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TERT (telomerase reverse transcriptase)

Identity

Other namesDKCA2
DKCB4
EST2
PFBMFT1
TCS1
TP2
TRT
hEST2
hTRT
HGNC (Hugo) TERT
LocusID (NCBI) 7015
Location 5p15.33
Location_base_pair Starts at 1253287 and ends at 1295162 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TERT   11730
Entrez_Gene (NCBI)TERT  7015  telomerase reverse transcriptase
Cards
GeneCards (Weizmann)TERT
Ensembl (Hinxton)ENSG00000164362 [Gene_View]  chr5:1253287-1295162 [Contig_View]  TERT [Vega]
AceView (NCBI)TERT
Genatlas (Paris)TERT
SOURCE (Stanford)NM_001193376 NM_198253 NM_198254 NM_198255
Genomic and cartography
GoldenPath (UCSC)TERT  -  5p15.33   chr5:1253287-1295162 -  5p15.33   [Description]    (hg19-Feb_2009)
EnsemblTERT - 5p15.33 [CytoView]
Mapping of homologs : NCBITERT [Mapview]
OMIM127550   178500   187270   601626   609135   613989   614742   
Gene and transcription
Genbank (Entrez)AB085628 AB086379 AB086950 AF015950 AF018167
RefSeq transcript (SRS)NM_001193376 NM_198253 NM_198254 NM_198255
RefSeq transcript (Entrez)NM_001193376 NM_198253 NM_198254 NM_198255
RefSeq genomic (SRS)AC_000137 NC_000005 NC_018916 NG_009265 NT_006576 NW_001838923 NW_004078022
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_009265 NT_006576 NW_001838923 NW_004078022
Consensus coding sequences : CCDS (NCBI)TERT
Cluster EST : UnigeneHs.492203 [ SRS ] Hs.492203 [ NCBI ]
CGAP (NCI)Hs.492203
Alternative Splicing : Fast-db (Paris)GSHG0024573
Alternative Splicing GalleryENSG00000164362
Gene ExpressionTERT [ NCBI-GEO ]   TERT [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14746 (SRS) O14746 (Uniprot)
NextProtO14746
With graphics : InterProO14746
Splice isoforms : SwissVarO14746(Swissvar)
Domaine pattern : Prosite (SRS)RT_POL (PS50878)   
Domaine pattern : Prosite (Expaxy)RT_POL (PS50878)   
Domains : Interpro (SRS)RVT    Telomerase_RBD    Telomerase_RT   
Domains : Interpro (EBI)RVT    Telomerase_RBD    Telomerase_RT   
Related proteins : CluSTrO14746
Domain families : Pfam (SRS)RVT_1 (PF00078)    Telomerase_RBD (PF12009)   
Domain families : Pfam (Sanger)RVT_1 (PF00078)    Telomerase_RBD (PF12009)   
Domain families : Pfam (NCBI)pfam00078    pfam12009   
Domain families : Smart (EMBL)Telomerase_RBD (SM00975)  
DMDM7015
Blocks (Seattle)O14746
PDB (SRS)2BCK   
PDB (PDBSum)2BCK   
PDB (IMB)2BCK   
PDB (RSDB)2BCK   
Human Protein AtlasENSG00000164362
HPRD01754
IPIIPI00298218   IPI00384469   IPI00168908   IPI00963895   
Protein Interaction databases
DIP (DOE-UCLA)O14746
IntAct (EBI)O14746
FunCoupENSG00000164362
REACTOMETERT
Protein Interaction Database7015
BioGRIDTERT
InParanoidO14746
Interologous Interaction database O14746
IntegromeDBTERT
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TERT
SNP (GeneSNP Utah)TERT
SNP : HGBaseTERT
Genetic variants : HAPMAPTERT
Somatic Mutations in Cancer : COSMICTERT 
CONAN: Copy Number AnalysisTERT 
Mutations and Diseases : HGMDTERT
OMIM127550    178500    187270    601626    609135    613989    614742   
GENETests127550    178500    187270    601626    609135    613989    614742   
Disease Genetic AssociationTERT
Huge Navigator TERT [HugePedia]  TERT [HugeCancerGEM]
Genomic VariantsTERT  TERT [DGVbeta]
snp3D : Map Gene to Disease7015
General knowledge
Homologs : HomoloGeneTERT
Homology/Alignments : Family Browser (UCSC)TERT
Phylogenetic Trees/Animal Genes : TreeFamTERT
Catalytic activity : Enzyme2.7.7.49 [ Enzyme-Expasy ]   2.7.7.49 [ Enzyme-SRS ]   2.7.7.49 [ IntEnz-EBI ]   2.7.7.49 [ BRENDA ]   2.7.7.49 [ KEGG ]   
Chemical/Protein Interactions : CTD7015
Chemical/Pharm GKB GenePA36447
Clinical trialTERT
Cancer Resource (Charite)ENSG00000164362
Ontology : AmiGOtelomere maintenance  chromosome, telomeric region  nuclear telomere cap complex  telomerase activity  telomeric template RNA reverse transcriptase activity  telomeric template RNA reverse transcriptase activity  protein binding  nucleoplasm  nucleoplasm  telomerase holoenzyme complex  nucleolus  cytoplasm  telomere maintenance via telomerase  telomere maintenance via telomerase  PML body  DNA strand elongation  telomere formation via telomerase  telomeric DNA binding  protein homodimerization activity  negative regulation of apoptotic process  metal ion binding  telomeric RNA binding  replicative senescence  
Ontology : EGO-EBItelomere maintenance  chromosome, telomeric region  nuclear telomere cap complex  telomerase activity  telomeric template RNA reverse transcriptase activity  telomeric template RNA reverse transcriptase activity  protein binding  nucleoplasm  nucleoplasm  telomerase holoenzyme complex  nucleolus  cytoplasm  telomere maintenance via telomerase  telomere maintenance via telomerase  PML body  DNA strand elongation  telomere formation via telomerase  telomeric DNA binding  protein homodimerization activity  negative regulation of apoptotic process  metal ion binding  telomeric RNA binding  replicative senescence  
Pathways : BIOCARTARole of nicotinic acetylcholine receptors in the regulation of apoptosis [Genes]    Telomeres, Telomerase, Cellular Aging, and Immortality [Genes]   
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
PubGeneTERT
iHOPTERT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:23:31 CEST 2013
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