Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TFAP2B (transcription factor AP-2 beta)

Identity

Alias_namestranscription factor AP-2 beta (activating enhancer-binding protein 2 beta)
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Alias_symbol (synonym)AP2-B
Other aliasAP-2B
PDA2
HGNC (Hugo) TFAP2B
LocusID (NCBI) 7021
Atlas_Id 42527
Location 6p12.3  [Link to chromosome band 6p12]
Location_base_pair Starts at 50818726 and ends at 50847613 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TFAP2B   11743
Cards
Entrez_Gene (NCBI)TFAP2B  7021  transcription factor AP-2 beta
AliasesAP-2B; AP2-B; PDA2
GeneCards (Weizmann)TFAP2B
Ensembl hg19 (Hinxton)ENSG00000008196 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008196 [Gene_View]  ENSG00000008196 [Sequence]  chr6:50818726-50847613 [Contig_View]  TFAP2B [Vega]
ICGC DataPortalENSG00000008196
TCGA cBioPortalTFAP2B
AceView (NCBI)TFAP2B
Genatlas (Paris)TFAP2B
WikiGenes7021
SOURCE (Princeton)TFAP2B
Genetics Home Reference (NIH)TFAP2B
Genomic and cartography
GoldenPath hg38 (UCSC)TFAP2B  -     chr6:50818726-50847613 +  6p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFAP2B  -     6p12.3   [Description]    (hg19-Feb_2009)
EnsemblTFAP2B - 6p12.3 [CytoView hg19]  TFAP2B - 6p12.3 [CytoView hg38]
Mapping of homologs : NCBITFAP2B [Mapview hg19]  TFAP2B [Mapview hg38]
OMIM169100   601601   617035   
Gene and transcription
Genbank (Entrez)AK291172 AK313749 AU141084 BC037225 BU738725
RefSeq transcript (Entrez)NM_003221
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TFAP2B
Cluster EST : UnigeneHs.33102 [ NCBI ]
CGAP (NCI)Hs.33102
Alternative Splicing GalleryENSG00000008196
Gene ExpressionTFAP2B [ NCBI-GEO ]   TFAP2B [ EBI - ARRAY_EXPRESS ]   TFAP2B [ SEEK ]   TFAP2B [ MEM ]
Gene Expression Viewer (FireBrowse)TFAP2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7021
GTEX Portal (Tissue expression)TFAP2B
Human Protein AtlasENSG00000008196-TFAP2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92481   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92481  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92481
Splice isoforms : SwissVarQ92481
PhosPhoSitePlusQ92481
Domains : Interpro (EBI)TF_AP2    TF_AP2_beta    TF_AP2_C   
Domain families : Pfam (Sanger)TF_AP-2 (PF03299)   
Domain families : Pfam (NCBI)pfam03299   
Conserved Domain (NCBI)TFAP2B
DMDM Disease mutations7021
Blocks (Seattle)TFAP2B
SuperfamilyQ92481
Human Protein Atlas [tissue]ENSG00000008196-TFAP2B [tissue]
Peptide AtlasQ92481
HPRD03360
IPIIPI00021557   IPI00216446   
Protein Interaction databases
DIP (DOE-UCLA)Q92481
IntAct (EBI)Q92481
FunCoupENSG00000008196
BioGRIDTFAP2B
STRING (EMBL)TFAP2B
ZODIACTFAP2B
Ontologies - Pathways
QuickGOQ92481
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  enhancer sequence-specific DNA binding  kidney development  renal water homeostasis  DNA binding  chromatin binding  DNA-binding transcription factor activity  transcription coactivator activity  transcription coactivator activity  transcription corepressor activity  transcription corepressor activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  glucose metabolic process  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  apoptotic process  positive regulation of cell proliferation  negative regulation of cell proliferation  response to lithium ion  retina layer formation  magnesium ion homeostasis  regulation of BMP signaling pathway  forelimb morphogenesis  hindlimb morphogenesis  positive regulation of urine volume  aorta morphogenesis  response to drug  glucose homeostasis  protein homodimerization activity  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of neuron apoptotic process  positive regulation of neuron apoptotic process  sequence-specific DNA binding  skin development  fat cell differentiation  regulation of cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  protein dimerization activity  sympathetic nervous system development  regulation of insulin secretion  phosphate ion homeostasis  calcium ion homeostasis  potassium ion homeostasis  sodium ion homeostasis  distal tubule development  collecting duct development  metanephric nephron development  ductus arteriosus closure  cellular ammonia homeostasis  cellular creatinine homeostasis  cellular urea homeostasis  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  enhancer sequence-specific DNA binding  kidney development  renal water homeostasis  DNA binding  chromatin binding  DNA-binding transcription factor activity  transcription coactivator activity  transcription coactivator activity  transcription corepressor activity  transcription corepressor activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  glucose metabolic process  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  apoptotic process  positive regulation of cell proliferation  negative regulation of cell proliferation  response to lithium ion  retina layer formation  magnesium ion homeostasis  regulation of BMP signaling pathway  forelimb morphogenesis  hindlimb morphogenesis  positive regulation of urine volume  aorta morphogenesis  response to drug  glucose homeostasis  protein homodimerization activity  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of neuron apoptotic process  positive regulation of neuron apoptotic process  sequence-specific DNA binding  skin development  fat cell differentiation  regulation of cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  protein dimerization activity  sympathetic nervous system development  regulation of insulin secretion  phosphate ion homeostasis  calcium ion homeostasis  potassium ion homeostasis  sodium ion homeostasis  distal tubule development  collecting duct development  metanephric nephron development  ductus arteriosus closure  cellular ammonia homeostasis  cellular creatinine homeostasis  cellular urea homeostasis  
NDEx NetworkTFAP2B
Atlas of Cancer Signalling NetworkTFAP2B
Wikipedia pathwaysTFAP2B
Orthology - Evolution
OrthoDB7021
GeneTree (enSembl)ENSG00000008196
Phylogenetic Trees/Animal Genes : TreeFamTFAP2B
HOVERGENQ92481
HOGENOMQ92481
Homologs : HomoloGeneTFAP2B
Homology/Alignments : Family Browser (UCSC)TFAP2B
Gene fusions - Rearrangements
Fusion : QuiverTFAP2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFAP2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFAP2B
dbVarTFAP2B
ClinVarTFAP2B
1000_GenomesTFAP2B 
Exome Variant ServerTFAP2B
ExAC (Exome Aggregation Consortium)ENSG00000008196
GNOMAD BrowserENSG00000008196
Varsome BrowserTFAP2B
Genetic variants : HAPMAP7021
Genomic Variants (DGV)TFAP2B [DGVbeta]
DECIPHERTFAP2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFAP2B 
Mutations
ICGC Data PortalTFAP2B 
TCGA Data PortalTFAP2B 
Broad Tumor PortalTFAP2B
OASIS PortalTFAP2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTFAP2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTFAP2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TFAP2B
DgiDB (Drug Gene Interaction Database)TFAP2B
DoCM (Curated mutations)TFAP2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TFAP2B (select a term)
intoGenTFAP2B
Cancer3DTFAP2B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM169100    601601    617035   
Orphanet208    10602   
DisGeNETTFAP2B
MedgenTFAP2B
Genetic Testing Registry TFAP2B
NextProtQ92481 [Medical]
TSGene7021
GENETestsTFAP2B
Target ValidationTFAP2B
Huge Navigator TFAP2B [HugePedia]
snp3D : Map Gene to Disease7021
BioCentury BCIQTFAP2B
ClinGenTFAP2B (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7021
Chemical/Pharm GKB GenePA36460
Clinical trialTFAP2B
Miscellaneous
canSAR (ICR)TFAP2B (select the gene name)
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTFAP2B
EVEXTFAP2B
GoPubMedTFAP2B
iHOPTFAP2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:44:40 CET 2018

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