Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TGFB1I1 (transforming growth factor beta 1 induced transcript 1)

Identity

Alias_symbol (synonym)Hic-5
TSC-5
ARA55
HIC-5
Other aliasHIC5
HGNC (Hugo) TGFB1I1
LocusID (NCBI) 7041
Atlas_Id 42535
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 31472155 and ends at 31477960 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;21)(q21;q22) RUNX1/LPXN


External links

Nomenclature
HGNC (Hugo)TGFB1I1   11767
Cards
Entrez_Gene (NCBI)TGFB1I1  7041  transforming growth factor beta 1 induced transcript 1
AliasesARA55; HIC-5; HIC5; TSC-5
GeneCards (Weizmann)TGFB1I1
Ensembl hg19 (Hinxton)ENSG00000140682 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140682 [Gene_View]  chr16:31472155-31477960 [Contig_View]  TGFB1I1 [Vega]
ICGC DataPortalENSG00000140682
TCGA cBioPortalTGFB1I1
AceView (NCBI)TGFB1I1
Genatlas (Paris)TGFB1I1
WikiGenes7041
SOURCE (Princeton)TGFB1I1
Genetics Home Reference (NIH)TGFB1I1
Genomic and cartography
GoldenPath hg38 (UCSC)TGFB1I1  -     chr16:31472155-31477960 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TGFB1I1  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblTGFB1I1 - 16p11.2 [CytoView hg19]  TGFB1I1 - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBITGFB1I1 [Mapview hg19]  TGFB1I1 [Mapview hg38]
OMIM602353   
Gene and transcription
Genbank (Entrez)AA992124 AB007836 AF116343 AK122975 AK313327
RefSeq transcript (Entrez)NM_001042454 NM_001164719 NM_015927
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TGFB1I1
Cluster EST : UnigeneHs.513530 [ NCBI ]
CGAP (NCI)Hs.513530
Alternative Splicing GalleryENSG00000140682
Gene ExpressionTGFB1I1 [ NCBI-GEO ]   TGFB1I1 [ EBI - ARRAY_EXPRESS ]   TGFB1I1 [ SEEK ]   TGFB1I1 [ MEM ]
Gene Expression Viewer (FireBrowse)TGFB1I1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7041
GTEX Portal (Tissue expression)TGFB1I1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43294   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43294  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43294
Splice isoforms : SwissVarO43294
PhosPhoSitePlusO43294
Domaine pattern : Prosite (Expaxy)LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)Tgfb1i1/Leupaxin    Znf_LIM   
Domain families : Pfam (Sanger)LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00412   
Domain families : Smart (EMBL)LIM (SM00132)  
Conserved Domain (NCBI)TGFB1I1
DMDM Disease mutations7041
Blocks (Seattle)TGFB1I1
SuperfamilyO43294
Human Protein AtlasENSG00000140682
Peptide AtlasO43294
HPRD03831
IPIIPI00761017   IPI00396399   
Protein Interaction databases
DIP (DOE-UCLA)O43294
IntAct (EBI)O43294
FunCoupENSG00000140682
BioGRIDTGFB1I1
STRING (EMBL)TGFB1I1
ZODIACTGFB1I1
Ontologies - Pathways
QuickGOO43294
Ontology : AmiGOtranscription coactivator activity  transcription coactivator activity  protein binding  intracellular  cytoplasm  cytoskeleton  focal adhesion  transcription from RNA polymerase II promoter  cell adhesion  zinc ion binding  negative regulation of cell proliferation  response to heat  positive regulation of epithelial to mesenchymal transition  Wnt signaling pathway  morphogenesis of embryonic epithelium  nuclear matrix  positive regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  androgen receptor signaling pathway  ubiquitin-dependent SMAD protein catabolic process  epithelial cell differentiation  extracellular matrix  cell fate commitment  negative regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  Roundabout binding  androgen receptor binding  androgen receptor binding  I-SMAD binding  
Ontology : EGO-EBItranscription coactivator activity  transcription coactivator activity  protein binding  intracellular  cytoplasm  cytoskeleton  focal adhesion  transcription from RNA polymerase II promoter  cell adhesion  zinc ion binding  negative regulation of cell proliferation  response to heat  positive regulation of epithelial to mesenchymal transition  Wnt signaling pathway  morphogenesis of embryonic epithelium  nuclear matrix  positive regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  androgen receptor signaling pathway  ubiquitin-dependent SMAD protein catabolic process  epithelial cell differentiation  extracellular matrix  cell fate commitment  negative regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  Roundabout binding  androgen receptor binding  androgen receptor binding  I-SMAD binding  
NDEx NetworkTGFB1I1
Atlas of Cancer Signalling NetworkTGFB1I1
Wikipedia pathwaysTGFB1I1
Orthology - Evolution
OrthoDB7041
GeneTree (enSembl)ENSG00000140682
Phylogenetic Trees/Animal Genes : TreeFamTGFB1I1
HOVERGENO43294
HOGENOMO43294
Homologs : HomoloGeneTGFB1I1
Homology/Alignments : Family Browser (UCSC)TGFB1I1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTGFB1I1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TGFB1I1
dbVarTGFB1I1
ClinVarTGFB1I1
1000_GenomesTGFB1I1 
Exome Variant ServerTGFB1I1
ExAC (Exome Aggregation Consortium)TGFB1I1 (select the gene name)
Genetic variants : HAPMAP7041
Genomic Variants (DGV)TGFB1I1 [DGVbeta]
DECIPHERTGFB1I1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTGFB1I1 
Mutations
ICGC Data PortalTGFB1I1 
TCGA Data PortalTGFB1I1 
Broad Tumor PortalTGFB1I1
OASIS PortalTGFB1I1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTGFB1I1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTGFB1I1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TGFB1I1
DgiDB (Drug Gene Interaction Database)TGFB1I1
DoCM (Curated mutations)TGFB1I1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TGFB1I1 (select a term)
intoGenTGFB1I1
Cancer3DTGFB1I1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602353   
Orphanet
MedgenTGFB1I1
Genetic Testing Registry TGFB1I1
NextProtO43294 [Medical]
TSGene7041
GENETestsTGFB1I1
Target ValidationTGFB1I1
Huge Navigator TGFB1I1 [HugePedia]
snp3D : Map Gene to Disease7041
BioCentury BCIQTGFB1I1
ClinGenTGFB1I1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7041
Chemical/Pharm GKB GenePA36481
Clinical trialTGFB1I1
Miscellaneous
canSAR (ICR)TGFB1I1 (select the gene name)
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTGFB1I1
EVEXTGFB1I1
GoPubMedTGFB1I1
iHOPTGFB1I1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:34:50 CEST 2017

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