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TFR2 (transferrin receptor 2)

Identity

Alias_symbol (synonym)HFE3
TFRC2
Other alias
HGNC (Hugo) TFR2
LocusID (NCBI) 7036
Atlas_Id 51246
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 100218039 and ends at 100231273 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TFR2   11762
Cards
Entrez_Gene (NCBI)TFR2  7036  transferrin receptor 2
AliasesHFE3; TFRC2
GeneCards (Weizmann)TFR2
Ensembl hg19 (Hinxton)ENSG00000106327 [Gene_View]  chr7:100218039-100231273 [Contig_View]  TFR2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000106327 [Gene_View]  chr7:100218039-100231273 [Contig_View]  TFR2 [Vega]
ICGC DataPortalENSG00000106327
TCGA cBioPortalTFR2
AceView (NCBI)TFR2
Genatlas (Paris)TFR2
WikiGenes7036
SOURCE (Princeton)TFR2
Genetics Home Reference (NIH)TFR2
Genomic and cartography
GoldenPath hg19 (UCSC)TFR2  -     chr7:100218039-100231273 -  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TFR2  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblTFR2 - 7q22.1 [CytoView hg19]  TFR2 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBITFR2 [Mapview hg19]  TFR2 [Mapview hg38]
OMIM604250   604720   
Gene and transcription
Genbank (Entrez)AF067864 AF085928 AK000421 AK022002 BC142630
RefSeq transcript (Entrez)NM_001206855 NM_003227
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_007989 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)TFR2
Cluster EST : UnigeneHs.544932 [ NCBI ]
CGAP (NCI)Hs.544932
Alternative Splicing GalleryENSG00000106327
Gene ExpressionTFR2 [ NCBI-GEO ]   TFR2 [ EBI - ARRAY_EXPRESS ]   TFR2 [ SEEK ]   TFR2 [ MEM ]
Gene Expression Viewer (FireBrowse)TFR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7036
GTEX Portal (Tissue expression)TFR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UP52   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UP52  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UP52
Splice isoforms : SwissVarQ9UP52
PhosPhoSitePlusQ9UP52
Domains : Interpro (EBI)PA_domain    Peptidase_M28    TFR-like_dimer_dom   
Domain families : Pfam (Sanger)PA (PF02225)    Peptidase_M28 (PF04389)   
Domain families : Pfam (NCBI)pfam02225    pfam04389   
Conserved Domain (NCBI)TFR2
DMDM Disease mutations7036
Blocks (Seattle)TFR2
SuperfamilyQ9UP52
Human Protein AtlasENSG00000106327
Peptide AtlasQ9UP52
HPRD05282
IPIIPI00215612   IPI00219900   IPI00219901   IPI00855864   IPI00946487   
Protein Interaction databases
DIP (DOE-UCLA)Q9UP52
IntAct (EBI)Q9UP52
FunCoupENSG00000106327
BioGRIDTFR2
STRING (EMBL)TFR2
ZODIACTFR2
Ontologies - Pathways
QuickGOQ9UP52
Ontology : AmiGOglycoprotein binding  transferrin receptor activity  transferrin receptor activity  protein binding  integral component of plasma membrane  integral component of plasma membrane  iron ion transport  cellular iron ion homeostasis  receptor-mediated endocytosis  external side of plasma membrane  response to iron ion  cytoplasmic vesicle  transferrin transport  co-receptor binding  positive regulation of endocytosis  positive regulation of transcription from RNA polymerase II promoter  iron ion homeostasis  iron ion homeostasis  cellular response to iron ion  positive regulation of peptide hormone secretion  ferrous iron import into cell  positive regulation of protein maturation  HFE-transferrin receptor complex  
Ontology : EGO-EBIglycoprotein binding  transferrin receptor activity  transferrin receptor activity  protein binding  integral component of plasma membrane  integral component of plasma membrane  iron ion transport  cellular iron ion homeostasis  receptor-mediated endocytosis  external side of plasma membrane  response to iron ion  cytoplasmic vesicle  transferrin transport  co-receptor binding  positive regulation of endocytosis  positive regulation of transcription from RNA polymerase II promoter  iron ion homeostasis  iron ion homeostasis  cellular response to iron ion  positive regulation of peptide hormone secretion  ferrous iron import into cell  positive regulation of protein maturation  HFE-transferrin receptor complex  
NDEx NetworkTFR2
Atlas of Cancer Signalling NetworkTFR2
Wikipedia pathwaysTFR2
Orthology - Evolution
OrthoDB7036
GeneTree (enSembl)ENSG00000106327
Phylogenetic Trees/Animal Genes : TreeFamTFR2
HOVERGENQ9UP52
HOGENOMQ9UP52
Homologs : HomoloGeneTFR2
Homology/Alignments : Family Browser (UCSC)TFR2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFR2
dbVarTFR2
ClinVarTFR2
1000_GenomesTFR2 
Exome Variant ServerTFR2
ExAC (Exome Aggregation Consortium)TFR2 (select the gene name)
Genetic variants : HAPMAP7036
Genomic Variants (DGV)TFR2 [DGVbeta]
DECIPHER (Syndromes)7:100218039-100231273  ENSG00000106327
CONAN: Copy Number AnalysisTFR2 
Mutations
ICGC Data PortalTFR2 
TCGA Data PortalTFR2 
Broad Tumor PortalTFR2
OASIS PortalTFR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTFR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTFR2
LOVD (Leiden Open Variation Database)FH UCL BHF
BioMutasearch TFR2
DgiDB (Drug Gene Interaction Database)TFR2
DoCM (Curated mutations)TFR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TFR2 (select a term)
intoGenTFR2
Cancer3DTFR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604250    604720   
Orphanet18976   
MedgenTFR2
Genetic Testing Registry TFR2
NextProtQ9UP52 [Medical]
TSGene7036
GENETestsTFR2
Huge Navigator TFR2 [HugePedia]
snp3D : Map Gene to Disease7036
BioCentury BCIQTFR2
ClinGenTFR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7036
Chemical/Pharm GKB GenePA36477
Clinical trialTFR2
Miscellaneous
canSAR (ICR)TFR2 (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTFR2
EVEXTFR2
GoPubMedTFR2
iHOPTFR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:30:55 CET 2017

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