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TFAM (transcription factor A, mitochondrial)

Identity

Alias (NCBI)MTDPS15
MTTF1
MTTFA
TCF6
TCF6L1
TCF6L2
TCF6L3
HGNC (Hugo) TFAM
HGNC Previous nameTCF6
 TCF6L2
LocusID (NCBI) 7019
Atlas_Id 52068
Location 10q21.1  [Link to chromosome band 10q21]
Location_base_pair Starts at 58385410 and ends at 58399220 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP8B3 (19p13.3) / TFAM (10q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TFAM   11741
Cards
Entrez_Gene (NCBI)TFAM    transcription factor A, mitochondrial
AliasesMTDPS15; MTTF1; MTTFA; TCF6; 
TCF6L1; TCF6L2; TCF6L3
GeneCards (Weizmann)TFAM
Ensembl hg19 (Hinxton)ENSG00000108064 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108064 [Gene_View]  ENSG00000108064 [Sequence]  chr10:58385410-58399220 [Contig_View]  TFAM [Vega]
ICGC DataPortalENSG00000108064
TCGA cBioPortalTFAM
AceView (NCBI)TFAM
Genatlas (Paris)TFAM
SOURCE (Princeton)TFAM
Genetics Home Reference (NIH)TFAM
Genomic and cartography
GoldenPath hg38 (UCSC)TFAM  -     chr10:58385410-58399220 +  10q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFAM  -     10q21.1   [Description]    (hg19-Feb_2009)
GoldenPathTFAM - 10q21.1 [CytoView hg19]  TFAM - 10q21.1 [CytoView hg38]
ImmunoBaseENSG00000108064
Genome Data Viewer NCBITFAM [Mapview hg19]  
OMIM600438   617156   
Gene and transcription
Genbank (Entrez)AB451241 AB451366 AK312558 BC018628 BC029815
RefSeq transcript (Entrez)NM_001270782 NM_003201 NM_012251
Consensus coding sequences : CCDS (NCBI)TFAM
Gene ExpressionTFAM [ NCBI-GEO ]   TFAM [ EBI - ARRAY_EXPRESS ]   TFAM [ SEEK ]   TFAM [ MEM ]
Gene Expression Viewer (FireBrowse)TFAM [ Firebrowse - Broad ]
GenevisibleExpression of TFAM in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7019
GTEX Portal (Tissue expression)TFAM
Human Protein AtlasENSG00000108064-TFAM [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00059   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00059  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00059
PhosPhoSitePlusQ00059
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)HMG_box_dom    HMG_box_dom_sf   
Domain families : Pfam (Sanger)HMG_box (PF00505)    HMG_box_2 (PF09011)   
Domain families : Pfam (NCBI)pfam00505    pfam09011   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)TFAM
PDB (RSDB)3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ    6HB4    6HC3   
PDB Europe3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ    6HB4    6HC3   
PDB (PDBSum)3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ    6HB4    6HC3   
PDB (IMB)3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ    6HB4    6HC3   
Structural Biology KnowledgeBase3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ    6HB4    6HC3   
SCOP (Structural Classification of Proteins)3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ    6HB4    6HC3   
CATH (Classification of proteins structures)3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ    6HB4    6HC3   
SuperfamilyQ00059
AlphaFold pdb e-kbQ00059   
Human Protein Atlas [tissue]ENSG00000108064-TFAM [tissue]
HPRD02702
Protein Interaction databases
DIP (DOE-UCLA)Q00059
IntAct (EBI)Q00059
BioGRIDTFAM
STRING (EMBL)TFAM
ZODIACTFAM
Ontologies - Pathways
QuickGOQ00059
Ontology : AmiGOtranscription cis-regulatory region binding  mitochondrial promoter sequence-specific DNA binding  transcription coactivator binding  chromatin binding  RNA binding  protein binding  nucleus  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  mitochondrial transcription  transcription initiation from mitochondrial promoter  transcription initiation from mitochondrial promoter  transcription initiation from mitochondrial promoter  mitochondrion organization  DNA binding, bending  heat shock protein binding  protein-containing complex  mitochondrial respiratory chain complex assembly  mitochondrial transcription factor activity  mitochondrial nucleoid  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  
Ontology : EGO-EBItranscription cis-regulatory region binding  mitochondrial promoter sequence-specific DNA binding  transcription coactivator binding  chromatin binding  RNA binding  protein binding  nucleus  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  mitochondrial transcription  transcription initiation from mitochondrial promoter  transcription initiation from mitochondrial promoter  transcription initiation from mitochondrial promoter  mitochondrion organization  DNA binding, bending  heat shock protein binding  protein-containing complex  mitochondrial respiratory chain complex assembly  mitochondrial transcription factor activity  mitochondrial nucleoid  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  
Pathways : KEGGHuntington's disease   
NDEx NetworkTFAM
Atlas of Cancer Signalling NetworkTFAM
Wikipedia pathwaysTFAM
Orthology - Evolution
OrthoDB7019
GeneTree (enSembl)ENSG00000108064
Phylogenetic Trees/Animal Genes : TreeFamTFAM
Homologs : HomoloGeneTFAM
Homology/Alignments : Family Browser (UCSC)TFAM
Gene fusions - Rearrangements
Fusion : QuiverTFAM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFAM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFAM
dbVarTFAM
ClinVarTFAM
MonarchTFAM
1000_GenomesTFAM 
Exome Variant ServerTFAM
GNOMAD BrowserENSG00000108064
Varsome BrowserTFAM
ACMGTFAM variants
VarityQ00059
Genomic Variants (DGV)TFAM [DGVbeta]
DECIPHERTFAM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFAM 
Mutations
ICGC Data PortalTFAM 
TCGA Data PortalTFAM 
Broad Tumor PortalTFAM
OASIS PortalTFAM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTFAM  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTFAM
Mutations and Diseases : HGMDTFAM
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTFAM
DgiDB (Drug Gene Interaction Database)TFAM
DoCM (Curated mutations)TFAM
CIViC (Clinical Interpretations of Variants in Cancer)TFAM
Cancer3DTFAM
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600438    617156   
Orphanet
DisGeNETTFAM
MedgenTFAM
Genetic Testing Registry TFAM
NextProtQ00059 [Medical]
GENETestsTFAM
Target ValidationTFAM
Huge Navigator TFAM [HugePedia]
ClinGenTFAM
Clinical trials, drugs, therapy
MyCancerGenomeTFAM
Protein Interactions : CTDTFAM
Pharm GKB GenePA36458
PharosQ00059
Clinical trialTFAM
Miscellaneous
canSAR (ICR)TFAM
HarmonizomeTFAM
DataMed IndexTFAM
Probes
Litterature
PubMed252 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTFAM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:34:51 CEST 2021

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