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TET3 (tet methylcytosine dioxygenase 3)

Identity

Alias_namestet oncogene family member 3
Alias_symbol (synonym)MGC22014
hCG_40738
Other alias
HGNC (Hugo) TET3
LocusID (NCBI) 200424
Atlas_Id 50084
Location 2p13.1  [Link to chromosome band 2p13]
Location_base_pair Starts at 73986404 and ends at 74108175 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HK2 (2p12) / TET3 (2p13.1)MIR548O2 (8p12) / TET3 (2p13.1)PTPRM (18p11.23) / TET3 (2p13.1)
TET3 (2p13.1) / ACTG2 (2p13.1)TET3 (2p13.1) / C2orf78 (2p13.1)TET3 (2p13.1) / DGUOK (2p13.1)
TET3 (2p13.1) / GRK4 (4p16.3)TET3 (2p13.1) / TET3 (2p13.1)TET3 2p13.1 / ACTG2 2p13.1
TET3 2p13.1 / C2orf78 2p13.1TET3 2p13.1 / DGUOK 2p13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Mixed phenotype acute leukemia (MPAL)


External links

Nomenclature
HGNC (Hugo)TET3   28313
Cards
Entrez_Gene (NCBI)TET3  200424  tet methylcytosine dioxygenase 3
AliaseshCG_40738
GeneCards (Weizmann)TET3
Ensembl hg19 (Hinxton)ENSG00000187605 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187605 [Gene_View]  chr2:73986404-74108175 [Contig_View]  TET3 [Vega]
ICGC DataPortalENSG00000187605
TCGA cBioPortalTET3
AceView (NCBI)TET3
Genatlas (Paris)TET3
WikiGenes200424
SOURCE (Princeton)TET3
Genetics Home Reference (NIH)TET3
Genomic and cartography
GoldenPath hg38 (UCSC)TET3  -     chr2:73986404-74108175 +  2p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TET3  -     2p13.1   [Description]    (hg19-Feb_2009)
EnsemblTET3 - 2p13.1 [CytoView hg19]  TET3 - 2p13.1 [CytoView hg38]
Mapping of homologs : NCBITET3 [Mapview hg19]  TET3 [Mapview hg38]
OMIM613555   
Gene and transcription
Genbank (Entrez)AB007861 AF466365 AI348471 BC022243 HQ220209
RefSeq transcript (Entrez)NM_001287491
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TET3
Cluster EST : UnigeneHs.516107 [ NCBI ]
CGAP (NCI)Hs.516107
Alternative Splicing GalleryENSG00000187605
Gene ExpressionTET3 [ NCBI-GEO ]   TET3 [ EBI - ARRAY_EXPRESS ]   TET3 [ SEEK ]   TET3 [ MEM ]
Gene Expression Viewer (FireBrowse)TET3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)200424
GTEX Portal (Tissue expression)TET3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43151   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43151  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43151
Splice isoforms : SwissVarO43151
PhosPhoSitePlusO43151
Domains : Interpro (EBI)2OGFeDO_noxygenase_dom   
Domain families : Pfam (Sanger)Tet_JBP (PF12851)   
Domain families : Pfam (NCBI)pfam12851   
Domain families : Smart (EMBL)Tet_JBP (SM01333)  
Conserved Domain (NCBI)TET3
DMDM Disease mutations200424
Blocks (Seattle)TET3
SuperfamilyO43151
Human Protein AtlasENSG00000187605
Peptide AtlasO43151
IPIIPI00739948   IPI00219986   IPI00384755   IPI00973191   
Protein Interaction databases
DIP (DOE-UCLA)O43151
IntAct (EBI)O43151
FunCoupENSG00000187605
BioGRIDTET3
STRING (EMBL)TET3
ZODIACTET3
Ontologies - Pathways
QuickGOO43151
Ontology : AmiGOfemale pronucleus  male pronucleus  DNA binding  protein binding  cytoplasm  protein O-linked glycosylation  DNA demethylation of male pronucleus  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  oxidation-reduction process  methylcytosine dioxygenase activity  DNA demethylation  histone H3-K4 trimethylation  
Ontology : EGO-EBIfemale pronucleus  male pronucleus  DNA binding  protein binding  cytoplasm  protein O-linked glycosylation  DNA demethylation of male pronucleus  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  oxidation-reduction process  methylcytosine dioxygenase activity  DNA demethylation  histone H3-K4 trimethylation  
NDEx NetworkTET3
Atlas of Cancer Signalling NetworkTET3
Wikipedia pathwaysTET3
Orthology - Evolution
OrthoDB200424
GeneTree (enSembl)ENSG00000187605
Phylogenetic Trees/Animal Genes : TreeFamTET3
HOVERGENO43151
HOGENOMO43151
Homologs : HomoloGeneTET3
Homology/Alignments : Family Browser (UCSC)TET3
Gene fusions - Rearrangements
Fusion : MitelmanTET3/ACTG2 [2p13.1/2p13.1]  
Fusion : MitelmanTET3/C2orf78 [2p13.1/2p13.1]  [t(2;2)(p13;p13)]  
Fusion : MitelmanTET3/DGUOK [2p13.1/2p13.1]  [t(2;2)(p13;p13)]  
Fusion: TCGATET3 2p13.1 ACTG2 2p13.1 BRCA
Fusion: TCGATET3 2p13.1 C2orf78 2p13.1 BRCA
Fusion: TCGATET3 2p13.1 DGUOK 2p13.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTET3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TET3
dbVarTET3
ClinVarTET3
1000_GenomesTET3 
Exome Variant ServerTET3
ExAC (Exome Aggregation Consortium)TET3 (select the gene name)
Genetic variants : HAPMAP200424
Genomic Variants (DGV)TET3 [DGVbeta]
DECIPHERTET3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTET3 
Mutations
ICGC Data PortalTET3 
TCGA Data PortalTET3 
Broad Tumor PortalTET3
OASIS PortalTET3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTET3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTET3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TET3
DgiDB (Drug Gene Interaction Database)TET3
DoCM (Curated mutations)TET3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TET3 (select a term)
intoGenTET3
Cancer3DTET3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613555   
Orphanet
MedgenTET3
Genetic Testing Registry TET3
NextProtO43151 [Medical]
TSGene200424
GENETestsTET3
Target ValidationTET3
Huge Navigator TET3 [HugePedia]
snp3D : Map Gene to Disease200424
BioCentury BCIQTET3
ClinGenTET3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD200424
Chemical/Pharm GKB GenePA162405645
Clinical trialTET3
Miscellaneous
canSAR (ICR)TET3 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTET3
EVEXTET3
GoPubMedTET3
iHOPTET3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:34:44 CEST 2017

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