TG (thyroglobulin)

2007-02-01  

Identity

HGNC
LOCATION
8q24.22
LOCUSID
ALIAS
AITD3,TGN
FUSION GENES

Other Information

Locus ID:

NCBI: 7038
MIM: 188450
HGNC: 11764
Ensembl: ENSG00000042832

Variants:

dbSNP: 7038
ClinVar: 7038
TCGA: ENSG00000042832
COSMIC: TG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000042832ENST00000220616P01266
ENSG00000042832ENST00000518058H0YBC5
ENSG00000042832ENST00000518108H0YBL4
ENSG00000042832ENST00000518505H0YBJ2
ENSG00000042832ENST00000519178H0YBY1
ENSG00000042832ENST00000519543E7EVM0
ENSG00000042832ENST00000521107H0YBR7
ENSG00000042832ENST00000522797H0YBQ6
ENSG00000042832ENST00000523756H0YB42
ENSG00000042832ENST00000523901E5RG33

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
7000
8000

Pathways

PathwaySourceExternal ID
Autoimmune thyroid diseaseKEGGko05320
Autoimmune thyroid diseaseKEGGhsa05320
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
185141602008Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function.46
225177452012Human fibrocytes coexpress thyroglobulin and thyrotropin receptor.36
178543962008Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptake.34
233450972013Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100-299 μg/L: a UNICEF/ICCIDD study group report.33
205737212010Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.30
217577242011Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism.30
166466802006Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease.25

Citation

Dessen P

TG (thyroglobulin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46096/tg