TFCP2 (transcription factor CP2)

2010-06-01  

Identity

HGNC
TFCP2
LOCATION
12q13.12
LOCUSID
7024
ALIAS
LBP1C,LSF,LSF1D,SEF,TFCP2C
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7024
MIM: 189889
HGNC: 11748
Ensembl: ENSG00000135457

Variants:

dbSNP: 7024
ClinVar: 7024
TCGA: ENSG00000135457
COSMIC: TFCP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135457ENST00000257915Q12800
ENSG00000135457ENST00000257915A0A024R120
ENSG00000135457ENST00000548108F8VWL0
ENSG00000135457ENST00000548115Q12800
ENSG00000135457ENST00000549867F8VX55

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
204041712010Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma.29
123937992002Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28.26
187874042008The fold recognition of CP2 transcription factors gives new insights into the function and evolution of tumor suppressor protein p53.20
198894752011No replication of genetic association between candidate polymorphisms and Alzheimer's disease.20
297387622018Circular RNA hsa_circ_0023404 exerts an oncogenic role in cervical cancer through regulating miR-136/TFCP2/YAP pathway.19
223965892012Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma.18
118650702002Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors.16
166484872006Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters.16
221671952012Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9).16
115746902001Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1.15

Citation

Dessen P

TFCP2 (transcription factor CP2)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51533/tfcp2