TFPI (tissue factor pathway inhibitor)

2007-02-01  

Identity

HGNC
LOCATION
2q32.1
LOCUSID
ALIAS
EPI,LACI,TFI,TFPI1
FUSION GENES

Other Information

Locus ID:

NCBI: 7035
MIM: 152310
HGNC: 11760
Ensembl: ENSG00000003436

Variants:

dbSNP: 7035
ClinVar: 7035
TCGA: ENSG00000003436
COSMIC: TFPI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000003436ENST00000233156P10646
ENSG00000003436ENST00000339091P10646
ENSG00000003436ENST00000392365P10646
ENSG00000003436ENST00000409676P10646
ENSG00000003436ENST00000417013C9J103
ENSG00000003436ENST00000420747C9JP39
ENSG00000003436ENST00000421427C9JQ14
ENSG00000003436ENST00000435414C9JKV3
ENSG00000003436ENST00000437725C9JQ14
ENSG00000003436ENST00000453013C9JT76

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Extrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140834

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
164889802006Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor.83
194016822010High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.52
246203492014Biology of tissue factor pathway inhibitor.50
170823212007Active tissue factor pathway inhibitor is expressed on the surface of coated platelets.42
241276052013Tissue factor pathway inhibitor-alpha inhibits prothrombinase during the initiation of blood coagulation.42
163804942006Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand.39
116863532001Structure and biology of tissue factor pathway inhibitor.34
218685742011Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen.31
239791622013Coagulation factor V(A2440G) causes east Texas bleeding disorder via TFPIα.29

Citation

Dessen P

TFPI (tissue factor pathway inhibitor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46172/tfpi