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TENT4A (terminal nucleotidyltransferase 4A)

Identity

Alias (NCBI)LAK-1
LAK1
PAPD7
POLK
POLS
TRF4
TRF4-1
TRF41
TUTASE5
HGNC (Hugo) TENT4A
HGNC Alias symbPOLK
TRF4
LAK-1
TRF4-1
HGNC Alias nametopoisomerase-related function protein 4-1
 polymerase (DNA-directed) sigma
 DNA polymerase kappa
 TUTase5
HGNC Previous namePOLS
 PAPD7
HGNC Previous namepolymerase (DNA directed) sigma
 PAP associated domain containing 7
 poly(A) RNA polymerase D7, non-canonical
LocusID (NCBI) 11044
Atlas_Id 51320
Location 5p15.31  [Link to chromosome band 5p15]
Location_base_pair Starts at 6713432 and ends at 6757044 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PAPD7 5p15.31 / SRD5A1 5p15.31
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)TENT4A   16705
Cards
Entrez_Gene (NCBI)TENT4A    terminal nucleotidyltransferase 4A
AliasesLAK-1; LAK1; PAPD7; POLK; 
POLS; TRF4; TRF4-1; TRF41; TUTASE5
GeneCards (Weizmann)TENT4A
Ensembl hg19 (Hinxton)ENSG00000112941 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112941 [Gene_View]  ENSG00000112941 [Sequence]  chr5:6713432-6757044 [Contig_View]  TENT4A [Vega]
ICGC DataPortalENSG00000112941
TCGA cBioPortalTENT4A
AceView (NCBI)TENT4A
Genatlas (Paris)TENT4A
SOURCE (Princeton)TENT4A
Genetics Home Reference (NIH)TENT4A
Genomic and cartography
GoldenPath hg38 (UCSC)TENT4A  -     chr5:6713432-6757044 +  5p15.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TENT4A  -     5p15.31   [Description]    (hg19-Feb_2009)
GoldenPathTENT4A - 5p15.31 [CytoView hg19]  TENT4A - 5p15.31 [CytoView hg38]
ImmunoBaseENSG00000112941
Genome Data Viewer NCBITENT4A [Mapview hg19]  
OMIM605198   
Gene and transcription
Genbank (Entrez)AB005754 AF089896 AI871781 AK289857 AK303516
RefSeq transcript (Entrez)NM_001171805 NM_001171806 NM_006999
Consensus coding sequences : CCDS (NCBI)TENT4A
Gene ExpressionTENT4A [ NCBI-GEO ]   TENT4A [ EBI - ARRAY_EXPRESS ]   TENT4A [ SEEK ]   TENT4A [ MEM ]
Gene Expression Viewer (FireBrowse)TENT4A [ Firebrowse - Broad ]
GenevisibleExpression of TENT4A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11044
GTEX Portal (Tissue expression)TENT4A
Human Protein AtlasENSG00000112941-TENT4A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5XG87   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5XG87  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5XG87
Catalytic activity : Enzyme2.7.7.19 [ Enzyme-Expasy ]   2.7.7.192.7.7.19 [ IntEnz-EBI ]   2.7.7.19 [ BRENDA ]   2.7.7.19 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ5XG87
Domains : Interpro (EBI)NT_sf    PAP_assoc    Polymerase_NTP_transf_dom    TENT4A   
Domain families : Pfam (Sanger)NTP_transf_2 (PF01909)    PAP_assoc (PF03828)   
Domain families : Pfam (NCBI)pfam01909    pfam03828   
Conserved Domain (NCBI)TENT4A
SuperfamilyQ5XG87
AlphaFold pdb e-kbQ5XG87   
Human Protein Atlas [tissue]ENSG00000112941-TENT4A [tissue]
HPRD09239
Protein Interaction databases
DIP (DOE-UCLA)Q5XG87
IntAct (EBI)Q5XG87
BioGRIDTENT4A
STRING (EMBL)TENT4A
ZODIACTENT4A
Ontologies - Pathways
QuickGOQ5XG87
Ontology : AmiGOpolynucleotide adenylyltransferase activity  ATP binding  nucleus  nucleoplasm  nucleolus  Golgi apparatus  double-strand break repair  mRNA processing  sister chromatid cohesion  mitotic chromosome condensation  RNA 3'-end processing  TRAMP complex  nuclear membrane  response to drug  SMC family protein binding  RNA polyadenylation  metal ion binding  negative regulation of nuclear-transcribed mRNA poly(A) tail shortening  guanylyltransferase activity  RNA 3' uridylation  positive regulation of 3'-UTR-mediated mRNA stabilization  
Ontology : EGO-EBIpolynucleotide adenylyltransferase activity  ATP binding  nucleus  nucleoplasm  nucleolus  Golgi apparatus  double-strand break repair  mRNA processing  sister chromatid cohesion  mitotic chromosome condensation  RNA 3'-end processing  TRAMP complex  nuclear membrane  response to drug  SMC family protein binding  RNA polyadenylation  metal ion binding  negative regulation of nuclear-transcribed mRNA poly(A) tail shortening  guanylyltransferase activity  RNA 3' uridylation  positive regulation of 3'-UTR-mediated mRNA stabilization  
NDEx NetworkTENT4A
Atlas of Cancer Signalling NetworkTENT4A
Wikipedia pathwaysTENT4A
Orthology - Evolution
OrthoDB11044
GeneTree (enSembl)ENSG00000112941
Phylogenetic Trees/Animal Genes : TreeFamTENT4A
Homologs : HomoloGeneTENT4A
Homology/Alignments : Family Browser (UCSC)TENT4A
Gene fusions - Rearrangements
Fusion : MitelmanPAPD7/SRD5A1 [5p15.31/5p15.31]  
Fusion : QuiverTENT4A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTENT4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TENT4A
dbVarTENT4A
ClinVarTENT4A
MonarchTENT4A
1000_GenomesTENT4A 
Exome Variant ServerTENT4A
GNOMAD BrowserENSG00000112941
Varsome BrowserTENT4A
ACMGTENT4A variants
VarityQ5XG87
Genomic Variants (DGV)TENT4A [DGVbeta]
DECIPHERTENT4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTENT4A 
Mutations
ICGC Data PortalTENT4A 
TCGA Data PortalTENT4A 
Broad Tumor PortalTENT4A
OASIS PortalTENT4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTENT4A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTENT4A
Mutations and Diseases : HGMDTENT4A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTENT4A
DgiDB (Drug Gene Interaction Database)TENT4A
DoCM (Curated mutations)TENT4A
CIViC (Clinical Interpretations of Variants in Cancer)TENT4A
Cancer3DTENT4A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605198   
Orphanet
DisGeNETTENT4A
MedgenTENT4A
Genetic Testing Registry TENT4A
NextProtQ5XG87 [Medical]
GENETestsTENT4A
Target ValidationTENT4A
Huge Navigator TENT4A [HugePedia]
ClinGenTENT4A
Clinical trials, drugs, therapy
MyCancerGenomeTENT4A
Protein Interactions : CTDTENT4A
Pharm GKB GenePA33523
PharosQ5XG87
Clinical trialTENT4A
Miscellaneous
canSAR (ICR)TENT4A
HarmonizomeTENT4A
DataMed IndexTENT4A
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTENT4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:34:45 CEST 2021

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