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TGIF1 (TGFB induced factor homeobox 1)

Identity

Other namesHPE4
TGIF
HGNC (Hugo) TGIF1
LocusID (NCBI) 7050
Atlas_Id 46146
Location 18p11.31  [Link to chromosome band 18p11]
Location_base_pair Starts at 3449411 and ends at 3458406 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANKRD11 (16q24.3) / TGIF1 (18p11.31)SLC35B1 (17q21.33) / TGIF1 (18p11.31)TGIF1 (18p11.31) / DDX19B (16q22.1)
ANKRD11 16q24.3 / TGIF1 18p11.31TGIF1 18p11.31 / DDX19B 16q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TGIF1   11776
Cards
Entrez_Gene (NCBI)TGIF1  7050  TGFB induced factor homeobox 1
AliasesHPE4; TGIF
GeneCards (Weizmann)TGIF1
Ensembl hg19 (Hinxton)ENSG00000177426 [Gene_View]  chr18:3449411-3458406 [Contig_View]  TGIF1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000177426 [Gene_View]  chr18:3449411-3458406 [Contig_View]  TGIF1 [Vega]
ICGC DataPortalENSG00000177426
TCGA cBioPortalTGIF1
AceView (NCBI)TGIF1
Genatlas (Paris)TGIF1
WikiGenes7050
SOURCE (Princeton)TGIF1
Genomic and cartography
GoldenPath hg19 (UCSC)TGIF1  -     chr18:3449411-3458406 +  18p11.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TGIF1  -     18p11.31   [Description]    (hg38-Dec_2013)
EnsemblTGIF1 - 18p11.31 [CytoView hg19]  TGIF1 - 18p11.31 [CytoView hg38]
Mapping of homologs : NCBITGIF1 [Mapview hg19]  TGIF1 [Mapview hg38]
OMIM142946   602630   
Gene and transcription
Genbank (Entrez)AF179900 AI813434 AK026766 AK291112 AK307230
RefSeq transcript (Entrez)NM_001278682 NM_001278684 NM_001278686 NM_003244 NM_170695 NM_173207 NM_173208 NM_173209 NM_173210 NM_173211 NM_174886
RefSeq genomic (Entrez)NC_000018 NC_018929 NG_007447 NT_010859 NW_004929409
Consensus coding sequences : CCDS (NCBI)TGIF1
Cluster EST : UnigeneHs.373550 [ NCBI ]
CGAP (NCI)Hs.373550
Alternative Splicing GalleryENSG00000177426
Gene ExpressionTGIF1 [ NCBI-GEO ]   TGIF1 [ EBI - ARRAY_EXPRESS ]   TGIF1 [ SEEK ]   TGIF1 [ MEM ]
Gene Expression Viewer (FireBrowse)TGIF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7050
GTEX Portal (Tissue expression)TGIF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15583 (Uniprot)
NextProtQ15583  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15583
Splice isoforms : SwissVarQ15583 (Swissvar)
PhosPhoSitePlusQ15583
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox_dom    Homeobox_KN_domain    Homeodomain-like   
Domain families : Pfam (Sanger)Homeobox_KN (PF05920)   
Domain families : Pfam (NCBI)pfam05920   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM Disease mutations7050
Blocks (Seattle)TGIF1
PDB (SRS)2LK2   
PDB (PDBSum)2LK2   
PDB (IMB)2LK2   
PDB (RSDB)2LK2   
Structural Biology KnowledgeBase2LK2   
SCOP (Structural Classification of Proteins)2LK2   
CATH (Classification of proteins structures)2LK2   
SuperfamilyQ15583
Human Protein AtlasENSG00000177426
Peptide AtlasQ15583
HPRD04023
IPIIPI00297138   IPI00396515   IPI00334585   IPI01022090   IPI01021959   IPI01021590   IPI01021438   IPI01020967   IPI01020738   IPI01022990   IPI01022819   IPI01022663   IPI00334558   
Protein Interaction databases
DIP (DOE-UCLA)Q15583
IntAct (EBI)Q15583
FunCoupENSG00000177426
BioGRIDTGIF1
STRING (EMBL)TGIF1
ZODIACTGIF1
Ontologies - Pathways
QuickGOQ15583
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleoplasm  transcription, DNA-templated  multicellular organism development  response to drug  co-SMAD binding  cellular response to growth factor stimulus  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleoplasm  transcription, DNA-templated  multicellular organism development  response to drug  co-SMAD binding  cellular response to growth factor stimulus  
NDEx NetworkTGIF1
Atlas of Cancer Signalling NetworkTGIF1
Wikipedia pathwaysTGIF1
Orthology - Evolution
OrthoDB7050
GeneTree (enSembl)ENSG00000177426
Phylogenetic Trees/Animal Genes : TreeFamTGIF1
Homologs : HomoloGeneTGIF1
Homology/Alignments : Family Browser (UCSC)TGIF1
Gene fusions - Rearrangements
Fusion: TCGAANKRD11 16q24.3 TGIF1 18p11.31 LUAD
Fusion: TCGATGIF1 18p11.31 DDX19B 16q22.1 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerTGIF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TGIF1
dbVarTGIF1
ClinVarTGIF1
1000_GenomesTGIF1 
Exome Variant ServerTGIF1
ExAC (Exome Aggregation Consortium)TGIF1 (select the gene name)
Genetic variants : HAPMAP7050
Genomic Variants (DGV)TGIF1 [DGVbeta]
Mutations
ICGC Data PortalTGIF1 
TCGA Data PortalTGIF1 
Broad Tumor PortalTGIF1
OASIS PortalTGIF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTGIF1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TGIF1
DgiDB (Drug Gene Interaction Database)TGIF1
DoCM (Curated mutations)TGIF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TGIF1 (select a term)
intoGenTGIF1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)18:3449411-3458406  ENSG00000177426
CONAN: Copy Number AnalysisTGIF1 
Mutations and Diseases : HGMDTGIF1
OMIM142946    602630   
MedgenTGIF1
Genetic Testing Registry TGIF1
NextProtQ15583 [Medical]
TSGene7050
GENETestsTGIF1
Huge Navigator TGIF1 [HugePedia]
snp3D : Map Gene to Disease7050
BioCentury BCIQTGIF1
ClinGenTGIF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7050
Chemical/Pharm GKB GenePA36489
Clinical trialTGIF1
Miscellaneous
canSAR (ICR)TGIF1 (select the gene name)
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTGIF1
EVEXTGIF1
GoPubMedTGIF1
iHOPTGIF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 19 19:16:30 CEST 2016

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