79441030 -  11q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TENM4  -     11q14.1   [Description]    (hg19-Feb_2009)
GoldenPathTENM4 - 11q14.1 [CytoView hg19]  TENM4 - 11q14.1 [CytoView hg38]
ImmunoBaseENSG00000149256
Genome Data Viewer NCBITENM4 [Mapview hg19]  
OMIM610084   616736   
Gene and transcription
Genbank (Entrez)AB037723 AK023935 AK056531 AK127101 AK127705
RefSeq transcript (Entrez)NM_001098816
Consensus coding sequences : CCDS (NCBI)TENM4
Gene ExpressionTENM4 [ NCBI-GEO ]   TENM4 [ EBI - ARRAY_EXPRESS ]   TENM4 [ SEEK ]   TENM4 [ MEM ]
Gene Expression Viewer (FireBrowse)TENM4 [ Firebrowse - Broad ]
GenevisibleExpression of TENM4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26011
GTEX Portal (Tissue expression)TENM4
Human Protein AtlasENSG00000149256-TENM4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6N022   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6N022  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6N022
PhosPhoSitePlusQ6N022
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    TENEURIN_N (PS51361)   
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like    CarboxyPept-like_regulatory    EGF-like_dom    EGF_extracell    Rhs_assc_core    Ten-3/4    Ten_N    Tox-GHH_dom    YD   
Domain families : Pfam (Sanger)EGF_2 (PF07974)    Ten_N (PF06484)    Tox-GHH (PF15636)   
Domain families : Pfam (NCBI)pfam07974    pfam06484    pfam15636   
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)TENM4
SuperfamilyQ6N022
AlphaFold pdb e-kbQ6N022   
Human Protein Atlas [tissue]ENSG00000149256-TENM4 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q6N022
IntAct (EBI)Q6N022
BioGRIDTENM4
STRING (EMBL)TENM4
ZODIACTENM4
Ontologies - Pathways
QuickGOQ6N022
Ontology : AmiGOgastrulation with mouth forming second  protein binding  nucleus  cytoplasm  plasma membrane  integral component of plasma membrane  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  signal transduction  regulation of myelination  positive regulation of myelination  central nervous system myelin formation  central nervous system myelin formation  protein homodimerization activity  protein homodimerization activity  neuron projection  neuron projection  protein heterodimerization activity  neuron development  neuron development  positive regulation of oligodendrocyte differentiation  cell adhesion molecule binding  cardiac muscle cell proliferation  cardiac cell fate specification  positive regulation of gastrulation  
Ontology : EGO-EBIgastrulation with mouth forming second  protein binding  nucleus  cytoplasm  plasma membrane  integral component of plasma membrane  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  signal transduction  regulation of myelination  positive regulation of myelination  central nervous system myelin formation  central nervous system myelin formation  protein homodimerization activity  protein homodimerization activity  neuron projection  neuron projection  protein heterodimerization activity  neuron development  neuron development  positive regulation of oligodendrocyte differentiation  cell adhesion molecule binding  cardiac muscle cell proliferation  cardiac cell fate specification  positive regulation of gastrulation  
NDEx NetworkTENM4
Atlas of Cancer Signalling NetworkTENM4
Wikipedia pathwaysTENM4
Orthology - Evolution
OrthoDB26011
GeneTree (enSembl)ENSG00000149256
Phylogenetic Trees/Animal Genes : TreeFamTENM4
Homologs : HomoloGeneTENM4
Homology/Alignments : Family Browser (UCSC)TENM4
Gene fusions - Rearrangements
Fusion : MitelmanC2CD3/TENM4 [11q13.4/11q14.1]  
Fusion : MitelmanDLEC1/TENM4 [3p22.2/11q14.1]  
Fusion : MitelmanGAB2/TENM4 [11q14.1/11q14.1]  
Fusion : MitelmanKIF13B/TENM4 [8p12/11q14.1]  
Fusion : MitelmanPOLD3/TENM4 [11q13.4/11q14.1]  
Fusion : MitelmanRSF1/TENM4 [11q14.1/11q14.1]  
Fusion : MitelmanTENM4/GRIK4 [11q14.1/11q23.3]  
Fusion : MitelmanTENM4/INTS4 [11q14.1/11q14.1]  
Fusion : MitelmanTENM4/NRG1 [11q14.1/8p12]  
Fusion : MitelmanTENM4/RBM4 [11q14.1/11q13.2]  
Fusion : MitelmanTENM4/TMTC2 [11q14.1/12q21.31]  
Fusion : QuiverTENM4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTENM4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TENM4
dbVarTENM4
ClinVarTENM4
MonarchTENM4
1000_GenomesTENM4 
Exome Variant ServerTENM4
GNOMAD BrowserENSG00000149256
Varsome BrowserTENM4
ACMGTENM4 variants
VarityQ6N022
Genomic Variants (DGV)TENM4 [DGVbeta]
DECIPHERTENM4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTENM4 
Mutations
ICGC Data PortalTENM4 
TCGA Data PortalTENM4 
Broad Tumor PortalTENM4
OASIS PortalTENM4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTENM4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTENM4
Mutations and Diseases : HGMDTENM4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTENM4
DgiDB (Drug Gene Interaction Database)TENM4
DoCM (Curated mutations)TENM4
CIViC (Clinical Interpretations of Variants in Cancer)TENM4
Cancer3DTENM4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610084    616736   
Orphanet
DisGeNETTENM4
MedgenTENM4
Genetic Testing Registry TENM4
NextProtQ6N022 [Medical]
GENETestsTENM4
Target ValidationTENM4
Huge Navigator TENM4 [HugePedia]
ClinGenTENM4
Clinical trials, drugs, therapy
MyCancerGenomeTENM4
Protein Interactions : CTDTENM4
Pharm GKB GenePA134896466
PharosQ6N022
Clinical trialTENM4
Miscellaneous
canSAR (ICR)TENM4
HarmonizomeTENM4
DataMed IndexTENM4
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTENM4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:34:45 CEST 2021

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