Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TGFB2 (transforming growth factor beta 2)

Identity

Alias_namestransforming growth factor
Other aliasG-TSF
LDS4
TGF-beta2
HGNC (Hugo) TGFB2
LocusID (NCBI) 7042
Atlas_Id 42537
Location 1q41  [Link to chromosome band 1q41]
Location_base_pair Starts at 218345284 and ends at 218444619 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TGFB2 (1q41) / CDH2 (18q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Colon: Colorectal adenocarcinoma

External links

Nomenclature
HGNC (Hugo)TGFB2   11768
Cards
Entrez_Gene (NCBI)TGFB2  7042  transforming growth factor beta 2
AliasesG-TSF; LDS4; TGF-beta2
GeneCards (Weizmann)TGFB2
Ensembl hg19 (Hinxton)ENSG00000092969 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000092969 [Gene_View]  chr1:218345284-218444619 [Contig_View]  TGFB2 [Vega]
ICGC DataPortalENSG00000092969
TCGA cBioPortalTGFB2
AceView (NCBI)TGFB2
Genatlas (Paris)TGFB2
WikiGenes7042
SOURCE (Princeton)TGFB2
Genetics Home Reference (NIH)TGFB2
Genomic and cartography
GoldenPath hg38 (UCSC)TGFB2  -     chr1:218345284-218444619 +  1q41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TGFB2  -     1q41   [Description]    (hg19-Feb_2009)
EnsemblTGFB2 - 1q41 [CytoView hg19]  TGFB2 - 1q41 [CytoView hg38]
Mapping of homologs : NCBITGFB2 [Mapview hg19]  TGFB2 [Mapview hg38]
OMIM190220   614816   
Gene and transcription
Genbank (Entrez)AB209842 AK295671 AK296504 AK299839 AK313106
RefSeq transcript (Entrez)NM_001135599 NM_003238
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TGFB2
Cluster EST : UnigeneHs.133379 [ NCBI ]
CGAP (NCI)Hs.133379
Alternative Splicing GalleryENSG00000092969
Gene ExpressionTGFB2 [ NCBI-GEO ]   TGFB2 [ EBI - ARRAY_EXPRESS ]   TGFB2 [ SEEK ]   TGFB2 [ MEM ]
Gene Expression Viewer (FireBrowse)TGFB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7042
GTEX Portal (Tissue expression)TGFB2
Human Protein AtlasENSG00000092969-TGFB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61812   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61812  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61812
Splice isoforms : SwissVarP61812
PhosPhoSitePlusP61812
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    TGF-b_C    TGF-b_propeptide    TGF-beta    TGF-beta-rel    TGFb2    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)TGFB2
DMDM Disease mutations7042
Blocks (Seattle)TGFB2
PDB (SRS)1TFG    2TGI    4KXZ   
PDB (PDBSum)1TFG    2TGI    4KXZ   
PDB (IMB)1TFG    2TGI    4KXZ   
PDB (RSDB)1TFG    2TGI    4KXZ   
Structural Biology KnowledgeBase1TFG    2TGI    4KXZ   
SCOP (Structural Classification of Proteins)1TFG    2TGI    4KXZ   
CATH (Classification of proteins structures)1TFG    2TGI    4KXZ   
SuperfamilyP61812
Human Protein Atlas [tissue]ENSG00000092969-TGFB2 [tissue]
Peptide AtlasP61812
HPRD01828
IPIIPI00235354   IPI00220156   IPI00556200   
Protein Interaction databases
DIP (DOE-UCLA)P61812
IntAct (EBI)P61812
FunCoupENSG00000092969
BioGRIDTGFB2
STRING (EMBL)TGFB2
ZODIACTGFB2
Ontologies - Pathways
QuickGOP61812
Ontology : AmiGOcell morphogenesis  skeletal system development  angiogenesis  amyloid-beta binding  eye development  response to hypoxia  kidney development  epithelial to mesenchymal transition  epithelial to mesenchymal transition  neural tube closure  hair follicle development  hair follicle development  platelet degranulation  heart morphogenesis  outflow tract septum morphogenesis  membranous septum morphogenesis  heart valve morphogenesis  atrioventricular valve morphogenesis  pulmonary valve morphogenesis  endocardial cushion morphogenesis  cardiac right ventricle morphogenesis  ventricular trabecula myocardium morphogenesis  endocardial cushion fusion  atrial septum primum morphogenesis  neural retina development  receptor binding  type II transforming growth factor beta receptor binding  type II transforming growth factor beta receptor binding  type II transforming growth factor beta receptor binding  cytokine activity  transforming growth factor beta receptor binding  protein binding  extracellular region  extracellular region  extracellular space  protein phosphorylation  cell cycle arrest  transforming growth factor beta receptor signaling pathway  cell-cell signaling  salivary gland morphogenesis  heart development  growth factor activity  cell death  cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  glial cell migration  male gonad development  response to wounding  embryo development ending in birth or egg hatching  cardioblast differentiation  regulation of receptor activity  negative regulation of gene expression  positive regulation of epithelial cell migration  negative regulation of alkaline phosphatase activity  positive regulation of epithelial to mesenchymal transition  positive regulation of pathway-restricted SMAD protein phosphorylation  negative regulation of macrophage cytokine production  positive regulation of phosphatidylinositol 3-kinase signaling  cell growth  cell migration  negative regulation of angiogenesis  hemopoiesis  collagen fibril organization  positive regulation of cell growth  negative regulation of cell growth  embryonic limb morphogenesis  axon  BMP signaling pathway  neutrophil chemotaxis  neutrophil chemotaxis  extracellular matrix  hair follicle morphogenesis  platelet alpha granule lumen  activation of protein kinase activity  response to progesterone  positive regulation of stress-activated MAPK cascade  regulation of transforming growth factor beta2 production  positive regulation of cell adhesion mediated by integrin  type III transforming growth factor beta receptor binding  type III transforming growth factor beta receptor binding  ascending aorta morphogenesis  wound healing  dopamine biosynthetic process  odontogenesis  response to drug  uterine wall breakdown  protein homodimerization activity  neuronal cell body  positive regulation of neuron apoptotic process  cell-cell junction organization  positive regulation of integrin biosynthetic process  positive regulation of Notch signaling pathway  positive regulation of ossification  positive regulation of cell cycle  positive regulation of heart contraction  negative regulation of Ras protein signal transduction  protein heterodimerization activity  somatic stem cell division  cell development  embryonic digestive tract development  neuron development  generation of neurons  inner ear development  negative regulation of epithelial cell proliferation  negative regulation of epithelial cell proliferation  positive regulation of protein secretion  negative regulation of immune response  positive regulation of immune response  positive regulation of cell division  regulation of timing of catagen  positive regulation of timing of catagen  positive regulation of cardioblast differentiation  palate development  cardiac muscle cell proliferation  uterus development  cardiac epithelial to mesenchymal transition  pathway-restricted SMAD protein phosphorylation  SMAD protein signal transduction  SMAD protein signal transduction  ventricular septum morphogenesis  atrial septum morphogenesis  pharyngeal arch artery morphogenesis  extrinsic apoptotic signaling pathway  regulation of apoptotic process involved in outflow tract morphogenesis  positive regulation of pri-miRNA transcription by RNA polymerase II  regulation of complement-dependent cytotoxicity  substantia propria of cornea development  cranial skeletal system development  negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  
Ontology : EGO-EBIcell morphogenesis  skeletal system development  angiogenesis  amyloid-beta binding  eye development  response to hypoxia  kidney development  epithelial to mesenchymal transition  epithelial to mesenchymal transition  neural tube closure  hair follicle development  hair follicle development  platelet degranulation  heart morphogenesis  outflow tract septum morphogenesis  membranous septum morphogenesis  heart valve morphogenesis  atrioventricular valve morphogenesis  pulmonary valve morphogenesis  endocardial cushion morphogenesis  cardiac right ventricle morphogenesis  ventricular trabecula myocardium morphogenesis  endocardial cushion fusion  atrial septum primum morphogenesis  neural retina development  receptor binding  type II transforming growth factor beta receptor binding  type II transforming growth factor beta receptor binding  type II transforming growth factor beta receptor binding  cytokine activity  transforming growth factor beta receptor binding  protein binding  extracellular region  extracellular region  extracellular space  protein phosphorylation  cell cycle arrest  transforming growth factor beta receptor signaling pathway  cell-cell signaling  salivary gland morphogenesis  heart development  growth factor activity  cell death  cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  glial cell migration  male gonad development  response to wounding  embryo development ending in birth or egg hatching  cardioblast differentiation  regulation of receptor activity  negative regulation of gene expression  positive regulation of epithelial cell migration  negative regulation of alkaline phosphatase activity  positive regulation of epithelial to mesenchymal transition  positive regulation of pathway-restricted SMAD protein phosphorylation  negative regulation of macrophage cytokine production  positive regulation of phosphatidylinositol 3-kinase signaling  cell growth  cell migration  negative regulation of angiogenesis  hemopoiesis  collagen fibril organization  positive regulation of cell growth  negative regulation of cell growth  embryonic limb morphogenesis  axon  BMP signaling pathway  neutrophil chemotaxis  neutrophil chemotaxis  extracellular matrix  hair follicle morphogenesis  platelet alpha granule lumen  activation of protein kinase activity  response to progesterone  positive regulation of stress-activated MAPK cascade  regulation of transforming growth factor beta2 production  positive regulation of cell adhesion mediated by integrin  type III transforming growth factor beta receptor binding  type III transforming growth factor beta receptor binding  ascending aorta morphogenesis  wound healing  dopamine biosynthetic process  odontogenesis  response to drug  uterine wall breakdown  protein homodimerization activity  neuronal cell body  positive regulation of neuron apoptotic process  cell-cell junction organization  positive regulation of integrin biosynthetic process  positive regulation of Notch signaling pathway  positive regulation of ossification  positive regulation of cell cycle  positive regulation of heart contraction  negative regulation of Ras protein signal transduction  protein heterodimerization activity  somatic stem cell division  cell development  embryonic digestive tract development  neuron development  generation of neurons  inner ear development  negative regulation of epithelial cell proliferation  negative regulation of epithelial cell proliferation  positive regulation of protein secretion  negative regulation of immune response  positive regulation of immune response  positive regulation of cell division  regulation of timing of catagen  positive regulation of timing of catagen  positive regulation of cardioblast differentiation  palate development  cardiac muscle cell proliferation  uterus development  cardiac epithelial to mesenchymal transition  pathway-restricted SMAD protein phosphorylation  SMAD protein signal transduction  SMAD protein signal transduction  ventricular septum morphogenesis  atrial septum morphogenesis  pharyngeal arch artery morphogenesis  extrinsic apoptotic signaling pathway  regulation of apoptotic process involved in outflow tract morphogenesis  positive regulation of pri-miRNA transcription by RNA polymerase II  regulation of complement-dependent cytotoxicity  substantia propria of cornea development  cranial skeletal system development  negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  
Pathways : BIOCARTACell Cycle: G1/S Check Point [Genes]    ALK in cardiac myocytes [Genes]    Cytokines and Inflammatory Response [Genes]    Signal transduction through IL1R [Genes]    TGF beta signaling pathway [Genes]    Role of Tob in T-cell activation [Genes]    Erythrocyte Differentiation Pathway [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]    p38 MAPK Signaling Pathway [Genes]    Function of SLRP in Bone: An Integrated View [Genes]    CTCF: First Multivalent Nuclear Factor [Genes]    MAPKinase Signaling Pathway [Genes]   
Pathways : KEGGTGF-beta signaling pathway    Cytokine-cytokine receptor interaction    Colorectal cancer    Cell cycle    MAPK signaling pathway   
NDEx NetworkTGFB2
Atlas of Cancer Signalling NetworkTGFB2
Wikipedia pathwaysTGFB2
Orthology - Evolution
OrthoDB7042
GeneTree (enSembl)ENSG00000092969
Phylogenetic Trees/Animal Genes : TreeFamTGFB2
HOVERGENP61812
HOGENOMP61812
Homologs : HomoloGeneTGFB2
Homology/Alignments : Family Browser (UCSC)TGFB2
Gene fusions - Rearrangements
Fusion : QuiverTGFB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTGFB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TGFB2
dbVarTGFB2
ClinVarTGFB2
1000_GenomesTGFB2 
Exome Variant ServerTGFB2
ExAC (Exome Aggregation Consortium)ENSG00000092969
GNOMAD BrowserENSG00000092969
Genetic variants : HAPMAP7042
Genomic Variants (DGV)TGFB2 [DGVbeta]
DECIPHERTGFB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTGFB2 
Mutations
ICGC Data PortalTGFB2 
TCGA Data PortalTGFB2 
Broad Tumor PortalTGFB2
OASIS PortalTGFB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTGFB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTGFB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch TGFB2
DgiDB (Drug Gene Interaction Database)TGFB2
DoCM (Curated mutations)TGFB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TGFB2 (select a term)
intoGenTGFB2
Cancer3DTGFB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM190220    614816   
Orphanet2590    12138   
DisGeNETTGFB2
MedgenTGFB2
Genetic Testing Registry TGFB2
NextProtP61812 [Medical]
TSGene7042
GENETestsTGFB2
Target ValidationTGFB2
Huge Navigator TGFB2 [HugePedia]
snp3D : Map Gene to Disease7042
BioCentury BCIQTGFB2
ClinGenTGFB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7042
Chemical/Pharm GKB GenePA36482
Clinical trialTGFB2
Miscellaneous
canSAR (ICR)TGFB2 (select the gene name)
Probes
Litterature
PubMed276 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTGFB2
EVEXTGFB2
GoPubMedTGFB2
iHOPTGFB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:41:29 CET 2018
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