TFAP4 (transcription factor AP-4)

2010-05-01  

Identity

HGNC
TFAP4
LOCATION
16p13.3
LOCUSID
7023
ALIAS
AP-4,bHLHc41
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7023
MIM: 600743
HGNC: 11745
Ensembl: ENSG00000090447

Variants:

dbSNP: 7023
ClinVar: 7023
TCGA: ENSG00000090447
COSMIC: TFAP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090447ENST00000204517Q01664
ENSG00000090447ENST00000572393I3L254
ENSG00000090447ENST00000573476I3L301
ENSG00000090447ENST00000574639I3L4L6

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
188183102008AP4 encodes a c-MYC-inducible repressor of p21.63
237522262013AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer.56
226159082012Down-regulation of AP-4 inhibits proliferation, induces cell cycle arrest and promotes apoptosis in human gastric cancer cells.18
213369892012The overexpression of AP-4 as a prognostic indicator for gastric carcinoma.15
280003702017Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway.15
239492242013AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation.13
184803852009Upregulation of activator protein-4 in human colorectal cancer with metastasis.10
230552002013High expression of AP-4 predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy.9
300268672018Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/β-catenin pathway in hepatocellular carcinoma.9
217195612011Breast cancer cells proliferation is regulated by tyrosine phosphatase SHP1 through c-jun N-terminal kinase and cooperative induction of RFX-1 and AP-4 transcription factors.8

Citation

Dessen P

TFAP4 (transcription factor AP-4)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51479/tfap4