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TESK2 (testis-specific kinase 2)

Identity

Other alias-
HGNC (Hugo) TESK2
LocusID (NCBI) 10420
Atlas_Id 43527
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 45343883 and ends at 45491168 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SEC23IP (10q26.11) / TESK2 (1p34.1)TESK2 (1p34.1) / CR2 (1q32.2)TESK2 (1p34.1) / GPR37L1 (1q32.1)
TESK2 (1p34.1) / IPP (1p34.1)TESK2 (1p34.1) / MAN1C1 (1p36.11)TESK2 (1p34.1) / PDZK1IP1 (1p33)
TESK2 (1p34.1) / UTS2 (1p36.23)TESK2 1p34.1 / GPR37L1 1q32.1TESK2 1p34.1 / UTS2 1p36.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)TESK2   11732
Cards
Entrez_Gene (NCBI)TESK2  10420  testis-specific kinase 2
Aliases
GeneCards (Weizmann)TESK2
Ensembl hg19 (Hinxton)ENSG00000070759 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070759 [Gene_View]  chr1:45343883-45491168 [Contig_View]  TESK2 [Vega]
ICGC DataPortalENSG00000070759
TCGA cBioPortalTESK2
AceView (NCBI)TESK2
Genatlas (Paris)TESK2
WikiGenes10420
SOURCE (Princeton)TESK2
Genetics Home Reference (NIH)TESK2
Genomic and cartography
GoldenPath hg38 (UCSC)TESK2  -     chr1:45343883-45491168 -  1p34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TESK2  -     1p34.1   [Description]    (hg19-Feb_2009)
EnsemblTESK2 - 1p34.1 [CytoView hg19]  TESK2 - 1p34.1 [CytoView hg38]
Mapping of homologs : NCBITESK2 [Mapview hg19]  TESK2 [Mapview hg38]
OMIM604746   
Gene and transcription
Genbank (Entrez)AB057597 AJ132545 AK027573 AK294172 AK299269
RefSeq transcript (Entrez)NM_001320800 NM_007170
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TESK2
Cluster EST : UnigeneHs.591499 [ NCBI ]
CGAP (NCI)Hs.591499
Alternative Splicing GalleryENSG00000070759
Gene ExpressionTESK2 [ NCBI-GEO ]   TESK2 [ EBI - ARRAY_EXPRESS ]   TESK2 [ SEEK ]   TESK2 [ MEM ]
Gene Expression Viewer (FireBrowse)TESK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10420
GTEX Portal (Tissue expression)TESK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96S53   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96S53  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96S53
Splice isoforms : SwissVarQ96S53
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   
PhosPhoSitePlusQ96S53
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Conserved Domain (NCBI)TESK2
DMDM Disease mutations10420
Blocks (Seattle)TESK2
SuperfamilyQ96S53
Human Protein AtlasENSG00000070759
Peptide AtlasQ96S53
IPIIPI00102677   IPI00217726   IPI00217728   IPI00910985   IPI01013200   
Protein Interaction databases
DIP (DOE-UCLA)Q96S53
IntAct (EBI)Q96S53
FunCoupENSG00000070759
BioGRIDTESK2
STRING (EMBL)TESK2
ZODIACTESK2
Ontologies - Pathways
QuickGOQ96S53
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  signal transducer activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  protein phosphorylation  spermatogenesis  nuclear body  peptidyl-tyrosine phosphorylation  actin cytoskeleton organization  intracellular signal transduction  metal ion binding  focal adhesion assembly  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  signal transducer activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  protein phosphorylation  spermatogenesis  nuclear body  peptidyl-tyrosine phosphorylation  actin cytoskeleton organization  intracellular signal transduction  metal ion binding  focal adhesion assembly  
NDEx NetworkTESK2
Atlas of Cancer Signalling NetworkTESK2
Wikipedia pathwaysTESK2
Orthology - Evolution
OrthoDB10420
GeneTree (enSembl)ENSG00000070759
Phylogenetic Trees/Animal Genes : TreeFamTESK2
HOVERGENQ96S53
HOGENOMQ96S53
Homologs : HomoloGeneTESK2
Homology/Alignments : Family Browser (UCSC)TESK2
Gene fusions - Rearrangements
Fusion : MitelmanTESK2/GPR37L1 [1p34.1/1q32.1]  
Fusion : MitelmanTESK2/UTS2 [1p34.1/1p36.23]  [t(1;1)(p34;p36)]  
Fusion: TCGATESK2 1p34.1 GPR37L1 1q32.1 BRCA
Fusion: TCGATESK2 1p34.1 UTS2 1p36.23 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTESK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TESK2
dbVarTESK2
ClinVarTESK2
1000_GenomesTESK2 
Exome Variant ServerTESK2
ExAC (Exome Aggregation Consortium)TESK2 (select the gene name)
Genetic variants : HAPMAP10420
Genomic Variants (DGV)TESK2 [DGVbeta]
DECIPHERTESK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTESK2 
Mutations
ICGC Data PortalTESK2 
TCGA Data PortalTESK2 
Broad Tumor PortalTESK2
OASIS PortalTESK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTESK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTESK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TESK2
DgiDB (Drug Gene Interaction Database)TESK2
DoCM (Curated mutations)TESK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TESK2 (select a term)
intoGenTESK2
Cancer3DTESK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604746   
Orphanet
MedgenTESK2
Genetic Testing Registry TESK2
NextProtQ96S53 [Medical]
TSGene10420
GENETestsTESK2
Target ValidationTESK2
Huge Navigator TESK2 [HugePedia]
snp3D : Map Gene to Disease10420
BioCentury BCIQTESK2
ClinGenTESK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10420
Chemical/Pharm GKB GenePA36449
Clinical trialTESK2
Miscellaneous
canSAR (ICR)TESK2 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTESK2
EVEXTESK2
GoPubMedTESK2
iHOPTESK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:16:43 CEST 2017

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