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TGFA (transforming growth factor alpha)

Identity

Alias_namestransforming growth factor
Other aliasTFGA
HGNC (Hugo) TGFA
LocusID (NCBI) 7039
Atlas_Id 32
Location 2p13.3  [Link to chromosome band 2p13]
Location_base_pair Starts at 70447280 and ends at 70554015 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TGFA (2p13.3) / TGFA (2p13.3)TIA1 (2p13.3) / TGFA (2p13.3)TIA1 2p13.3 / TGFA 2p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Gallbladder: Intrahepatic cholangiocarcinoma


External links

Nomenclature
HGNC (Hugo)TGFA   11765
Cards
Entrez_Gene (NCBI)TGFA  7039  transforming growth factor alpha
AliasesTFGA
GeneCards (Weizmann)TGFA
Ensembl hg19 (Hinxton)ENSG00000163235 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163235 [Gene_View]  chr2:70447280-70554015 [Contig_View]  TGFA [Vega]
ICGC DataPortalENSG00000163235
TCGA cBioPortalTGFA
AceView (NCBI)TGFA
Genatlas (Paris)TGFA
WikiGenes7039
SOURCE (Princeton)TGFA
Genetics Home Reference (NIH)TGFA
Genomic and cartography
GoldenPath hg38 (UCSC)TGFA  -     chr2:70447280-70554015 -  2p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TGFA  -     2p13.3   [Description]    (hg19-Feb_2009)
EnsemblTGFA - 2p13.3 [CytoView hg19]  TGFA - 2p13.3 [CytoView hg38]
Mapping of homologs : NCBITGFA [Mapview hg19]  TGFA [Mapview hg38]
OMIM190170   
Gene and transcription
Genbank (Entrez)AF149096 AF149097 AF149098 AK290151 AK309066
RefSeq transcript (Entrez)NM_001099691 NM_001308158 NM_001308159 NM_003236
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TGFA
Cluster EST : UnigeneHs.628298 [ NCBI ]
CGAP (NCI)Hs.628298
Alternative Splicing GalleryENSG00000163235
Gene ExpressionTGFA [ NCBI-GEO ]   TGFA [ EBI - ARRAY_EXPRESS ]   TGFA [ SEEK ]   TGFA [ MEM ]
Gene Expression Viewer (FireBrowse)TGFA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7039
GTEX Portal (Tissue expression)TGFA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01135   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01135  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01135
Splice isoforms : SwissVarP01135
PhosPhoSitePlusP01135
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    EGF_rcpt_ligand   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TGFA
DMDM Disease mutations7039
Blocks (Seattle)TGFA
PDB (SRS)1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
PDB (PDBSum)1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
PDB (IMB)1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
PDB (RSDB)1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
Structural Biology KnowledgeBase1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
SCOP (Structural Classification of Proteins)1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
CATH (Classification of proteins structures)1GK5    1MOX    1YUF    1YUG    2TGF    3E50    3TGF    4TGF    5KN5   
SuperfamilyP01135
Human Protein AtlasENSG00000163235
Peptide AtlasP01135
HPRD07522
IPIIPI00872280   IPI00856067   IPI00926333   IPI00465177   IPI00954043   IPI00927684   IPI00926969   IPI01015131   
Protein Interaction databases
DIP (DOE-UCLA)P01135
IntAct (EBI)P01135
FunCoupENSG00000163235
BioGRIDTGFA
STRING (EMBL)TGFA
ZODIACTGFA
Ontologies - Pathways
QuickGOP01135
Ontology : AmiGOGolgi membrane  activation of MAPK activity  epidermal growth factor receptor binding  protein binding  extracellular space  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  regulation of transcription from RNA polymerase II promoter  ER to Golgi vesicle-mediated transport  growth factor activity  cell proliferation  cell surface  ER to Golgi transport vesicle membrane  basolateral plasma membrane  cytoplasmic vesicle  endoplasmic reticulum-Golgi intermediate compartment membrane  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of mitotic nuclear division  COPII vesicle coating  perinuclear region of cytoplasm  positive regulation of epithelial cell proliferation  positive regulation of cell division  
Ontology : EGO-EBIGolgi membrane  activation of MAPK activity  epidermal growth factor receptor binding  protein binding  extracellular space  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  regulation of transcription from RNA polymerase II promoter  ER to Golgi vesicle-mediated transport  growth factor activity  cell proliferation  cell surface  ER to Golgi transport vesicle membrane  basolateral plasma membrane  cytoplasmic vesicle  endoplasmic reticulum-Golgi intermediate compartment membrane  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of mitotic nuclear division  COPII vesicle coating  perinuclear region of cytoplasm  positive regulation of epithelial cell proliferation  positive regulation of cell division  
Pathways : KEGGErbB signaling pathway    Pathways in cancer    Renal cell carcinoma    Pancreatic cancer    Glioma    Prostate cancer    Non-small cell lung cancer   
NDEx NetworkTGFA
Atlas of Cancer Signalling NetworkTGFA
Wikipedia pathwaysTGFA
Orthology - Evolution
OrthoDB7039
GeneTree (enSembl)ENSG00000163235
Phylogenetic Trees/Animal Genes : TreeFamTGFA
HOVERGENP01135
HOGENOMP01135
Homologs : HomoloGeneTGFA
Homology/Alignments : Family Browser (UCSC)TGFA
Gene fusions - Rearrangements
Fusion : MitelmanTIA1/TGFA [2p13.3/2p13.3]  [t(2;2)(p13;p13)]  
Fusion: TCGATIA1 2p13.3 TGFA 2p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTGFA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TGFA
dbVarTGFA
ClinVarTGFA
1000_GenomesTGFA 
Exome Variant ServerTGFA
ExAC (Exome Aggregation Consortium)TGFA (select the gene name)
Genetic variants : HAPMAP7039
Genomic Variants (DGV)TGFA [DGVbeta]
DECIPHERTGFA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTGFA 
Mutations
ICGC Data PortalTGFA 
TCGA Data PortalTGFA 
Broad Tumor PortalTGFA
OASIS PortalTGFA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTGFA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTGFA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TGFA
DgiDB (Drug Gene Interaction Database)TGFA
DoCM (Curated mutations)TGFA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TGFA (select a term)
intoGenTGFA
Cancer3DTGFA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM190170   
Orphanet14371   
MedgenTGFA
Genetic Testing Registry TGFA
NextProtP01135 [Medical]
TSGene7039
GENETestsTGFA
Target ValidationTGFA
Huge Navigator TGFA [HugePedia]
snp3D : Map Gene to Disease7039
BioCentury BCIQTGFA
ClinGenTGFA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7039
Chemical/Pharm GKB GenePA36480
Clinical trialTGFA
Miscellaneous
canSAR (ICR)TGFA (select the gene name)
Probes
Litterature
PubMed211 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTGFA
EVEXTGFA
GoPubMedTGFA
iHOPTGFA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:59:11 CEST 2017

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