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TFF1 (trefoil factor 1)

Written2000-08Catherine Tomasetto, Marie-Christine Rio
I.G.B.M.C, 1, rue Laurent FRIES, BP 163 67404 ILLKIRH, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesBCEI
breast cancer
Alias_symbol (synonym)D21S21
HPS2
pS2
pNR-2
HP1.A
Other alias
HGNC (Hugo) TFF1
LocusID (NCBI) 7031
Atlas_Id 201
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 42362282 and ends at 42366535 bp from pter ( according to hg19-Feb_2009)  [Mapping TFF1.png]
Local_order belongs to the TFF cluster
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C2CD2 (21q22.3) / TFF1 (21q22.3)TFF1 (21q22.3) / RABEP1 (17p13.2)TFF1 (21q22.3) / RALB (2q14.2)

DNA/RNA

Description 5kb gene; 3 exons
Transcription 600bp cDNA; coding sequence: 252 bp

Protein

Description 84 amino acids, containing a peptide signal; the 60 AA-long mature secreted peptide contains one TFF (TreFoil Factor) domain and one acidic C-terminal domain
Expression epithelial cells of the stomach surface
Localisation cytoplasmic
Function in the maintenance of mucosa integrity; unknown at the molecular level; deficient mice develop antro-pyloric adenoma
Homology TFF2/SP (spasmolytic peptide) and TFF3/ITF (intestinal trefoil factor)

Implicated in

Note
Disease overexpressed in estradiol-dependent breast carcinomas; overexpressed in carcinoma of several other organs; loss of expression in half of gastric carcinomas (TFF1 is normally expressed in the stomach)
Prognosis good prognosis factor, and marker of response to hormonal treatment in breast carcinomas
  

Bibliography

Prediction of relapse and survival in breast cancer patients by pS2 protein status.
Foekens JA, Rio MC, Seguin P, van Putten WL, Fauque J, Nap M, Klijn JG, Chambon P
Cancer research. 1990 ; 50 (13) : 3832-3837.
PMID 2354435
 
Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein.
Lefebvre O, Chenard MP, Masson R, Linares J, Dierich A, LeMeur M, Wendling C, Tomasetto C, Chambon P, Rio MC
Science (New York, N.Y.). 1996 ; 274 (5285) : 259-262.
PMID 8824193
 
The pS2/TFF1 trefoil factor, from basic research to clinical applications.
Ribieras S, Tomasetto C, Rio MC
Biochimica et biophysica acta. 1998 ; 1378 (1) : F61-F77.
PMID 9739760
 
pS2 and response to adjuvant hormone therapy in primary breast cancer.
Spyratos F, Andrieu C, Hacène K, Chambon P, Rio MC
British journal of cancer. 1994 ; 69 (2) : 394-397.
PMID 8297741
 
pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins.
Tomasetto C, Masson R, Linares JL, Wendling C, Lefebvre O, Chenard MP, Rio MC
Gastroenterology. 2000 ; 118 (1) : 70-80.
PMID 10611155
 

Citation

This paper should be referenced as such :
Tomasetto, C ; Rio, MC
TFF1 (TreFoil Factor 1)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(4):185-185.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/TFF1ID201.html

External links

Nomenclature
HGNC (Hugo)TFF1   11755
Cards
AtlasTFF1ID201
Entrez_Gene (NCBI)TFF1  7031  trefoil factor 1
AliasesBCEI; D21S21; HP1.A; HPS2; 
pNR-2; pS2
GeneCards (Weizmann)TFF1
Ensembl hg19 (Hinxton)ENSG00000160182 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160182 [Gene_View]  chr21:42362282-42366535 [Contig_View]  TFF1 [Vega]
ICGC DataPortalENSG00000160182
TCGA cBioPortalTFF1
AceView (NCBI)TFF1
Genatlas (Paris)TFF1
WikiGenes7031
SOURCE (Princeton)TFF1
Genetics Home Reference (NIH)TFF1
Genomic and cartography
GoldenPath hg38 (UCSC)TFF1  -     chr21:42362282-42366535 -  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFF1  -     21q22.3   [Description]    (hg19-Feb_2009)
EnsemblTFF1 - 21q22.3 [CytoView hg19]  TFF1 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBITFF1 [Mapview hg19]  TFF1 [Mapview hg38]
OMIM113710   
Gene and transcription
Genbank (Entrez)BC032811 BQ083523 BU539534 M12075 X00474
RefSeq transcript (Entrez)NM_003225
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TFF1
Cluster EST : UnigeneHs.162807 [ NCBI ]
CGAP (NCI)Hs.162807
Alternative Splicing GalleryENSG00000160182
Gene ExpressionTFF1 [ NCBI-GEO ]   TFF1 [ EBI - ARRAY_EXPRESS ]   TFF1 [ SEEK ]   TFF1 [ MEM ]
Gene Expression Viewer (FireBrowse)TFF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7031
GTEX Portal (Tissue expression)TFF1
Human Protein AtlasENSG00000160182-TFF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04155   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04155  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04155
Splice isoforms : SwissVarP04155
PhosPhoSitePlusP04155
Domaine pattern : Prosite (Expaxy)P_TREFOIL_1 (PS00025)    P_TREFOIL_2 (PS51448)   
Domains : Interpro (EBI)P_trefoil_chordata    P_trefoil_CS    P_trefoil_dom   
Domain families : Pfam (Sanger)Trefoil (PF00088)   
Domain families : Pfam (NCBI)pfam00088   
Domain families : Smart (EMBL)PD (SM00018)  
Conserved Domain (NCBI)TFF1
DMDM Disease mutations7031
Blocks (Seattle)TFF1
PDB (SRS)1HI7    1PS2   
PDB (PDBSum)1HI7    1PS2   
PDB (IMB)1HI7    1PS2   
PDB (RSDB)1HI7    1PS2   
Structural Biology KnowledgeBase1HI7    1PS2   
SCOP (Structural Classification of Proteins)1HI7    1PS2   
CATH (Classification of proteins structures)1HI7    1PS2   
SuperfamilyP04155
Human Protein Atlas [tissue]ENSG00000160182-TFF1 [tissue]
Peptide AtlasP04155
HPRD00219
IPIIPI00022283   
Protein Interaction databases
DIP (DOE-UCLA)P04155
IntAct (EBI)P04155
FunCoupENSG00000160182
BioGRIDTFF1
STRING (EMBL)TFF1
ZODIACTFF1
Ontologies - Pathways
QuickGOP04155
Ontology : AmiGOprotein binding  extracellular space  carbohydrate metabolic process  digestion  growth factor activity  negative regulation of cell proliferation  response to iron ion  cell differentiation  maintenance of gastrointestinal epithelium  response to immobilization stress  wound healing  response to peptide hormone  
Ontology : EGO-EBIprotein binding  extracellular space  carbohydrate metabolic process  digestion  growth factor activity  negative regulation of cell proliferation  response to iron ion  cell differentiation  maintenance of gastrointestinal epithelium  response to immobilization stress  wound healing  response to peptide hormone  
Pathways : BIOCARTATrefoil Factors Initiate Mucosal Healing [Genes]   
NDEx NetworkTFF1
Atlas of Cancer Signalling NetworkTFF1
Wikipedia pathwaysTFF1
Orthology - Evolution
OrthoDB7031
GeneTree (enSembl)ENSG00000160182
Phylogenetic Trees/Animal Genes : TreeFamTFF1
HOVERGENP04155
HOGENOMP04155
Homologs : HomoloGeneTFF1
Homology/Alignments : Family Browser (UCSC)TFF1
Gene fusions - Rearrangements
Fusion : MitelmanTFF1/RABEP1 [21q22.3/17p13.2]  
Fusion: TCGATFF1 21q22.3 RABEP1 17p13.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFF1
dbVarTFF1
ClinVarTFF1
1000_GenomesTFF1 
Exome Variant ServerTFF1
ExAC (Exome Aggregation Consortium)ENSG00000160182
GNOMAD BrowserENSG00000160182
Genetic variants : HAPMAP7031
Genomic Variants (DGV)TFF1 [DGVbeta]
DECIPHERTFF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFF1 
Mutations
ICGC Data PortalTFF1 
TCGA Data PortalTFF1 
Broad Tumor PortalTFF1
OASIS PortalTFF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTFF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTFF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TFF1
DgiDB (Drug Gene Interaction Database)TFF1
DoCM (Curated mutations)TFF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TFF1 (select a term)
intoGenTFF1
NCG5 (London)TFF1
Cancer3DTFF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM113710   
Orphanet
MedgenTFF1
Genetic Testing Registry TFF1
NextProtP04155 [Medical]
TSGene7031
GENETestsTFF1
Target ValidationTFF1
Huge Navigator TFF1 [HugePedia]
snp3D : Map Gene to Disease7031
BioCentury BCIQTFF1
ClinGenTFF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7031
Chemical/Pharm GKB GenePA36470
Clinical trialTFF1
Miscellaneous
canSAR (ICR)TFF1 (select the gene name)
Probes
Litterature
PubMed142 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTFF1
EVEXTFF1
GoPubMedTFF1
iHOPTFF1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Oct 12 16:35:12 CEST 2017
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