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TFPI2 (tissue factor pathway inhibitor 2)

Identity

Alias (NCBI)PP5
REF1
TFPI-2
HGNC (Hugo) TFPI2
HGNC Alias symbPP5
TFPI-2
REF1
LocusID (NCBI) 7980
Atlas_Id 42532
Location 7q21.3  [Link to chromosome band 7q21]
Location_base_pair Starts at 93885396 and ends at 93890753 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)TFPI2   11761
Cards
Entrez_Gene (NCBI)TFPI2    tissue factor pathway inhibitor 2
AliasesPP5; REF1; TFPI-2
GeneCards (Weizmann)TFPI2
Ensembl hg19 (Hinxton)ENSG00000105825 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105825 [Gene_View]  ENSG00000105825 [Sequence]  chr7:93885396-93890753 [Contig_View]  TFPI2 [Vega]
ICGC DataPortalENSG00000105825
TCGA cBioPortalTFPI2
AceView (NCBI)TFPI2
Genatlas (Paris)TFPI2
SOURCE (Princeton)TFPI2
Genetics Home Reference (NIH)TFPI2
Genomic and cartography
GoldenPath hg38 (UCSC)TFPI2  -     chr7:93885396-93890753 -  7q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFPI2  -     7q21.3   [Description]    (hg19-Feb_2009)
GoldenPathTFPI2 - 7q21.3 [CytoView hg19]  TFPI2 - 7q21.3 [CytoView hg38]
ImmunoBaseENSG00000105825
Genome Data Viewer NCBITFPI2 [Mapview hg19]  
OMIM600033   
Gene and transcription
Genbank (Entrez)AK024817 AK075425 AK075427 AK092499 AK129833
RefSeq transcript (Entrez)NM_001271003 NM_001271004 NM_006528
Consensus coding sequences : CCDS (NCBI)TFPI2
Gene ExpressionTFPI2 [ NCBI-GEO ]   TFPI2 [ EBI - ARRAY_EXPRESS ]   TFPI2 [ SEEK ]   TFPI2 [ MEM ]
Gene Expression Viewer (FireBrowse)TFPI2 [ Firebrowse - Broad ]
GenevisibleExpression of TFPI2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7980
GTEX Portal (Tissue expression)TFPI2
Human Protein AtlasENSG00000105825-TFPI2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48307   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48307  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48307
PhosPhoSitePlusP48307
Domaine pattern : Prosite (Expaxy)BPTI_KUNITZ_1 (PS00280)    BPTI_KUNITZ_2 (PS50279)   
Domains : Interpro (EBI)Kunitz_BPTI    Kunitz_BPTI_sf    Prtase_inh_Kunz-CS    TFPI-like    TFPI2   
Domain families : Pfam (Sanger)Kunitz_BPTI (PF00014)   
Domain families : Pfam (NCBI)pfam00014   
Domain families : Smart (EMBL)KU (SM00131)  
Conserved Domain (NCBI)TFPI2
PDB (RSDB)1ZR0   
PDB Europe1ZR0   
PDB (PDBSum)1ZR0   
PDB (IMB)1ZR0   
Structural Biology KnowledgeBase1ZR0   
SCOP (Structural Classification of Proteins)1ZR0   
CATH (Classification of proteins structures)1ZR0   
SuperfamilyP48307
AlphaFold pdb e-kbP48307   
Human Protein Atlas [tissue]ENSG00000105825-TFPI2 [tissue]
HPRD08962
Protein Interaction databases
DIP (DOE-UCLA)P48307
IntAct (EBI)P48307
BioGRIDTFPI2
STRING (EMBL)TFPI2
ZODIACTFPI2
Ontologies - Pathways
QuickGOP48307
Ontology : AmiGOserine-type endopeptidase inhibitor activity  extracellular matrix structural constituent  extracellular space  blood coagulation  negative regulation of endopeptidase activity  extracellular matrix  cellular response to fluid shear stress  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  extracellular matrix structural constituent  extracellular space  blood coagulation  negative regulation of endopeptidase activity  extracellular matrix  cellular response to fluid shear stress  
NDEx NetworkTFPI2
Atlas of Cancer Signalling NetworkTFPI2
Wikipedia pathwaysTFPI2
Orthology - Evolution
OrthoDB7980
GeneTree (enSembl)ENSG00000105825
Phylogenetic Trees/Animal Genes : TreeFamTFPI2
Homologs : HomoloGeneTFPI2
Homology/Alignments : Family Browser (UCSC)TFPI2
Gene fusions - Rearrangements
Fusion : QuiverTFPI2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFPI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFPI2
dbVarTFPI2
ClinVarTFPI2
MonarchTFPI2
1000_GenomesTFPI2 
Exome Variant ServerTFPI2
GNOMAD BrowserENSG00000105825
Varsome BrowserTFPI2
ACMGTFPI2 variants
VarityP48307
Genomic Variants (DGV)TFPI2 [DGVbeta]
DECIPHERTFPI2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFPI2 
Mutations
ICGC Data PortalTFPI2 
TCGA Data PortalTFPI2 
Broad Tumor PortalTFPI2
OASIS PortalTFPI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTFPI2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTFPI2
Mutations and Diseases : HGMDTFPI2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTFPI2
DgiDB (Drug Gene Interaction Database)TFPI2
DoCM (Curated mutations)TFPI2
CIViC (Clinical Interpretations of Variants in Cancer)TFPI2
Cancer3DTFPI2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600033   
Orphanet
DisGeNETTFPI2
MedgenTFPI2
Genetic Testing Registry TFPI2
NextProtP48307 [Medical]
GENETestsTFPI2
Target ValidationTFPI2
Huge Navigator TFPI2 [HugePedia]
ClinGenTFPI2
Clinical trials, drugs, therapy
MyCancerGenomeTFPI2
Protein Interactions : CTDTFPI2
Pharm GKB GenePA36476
PharosP48307
Clinical trialTFPI2
Miscellaneous
canSAR (ICR)TFPI2
HarmonizomeTFPI2
DataMed IndexTFPI2
Probes
Litterature
PubMed138 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTFPI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:34:54 CEST 2021
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