| Written | 2000-08 | Catherine Tomasetto, Marie-Christine Rio |
| I.G.B.M.C, 1, rue Laurent FRIES, BP 163 67404 ILLKIRH, France |
| Identity |
| Alias_names | BCEI |
| breast cancer | |
| Alias_symbol (synonym) | D21S21 |
| HPS2 | |
| pS2 | |
| pNR-2 | |
| HP1.A | |
| Other alias | |
| HGNC (Hugo) | TFF1 |
| LocusID (NCBI) | 7031 |
| Atlas_Id | 201 |
| Location | 21q22.3 [Link to chromosome band 21q22] |
| Location_base_pair | Starts at 42362282 and ends at 42366535 bp from pter ( according to hg19-Feb_2009) [Mapping TFF1.png] |
| Local_order | belongs to the TFF cluster |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| C2CD2 (21q22.3) / TFF1 (21q22.3) | TFF1 (21q22.3) / RABEP1 (17p13.2) | TFF1 (21q22.3) / RALB (2q14.2) | |
| DNA/RNA |
| Description | 5kb gene; 3 exons |
| Transcription | 600bp cDNA; coding sequence: 252 bp |
| Protein |
| Description | 84 amino acids, containing a peptide signal; the 60 AA-long mature secreted peptide contains one TFF (TreFoil Factor) domain and one acidic C-terminal domain |
| Expression | epithelial cells of the stomach surface |
| Localisation | cytoplasmic |
| Function | in the maintenance of mucosa integrity; unknown at the molecular level; deficient mice develop antro-pyloric adenoma |
| Homology | TFF2/SP (spasmolytic peptide) and TFF3/ITF (intestinal trefoil factor) |
| Implicated in |
| Note | |
| Disease | overexpressed in estradiol-dependent breast carcinomas; overexpressed in carcinoma of several other organs; loss of expression in half of gastric carcinomas (TFF1 is normally expressed in the stomach) |
| Prognosis | good prognosis factor, and marker of response to hormonal treatment in breast carcinomas |
| Bibliography |
| Prediction of relapse and survival in breast cancer patients by pS2 protein status. |
| Foekens JA, Rio MC, Seguin P, van Putten WL, Fauque J, Nap M, Klijn JG, Chambon P |
| Cancer research. 1990 ; 50 (13) : 3832-3837. |
| PMID 2354435 |
| Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. |
| Lefebvre O, Chenard MP, Masson R, Linares J, Dierich A, LeMeur M, Wendling C, Tomasetto C, Chambon P, Rio MC |
| Science (New York, N.Y.). 1996 ; 274 (5285) : 259-262. |
| PMID 8824193 |
| The pS2/TFF1 trefoil factor, from basic research to clinical applications. |
| Ribieras S, Tomasetto C, Rio MC |
| Biochimica et biophysica acta. 1998 ; 1378 (1) : F61-F77. |
| PMID 9739760 |
| pS2 and response to adjuvant hormone therapy in primary breast cancer. |
| Spyratos F, Andrieu C, Hacène K, Chambon P, Rio MC |
| British journal of cancer. 1994 ; 69 (2) : 394-397. |
| PMID 8297741 |
| pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins. |
| Tomasetto C, Masson R, Linares JL, Wendling C, Lefebvre O, Chenard MP, Rio MC |
| Gastroenterology. 2000 ; 118 (1) : 70-80. |
| PMID 10611155 |
| Citation |
| This paper should be referenced as such : |
| Tomasetto, C ; Rio, MC |
| TFF1 (TreFoil Factor 1) |
| Atlas Genet Cytogenet Oncol Haematol. 2000;4(4):185-185. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/TFF1ID201.html |
| Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ] |
|
t(17;21)(p13;q22) TFF1/RABEP1
C2CD2/TFF1 (21q22) |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Nov 6 13:15:18 CET 2018 |
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