Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TGFBR2 (transforming growth factor, beta receptor II (70/80kDa))

Identity

Other namesAAT3
FAA3
LDS1B
LDS2B
MFS2
RIIC
TAAD2
TGFR-2
TGFbeta-RII
HGNC (Hugo) TGFBR2
LocusID (NCBI) 7048
Location 3p24.1
Location_base_pair Starts at 30647994 and ends at 30735633 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TGFBR2   11773
Cards
Entrez_Gene (NCBI)TGFBR2  7048  transforming growth factor, beta receptor II (70/80kDa)
GeneCards (Weizmann)TGFBR2
Ensembl (Hinxton)ENSG00000163513 [Gene_View]  chr3:30647994-30735633 [Contig_View]  TGFBR2 [Vega]
AceView (NCBI)TGFBR2
Genatlas (Paris)TGFBR2
WikiGenes7048
SOURCE (Princeton)NM_001024847 NM_003242
Genomic and cartography
GoldenPath (UCSC)TGFBR2  -  3p24.1   chr3:30647994-30735633 +  3p24.1   [Description]    (hg19-Feb_2009)
EnsemblTGFBR2 - 3p24.1 [CytoView]
Mapping of homologs : NCBITGFBR2 [Mapview]
OMIM133239   190182   610168   610380   614331   
Gene and transcription
Genbank (Entrez)AI279872 AJ786388 AK300383 AK304404 AK314102
RefSeq transcript (Entrez)NM_001024847 NM_003242
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_007490 NT_022517 NW_001838877 NW_004929309
Consensus coding sequences : CCDS (NCBI)TGFBR2
Cluster EST : UnigeneHs.604277 [ NCBI ]
CGAP (NCI)Hs.604277
Alternative Splicing : Fast-db (Paris)GSHG0020667
Alternative Splicing GalleryENSG00000163513
Gene ExpressionTGFBR2 [ NCBI-GEO ]     TGFBR2 [ SEEK ]   TGFBR2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP37173 (Uniprot)
NextProtP37173  [Medical]
With graphics : InterProP37173
Splice isoforms : SwissVarP37173 (Swissvar)
Catalytic activity : Enzyme2.7.11.30 [ Enzyme-Expasy ]   2.7.11.302.7.11.30 [ IntEnz-EBI ]   2.7.11.30 [ BRENDA ]   2.7.11.30 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    TGFB_receptor    Transform_growth_fac-b_typ-2    Transforming_GF_b_rcpt_2_ecto   
Related proteins : CluSTrP37173
Domain families : Pfam (Sanger)ecTbetaR2 (PF08917)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam08917    pfam00069   
DMDM Disease mutations7048
Blocks (Seattle)P37173
PDB (SRS)1KTZ    1M9Z    1PLO    2PJY    3KFD   
PDB (PDBSum)1KTZ    1M9Z    1PLO    2PJY    3KFD   
PDB (IMB)1KTZ    1M9Z    1PLO    2PJY    3KFD   
PDB (RSDB)1KTZ    1M9Z    1PLO    2PJY    3KFD   
Human Protein AtlasENSG00000163513
Peptide AtlasP37173
HPRD01823
IPIIPI00020431   IPI00164934   IPI00909103   IPI00465333   
Protein Interaction databases
DIP (DOE-UCLA)P37173
IntAct (EBI)P37173
FunCoupENSG00000163513
BioGRIDTGFBR2
InParanoidP37173
Interologous Interaction database P37173
IntegromeDBTGFBR2
STRING (EMBL)TGFBR2
Ontologies - Pathways
Ontology : AmiGOblood vessel development  patterning of blood vessels  vasculogenesis  in utero embryonic development  positive regulation of mesenchymal cell proliferation  lens development in camera-type eye  positive regulation of tolerance induction to self antigen  positive regulation of B cell tolerance induction  positive regulation of T cell tolerance induction  transmembrane receptor protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  transforming growth factor beta-activated receptor activity  transforming growth factor beta-activated receptor activity  transforming growth factor beta-activated receptor activity  transforming growth factor beta receptor activity, type II  protein binding  protein binding  ATP binding  glycosaminoglycan binding  cytosol  plasma membrane  caveola  protein phosphorylation  receptor-mediated endocytosis  apoptotic process  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  common-partner SMAD protein phosphorylation  smoothened signaling pathway  gastrulation  brain development  heart development  embryo implantation  aging  response to nutrient  positive regulation of cell proliferation  response to mechanical stimulus  response to glucose  external side of plasma membrane  positive regulation of epithelial cell migration  integral to membrane  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  negative regulation of transforming growth factor beta receptor signaling pathway  organ regeneration  mitogen-activated protein kinase kinase kinase binding  activation of protein kinase activity  type I transforming growth factor beta receptor binding  type I transforming growth factor beta receptor binding  type III transforming growth factor beta receptor binding  embryonic hemopoiesis  wound healing  regulation of cell proliferation  response to drug  myeloid dendritic cell differentiation  receptor complex  positive regulation of skeletal muscle tissue regeneration  response to estrogen  SMAD binding  metal ion binding  digestive tract development  positive regulation of smooth muscle cell proliferation  embryonic cranial skeleton morphogenesis  transforming growth factor beta binding  transforming growth factor beta binding  positive regulation of NK T cell differentiation  cartilage development  palate development  negative regulation of cardiac muscle cell proliferation  pathway-restricted SMAD protein phosphorylation  bronchus morphogenesis  trachea formation  mammary gland morphogenesis  lung lobe morphogenesis  transforming growth factor beta receptor homodimeric complex  response to cholesterol  positive regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIblood vessel development  patterning of blood vessels  vasculogenesis  in utero embryonic development  positive regulation of mesenchymal cell proliferation  lens development in camera-type eye  positive regulation of tolerance induction to self antigen  positive regulation of B cell tolerance induction  positive regulation of T cell tolerance induction  transmembrane receptor protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  transforming growth factor beta-activated receptor activity  transforming growth factor beta-activated receptor activity  transforming growth factor beta-activated receptor activity  transforming growth factor beta receptor activity, type II  protein binding  protein binding  ATP binding  glycosaminoglycan binding  cytosol  plasma membrane  caveola  protein phosphorylation  receptor-mediated endocytosis  apoptotic process  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  common-partner SMAD protein phosphorylation  smoothened signaling pathway  gastrulation  brain development  heart development  embryo implantation  aging  response to nutrient  positive regulation of cell proliferation  response to mechanical stimulus  response to glucose  external side of plasma membrane  positive regulation of epithelial cell migration  integral to membrane  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  negative regulation of transforming growth factor beta receptor signaling pathway  organ regeneration  mitogen-activated protein kinase kinase kinase binding  activation of protein kinase activity  type I transforming growth factor beta receptor binding  type I transforming growth factor beta receptor binding  type III transforming growth factor beta receptor binding  embryonic hemopoiesis  wound healing  regulation of cell proliferation  response to drug  myeloid dendritic cell differentiation  receptor complex  positive regulation of skeletal muscle tissue regeneration  response to estrogen  SMAD binding  metal ion binding  digestive tract development  positive regulation of smooth muscle cell proliferation  embryonic cranial skeleton morphogenesis  transforming growth factor beta binding  transforming growth factor beta binding  positive regulation of NK T cell differentiation  cartilage development  palate development  negative regulation of cardiac muscle cell proliferation  pathway-restricted SMAD protein phosphorylation  bronchus morphogenesis  trachea formation  mammary gland morphogenesis  lung lobe morphogenesis  transforming growth factor beta receptor homodimeric complex  response to cholesterol  positive regulation of reactive oxygen species metabolic process  
Pathways : BIOCARTATGF beta signaling pathway [Genes]    NFkB activation by Nontypeable Hemophilus influenzae [Genes]    ALK in cardiac myocytes [Genes]    CTCF: First Multivalent Nuclear Factor [Genes]    Role of Tob in T-cell activation [Genes]   
Pathways : KEGGMAPK signaling pathway    Cytokine-cytokine receptor interaction    FoxO signaling pathway    Endocytosis    TGF-beta signaling pathway    Osteoclast differentiation    Hippo signaling pathway    Adherens junction    Chagas disease (American trypanosomiasis)    HTLV-I infection    Pathways in cancer    Transcriptional misregulation in cancer    Colorectal cancer    Pancreatic cancer    Chronic myeloid leukemia   
REACTOMETGFBR2
Protein Interaction DatabaseTGFBR2
Wikipedia pathwaysTGFBR2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TGFBR2
SNP (GeneSNP Utah)TGFBR2
SNP : HGBaseTGFBR2
Genetic variants : HAPMAPTGFBR2
1000_GenomesTGFBR2 
ICGC programENSG00000163513 
Somatic Mutations in Cancer : COSMICTGFBR2 
CONAN: Copy Number AnalysisTGFBR2 
Mutations and Diseases : HGMDTGFBR2
OMIM133239    190182    610168    610380    614331   
GENETestsTGFBR2
Disease Genetic AssociationTGFBR2
Huge Navigator TGFBR2 [HugePedia]  TGFBR2 [HugeCancerGEM]
Genomic VariantsTGFBR2  TGFBR2 [DGVbeta]
Exome VariantTGFBR2
dbVarTGFBR2
ClinVarTGFBR2
snp3D : Map Gene to Disease7048
General knowledge
Homologs : HomoloGeneTGFBR2
Homology/Alignments : Family Browser (UCSC)TGFBR2
Phylogenetic Trees/Animal Genes : TreeFamTGFBR2
Chemical/Protein Interactions : CTD7048
Chemical/Pharm GKB GenePA36486
Clinical trialTGFBR2
Cancer Resource (Charite)ENSG00000163513
Other databases
Probes
Litterature
PubMed348 Pubmed reference(s) in Entrez
CoreMineTGFBR2
iHOPTGFBR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:43:41 CEST 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.