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TESK1 (testis-specific kinase 1)

Identity

Other alias-
HGNC (Hugo) TESK1
LocusID (NCBI) 7016
Atlas_Id 42525
Location 9p13.3  [Link to chromosome band 9p13]
Location_base_pair Starts at 35605284 and ends at 35610041 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ZSCAN5A (19q13.43) / TESK1 (9p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;17)(p13;q11) PAX5/TAOK1


External links

Nomenclature
HGNC (Hugo)TESK1   11731
Cards
Entrez_Gene (NCBI)TESK1  7016  testis-specific kinase 1
Aliases
GeneCards (Weizmann)TESK1
Ensembl hg19 (Hinxton)ENSG00000107140 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107140 [Gene_View]  chr9:35605284-35610041 [Contig_View]  TESK1 [Vega]
ICGC DataPortalENSG00000107140
TCGA cBioPortalTESK1
AceView (NCBI)TESK1
Genatlas (Paris)TESK1
WikiGenes7016
SOURCE (Princeton)TESK1
Genetics Home Reference (NIH)TESK1
Genomic and cartography
GoldenPath hg38 (UCSC)TESK1  -     chr9:35605284-35610041 +  9p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TESK1  -     9p13.3   [Description]    (hg19-Feb_2009)
EnsemblTESK1 - 9p13.3 [CytoView hg19]  TESK1 - 9p13.3 [CytoView hg38]
Mapping of homologs : NCBITESK1 [Mapview hg19]  TESK1 [Mapview hg38]
OMIM601782   
Gene and transcription
Genbank (Entrez)AF452589 AF479317 AF507907 AF507908 AF507909
RefSeq transcript (Entrez)NM_001318230 NM_006285
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TESK1
Cluster EST : UnigeneHs.708096 [ NCBI ]
CGAP (NCI)Hs.708096
Alternative Splicing GalleryENSG00000107140
Gene ExpressionTESK1 [ NCBI-GEO ]   TESK1 [ EBI - ARRAY_EXPRESS ]   TESK1 [ SEEK ]   TESK1 [ MEM ]
Gene Expression Viewer (FireBrowse)TESK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7016
GTEX Portal (Tissue expression)TESK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15569   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15569  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15569
Splice isoforms : SwissVarQ15569
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   
PhosPhoSitePlusQ15569
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    TESK1    Tyr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Conserved Domain (NCBI)TESK1
DMDM Disease mutations7016
Blocks (Seattle)TESK1
SuperfamilyQ15569
Human Protein AtlasENSG00000107140
Peptide AtlasQ15569
HPRD03470
IPIIPI00018182   IPI01011445   IPI00383130   
Protein Interaction databases
DIP (DOE-UCLA)Q15569
IntAct (EBI)Q15569
FunCoupENSG00000107140
BioGRIDTESK1
STRING (EMBL)TESK1
ZODIACTESK1
Ontologies - Pathways
QuickGOQ15569
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  signal transducer activity  protein binding  ATP binding  cytoplasm  cytosol  protein phosphorylation  spermatogenesis  peptidyl-tyrosine phosphorylation  intracellular signal transduction  metal ion binding  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  signal transducer activity  protein binding  ATP binding  cytoplasm  cytosol  protein phosphorylation  spermatogenesis  peptidyl-tyrosine phosphorylation  intracellular signal transduction  metal ion binding  
NDEx NetworkTESK1
Atlas of Cancer Signalling NetworkTESK1
Wikipedia pathwaysTESK1
Orthology - Evolution
OrthoDB7016
GeneTree (enSembl)ENSG00000107140
Phylogenetic Trees/Animal Genes : TreeFamTESK1
HOVERGENQ15569
HOGENOMQ15569
Homologs : HomoloGeneTESK1
Homology/Alignments : Family Browser (UCSC)TESK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTESK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TESK1
dbVarTESK1
ClinVarTESK1
1000_GenomesTESK1 
Exome Variant ServerTESK1
ExAC (Exome Aggregation Consortium)TESK1 (select the gene name)
Genetic variants : HAPMAP7016
Genomic Variants (DGV)TESK1 [DGVbeta]
DECIPHERTESK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTESK1 
Mutations
ICGC Data PortalTESK1 
TCGA Data PortalTESK1 
Broad Tumor PortalTESK1
OASIS PortalTESK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTESK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTESK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TESK1
DgiDB (Drug Gene Interaction Database)TESK1
DoCM (Curated mutations)TESK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TESK1 (select a term)
intoGenTESK1
Cancer3DTESK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601782   
Orphanet
MedgenTESK1
Genetic Testing Registry TESK1
NextProtQ15569 [Medical]
TSGene7016
GENETestsTESK1
Target ValidationTESK1
Huge Navigator TESK1 [HugePedia]
snp3D : Map Gene to Disease7016
BioCentury BCIQTESK1
ClinGenTESK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7016
Chemical/Pharm GKB GenePA36448
Clinical trialTESK1
Miscellaneous
canSAR (ICR)TESK1 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTESK1
EVEXTESK1
GoPubMedTESK1
iHOPTESK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:59:05 CEST 2017

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