TFPI2 (tissue factor pathway inhibitor 2)

2003-02-01  

Identity

HGNC
LOCATION
7q21.3
LOCUSID
ALIAS
PP5,REF1,TFPI-2

Other Information

Locus ID:

NCBI: 7980
MIM: 600033
HGNC: 11761
Ensembl: ENSG00000105825

Variants:

dbSNP: 7980
ClinVar: 7980
TCGA: ENSG00000105825
COSMIC: TFPI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105825ENST00000222543P48307
ENSG00000105825ENST00000451238H7C4A3
ENSG00000105825ENST00000647793A0A3B3IRW1
ENSG00000105825ENST00000649913A0A3B3ISY1
ENSG00000105825ENST00000650573A0A3B3IS67

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194359262009Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer.77
155925282005Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma.47
184804702008Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.36
174649892007Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma.32
212243452011MicroRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2.25
195712602009Characterization of conserved and nonconserved imprinted genes in swine.24
128817072003Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells.22
172083282007Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer.22
149702252004Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2.21
210624552010TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma.21

Citation

Dessen P

TFPI2 (tissue factor pathway inhibitor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42532/tfpi2