Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TFF2 (TreFoil Factor 2)

Written2000-12Catherine Tomasetto
I.G.B.M.C., BP 163, 1 rue Laurent Fries, 67404 Illkirch, France

(Note : for Links provided by Atlas : click)


Alias (NCBI)SP (Spasmolytic Polypeptide)
HGNC (Hugo) TFF2
HGNC Previous nameSML1
HGNC Previous namespasmolytic protein 1
LocusID (NCBI) 7032
Atlas_Id 264
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 42346358 and ends at 42350994 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping TFF2.png]
Local_order belongs to the TFF cluster
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)


Description 5.1 kb gene, 4 exons
Transcription 600 bp


Description precursor: 129 amino acids; mature peptide: 106 amino acids; 3-dimentional structure was solved; the129 amino acids TFF2 protein contains a signal peptide; the mature secreted peptide of 106 amino acids contains two TFF (TreFoil Factor) domains and one acidic C-terminal domain
Expression under normal condition, TFF2 is expressed in mucus neck cells of the fundus, basal cells of the antral and pyloric glands and by the Brunner's glands of the duodenum
Localisation secreted in gastric fluid
Function in repair and epithelial restitution of the gastro-intestinal mucosa
Homology TFF2 belongs to the Trefoil peptide Family (TFF) and possesses two tandemly duplicated TFF motifs each being homologous to the TFF motif of TFF1 and TFF3. The TFF motif spans about 40 amino acids and is formed by 6 conserved residues involved in specific disulfides bridges

Implicated in

Entity TFF2 was found implicated in inflamatory bowel diseases, cancers of gastrointestinal organs such as stomach and pancreas; in constrast to TFF1 and TFF3, TFF2 expression was not found in breast carcinomas


Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats.
Babyatsky MW, deBeaumont M, Thim L, Podolsky DK
Gastroenterology. 1996 ; 110 (2) : 489-497.
PMID 8566596
Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the mammalian trefoil family of peptides.
Gajhede M, Petersen TN, Henriksen A, Petersen JF, Dauter Z, Wilson KS, Thim L
Structure (London, England : 1993). 1993 ; 1 (4) : 253-262.
PMID 8081739
The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression.
Lefebvre O, Wolf C, Kédinger M, Chenard MP, Tomasetto C, Chambon P, Rio MC
The Journal of cell biology. 1993 ; 122 (1) : 191-198.
PMID 8314841
Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration.
Playford RJ, Marchbank T, Chinery R, Evison R, Pignatelli M, Boulton RA, Thim L, Hanby AM
Gastroenterology. 1995 ; 108 (1) : 108-116.
PMID 7806031
Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.
Rio MC, Bellocq JP, Daniel JY, Tomasetto C, Lathe R, Chenard MP, Batzenschlager A, Chambon P
Science (New York, N.Y.). 1988 ; 241 (4866) : 705-708.
PMID 3041593
Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract.
Rio MC, Chenard MP, Wolf C, Marcellin L, Tomasetto C, Lathe R, Bellocq JP, Chambon P
Gastroenterology. 1991 ; 100 (2) : 375-379.
PMID 1985035
The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.
Seib T, Blin N, Hilgert K, Seifert M, Theisinger B, Engel M, Dooley S, Zang KD, Welter C
Genomics. 1997 ; 40 (1) : 200-202.
PMID 9070946
Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma.
Theisinger B, Welter C, Seitz G, Rio MC, Lathe R, Chambon P, Blin N
European journal of cancer (Oxford, England : 1990). 1991 ; 27 (6) : 770-773.
PMID 1829922
A new family of growth factor-like peptides. 'Trefoil' disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins).
Thim L
FEBS letters. 1989 ; 250 (1) : 85-90.
PMID 2737304
The amino acid sequence of pancreatic spasmolytic polypeptide.
Thim L, Thomsen J, Christensen M, J&oring;rgensen KH
Biochimica et biophysica acta. 1985 ; 827 (3) : 410-418.
PMID 2857575
hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.
Tomasetto C, Rio MC, Gautier C, Wolf C, Hareuveni M, Chambon P, Lathe R
The EMBO journal. 1990 ; 9 (2) : 407-414.
PMID 2303034
Association of the human spasmolytic polypeptide and an estrogen-induced breast cancer protein (pS2) with human pancreatic carcinoma.
Welter C, Theisinger B, Seitz G, Tomasetto C, Rio MC, Chambon P, Blin N
Laboratory investigation; a journal of technical methods and pathology. 1992 ; 66 (2) : 187-192.
PMID 1735955
Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease.
Wright NA, Poulsom R, Stamp G, Van Noorden S, Sarraf C, Elia G, Ahnen D, Jeffery R, Longcroft J, Pike C
Gastroenterology. 1993 ; 104 (1) : 12-20.
PMID 8419234


This paper should be referenced as such :
Tomasetto, C
TFF2 (TreFoil Factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):19-20.
Free journal version : [ pdf ]   [ DOI ]

External links

HGNC (Hugo)TFF2   11756
Entrez_Gene (NCBI)TFF2    trefoil factor 2
AliasesSML1; SP
GeneCards (Weizmann)TFF2
Ensembl hg19 (Hinxton)ENSG00000160181 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160181 [Gene_View]  ENSG00000160181 [Sequence]  chr21:42346358-42350994 [Contig_View]  TFF2 [Vega]
ICGC DataPortalENSG00000160181
TCGA cBioPortalTFF2
AceView (NCBI)TFF2
Genatlas (Paris)TFF2
SOURCE (Princeton)TFF2
Genetics Home Reference (NIH)TFF2
Genomic and cartography
GoldenPath hg38 (UCSC)TFF2  -     chr21:42346358-42350994 -  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFF2  -     21q22.3   [Description]    (hg19-Feb_2009)
GoldenPathTFF2 - 21q22.3 [CytoView hg19]  TFF2 - 21q22.3 [CytoView hg38]
genome Data Viewer NCBITFF2 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AA307808 BC032820 BM817851 BM853946 X51698
RefSeq transcript (Entrez)NM_005423
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TFF2
Alternative Splicing GalleryENSG00000160181
Gene ExpressionTFF2 [ NCBI-GEO ]   TFF2 [ EBI - ARRAY_EXPRESS ]   TFF2 [ SEEK ]   TFF2 [ MEM ]
Gene Expression Viewer (FireBrowse)TFF2 [ Firebrowse - Broad ]
GenevisibleExpression of TFF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7032
GTEX Portal (Tissue expression)TFF2
Human Protein AtlasENSG00000160181-TFF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ03403   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ03403  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ03403
Splice isoforms : SwissVarQ03403
Domaine pattern : Prosite (Expaxy)P_TREFOIL_1 (PS00025)    P_TREFOIL_2 (PS51448)   
Domains : Interpro (EBI)P_trefoil_chordata    P_trefoil_CS    P_trefoil_dom   
Domain families : Pfam (Sanger)Trefoil (PF00088)   
Domain families : Pfam (NCBI)pfam00088   
Domain families : Smart (EMBL)PD (SM00018)  
Conserved Domain (NCBI)TFF2
Blocks (Seattle)TFF2
Human Protein Atlas [tissue]ENSG00000160181-TFF2 [tissue]
Peptide AtlasQ03403
Protein Interaction databases
IntAct (EBI)Q03403
Ontologies - Pathways
Ontology : AmiGOprotein binding  extracellular space  maintenance of gastrointestinal epithelium  CXCR4 chemokine receptor binding  negative regulation of gastric acid secretion  chemokine-mediated signaling pathway  
Ontology : EGO-EBIprotein binding  extracellular space  maintenance of gastrointestinal epithelium  CXCR4 chemokine receptor binding  negative regulation of gastric acid secretion  chemokine-mediated signaling pathway  
NDEx NetworkTFF2
Atlas of Cancer Signalling NetworkTFF2
Wikipedia pathwaysTFF2
Orthology - Evolution
GeneTree (enSembl)ENSG00000160181
Phylogenetic Trees/Animal Genes : TreeFamTFF2
Homologs : HomoloGeneTFF2
Homology/Alignments : Family Browser (UCSC)TFF2
Gene fusions - Rearrangements
Fusion : Fusion_HubGKN2--TFF2    IGH@--TFF2    REG4--TFF2    TFF1--TFF2    TFF2--B2M   
Fusion : QuiverTFF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFF2 [hg38]
Exome Variant ServerTFF2
GNOMAD BrowserENSG00000160181
Varsome BrowserTFF2
Genomic Variants (DGV)TFF2 [DGVbeta]
DECIPHERTFF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFF2 
ICGC Data PortalTFF2 
TCGA Data PortalTFF2 
Broad Tumor PortalTFF2
OASIS PortalTFF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTFF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTFF2
Mutations and Diseases : HGMDTFF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TFF2
DgiDB (Drug Gene Interaction Database)TFF2
DoCM (Curated mutations)TFF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TFF2 (select a term)
NCG6 (London) select TFF2
Cancer3DTFF2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry TFF2
NextProtQ03403 [Medical]
Target ValidationTFF2
Huge Navigator TFF2 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTD
Pharm GKB GenePA36471
Clinical trialTFF2
canSAR (ICR)TFF2 (select the gene name)
DataMed IndexTFF2
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Feb 19 18:01:30 CET 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us