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TFF2 (TreFoil Factor 2)

Written2000-12Catherine Tomasetto
I.G.B.M.C., BP 163, 1 rue Laurent Fries, 67404 Illkirch, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesSML1
spasmolytic protein 1
Other aliasSP (Spasmolytic Polypeptide)
HGNC (Hugo) TFF2
LocusID (NCBI) 7032
Atlas_Id 264
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 42346358 and ends at 42351099 bp from pter ( according to hg19-Feb_2009)  [Mapping TFF2.png]
Local_order belongs to the TFF cluster
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

DNA/RNA

Description 5.1 kb gene, 4 exons
Transcription 600 bp

Protein

Description precursor: 129 amino acids; mature peptide: 106 amino acids; 3-dimentional structure was solved; the129 amino acids TFF2 protein contains a signal peptide; the mature secreted peptide of 106 amino acids contains two TFF (TreFoil Factor) domains and one acidic C-terminal domain
Expression under normal condition, TFF2 is expressed in mucus neck cells of the fundus, basal cells of the antral and pyloric glands and by the Brunner's glands of the duodenum
Localisation secreted in gastric fluid
Function in repair and epithelial restitution of the gastro-intestinal mucosa
Homology TFF2 belongs to the Trefoil peptide Family (TFF) and possesses two tandemly duplicated TFF motifs each being homologous to the TFF motif of TFF1 and TFF3. The TFF motif spans about 40 amino acids and is formed by 6 conserved residues involved in specific disulfides bridges

Implicated in

Note
  
Entity TFF2 was found implicated in inflamatory bowel diseases, cancers of gastrointestinal organs such as stomach and pancreas; in constrast to TFF1 and TFF3, TFF2 expression was not found in breast carcinomas
  

Bibliography

Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats.
Babyatsky MW, deBeaumont M, Thim L, Podolsky DK
Gastroenterology. 1996 ; 110 (2) : 489-497.
PMID 8566596
 
Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the mammalian trefoil family of peptides.
Gajhede M, Petersen TN, Henriksen A, Petersen JF, Dauter Z, Wilson KS, Thim L
Structure (London, England : 1993). 1993 ; 1 (4) : 253-262.
PMID 8081739
 
The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression.
Lefebvre O, Wolf C, Kédinger M, Chenard MP, Tomasetto C, Chambon P, Rio MC
The Journal of cell biology. 1993 ; 122 (1) : 191-198.
PMID 8314841
 
Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration.
Playford RJ, Marchbank T, Chinery R, Evison R, Pignatelli M, Boulton RA, Thim L, Hanby AM
Gastroenterology. 1995 ; 108 (1) : 108-116.
PMID 7806031
 
Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.
Rio MC, Bellocq JP, Daniel JY, Tomasetto C, Lathe R, Chenard MP, Batzenschlager A, Chambon P
Science (New York, N.Y.). 1988 ; 241 (4866) : 705-708.
PMID 3041593
 
Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract.
Rio MC, Chenard MP, Wolf C, Marcellin L, Tomasetto C, Lathe R, Bellocq JP, Chambon P
Gastroenterology. 1991 ; 100 (2) : 375-379.
PMID 1985035
 
The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.
Seib T, Blin N, Hilgert K, Seifert M, Theisinger B, Engel M, Dooley S, Zang KD, Welter C
Genomics. 1997 ; 40 (1) : 200-202.
PMID 9070946
 
Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma.
Theisinger B, Welter C, Seitz G, Rio MC, Lathe R, Chambon P, Blin N
European journal of cancer (Oxford, England : 1990). 1991 ; 27 (6) : 770-773.
PMID 1829922
 
A new family of growth factor-like peptides. 'Trefoil' disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins).
Thim L
FEBS letters. 1989 ; 250 (1) : 85-90.
PMID 2737304
 
The amino acid sequence of pancreatic spasmolytic polypeptide.
Thim L, Thomsen J, Christensen M, J&oring;rgensen KH
Biochimica et biophysica acta. 1985 ; 827 (3) : 410-418.
PMID 2857575
 
hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.
Tomasetto C, Rio MC, Gautier C, Wolf C, Hareuveni M, Chambon P, Lathe R
The EMBO journal. 1990 ; 9 (2) : 407-414.
PMID 2303034
 
Association of the human spasmolytic polypeptide and an estrogen-induced breast cancer protein (pS2) with human pancreatic carcinoma.
Welter C, Theisinger B, Seitz G, Tomasetto C, Rio MC, Chambon P, Blin N
Laboratory investigation; a journal of technical methods and pathology. 1992 ; 66 (2) : 187-192.
PMID 1735955
 
Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease.
Wright NA, Poulsom R, Stamp G, Van Noorden S, Sarraf C, Elia G, Ahnen D, Jeffery R, Longcroft J, Pike C
Gastroenterology. 1993 ; 104 (1) : 12-20.
PMID 8419234
 

Citation

This paper should be referenced as such :
Tomasetto, C
TFF2 (TreFoil Factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):19-20.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/TFF2ID264.html


External links

Nomenclature
HGNC (Hugo)TFF2   11756
Cards
AtlasTFF2ID264
Entrez_Gene (NCBI)TFF2  7032  trefoil factor 2
AliasesSML1; SP
GeneCards (Weizmann)TFF2
Ensembl hg19 (Hinxton)ENSG00000160181 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160181 [Gene_View]  chr21:42346358-42351099 [Contig_View]  TFF2 [Vega]
ICGC DataPortalENSG00000160181
TCGA cBioPortalTFF2
AceView (NCBI)TFF2
Genatlas (Paris)TFF2
WikiGenes7032
SOURCE (Princeton)TFF2
Genetics Home Reference (NIH)TFF2
Genomic and cartography
GoldenPath hg38 (UCSC)TFF2  -     chr21:42346358-42351099 -  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFF2  -     21q22.3   [Description]    (hg19-Feb_2009)
EnsemblTFF2 - 21q22.3 [CytoView hg19]  TFF2 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBITFF2 [Mapview hg19]  TFF2 [Mapview hg38]
OMIM182590   
Gene and transcription
Genbank (Entrez)AA307808 BC032820 BM817851 BM853946 HQ448369
RefSeq transcript (Entrez)NM_005423
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TFF2
Cluster EST : UnigeneHs.2979 [ NCBI ]
CGAP (NCI)Hs.2979
Alternative Splicing GalleryENSG00000160181
Gene ExpressionTFF2 [ NCBI-GEO ]   TFF2 [ EBI - ARRAY_EXPRESS ]   TFF2 [ SEEK ]   TFF2 [ MEM ]
Gene Expression Viewer (FireBrowse)TFF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7032
GTEX Portal (Tissue expression)TFF2
Human Protein AtlasENSG00000160181-TFF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ03403   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ03403  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ03403
Splice isoforms : SwissVarQ03403
PhosPhoSitePlusQ03403
Domaine pattern : Prosite (Expaxy)P_TREFOIL_1 (PS00025)    P_TREFOIL_2 (PS51448)   
Domains : Interpro (EBI)P_trefoil_chordata    P_trefoil_CS    P_trefoil_dom   
Domain families : Pfam (Sanger)Trefoil (PF00088)   
Domain families : Pfam (NCBI)pfam00088   
Domain families : Smart (EMBL)PD (SM00018)  
Conserved Domain (NCBI)TFF2
DMDM Disease mutations7032
Blocks (Seattle)TFF2
SuperfamilyQ03403
Human Protein Atlas [tissue]ENSG00000160181-TFF2 [tissue]
Peptide AtlasQ03403
HPRD01682
IPIIPI00010675   
Protein Interaction databases
DIP (DOE-UCLA)Q03403
IntAct (EBI)Q03403
FunCoupENSG00000160181
BioGRIDTFF2
STRING (EMBL)TFF2
ZODIACTFF2
Ontologies - Pathways
QuickGOQ03403
Ontology : AmiGOprotein binding  extracellular space  digestion  wound healing  extracellular exosome  
Ontology : EGO-EBIprotein binding  extracellular space  digestion  wound healing  extracellular exosome  
Pathways : BIOCARTATrefoil Factors Initiate Mucosal Healing [Genes]   
NDEx NetworkTFF2
Atlas of Cancer Signalling NetworkTFF2
Wikipedia pathwaysTFF2
Orthology - Evolution
OrthoDB7032
GeneTree (enSembl)ENSG00000160181
Phylogenetic Trees/Animal Genes : TreeFamTFF2
HOVERGENQ03403
HOGENOMQ03403
Homologs : HomoloGeneTFF2
Homology/Alignments : Family Browser (UCSC)TFF2
Gene fusions - Rearrangements
Tumor Fusion PortalTFF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFF2
dbVarTFF2
ClinVarTFF2
1000_GenomesTFF2 
Exome Variant ServerTFF2
ExAC (Exome Aggregation Consortium)ENSG00000160181
GNOMAD BrowserENSG00000160181
Genetic variants : HAPMAP7032
Genomic Variants (DGV)TFF2 [DGVbeta]
DECIPHERTFF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFF2 
Mutations
ICGC Data PortalTFF2 
TCGA Data PortalTFF2 
Broad Tumor PortalTFF2
OASIS PortalTFF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTFF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTFF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TFF2
DgiDB (Drug Gene Interaction Database)TFF2
DoCM (Curated mutations)TFF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TFF2 (select a term)
intoGenTFF2
NCG5 (London)TFF2
Cancer3DTFF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182590   
Orphanet
DisGeNETTFF2
MedgenTFF2
Genetic Testing Registry TFF2
NextProtQ03403 [Medical]
TSGene7032
GENETestsTFF2
Target ValidationTFF2
Huge Navigator TFF2 [HugePedia]
snp3D : Map Gene to Disease7032
BioCentury BCIQTFF2
ClinGenTFF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7032
Chemical/Pharm GKB GenePA36471
Clinical trialTFF2
Miscellaneous
canSAR (ICR)TFF2 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTFF2
EVEXTFF2
GoPubMedTFF2
iHOPTFF2
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 15:04:31 CET 2017

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