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TGFB1I1 (transforming growth factor beta 1 induced transcript 1)

Identity

Alias (NCBI)ARA55
HIC-5
HIC5
TSC-5
HGNC (Hugo) TGFB1I1
HGNC Alias symbHic-5
TSC-5
ARA55
HIC-5
HGNC Alias namehydrogen peroxide-inducible clone-5
LocusID (NCBI) 7041
Atlas_Id 42535
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 31473205 and ends at 31477960 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;21)(q21;q22) RUNX1/LPXN


External links

 

Nomenclature
HGNC (Hugo)TGFB1I1   11767
Cards
Entrez_Gene (NCBI)TGFB1I1    transforming growth factor beta 1 induced transcript 1
AliasesARA55; HIC-5; HIC5; TSC-5
GeneCards (Weizmann)TGFB1I1
Ensembl hg19 (Hinxton)ENSG00000140682 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140682 [Gene_View]  ENSG00000140682 [Sequence]  chr16:31473205-31477960 [Contig_View]  TGFB1I1 [Vega]
ICGC DataPortalENSG00000140682
TCGA cBioPortalTGFB1I1
AceView (NCBI)TGFB1I1
Genatlas (Paris)TGFB1I1
SOURCE (Princeton)TGFB1I1
Genetics Home Reference (NIH)TGFB1I1
Genomic and cartography
GoldenPath hg38 (UCSC)TGFB1I1  -     chr16:31473205-31477960 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TGFB1I1  -     16p11.2   [Description]    (hg19-Feb_2009)
GoldenPathTGFB1I1 - 16p11.2 [CytoView hg19]  TGFB1I1 - 16p11.2 [CytoView hg38]
ImmunoBaseENSG00000140682
Genome Data Viewer NCBITGFB1I1 [Mapview hg19]  
OMIM602353   
Gene and transcription
Genbank (Entrez)AA992124 AB007836 AF116343 AK122975 AK313327
RefSeq transcript (Entrez)NM_001042454 NM_001164719 NM_015927
Consensus coding sequences : CCDS (NCBI)TGFB1I1
Gene ExpressionTGFB1I1 [ NCBI-GEO ]   TGFB1I1 [ EBI - ARRAY_EXPRESS ]   TGFB1I1 [ SEEK ]   TGFB1I1 [ MEM ]
Gene Expression Viewer (FireBrowse)TGFB1I1 [ Firebrowse - Broad ]
GenevisibleExpression of TGFB1I1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7041
GTEX Portal (Tissue expression)TGFB1I1
Human Protein AtlasENSG00000140682-TGFB1I1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43294   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43294  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43294
PhosPhoSitePlusO43294
Domaine pattern : Prosite (Expaxy)LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)Tgfb1i1/Leupaxin/TGFB1I1    Znf_LIM   
Domain families : Pfam (Sanger)LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00412   
Domain families : Smart (EMBL)LIM (SM00132)  
Conserved Domain (NCBI)TGFB1I1
SuperfamilyO43294
AlphaFold pdb e-kbO43294   
Human Protein Atlas [tissue]ENSG00000140682-TGFB1I1 [tissue]
HPRD03831
Protein Interaction databases
DIP (DOE-UCLA)O43294
IntAct (EBI)O43294
BioGRIDTGFB1I1
STRING (EMBL)TGFB1I1
ZODIACTGFB1I1
Ontologies - Pathways
QuickGOO43294
Ontology : AmiGOtranscription coregulator activity  transcription coactivator activity  transcription coactivator activity  protein binding  cytosol  cytoskeleton  plasma membrane  focal adhesion  focal adhesion  cell adhesion  negative regulation of cell population proliferation  response to heat  positive regulation of epithelial to mesenchymal transition  Wnt signaling pathway  morphogenesis of embryonic epithelium  nuclear matrix  positive regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  ubiquitin-dependent SMAD protein catabolic process  epithelial cell differentiation  cell fate commitment  negative regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  metal ion binding  Roundabout binding  androgen receptor binding  collagen-containing extracellular matrix  I-SMAD binding  
Ontology : EGO-EBItranscription coregulator activity  transcription coactivator activity  transcription coactivator activity  protein binding  cytosol  cytoskeleton  plasma membrane  focal adhesion  focal adhesion  cell adhesion  negative regulation of cell population proliferation  response to heat  positive regulation of epithelial to mesenchymal transition  Wnt signaling pathway  morphogenesis of embryonic epithelium  nuclear matrix  positive regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  ubiquitin-dependent SMAD protein catabolic process  epithelial cell differentiation  cell fate commitment  negative regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  metal ion binding  Roundabout binding  androgen receptor binding  collagen-containing extracellular matrix  I-SMAD binding  
NDEx NetworkTGFB1I1
Atlas of Cancer Signalling NetworkTGFB1I1
Wikipedia pathwaysTGFB1I1
Orthology - Evolution
OrthoDB7041
GeneTree (enSembl)ENSG00000140682
Phylogenetic Trees/Animal Genes : TreeFamTGFB1I1
Homologs : HomoloGeneTGFB1I1
Homology/Alignments : Family Browser (UCSC)TGFB1I1
Gene fusions - Rearrangements
Fusion : QuiverTGFB1I1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTGFB1I1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TGFB1I1
dbVarTGFB1I1
ClinVarTGFB1I1
MonarchTGFB1I1
1000_GenomesTGFB1I1 
Exome Variant ServerTGFB1I1
GNOMAD BrowserENSG00000140682
Varsome BrowserTGFB1I1
ACMGTGFB1I1 variants
VarityO43294
Genomic Variants (DGV)TGFB1I1 [DGVbeta]
DECIPHERTGFB1I1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTGFB1I1 
Mutations
ICGC Data PortalTGFB1I1 
TCGA Data PortalTGFB1I1 
Broad Tumor PortalTGFB1I1
OASIS PortalTGFB1I1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTGFB1I1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTGFB1I1
Mutations and Diseases : HGMDTGFB1I1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTGFB1I1
DgiDB (Drug Gene Interaction Database)TGFB1I1
DoCM (Curated mutations)TGFB1I1
CIViC (Clinical Interpretations of Variants in Cancer)TGFB1I1
Cancer3DTGFB1I1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602353   
Orphanet
DisGeNETTGFB1I1
MedgenTGFB1I1
Genetic Testing Registry TGFB1I1
NextProtO43294 [Medical]
GENETestsTGFB1I1
Target ValidationTGFB1I1
Huge Navigator TGFB1I1 [HugePedia]
ClinGenTGFB1I1
Clinical trials, drugs, therapy
MyCancerGenomeTGFB1I1
Protein Interactions : CTDTGFB1I1
Pharm GKB GenePA36481
PharosO43294
Clinical trialTGFB1I1
Miscellaneous
canSAR (ICR)TGFB1I1
HarmonizomeTGFB1I1
DataMed IndexTGFB1I1
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTGFB1I1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:34:55 CEST 2021

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