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TFAP2B (transcription factor AP-2 beta)

Identity

Alias (NCBI)AP-2B
AP-2beta
AP2-B
PDA2
HGNC (Hugo) TFAP2B
HGNC Alias symbAP2-B
AP-2beta
HGNC Previous nametranscription factor AP-2 beta (activating enhancer-binding protein 2 beta)
 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
LocusID (NCBI) 7021
Atlas_Id 42527
Location 6p12.3  [Link to chromosome band 6p12]
Location_base_pair Starts at 50818871 and ends at 50847619 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TFAP2B   11743
Cards
Entrez_Gene (NCBI)TFAP2B    transcription factor AP-2 beta
AliasesAP-2B; AP-2beta; AP2-B; PDA2
GeneCards (Weizmann)TFAP2B
Ensembl hg19 (Hinxton)ENSG00000008196 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008196 [Gene_View]  ENSG00000008196 [Sequence]  chr6:50818871-50847619 [Contig_View]  TFAP2B [Vega]
ICGC DataPortalENSG00000008196
TCGA cBioPortalTFAP2B
AceView (NCBI)TFAP2B
Genatlas (Paris)TFAP2B
SOURCE (Princeton)TFAP2B
Genetics Home Reference (NIH)TFAP2B
Genomic and cartography
GoldenPath hg38 (UCSC)TFAP2B  -     chr6:50818871-50847619 +  6p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFAP2B  -     6p12.3   [Description]    (hg19-Feb_2009)
GoldenPathTFAP2B - 6p12.3 [CytoView hg19]  TFAP2B - 6p12.3 [CytoView hg38]
ImmunoBaseENSG00000008196
Genome Data Viewer NCBITFAP2B [Mapview hg19]  
OMIM169100   601601   617035   
Gene and transcription
Genbank (Entrez)AK291172 AK313749 AU141084 BC037225 BU738725
RefSeq transcript (Entrez)NM_003221
Consensus coding sequences : CCDS (NCBI)TFAP2B
Gene ExpressionTFAP2B [ NCBI-GEO ]   TFAP2B [ EBI - ARRAY_EXPRESS ]   TFAP2B [ SEEK ]   TFAP2B [ MEM ]
Gene Expression Viewer (FireBrowse)TFAP2B [ Firebrowse - Broad ]
GenevisibleExpression of TFAP2B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7021
GTEX Portal (Tissue expression)TFAP2B
Human Protein AtlasENSG00000008196-TFAP2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92481   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92481  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92481
PhosPhoSitePlusQ92481
Domains : Interpro (EBI)TF_AP2    TF_AP2_beta    TF_AP2_C   
Domain families : Pfam (Sanger)TF_AP-2 (PF03299)   
Domain families : Pfam (NCBI)pfam03299   
Conserved Domain (NCBI)TFAP2B
SuperfamilyQ92481
AlphaFold pdb e-kbQ92481   
Human Protein Atlas [tissue]ENSG00000008196-TFAP2B [tissue]
HPRD03360
Protein Interaction databases
DIP (DOE-UCLA)Q92481
IntAct (EBI)Q92481
BioGRIDTFAP2B
STRING (EMBL)TFAP2B
ZODIACTFAP2B
Ontologies - Pathways
QuickGOQ92481
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  cis-regulatory region sequence-specific DNA binding  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  kidney development  renal water homeostasis  DNA binding  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  glucose metabolic process  regulation of transcription by RNA polymerase II  positive regulation of cell population proliferation  negative regulation of cell population proliferation  retina layer formation  magnesium ion homeostasis  regulation of BMP signaling pathway  forelimb morphogenesis  hindlimb morphogenesis  positive regulation of urine volume  aorta morphogenesis  regulation of cell population proliferation  response to drug  glucose homeostasis  protein homodimerization activity  negative regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of neuron apoptotic process  positive regulation of neuron apoptotic process  sequence-specific DNA binding  skin development  fat cell differentiation  regulation of cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  sympathetic nervous system development  anatomical structure development  regulation of insulin secretion  phosphate ion homeostasis  calcium ion homeostasis  potassium ion homeostasis  sodium ion homeostasis  distal tubule development  collecting duct development  metanephric nephron development  ductus arteriosus closure  cellular ammonium homeostasis  cellular creatinine homeostasis  cellular urea homeostasis  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  cis-regulatory region sequence-specific DNA binding  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  kidney development  renal water homeostasis  DNA binding  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  glucose metabolic process  regulation of transcription by RNA polymerase II  positive regulation of cell population proliferation  negative regulation of cell population proliferation  retina layer formation  magnesium ion homeostasis  regulation of BMP signaling pathway  forelimb morphogenesis  hindlimb morphogenesis  positive regulation of urine volume  aorta morphogenesis  regulation of cell population proliferation  response to drug  glucose homeostasis  protein homodimerization activity  negative regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of neuron apoptotic process  positive regulation of neuron apoptotic process  sequence-specific DNA binding  skin development  fat cell differentiation  regulation of cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  sympathetic nervous system development  anatomical structure development  regulation of insulin secretion  phosphate ion homeostasis  calcium ion homeostasis  potassium ion homeostasis  sodium ion homeostasis  distal tubule development  collecting duct development  metanephric nephron development  ductus arteriosus closure  cellular ammonium homeostasis  cellular creatinine homeostasis  cellular urea homeostasis  sequence-specific double-stranded DNA binding  
NDEx NetworkTFAP2B
Atlas of Cancer Signalling NetworkTFAP2B
Wikipedia pathwaysTFAP2B
Orthology - Evolution
OrthoDB7021
GeneTree (enSembl)ENSG00000008196
Phylogenetic Trees/Animal Genes : TreeFamTFAP2B
Homologs : HomoloGeneTFAP2B
Homology/Alignments : Family Browser (UCSC)TFAP2B
Gene fusions - Rearrangements
Fusion : QuiverTFAP2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFAP2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFAP2B
dbVarTFAP2B
ClinVarTFAP2B
MonarchTFAP2B
1000_GenomesTFAP2B 
Exome Variant ServerTFAP2B
GNOMAD BrowserENSG00000008196
Varsome BrowserTFAP2B
ACMGTFAP2B variants
VarityQ92481
Genomic Variants (DGV)TFAP2B [DGVbeta]
DECIPHERTFAP2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFAP2B 
Mutations
ICGC Data PortalTFAP2B 
TCGA Data PortalTFAP2B 
Broad Tumor PortalTFAP2B
OASIS PortalTFAP2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTFAP2B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTFAP2B
Mutations and Diseases : HGMDTFAP2B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTFAP2B
DgiDB (Drug Gene Interaction Database)TFAP2B
DoCM (Curated mutations)TFAP2B
CIViC (Clinical Interpretations of Variants in Cancer)TFAP2B
Cancer3DTFAP2B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM169100    601601    617035   
Orphanet208    10602   
DisGeNETTFAP2B
MedgenTFAP2B
Genetic Testing Registry TFAP2B
NextProtQ92481 [Medical]
GENETestsTFAP2B
Target ValidationTFAP2B
Huge Navigator TFAP2B [HugePedia]
ClinGenTFAP2B (curated)
Clinical trials, drugs, therapy
MyCancerGenomeTFAP2B
Protein Interactions : CTDTFAP2B
Pharm GKB GenePA36460
PharosQ92481
Clinical trialTFAP2B
Miscellaneous
canSAR (ICR)TFAP2B
HarmonizomeTFAP2B
DataMed IndexTFAP2B
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTFAP2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:34:51 CEST 2021

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