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TESK1 (testis associated actin remodelling kinase 1)

Identity

Alias (NCBI)-
HGNC (Hugo) TESK1
HGNC Alias nametestis specific kinase-1
HGNC Previous nametestis-specific kinase 1
LocusID (NCBI) 7016
Atlas_Id 42525
Location 9p13.3  [Link to chromosome band 9p13]
Location_base_pair Starts at 35605262 and ends at 35610033 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZSCAN5A (19q13.43) / TESK1 (9p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;17)(p13;q11) PAX5/TAOK1


External links

 

Nomenclature
HGNC (Hugo)TESK1   11731
Cards
Entrez_Gene (NCBI)TESK1    testis associated actin remodelling kinase 1
Aliases
GeneCards (Weizmann)TESK1
Ensembl hg19 (Hinxton)ENSG00000107140 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107140 [Gene_View]  ENSG00000107140 [Sequence]  chr9:35605262-35610033 [Contig_View]  TESK1 [Vega]
ICGC DataPortalENSG00000107140
TCGA cBioPortalTESK1
AceView (NCBI)TESK1
Genatlas (Paris)TESK1
SOURCE (Princeton)TESK1
Genetics Home Reference (NIH)TESK1
Genomic and cartography
GoldenPath hg38 (UCSC)TESK1  -     chr9:35605262-35610033 +  9p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TESK1  -     9p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTESK1 - 9p13.3 [CytoView hg19]  TESK1 - 9p13.3 [CytoView hg38]
ImmunoBaseENSG00000107140
Genome Data Viewer NCBITESK1 [Mapview hg19]  
OMIM601782   
Gene and transcription
Genbank (Entrez)AF452589 AF479317 AF507907 AF507908 AF507909
RefSeq transcript (Entrez)NM_001318230 NM_006285
Consensus coding sequences : CCDS (NCBI)TESK1
Gene ExpressionTESK1 [ NCBI-GEO ]   TESK1 [ EBI - ARRAY_EXPRESS ]   TESK1 [ SEEK ]   TESK1 [ MEM ]
Gene Expression Viewer (FireBrowse)TESK1 [ Firebrowse - Broad ]
GenevisibleExpression of TESK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7016
GTEX Portal (Tissue expression)TESK1
Human Protein AtlasENSG00000107140-TESK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15569   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15569  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15569
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ15569
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    TESK1    Tyr_kinase_AS   
Domain families : Pfam (Sanger)PK_Tyr_Ser-Thr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Conserved Domain (NCBI)TESK1
SuperfamilyQ15569
AlphaFold pdb e-kbQ15569   
Human Protein Atlas [tissue]ENSG00000107140-TESK1 [tissue]
HPRD03470
Protein Interaction databases
DIP (DOE-UCLA)Q15569
IntAct (EBI)Q15569
BioGRIDTESK1
STRING (EMBL)TESK1
ZODIACTESK1
Ontologies - Pathways
QuickGOQ15569
Ontology : AmiGOpositive regulation of protein phosphorylation  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  centrosome  cytosol  spermatogenesis  protein C-terminus binding  peptidyl-tyrosine phosphorylation  protein kinase binding  lamellipodium  actin cytoskeleton organization  cytoplasmic vesicle  negative regulation of protein autophosphorylation  regulation of protein localization  regulation of actin cytoskeleton organization  negative regulation of phosphorylation  metal ion binding  perinuclear region of cytoplasm  positive regulation of stress fiber assembly  positive regulation of stress fiber assembly  positive regulation of stress fiber assembly  establishment of vesicle localization  negative regulation of protein serine/threonine kinase activity  glomerular visceral epithelial cell migration  protein serine kinase activity  protein threonine kinase activity  positive regulation of substrate adhesion-dependent cell spreading  positive regulation of protein localization to nucleus  negative regulation of cilium assembly  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  centrosome  cytosol  spermatogenesis  protein C-terminus binding  peptidyl-tyrosine phosphorylation  protein kinase binding  lamellipodium  actin cytoskeleton organization  cytoplasmic vesicle  negative regulation of protein autophosphorylation  regulation of protein localization  regulation of actin cytoskeleton organization  negative regulation of phosphorylation  metal ion binding  perinuclear region of cytoplasm  positive regulation of stress fiber assembly  positive regulation of stress fiber assembly  positive regulation of stress fiber assembly  establishment of vesicle localization  negative regulation of protein serine/threonine kinase activity  glomerular visceral epithelial cell migration  protein serine kinase activity  protein threonine kinase activity  positive regulation of substrate adhesion-dependent cell spreading  positive regulation of protein localization to nucleus  negative regulation of cilium assembly  
NDEx NetworkTESK1
Atlas of Cancer Signalling NetworkTESK1
Wikipedia pathwaysTESK1
Orthology - Evolution
OrthoDB7016
GeneTree (enSembl)ENSG00000107140
Phylogenetic Trees/Animal Genes : TreeFamTESK1
Homologs : HomoloGeneTESK1
Homology/Alignments : Family Browser (UCSC)TESK1
Gene fusions - Rearrangements
Fusion : QuiverTESK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTESK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TESK1
dbVarTESK1
ClinVarTESK1
MonarchTESK1
1000_GenomesTESK1 
Exome Variant ServerTESK1
GNOMAD BrowserENSG00000107140
Varsome BrowserTESK1
ACMGTESK1 variants
VarityQ15569
Genomic Variants (DGV)TESK1 [DGVbeta]
DECIPHERTESK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTESK1 
Mutations
ICGC Data PortalTESK1 
TCGA Data PortalTESK1 
Broad Tumor PortalTESK1
OASIS PortalTESK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTESK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTESK1
Mutations and Diseases : HGMDTESK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTESK1
DgiDB (Drug Gene Interaction Database)TESK1
DoCM (Curated mutations)TESK1
CIViC (Clinical Interpretations of Variants in Cancer)TESK1
Cancer3DTESK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601782   
Orphanet
DisGeNETTESK1
MedgenTESK1
Genetic Testing Registry TESK1
NextProtQ15569 [Medical]
GENETestsTESK1
Target ValidationTESK1
Huge Navigator TESK1 [HugePedia]
ClinGenTESK1
Clinical trials, drugs, therapy
MyCancerGenomeTESK1
Protein Interactions : CTDTESK1
Pharm GKB GenePA36448
PharosQ15569
Clinical trialTESK1
Miscellaneous
canSAR (ICR)TESK1
HarmonizomeTESK1
DataMed IndexTESK1
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTESK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:34:48 CEST 2021

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