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TFPI (tissue factor pathway inhibitor)

Identity

Alias_namesLACI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Alias_symbol (synonym)EPI
TFI
TFPI1
Other alias
HGNC (Hugo) TFPI
LocusID (NCBI) 7035
Atlas_Id 46172
Location 2q32.1  [Link to chromosome band 2q32]
Location_base_pair Starts at 187478579 and ends at 187554505 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARID1A (1p36.11) / TFPI (2q32.1)GPATCH1 (19q13.11) / TFPI (2q32.1)RPS6KC1 (1q32.3) / TFPI (2q32.1)
SCAF11 (12q12) / TFPI (2q32.1)TFPI (2q32.1) / ARID1A (1p36.11)RPS6KC1 1q32.3 / TFPI 2q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TFPI   11760
Cards
Entrez_Gene (NCBI)TFPI  7035  tissue factor pathway inhibitor
AliasesEPI; LACI; TFI; TFPI1
GeneCards (Weizmann)TFPI
Ensembl hg19 (Hinxton)ENSG00000003436 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000003436 [Gene_View]  chr2:187478579-187554505 [Contig_View]  TFPI [Vega]
ICGC DataPortalENSG00000003436
TCGA cBioPortalTFPI
AceView (NCBI)TFPI
Genatlas (Paris)TFPI
WikiGenes7035
SOURCE (Princeton)TFPI
Genetics Home Reference (NIH)TFPI
Genomic and cartography
GoldenPath hg38 (UCSC)TFPI  -     chr2:187478579-187554505 -  2q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFPI  -     2q32.1   [Description]    (hg19-Feb_2009)
EnsemblTFPI - 2q32.1 [CytoView hg19]  TFPI - 2q32.1 [CytoView hg38]
Mapping of homologs : NCBITFPI [Mapview hg19]  TFPI [Mapview hg38]
OMIM152310   
Gene and transcription
Genbank (Entrez)AB209866 AF021834 AK130306 AK313562 AU136083
RefSeq transcript (Entrez)NM_001032281 NM_001318941 NM_001329239 NM_001329240 NM_001329241 NM_006287
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TFPI
Cluster EST : UnigeneHs.516578 [ NCBI ]
CGAP (NCI)Hs.516578
Alternative Splicing GalleryENSG00000003436
Gene ExpressionTFPI [ NCBI-GEO ]   TFPI [ EBI - ARRAY_EXPRESS ]   TFPI [ SEEK ]   TFPI [ MEM ]
Gene Expression Viewer (FireBrowse)TFPI [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7035
GTEX Portal (Tissue expression)TFPI
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10646   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10646  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10646
Splice isoforms : SwissVarP10646
PhosPhoSitePlusP10646
Domaine pattern : Prosite (Expaxy)BPTI_KUNITZ_1 (PS00280)    BPTI_KUNITZ_2 (PS50279)   
Domains : Interpro (EBI)Kunitz_BPTI    Prtase_inh_Kunz-CS   
Domain families : Pfam (Sanger)Kunitz_BPTI (PF00014)   
Domain families : Pfam (NCBI)pfam00014   
Domain families : Smart (EMBL)KU (SM00131)  
Conserved Domain (NCBI)TFPI
DMDM Disease mutations7035
Blocks (Seattle)TFPI
PDB (SRS)1ADZ    1IRH    1TFX    4BQD    4DTG   
PDB (PDBSum)1ADZ    1IRH    1TFX    4BQD    4DTG   
PDB (IMB)1ADZ    1IRH    1TFX    4BQD    4DTG   
PDB (RSDB)1ADZ    1IRH    1TFX    4BQD    4DTG   
Structural Biology KnowledgeBase1ADZ    1IRH    1TFX    4BQD    4DTG   
SCOP (Structural Classification of Proteins)1ADZ    1IRH    1TFX    4BQD    4DTG   
CATH (Classification of proteins structures)1ADZ    1IRH    1TFX    4BQD    4DTG   
SuperfamilyP10646
Human Protein AtlasENSG00000003436
Peptide AtlasP10646
HPRD01064
IPIIPI00021834   IPI00218184   IPI00917946   IPI00917813   IPI00917029   IPI00916882   IPI00555718   IPI00916075   
Protein Interaction databases
DIP (DOE-UCLA)P10646
IntAct (EBI)P10646
FunCoupENSG00000003436
BioGRIDTFPI
STRING (EMBL)TFPI
ZODIACTFPI
Ontologies - Pathways
QuickGOP10646
Ontology : AmiGOendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular region  extracellular space  endoplasmic reticulum  plasma membrane  blood coagulation  blood coagulation, extrinsic pathway  cell surface  negative regulation of endopeptidase activity  organelle membrane  anchored component of membrane  response to estradiol  cellular response to lipopolysaccharide  cellular response to interleukin-1  
Ontology : EGO-EBIendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular region  extracellular space  endoplasmic reticulum  plasma membrane  blood coagulation  blood coagulation, extrinsic pathway  cell surface  negative regulation of endopeptidase activity  organelle membrane  anchored component of membrane  response to estradiol  cellular response to lipopolysaccharide  cellular response to interleukin-1  
Pathways : BIOCARTAExtrinsic Prothrombin Activation Pathway [Genes]    Acute Myocardial Infarction [Genes]   
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkTFPI
Atlas of Cancer Signalling NetworkTFPI
Wikipedia pathwaysTFPI
Orthology - Evolution
OrthoDB7035
GeneTree (enSembl)ENSG00000003436
Phylogenetic Trees/Animal Genes : TreeFamTFPI
HOVERGENP10646
HOGENOMP10646
Homologs : HomoloGeneTFPI
Homology/Alignments : Family Browser (UCSC)TFPI
Gene fusions - Rearrangements
Fusion : MitelmanRPS6KC1/TFPI [1q32.3/2q32.1]  [t(1;2)(q32;q32)]  
Fusion: TCGARPS6KC1 1q32.3 TFPI 2q32.1 LUAD
Fusion Cancer (Beijing)SRSF2IP [TFPI]  -  2q32.1 [FUSC001461]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFPI [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFPI
dbVarTFPI
ClinVarTFPI
1000_GenomesTFPI 
Exome Variant ServerTFPI
ExAC (Exome Aggregation Consortium)TFPI (select the gene name)
Genetic variants : HAPMAP7035
Genomic Variants (DGV)TFPI [DGVbeta]
DECIPHERTFPI [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFPI 
Mutations
ICGC Data PortalTFPI 
TCGA Data PortalTFPI 
Broad Tumor PortalTFPI
OASIS PortalTFPI [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTFPI  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTFPI
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TFPI
DgiDB (Drug Gene Interaction Database)TFPI
DoCM (Curated mutations)TFPI (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TFPI (select a term)
intoGenTFPI
Cancer3DTFPI(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM152310   
Orphanet
MedgenTFPI
Genetic Testing Registry TFPI
NextProtP10646 [Medical]
TSGene7035
GENETestsTFPI
Target ValidationTFPI
Huge Navigator TFPI [HugePedia]
snp3D : Map Gene to Disease7035
BioCentury BCIQTFPI
ClinGenTFPI
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7035
Chemical/Pharm GKB GenePA36475
Clinical trialTFPI
Miscellaneous
canSAR (ICR)TFPI (select the gene name)
Probes
Litterature
PubMed218 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTFPI
EVEXTFPI
GoPubMedTFPI
iHOPTFPI
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:59:10 CEST 2017

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