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TGFA (transforming growth factor alpha)

Identity

Alias (NCBI)TFGA
HGNC (Hugo) TGFA
HGNC Previous nametransforming growth factor, alpha
LocusID (NCBI) 7039
Atlas_Id 32
Location 2p13.3  [Link to chromosome band 2p13]
Location_base_pair Starts at 70447285 and ends at 70553826 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TGFA (2p13.3) / TGFA (2p13.3)TIA1 (2p13.3) / TGFA (2p13.3)TIA1 2p13.3 / TGFA 2p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TGFA   11765
Cards
Entrez_Gene (NCBI)TGFA    transforming growth factor alpha
AliasesTFGA
GeneCards (Weizmann)TGFA
Ensembl hg19 (Hinxton)ENSG00000163235 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163235 [Gene_View]  ENSG00000163235 [Sequence]  chr2:70447285-70553826 [Contig_View]  TGFA [Vega]
ICGC DataPortalENSG00000163235
TCGA cBioPortalTGFA
AceView (NCBI)TGFA
Genatlas (Paris)TGFA
SOURCE (Princeton)TGFA
Genetics Home Reference (NIH)TGFA
Genomic and cartography
GoldenPath hg38 (UCSC)TGFA  -     chr2:70447285-70553826 -  2p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TGFA  -     2p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTGFA - 2p13.3 [CytoView hg19]  TGFA - 2p13.3 [CytoView hg38]
ImmunoBaseENSG00000163235
Genome Data Viewer NCBITGFA [Mapview hg19]  
OMIM190170   
Gene and transcription
Genbank (Entrez)AF149096 AF149097 AF149098 AK290151 AK309066
RefSeq transcript (Entrez)NM_001099691 NM_001308158 NM_001308159 NM_003236
Consensus coding sequences : CCDS (NCBI)TGFA
Gene ExpressionTGFA [ NCBI-GEO ]   TGFA [ EBI - ARRAY_EXPRESS ]   TGFA [ SEEK ]   TGFA [ MEM ]
Gene Expression Viewer (FireBrowse)TGFA [ Firebrowse - Broad ]
GenevisibleExpression of TGFA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7039
GTEX Portal (Tissue expression)TGFA
Human Protein AtlasENSG00000163235-TGFA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01135   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01135  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01135
PhosPhoSitePlusP01135
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_dom    EGF_rcpt_ligand   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TGFA
PDB (RSDB)1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
PDB Europe1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
PDB (PDBSum)1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
PDB (IMB)1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
Structural Biology KnowledgeBase1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
SCOP (Structural Classification of Proteins)1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
CATH (Classification of proteins structures)1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
SuperfamilyP01135
AlphaFold pdb e-kbP01135   
Human Protein Atlas [tissue]ENSG00000163235-TGFA [tissue]
HPRD07522
Protein Interaction databases
DIP (DOE-UCLA)P01135
IntAct (EBI)P01135
BioGRIDTGFA
STRING (EMBL)TGFA
ZODIACTGFA
Ontologies - Pathways
QuickGOP01135
Ontology : AmiGOMAPK cascade  activation of MAPK activity  activation of MAPK activity  angiogenesis  epidermal growth factor receptor binding  epidermal growth factor receptor binding  protein binding  extracellular region  extracellular space  extracellular space  nucleus  endoplasmic reticulum membrane  plasma membrane  regulation of transcription by RNA polymerase II  endoplasmic reticulum to Golgi vesicle-mediated transport  signal transduction  epidermal growth factor receptor signaling pathway  epidermal growth factor receptor signaling pathway  growth factor activity  growth factor activity  positive regulation of cell population proliferation  cell surface  ER to Golgi transport vesicle membrane  integral component of membrane  basolateral plasma membrane  clathrin-coated endocytic vesicle membrane  cytoplasmic vesicle  endoplasmic reticulum-Golgi intermediate compartment membrane  intracellular signal transduction  negative regulation of epidermal growth factor receptor signaling pathway  wound healing  response to drug  negative regulation of apoptotic process  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of mitotic nuclear division  positive regulation of mitotic nuclear division  COPII vesicle coating  perinuclear region of cytoplasm  positive regulation of epithelial cell proliferation  positive regulation of cell division  positive regulation of protein kinase B signaling  mammary gland alveolus development  membrane organization  hepatocyte proliferation  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  activation of MAPK activity  angiogenesis  epidermal growth factor receptor binding  epidermal growth factor receptor binding  protein binding  extracellular region  extracellular space  extracellular space  nucleus  endoplasmic reticulum membrane  plasma membrane  regulation of transcription by RNA polymerase II  endoplasmic reticulum to Golgi vesicle-mediated transport  signal transduction  epidermal growth factor receptor signaling pathway  epidermal growth factor receptor signaling pathway  growth factor activity  growth factor activity  positive regulation of cell population proliferation  cell surface  ER to Golgi transport vesicle membrane  integral component of membrane  basolateral plasma membrane  clathrin-coated endocytic vesicle membrane  cytoplasmic vesicle  endoplasmic reticulum-Golgi intermediate compartment membrane  intracellular signal transduction  negative regulation of epidermal growth factor receptor signaling pathway  wound healing  response to drug  negative regulation of apoptotic process  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of mitotic nuclear division  positive regulation of mitotic nuclear division  COPII vesicle coating  perinuclear region of cytoplasm  positive regulation of epithelial cell proliferation  positive regulation of cell division  positive regulation of protein kinase B signaling  mammary gland alveolus development  membrane organization  hepatocyte proliferation  
Pathways : KEGGErbB signaling pathway    Pathways in cancer    Renal cell carcinoma    Pancreatic cancer    Glioma    Prostate cancer    Non-small cell lung cancer   
NDEx NetworkTGFA
Atlas of Cancer Signalling NetworkTGFA
Wikipedia pathwaysTGFA
Orthology - Evolution
OrthoDB7039
GeneTree (enSembl)ENSG00000163235
Phylogenetic Trees/Animal Genes : TreeFamTGFA
Homologs : HomoloGeneTGFA
Homology/Alignments : Family Browser (UCSC)TGFA
Gene fusions - Rearrangements
Fusion : MitelmanTIA1/TGFA [2p13.3/2p13.3]  
Fusion : QuiverTGFA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTGFA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TGFA
dbVarTGFA
ClinVarTGFA
MonarchTGFA
1000_GenomesTGFA 
Exome Variant ServerTGFA
GNOMAD BrowserENSG00000163235
Varsome BrowserTGFA
ACMGTGFA variants
VarityP01135
Genomic Variants (DGV)TGFA [DGVbeta]
DECIPHERTGFA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTGFA 
Mutations
ICGC Data PortalTGFA 
TCGA Data PortalTGFA 
Broad Tumor PortalTGFA
OASIS PortalTGFA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTGFA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTGFA
Mutations and Diseases : HGMDTGFA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTGFA
DgiDB (Drug Gene Interaction Database)TGFA
DoCM (Curated mutations)TGFA
CIViC (Clinical Interpretations of Variants in Cancer)TGFA
Cancer3DTGFA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM190170   
Orphanet14371   
DisGeNETTGFA
MedgenTGFA
Genetic Testing Registry TGFA
NextProtP01135 [Medical]
GENETestsTGFA
Target ValidationTGFA
Huge Navigator TGFA [HugePedia]
ClinGenTGFA
Clinical trials, drugs, therapy
MyCancerGenomeTGFA
Protein Interactions : CTDTGFA
Pharm GKB GenePA36480
Pharm GKB PathwaysPA162356267   
PharosP01135
Clinical trialTGFA
Miscellaneous
canSAR (ICR)TGFA
HarmonizomeTGFA
DataMed IndexTGFA
Probes
Litterature
PubMed234 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTGFA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:34:54 CEST 2021

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