| Nomenclature | | HGNC (Hugo) | TGFBR1 11772 |
| Cards | | Entrez_Gene (NCBI) | TGFBR1 7046 transforming growth factor, beta receptor 1 |
| GeneCards (Weizmann) | TGFBR1 |
| Ensembl (Hinxton) | ENSG00000106799 [Gene_View] chr9:101867412-101916473 [Contig_View] TGFBR1 [Vega] |
| AceView (NCBI) | TGFBR1 |
| Genatlas (Paris) | TGFBR1 |
| WikiGenes | 7046 |
| SOURCE (Princeton) | NM_001130916 NM_004612 |
| Genomic and cartography | | GoldenPath (UCSC) | TGFBR1 - 9q22.33 chr9:101867412-101916473 + 9q22.33 [Description] (hg19-Feb_2009) |
| Ensembl | TGFBR1 - 9q22.33 [CytoView] |
| Mapping of homologs : NCBI | TGFBR1 [Mapview] |
| OMIM | 132800 190181 608967 609129 609192 |
| Gene and transcription |
| Genbank (Entrez) | AJ420419 AJ619019 AJ619020 AK002171 AK129793 |
| RefSeq transcript (Entrez) | NM_001130916 NM_004612 |
| RefSeq genomic (Entrez) | AC_000141 NC_000009 NC_018920 NG_007461 NT_008470 NW_001839236 NW_004929366 |
| Consensus coding sequences : CCDS (NCBI) | TGFBR1 |
| Cluster EST : Unigene | Hs.494622 [ NCBI ] |
| CGAP (NCI) | Hs.494622 |
| Alternative Splicing : Fast-db (Paris) | GSHG0030313 |
| Alternative Splicing Gallery | ENSG00000106799 |
| Gene Expression | TGFBR1 [ NCBI-GEO ] TGFBR1 [ SEEK ] TGFBR1 [ MEM ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P36897 (Uniprot) |
| NextProt | P36897 [Medical] |
| With graphics : InterPro | P36897 |
| Splice isoforms : SwissVar | P36897 (Swissvar) |
| Catalytic activity : Enzyme | 2.7.11.30 [ Enzyme-Expasy ] 2.7.11.302.7.11.30 [ IntEnz-EBI ] 2.7.11.30 [ BRENDA ] 2.7.11.30 [ KEGG ] |
| Domaine pattern : Prosite (Expaxy) | GS (PS51256) PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) |
| Domains : Interpro (EBI) | Activin_rcpt Kinase-like_dom Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_kinase_AS TGF_beta_rcpt_GS |
| Related proteins : CluSTr | P36897 |
| Domain families : Pfam (Sanger) | Activin_recp (PF01064) Pkinase (PF00069) TGF_beta_GS (PF08515) |
| Domain families : Pfam (NCBI) | pfam01064 pfam00069 pfam08515 |
| Domain families : Smart (EMBL) | GS (SM00467) |
| DMDM Disease mutations | 7046 |
| Blocks (Seattle) | P36897 |
| PDB (SRS) | 1B6C 1IAS 1PY5 1RW8 1TBI 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM |
| PDB (PDBSum) | 1B6C 1IAS 1PY5 1RW8 1TBI 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM |
| PDB (IMB) | 1B6C 1IAS 1PY5 1RW8 1TBI 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM |
| PDB (RSDB) | 1B6C 1IAS 1PY5 1RW8 1TBI 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM |
| Human Protein Atlas | ENSG00000106799 |
| Peptide Atlas | P36897 |
| HPRD | 01822 |
| IPI | IPI00005733 IPI01018344 IPI00844074 IPI01014570 IPI01010650 IPI01021053 IPI01021173 IPI01022170 IPI01022370 IPI01021295 IPI01022749 IPI01022905 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P36897 |
| IntAct (EBI) | P36897 |
| FunCoup | ENSG00000106799 |
| BioGRID | TGFBR1 |
| InParanoid | P36897 |
| Interologous Interaction database | P36897 |
| IntegromeDB | TGFBR1 |
| STRING (EMBL) | TGFBR1 |
| Ontologies - Pathways | | Ontology : AmiGO | activation of MAPKK activity skeletal system development angiogenesis in utero embryonic development kidney development blastocyst development epithelial to mesenchymal transition negative regulation of endothelial cell proliferation lens development in camera-type eye protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta-activated receptor activity transforming growth factor beta-activated receptor activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I type II transforming growth factor beta receptor binding type II transforming growth factor beta receptor binding protein binding ATP binding plasma membrane plasma membrane tight junction regulation of transcription, DNA-dependent regulation of transcription, DNA-dependent protein phosphorylation apoptotic process cell cycle arrest signal transduction transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway heart development positive regulation of cell proliferation germ cell migration post-embryonic development anterior/posterior pattern specification positive regulation of pathway-restricted SMAD protein phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation growth factor binding collagen fibril organization positive regulation of cell growth negative regulation of transforming growth factor beta receptor signaling pathway regulation of protein ubiquitination negative regulation of chondrocyte differentiation wound healing extracellular structure organization negative regulation of apoptotic process receptor complex regulation of protein binding endothelial cell migration positive regulation of transcription, DNA-dependent SMAD binding SMAD binding metal ion binding thymus development neuron fate commitment embryonic cranial skeleton morphogenesis skeletal system morphogenesis mesenchymal cell differentiation artery morphogenesis cell motility transforming growth factor beta binding transforming growth factor beta binding transforming growth factor beta binding positive regulation of cellular component movement positive regulation of filopodium assembly positive regulation of protein kinase B signaling cascade parathyroid gland development palate development pharyngeal system development pathway-restricted SMAD protein phosphorylation positive regulation of SMAD protein import into nucleus transforming growth factor beta receptor homodimeric complex I-SMAD binding response to cholesterol cellular response to transforming growth factor beta stimulus positive regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway |
| Ontology : EGO-EBI | activation of MAPKK activity skeletal system development angiogenesis in utero embryonic development kidney development blastocyst development epithelial to mesenchymal transition negative regulation of endothelial cell proliferation lens development in camera-type eye protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta-activated receptor activity transforming growth factor beta-activated receptor activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I type II transforming growth factor beta receptor binding type II transforming growth factor beta receptor binding protein binding ATP binding plasma membrane plasma membrane tight junction regulation of transcription, DNA-dependent regulation of transcription, DNA-dependent protein phosphorylation apoptotic process cell cycle arrest signal transduction transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway heart development positive regulation of cell proliferation germ cell migration post-embryonic development anterior/posterior pattern specification positive regulation of pathway-restricted SMAD protein phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation growth factor binding collagen fibril organization positive regulation of cell growth negative regulation of transforming growth factor beta receptor signaling pathway regulation of protein ubiquitination negative regulation of chondrocyte differentiation wound healing extracellular structure organization negative regulation of apoptotic process receptor complex regulation of protein binding endothelial cell migration positive regulation of transcription, DNA-dependent SMAD binding SMAD binding metal ion binding thymus development neuron fate commitment embryonic cranial skeleton morphogenesis skeletal system morphogenesis mesenchymal cell differentiation artery morphogenesis cell motility transforming growth factor beta binding transforming growth factor beta binding transforming growth factor beta binding positive regulation of cellular component movement positive regulation of filopodium assembly positive regulation of protein kinase B signaling cascade parathyroid gland development palate development pharyngeal system development pathway-restricted SMAD protein phosphorylation positive regulation of SMAD protein import into nucleus transforming growth factor beta receptor homodimeric complex I-SMAD binding response to cholesterol cellular response to transforming growth factor beta stimulus positive regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway |
| Pathways : BIOCARTA | Role of Tob in T-cell activation [Genes] MAPKinase Signaling Pathway [Genes] NFkB activation by Nontypeable Hemophilus influenzae [Genes] CTCF: First Multivalent Nuclear Factor [Genes] TGF beta signaling pathway [Genes] ALK in cardiac myocytes [Genes] Function of SLRP in Bone: An Integrated View [Genes] p38 MAPK Signaling Pathway [Genes] |
| Pathways : KEGG | Cytokine-cytokine receptor interaction Colorectal cancer Adherens junction TGF-beta signaling pathway MAPK signaling pathway |
| REACTOME | TGFBR1 |
| Protein Interaction Database | TGFBR1 |
| Wikipedia pathways | TGFBR1 |
| Gene fusion - rearrangments | | Polymorphisms : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | TGFBR1 |
| SNP (GeneSNP Utah) | TGFBR1 |
| SNP : HGBase | TGFBR1 |
| Genetic variants : HAPMAP | TGFBR1 |
| 1000_Genomes | TGFBR1 |
| ICGC program | ENSG00000106799 |
| Somatic Mutations in Cancer : COSMIC | TGFBR1 |
| CONAN: Copy Number Analysis | TGFBR1 |
| Mutations and Diseases : HGMD | TGFBR1 |
| OMIM | 132800 190181 608967 609129 609192 |
| GENETests | TGFBR1 |
| Disease Genetic Association | TGFBR1 |
| Huge Navigator |
TGFBR1 [HugePedia] TGFBR1 [HugeCancerGEM] |
| Genomic Variants | TGFBR1 TGFBR1 [DGVbeta] |
| Exome Variant | TGFBR1 |
| dbVar | TGFBR1 |
| ClinVar | TGFBR1 |
| snp3D : Map Gene to Disease | 7046 |
| General knowledge |
|---|
| Homologs : HomoloGene | TGFBR1 |
| Homology/Alignments : Family Browser (UCSC) | TGFBR1 |
| Phylogenetic Trees/Animal Genes : TreeFam | TGFBR1 |
| Chemical/Protein Interactions : CTD | 7046 |
| Chemical/Pharm GKB Gene | PA36485 |
| Clinical trial | TGFBR1 |
| Cancer Resource (Charite) | ENSG00000106799 |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 357 Pubmed reference(s) in Entrez |
| CoreMine | TGFBR1 |
| iHOP | TGFBR1 |
