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TENT4A (terminal nucleotidyltransferase 4A)

Identity

Alias_namesPOLS
polymerase (DNA directed) sigma
PAP associated domain containing 7
Alias_symbol (synonym)POLK
TRF4
LAK-1
TRF4-1
Other aliasLAK1
PAPD7
TRF41
TUTASE5
HGNC (Hugo) TENT4A
LocusID (NCBI) 11044
Atlas_Id 51320
Location 5p15.31  [Link to chromosome band 5p15]
Location_base_pair Starts at 6714605 and ends at 6757048 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PAPD7 5p15.31 / SRD5A1 5p15.31
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)TENT4A   16705
Cards
Entrez_Gene (NCBI)TENT4A  11044  terminal nucleotidyltransferase 4A
AliasesLAK-1; LAK1; PAPD7; POLK; 
POLS; TRF4; TRF4-1; TRF41; TUTASE5
GeneCards (Weizmann)TENT4A
Ensembl hg19 (Hinxton)ENSG00000112941 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112941 [Gene_View]  ENSG00000112941 [Sequence]  chr5:6714605-6757048 [Contig_View]  TENT4A [Vega]
ICGC DataPortalENSG00000112941
TCGA cBioPortalTENT4A
AceView (NCBI)TENT4A
Genatlas (Paris)TENT4A
WikiGenes11044
SOURCE (Princeton)TENT4A
Genetics Home Reference (NIH)TENT4A
Genomic and cartography
GoldenPath hg38 (UCSC)TENT4A  -     chr5:6714605-6757048 +  5p15.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TENT4A  -     5p15.31   [Description]    (hg19-Feb_2009)
EnsemblTENT4A - 5p15.31 [CytoView hg19]  TENT4A - 5p15.31 [CytoView hg38]
Mapping of homologs : NCBITENT4A [Mapview hg19]  TENT4A [Mapview hg38]
OMIM605198   
Gene and transcription
Genbank (Entrez)AB005754 AF089896 AI871781 AK289857 AK303516
RefSeq transcript (Entrez)NM_001171805 NM_001171806 NM_006999
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TENT4A
Cluster EST : UnigeneHs.481542 [ NCBI ]
CGAP (NCI)Hs.481542
Alternative Splicing GalleryENSG00000112941
Gene ExpressionTENT4A [ NCBI-GEO ]   TENT4A [ EBI - ARRAY_EXPRESS ]   TENT4A [ SEEK ]   TENT4A [ MEM ]
Gene Expression Viewer (FireBrowse)TENT4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11044
GTEX Portal (Tissue expression)TENT4A
Human Protein AtlasENSG00000112941-TENT4A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5XG87   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5XG87  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5XG87
Splice isoforms : SwissVarQ5XG87
Catalytic activity : Enzyme2.7.7.19 [ Enzyme-Expasy ]   2.7.7.192.7.7.19 [ IntEnz-EBI ]   2.7.7.19 [ BRENDA ]   2.7.7.19 [ KEGG ]   
PhosPhoSitePlusQ5XG87
Domains : Interpro (EBI)PAP_assoc    Polymerase_NTP_transf_dom   
Domain families : Pfam (Sanger)NTP_transf_2 (PF01909)    PAP_assoc (PF03828)   
Domain families : Pfam (NCBI)pfam01909    pfam03828   
Conserved Domain (NCBI)TENT4A
DMDM Disease mutations11044
Blocks (Seattle)TENT4A
SuperfamilyQ5XG87
Human Protein Atlas [tissue]ENSG00000112941-TENT4A [tissue]
Peptide AtlasQ5XG87
HPRD09239
IPIIPI00418630   IPI00955501   IPI00955495   
Protein Interaction databases
DIP (DOE-UCLA)Q5XG87
IntAct (EBI)Q5XG87
FunCoupENSG00000112941
BioGRIDTENT4A
STRING (EMBL)TENT4A
ZODIACTENT4A
Ontologies - Pathways
QuickGOQ5XG87
Ontology : AmiGOpolynucleotide adenylyltransferase activity  polynucleotide adenylyltransferase activity  ATP binding  nucleus  nucleoplasm  nucleolus  Golgi apparatus  double-strand break repair  mRNA polyadenylation  mRNA processing  sister chromatid cohesion  mitotic chromosome condensation  TRAMP complex  nuclear membrane  response to drug  SMC family protein binding  ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process  metal ion binding  nuclear polyadenylation-dependent rRNA catabolic process  nuclear polyadenylation-dependent snoRNA catabolic process  nuclear polyadenylation-dependent snRNA catabolic process  nuclear polyadenylation-dependent tRNA catabolic process  nuclear polyadenylation-dependent mRNA catabolic process  histone mRNA catabolic process  snoRNA polyadenylation  polyadenylation-dependent snoRNA 3'-end processing  
Ontology : EGO-EBIpolynucleotide adenylyltransferase activity  polynucleotide adenylyltransferase activity  ATP binding  nucleus  nucleoplasm  nucleolus  Golgi apparatus  double-strand break repair  mRNA polyadenylation  mRNA processing  sister chromatid cohesion  mitotic chromosome condensation  TRAMP complex  nuclear membrane  response to drug  SMC family protein binding  ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process  metal ion binding  nuclear polyadenylation-dependent rRNA catabolic process  nuclear polyadenylation-dependent snoRNA catabolic process  nuclear polyadenylation-dependent snRNA catabolic process  nuclear polyadenylation-dependent tRNA catabolic process  nuclear polyadenylation-dependent mRNA catabolic process  histone mRNA catabolic process  snoRNA polyadenylation  polyadenylation-dependent snoRNA 3'-end processing  
NDEx NetworkTENT4A
Atlas of Cancer Signalling NetworkTENT4A
Wikipedia pathwaysTENT4A
Orthology - Evolution
OrthoDB11044
GeneTree (enSembl)ENSG00000112941
Phylogenetic Trees/Animal Genes : TreeFamTENT4A
HOVERGENQ5XG87
HOGENOMQ5XG87
Homologs : HomoloGeneTENT4A
Homology/Alignments : Family Browser (UCSC)TENT4A
Gene fusions - Rearrangements
Fusion : MitelmanPAPD7/SRD5A1 [5p15.31/5p15.31]  
Fusion PortalPAPD7 5p15.31 SRD5A1 5p15.31 BRCA
Fusion : QuiverTENT4A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTENT4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TENT4A
dbVarTENT4A
ClinVarTENT4A
1000_GenomesTENT4A 
Exome Variant ServerTENT4A
ExAC (Exome Aggregation Consortium)ENSG00000112941
GNOMAD BrowserENSG00000112941
Varsome BrowserTENT4A
Genetic variants : HAPMAP11044
Genomic Variants (DGV)TENT4A [DGVbeta]
DECIPHERTENT4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTENT4A 
Mutations
ICGC Data PortalTENT4A 
TCGA Data PortalTENT4A 
Broad Tumor PortalTENT4A
OASIS PortalTENT4A [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTENT4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TENT4A
DgiDB (Drug Gene Interaction Database)TENT4A
DoCM (Curated mutations)TENT4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TENT4A (select a term)
intoGenTENT4A
Cancer3DTENT4A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605198   
Orphanet
DisGeNETTENT4A
MedgenTENT4A
Genetic Testing Registry TENT4A
NextProtQ5XG87 [Medical]
TSGene11044
GENETestsTENT4A
Target ValidationTENT4A
Huge Navigator TENT4A [HugePedia]
snp3D : Map Gene to Disease11044
BioCentury BCIQTENT4A
ClinGenTENT4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11044
Chemical/Pharm GKB GenePA33523
Clinical trialTENT4A
Miscellaneous
canSAR (ICR)TENT4A (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTENT4A
EVEXTENT4A
GoPubMedTENT4A
iHOPTENT4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:57:03 CEST 2018

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