Written | 2000-08 | Catherine Tomasetto, Marie-Christine Rio |
I.G.B.M.C, 1, rue Laurent FRIES, BP 163 67404 ILLKIRH, France |
Identity |
Alias (NCBI) | pS2 |
HGNC (Hugo) | TFF1 |
HGNC Alias symb | D21S21 | HPS2 | pS2 | pNR-2 | HP1.A |
HGNC Previous name | BCEI |
HGNC Previous name | "breast cancer, estrogen-inducible sequence expressed in" |
LocusID (NCBI) | 7031 |
Atlas_Id | 201 |
Location | 21q22.3 [Link to chromosome band 21q22] |
Location_base_pair | Starts at 42362282 and ends at 42366535 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping TFF1.png] |
Local_order | belongs to the TFF cluster |
Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
C2CD2 (21q22.3) / TFF1 (21q22.3) | TFF1 (21q22.3) / RABEP1 (17p13.2) | TFF1 (21q22.3) / RALB (2q14.2) | |
DNA/RNA |
Description | 5kb gene; 3 exons |
Transcription | 600bp cDNA; coding sequence: 252 bp |
Protein |
Description | 84 amino acids, containing a peptide signal; the 60 AA-long mature secreted peptide contains one TFF (TreFoil Factor) domain and one acidic C-terminal domain |
Expression | epithelial cells of the stomach surface |
Localisation | cytoplasmic |
Function | in the maintenance of mucosa integrity; unknown at the molecular level; deficient mice develop antro-pyloric adenoma |
Homology | TFF2/SP (spasmolytic peptide) and TFF3/ITF (intestinal trefoil factor) |
Implicated in |
Note | |
Disease | overexpressed in estradiol-dependent breast carcinomas; overexpressed in carcinoma of several other organs; loss of expression in half of gastric carcinomas (TFF1 is normally expressed in the stomach) |
Prognosis | good prognosis factor, and marker of response to hormonal treatment in breast carcinomas |
Bibliography |
Prediction of relapse and survival in breast cancer patients by pS2 protein status. |
Foekens JA, Rio MC, Seguin P, van Putten WL, Fauque J, Nap M, Klijn JG, Chambon P |
Cancer research. 1990 ; 50 (13) : 3832-3837. |
PMID 2354435 |
Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. |
Lefebvre O, Chenard MP, Masson R, Linares J, Dierich A, LeMeur M, Wendling C, Tomasetto C, Chambon P, Rio MC |
Science (New York, N.Y.). 1996 ; 274 (5285) : 259-262. |
PMID 8824193 |
The pS2/TFF1 trefoil factor, from basic research to clinical applications. |
Ribieras S, Tomasetto C, Rio MC |
Biochimica et biophysica acta. 1998 ; 1378 (1) : F61-F77. |
PMID 9739760 |
pS2 and response to adjuvant hormone therapy in primary breast cancer. |
Spyratos F, Andrieu C, Hacène K, Chambon P, Rio MC |
British journal of cancer. 1994 ; 69 (2) : 394-397. |
PMID 8297741 |
pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins. |
Tomasetto C, Masson R, Linares JL, Wendling C, Lefebvre O, Chenard MP, Rio MC |
Gastroenterology. 2000 ; 118 (1) : 70-80. |
PMID 10611155 |
Citation |
This paper should be referenced as such : |
Tomasetto, C ; Rio, MC |
TFF1 (TreFoil Factor 1) |
Atlas Genet Cytogenet Oncol Haematol. 2000;4(4):185-185. |
Free journal version : [ pdf ] [ DOI ] |
Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ] |
t(17;21)(p13;q22) TFF1/RABEP1
C2CD2/TFF1 (21q22) |
External links |
REVIEW articles | automatic search in PubMed |
Last year publications | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Feb 19 18:01:30 CET 2021 |
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