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TET1 (tet methylcytosine dioxygenase 1)

Identity

Alias (NCBI)CXXC6
LCX
bA119F7.1
HGNC (Hugo) TET1
HGNC Alias symbLCX
KIAA1676
bA119F7.1
HGNC Alias nameleukemia-associated protein with a CXXC domain
 ten-eleven translocation 1
HGNC Previous nameCXXC6
HGNC Previous nameCXXC zinc finger 6
 tet oncogene 1
LocusID (NCBI) 80312
Atlas_Id 40227
Location 10q21.3  [Link to chromosome band 10q21]
Location_base_pair Starts at 68560337 and ends at 68694485 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KMT2A (11q23.3) / TET1 (10q21.3)TET1 (10q21.3) / CCAR1 (10q21.3)TET1 (10q21.3) / HFM1 (1p22.2)
TET1 (10q21.3) / KMT2A (11q23.3)TET1 10q21.3 / KMT2A 11q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;11)(q22;q23) KMT2A/TET1


External links

 

Nomenclature
HGNC (Hugo)TET1   29484
Cards
Entrez_Gene (NCBI)TET1    tet methylcytosine dioxygenase 1
AliasesCXXC6; LCX; bA119F7.1
GeneCards (Weizmann)TET1
Ensembl hg19 (Hinxton)ENSG00000138336 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138336 [Gene_View]  ENSG00000138336 [Sequence]  chr10:68560337-68694485 [Contig_View]  TET1 [Vega]
ICGC DataPortalENSG00000138336
TCGA cBioPortalTET1
AceView (NCBI)TET1
Genatlas (Paris)TET1
SOURCE (Princeton)TET1
Genetics Home Reference (NIH)TET1
Genomic and cartography
GoldenPath hg38 (UCSC)TET1  -     chr10:68560337-68694485 +  10q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TET1  -     10q21.3   [Description]    (hg19-Feb_2009)
GoldenPathTET1 - 10q21.3 [CytoView hg19]  TET1 - 10q21.3 [CytoView hg38]
ImmunoBaseENSG00000138336
Genome Data Viewer NCBITET1 [Mapview hg19]  
OMIM607790   
Gene and transcription
Genbank (Entrez)AB051463 AF430147 AK123436 AL080082 AL713658
RefSeq transcript (Entrez)NM_030625
Consensus coding sequences : CCDS (NCBI)TET1
Gene ExpressionTET1 [ NCBI-GEO ]   TET1 [ EBI - ARRAY_EXPRESS ]   TET1 [ SEEK ]   TET1 [ MEM ]
Gene Expression Viewer (FireBrowse)TET1 [ Firebrowse - Broad ]
GenevisibleExpression of TET1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80312
GTEX Portal (Tissue expression)TET1
Human Protein AtlasENSG00000138336-TET1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NFU7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NFU7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NFU7
PhosPhoSitePlusQ8NFU7
Domaine pattern : Prosite (Expaxy)ZF_CXXC (PS51058)   
Domains : Interpro (EBI)2OGFeDO_noxygenase_dom    TET1/2/3    Znf_CXXC   
Domain families : Pfam (Sanger)Tet_JBP (PF12851)    zf-CXXC (PF02008)   
Domain families : Pfam (NCBI)pfam12851    pfam02008   
Domain families : Smart (EMBL)Tet_JBP (SM01333)  
Conserved Domain (NCBI)TET1
PDB (RSDB)6ASD   
PDB Europe6ASD   
PDB (PDBSum)6ASD   
PDB (IMB)6ASD   
Structural Biology KnowledgeBase6ASD   
SCOP (Structural Classification of Proteins)6ASD   
CATH (Classification of proteins structures)6ASD   
SuperfamilyQ8NFU7
AlphaFold pdb e-kbQ8NFU7   
Human Protein Atlas [tissue]ENSG00000138336-TET1 [tissue]
HPRD09694
Protein Interaction databases
DIP (DOE-UCLA)Q8NFU7
IntAct (EBI)Q8NFU7
BioGRIDTET1
STRING (EMBL)TET1
ZODIACTET1
Ontologies - Pathways
QuickGOQ8NFU7
Ontology : AmiGOinner cell mass cell differentiation  DNA binding  iron ion binding  nucleus  nucleus  5-methylcytosine catabolic process  chromatin organization  protein O-linked glycosylation  zinc ion binding  positive regulation of cell population proliferation  methyl-CpG binding  stem cell population maintenance  positive regulation of histone methylation  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  methylcytosine dioxygenase activity  methylcytosine dioxygenase activity  methylcytosine dioxygenase activity  oxidative demethylation  DNA demethylation  DNA demethylation  negative regulation of DNA methylation-dependent heterochromatin assembly  
Ontology : EGO-EBIinner cell mass cell differentiation  DNA binding  iron ion binding  nucleus  nucleus  5-methylcytosine catabolic process  chromatin organization  protein O-linked glycosylation  zinc ion binding  positive regulation of cell population proliferation  methyl-CpG binding  stem cell population maintenance  positive regulation of histone methylation  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  methylcytosine dioxygenase activity  methylcytosine dioxygenase activity  methylcytosine dioxygenase activity  oxidative demethylation  DNA demethylation  DNA demethylation  negative regulation of DNA methylation-dependent heterochromatin assembly  
NDEx NetworkTET1
Atlas of Cancer Signalling NetworkTET1
Wikipedia pathwaysTET1
Orthology - Evolution
OrthoDB80312
GeneTree (enSembl)ENSG00000138336
Phylogenetic Trees/Animal Genes : TreeFamTET1
Homologs : HomoloGeneTET1
Homology/Alignments : Family Browser (UCSC)TET1
Gene fusions - Rearrangements
Fusion : MitelmanTET1/CCAR1 [10q21.3/10q21.3]  
Fusion : QuiverTET1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTET1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TET1
dbVarTET1
ClinVarTET1
MonarchTET1
1000_GenomesTET1 
Exome Variant ServerTET1
GNOMAD BrowserENSG00000138336
Varsome BrowserTET1
ACMGTET1 variants
VarityQ8NFU7
Genomic Variants (DGV)TET1 [DGVbeta]
DECIPHERTET1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTET1 
Mutations
ICGC Data PortalTET1 
TCGA Data PortalTET1 
Broad Tumor PortalTET1
OASIS PortalTET1 [ Somatic mutations - Copy number]
Cancer Gene: CensusTET1 
Somatic Mutations in Cancer : COSMICTET1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTET1
Mutations and Diseases : HGMDTET1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTET1
DgiDB (Drug Gene Interaction Database)TET1
DoCM (Curated mutations)TET1
CIViC (Clinical Interpretations of Variants in Cancer)TET1
Cancer3DTET1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607790   
Orphanet
DisGeNETTET1
MedgenTET1
Genetic Testing Registry TET1
NextProtQ8NFU7 [Medical]
GENETestsTET1
Target ValidationTET1
Huge Navigator TET1 [HugePedia]
ClinGenTET1
Clinical trials, drugs, therapy
MyCancerGenomeTET1
Protein Interactions : CTDTET1
Pharm GKB GenePA162405605
PharosQ8NFU7
Clinical trialTET1
Miscellaneous
canSAR (ICR)TET1
HarmonizomeTET1
DataMed IndexTET1
Probes
Litterature
PubMed165 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTET1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:34:48 CEST 2021

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