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TET1 (tet methylcytosine dioxygenase 1)

Identity

Alias_namesCXXC6
CXXC zinc finger 6
tet oncogene 1
Alias_symbol (synonym)LCX
KIAA1676
bA119F7.1
Other alias
HGNC (Hugo) TET1
LocusID (NCBI) 80312
Atlas_Id 40227
Location 10q21.3  [Link to chromosome band 10q21]
Location_base_pair Starts at 68560360 and ends at 68694482 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KMT2A (11q23.3) / TET1 (10q21.3)TET1 (10q21.3) / CCAR1 (10q21.3)TET1 (10q21.3) / HFM1 (1p22.2)
TET1 (10q21.3) / KMT2A (11q23.3)KMT2A TET1TET1 KMT2A

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(10;11)(q22;q23) KMT2A/TET1
t(10;11)(q21;q23) KMT2A/TET1


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  TET1/CCAR1 (10q21)


External links

Nomenclature
HGNC (Hugo)TET1   29484
Cards
Entrez_Gene (NCBI)TET1  80312  tet methylcytosine dioxygenase 1
AliasesCXXC6; LCX; bA119F7.1
GeneCards (Weizmann)TET1
Ensembl hg19 (Hinxton)ENSG00000138336 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138336 [Gene_View]  ENSG00000138336 [Sequence]  chr10:68560360-68694482 [Contig_View]  TET1 [Vega]
ICGC DataPortalENSG00000138336
TCGA cBioPortalTET1
AceView (NCBI)TET1
Genatlas (Paris)TET1
WikiGenes80312
SOURCE (Princeton)TET1
Genetics Home Reference (NIH)TET1
Genomic and cartography
GoldenPath hg38 (UCSC)TET1  -     chr10:68560360-68694482 +  10q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TET1  -     10q21.3   [Description]    (hg19-Feb_2009)
EnsemblTET1 - 10q21.3 [CytoView hg19]  TET1 - 10q21.3 [CytoView hg38]
Mapping of homologs : NCBITET1 [Mapview hg19]  TET1 [Mapview hg38]
OMIM607790   
Gene and transcription
Genbank (Entrez)AB051463 AF430147 AK123436 AL080082 AL713658
RefSeq transcript (Entrez)NM_030625
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TET1
Cluster EST : UnigeneHs.708977 [ NCBI ]
CGAP (NCI)Hs.708977
Alternative Splicing GalleryENSG00000138336
Gene ExpressionTET1 [ NCBI-GEO ]   TET1 [ EBI - ARRAY_EXPRESS ]   TET1 [ SEEK ]   TET1 [ MEM ]
Gene Expression Viewer (FireBrowse)TET1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80312
GTEX Portal (Tissue expression)TET1
Human Protein AtlasENSG00000138336-TET1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NFU7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NFU7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NFU7
Splice isoforms : SwissVarQ8NFU7
PhosPhoSitePlusQ8NFU7
Domaine pattern : Prosite (Expaxy)ZF_CXXC (PS51058)   
Domains : Interpro (EBI)2OGFeDO_noxygenase_dom    Znf_CXXC   
Domain families : Pfam (Sanger)Tet_JBP (PF12851)    zf-CXXC (PF02008)   
Domain families : Pfam (NCBI)pfam12851    pfam02008   
Domain families : Smart (EMBL)Tet_JBP (SM01333)  
Conserved Domain (NCBI)TET1
DMDM Disease mutations80312
Blocks (Seattle)TET1
PDB (SRS)6ASD   
PDB (PDBSum)6ASD   
PDB (IMB)6ASD   
PDB (RSDB)6ASD   
Structural Biology KnowledgeBase6ASD   
SCOP (Structural Classification of Proteins)6ASD   
CATH (Classification of proteins structures)6ASD   
SuperfamilyQ8NFU7
Human Protein Atlas [tissue]ENSG00000138336-TET1 [tissue]
Peptide AtlasQ8NFU7
HPRD09694
IPIIPI00303112   IPI01014447   
Protein Interaction databases
DIP (DOE-UCLA)Q8NFU7
IntAct (EBI)Q8NFU7
FunCoupENSG00000138336
BioGRIDTET1
STRING (EMBL)TET1
ZODIACTET1
Ontologies - Pathways
QuickGOQ8NFU7
Ontology : AmiGORNA polymerase II transcription factor activity, sequence-specific DNA binding  inner cell mass cell differentiation  DNA binding  iron ion binding  iron ion binding  nucleus  nucleus  5-methylcytosine catabolic process  chromatin organization  transcription, DNA-templated  protein O-linked glycosylation  zinc ion binding  positive regulation of cell proliferation  stem cell population maintenance  positive regulation of histone methylation  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  oxidation-reduction process  methylcytosine dioxygenase activity  methylcytosine dioxygenase activity  methylcytosine dioxygenase activity  oxidative demethylation  DNA demethylation  DNA demethylation  negative regulation of methylation-dependent chromatin silencing  
Ontology : EGO-EBIRNA polymerase II transcription factor activity, sequence-specific DNA binding  inner cell mass cell differentiation  DNA binding  iron ion binding  iron ion binding  nucleus  nucleus  5-methylcytosine catabolic process  chromatin organization  transcription, DNA-templated  protein O-linked glycosylation  zinc ion binding  positive regulation of cell proliferation  stem cell population maintenance  positive regulation of histone methylation  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  oxidation-reduction process  methylcytosine dioxygenase activity  methylcytosine dioxygenase activity  methylcytosine dioxygenase activity  oxidative demethylation  DNA demethylation  DNA demethylation  negative regulation of methylation-dependent chromatin silencing  
NDEx NetworkTET1
Atlas of Cancer Signalling NetworkTET1
Wikipedia pathwaysTET1
Orthology - Evolution
OrthoDB80312
GeneTree (enSembl)ENSG00000138336
Phylogenetic Trees/Animal Genes : TreeFamTET1
HOVERGENQ8NFU7
HOGENOMQ8NFU7
Homologs : HomoloGeneTET1
Homology/Alignments : Family Browser (UCSC)TET1
Gene fusions - Rearrangements
Fusion : MitelmanTET1/CCAR1 [10q21.3/10q21.3]  
Fusion : QuiverTET1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTET1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TET1
dbVarTET1
ClinVarTET1
1000_GenomesTET1 
Exome Variant ServerTET1
ExAC (Exome Aggregation Consortium)ENSG00000138336
GNOMAD BrowserENSG00000138336
Varsome BrowserTET1
Genetic variants : HAPMAP80312
Genomic Variants (DGV)TET1 [DGVbeta]
DECIPHERTET1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTET1 
Mutations
ICGC Data PortalTET1 
TCGA Data PortalTET1 
Broad Tumor PortalTET1
OASIS PortalTET1 [ Somatic mutations - Copy number]
Cancer Gene: CensusTET1 
Somatic Mutations in Cancer : COSMICTET1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTET1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TET1
DgiDB (Drug Gene Interaction Database)TET1
DoCM (Curated mutations)TET1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TET1 (select a term)
intoGenTET1
Cancer3DTET1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607790   
Orphanet
DisGeNETTET1
MedgenTET1
Genetic Testing Registry TET1
NextProtQ8NFU7 [Medical]
TSGene80312
GENETestsTET1
Target ValidationTET1
Huge Navigator TET1 [HugePedia]
snp3D : Map Gene to Disease80312
BioCentury BCIQTET1
ClinGenTET1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80312
Chemical/Pharm GKB GenePA162405605
Clinical trialTET1
Miscellaneous
canSAR (ICR)TET1 (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTET1
EVEXTET1
GoPubMedTET1
iHOPTET1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:57:07 CEST 2018

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