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TFPI2 (tissue factor pathway inhibitor 2)

Identity

Alias_symbol (synonym)PP5
TFPI-2
REF1
Other alias
HGNC (Hugo) TFPI2
LocusID (NCBI) 7980
Atlas_Id 42532
Location 7q21.3  [Link to chromosome band 7q21]
Location_base_pair Starts at 93885397 and ends at 93890991 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TFPI2   11761
Cards
Entrez_Gene (NCBI)TFPI2  7980  tissue factor pathway inhibitor 2
AliasesPP5; REF1; TFPI-2
GeneCards (Weizmann)TFPI2
Ensembl hg19 (Hinxton)ENSG00000105825 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105825 [Gene_View]  ENSG00000105825 [Sequence]  chr7:93885397-93890991 [Contig_View]  TFPI2 [Vega]
ICGC DataPortalENSG00000105825
TCGA cBioPortalTFPI2
AceView (NCBI)TFPI2
Genatlas (Paris)TFPI2
WikiGenes7980
SOURCE (Princeton)TFPI2
Genetics Home Reference (NIH)TFPI2
Genomic and cartography
GoldenPath hg38 (UCSC)TFPI2  -     chr7:93885397-93890991 -  7q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFPI2  -     7q21.3   [Description]    (hg19-Feb_2009)
EnsemblTFPI2 - 7q21.3 [CytoView hg19]  TFPI2 - 7q21.3 [CytoView hg38]
Mapping of homologs : NCBITFPI2 [Mapview hg19]  TFPI2 [Mapview hg38]
OMIM600033   
Gene and transcription
Genbank (Entrez)AK024817 AK075425 AK075427 AK092499 AK129833
RefSeq transcript (Entrez)NM_001271003 NM_001271004 NM_006528
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TFPI2
Cluster EST : UnigeneHs.438231 [ NCBI ]
CGAP (NCI)Hs.438231
Alternative Splicing GalleryENSG00000105825
Gene ExpressionTFPI2 [ NCBI-GEO ]   TFPI2 [ EBI - ARRAY_EXPRESS ]   TFPI2 [ SEEK ]   TFPI2 [ MEM ]
Gene Expression Viewer (FireBrowse)TFPI2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7980
GTEX Portal (Tissue expression)TFPI2
Human Protein AtlasENSG00000105825-TFPI2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48307   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48307  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48307
Splice isoforms : SwissVarP48307
PhosPhoSitePlusP48307
Domaine pattern : Prosite (Expaxy)BPTI_KUNITZ_1 (PS00280)    BPTI_KUNITZ_2 (PS50279)   
Domains : Interpro (EBI)Kunitz_BPTI    Kunitz_BPTI_sf    Prtase_inh_Kunz-CS    TFPI-like   
Domain families : Pfam (Sanger)Kunitz_BPTI (PF00014)   
Domain families : Pfam (NCBI)pfam00014   
Domain families : Smart (EMBL)KU (SM00131)  
Conserved Domain (NCBI)TFPI2
DMDM Disease mutations7980
Blocks (Seattle)TFPI2
PDB (SRS)1ZR0   
PDB (PDBSum)1ZR0   
PDB (IMB)1ZR0   
PDB (RSDB)1ZR0   
Structural Biology KnowledgeBase1ZR0   
SCOP (Structural Classification of Proteins)1ZR0   
CATH (Classification of proteins structures)1ZR0   
SuperfamilyP48307
Human Protein Atlas [tissue]ENSG00000105825-TFPI2 [tissue]
Peptide AtlasP48307
HPRD08962
IPIIPI00009198   IPI01009667   IPI00926923   
Protein Interaction databases
DIP (DOE-UCLA)P48307
IntAct (EBI)P48307
FunCoupENSG00000105825
BioGRIDTFPI2
STRING (EMBL)TFPI2
ZODIACTFPI2
Ontologies - Pathways
QuickGOP48307
Ontology : AmiGOserine-type endopeptidase inhibitor activity  extracellular matrix structural constituent  extracellular space  blood coagulation  negative regulation of endopeptidase activity  extracellular matrix  cellular response to fluid shear stress  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  extracellular matrix structural constituent  extracellular space  blood coagulation  negative regulation of endopeptidase activity  extracellular matrix  cellular response to fluid shear stress  
NDEx NetworkTFPI2
Atlas of Cancer Signalling NetworkTFPI2
Wikipedia pathwaysTFPI2
Orthology - Evolution
OrthoDB7980
GeneTree (enSembl)ENSG00000105825
Phylogenetic Trees/Animal Genes : TreeFamTFPI2
HOVERGENP48307
HOGENOMP48307
Homologs : HomoloGeneTFPI2
Homology/Alignments : Family Browser (UCSC)TFPI2
Gene fusions - Rearrangements
Fusion : QuiverTFPI2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFPI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFPI2
dbVarTFPI2
ClinVarTFPI2
1000_GenomesTFPI2 
Exome Variant ServerTFPI2
ExAC (Exome Aggregation Consortium)ENSG00000105825
GNOMAD BrowserENSG00000105825
Varsome BrowserTFPI2
Genetic variants : HAPMAP7980
Genomic Variants (DGV)TFPI2 [DGVbeta]
DECIPHERTFPI2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFPI2 
Mutations
ICGC Data PortalTFPI2 
TCGA Data PortalTFPI2 
Broad Tumor PortalTFPI2
OASIS PortalTFPI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTFPI2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTFPI2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TFPI2
DgiDB (Drug Gene Interaction Database)TFPI2
DoCM (Curated mutations)TFPI2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TFPI2 (select a term)
intoGenTFPI2
Cancer3DTFPI2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600033   
Orphanet
DisGeNETTFPI2
MedgenTFPI2
Genetic Testing Registry TFPI2
NextProtP48307 [Medical]
TSGene7980
GENETestsTFPI2
Target ValidationTFPI2
Huge Navigator TFPI2 [HugePedia]
snp3D : Map Gene to Disease7980
BioCentury BCIQTFPI2
ClinGenTFPI2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7980
Chemical/Pharm GKB GenePA36476
Clinical trialTFPI2
Miscellaneous
canSAR (ICR)TFPI2 (select the gene name)
Probes
Litterature
PubMed125 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTFPI2
EVEXTFPI2
GoPubMedTFPI2
iHOPTFPI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:44:43 CET 2018
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