TGIF2 (TGFB induced factor homeobox 2)

2003-12-01  

Identity

HGNC
LOCATION
20q11.23
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 60436
MIM: 607294
HGNC: 15764
Ensembl: ENSG00000118707

Variants:

dbSNP: 60436
ClinVar: 60436
TCGA: ENSG00000118707
COSMIC: TGIF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118707ENST00000373872Q9GZN2
ENSG00000118707ENST00000373874Q9GZN2
ENSG00000118707ENST00000557885U3KQS0
ENSG00000118707ENST00000558028H0YKN5
ENSG00000118707ENST00000558465U3KQ25
ENSG00000118707ENST00000560025Q9GZN2
ENSG00000118707ENST00000561398U3KQB5
ENSG00000118707ENST00000611732Q9GZN2
ENSG00000118707ENST00000650844Q9GZN2

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionREACTOMER-HSA-2173796
Downregulation of SMAD2/3:SMAD4 transcriptional activityREACTOMER-HSA-2173795
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

References

Pubmed IDYearTitleCitations
200404912010Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.33
264646332015MicroRNA-34a inhibits tumor invasion and metastasis in gastric cancer by targeting Tgif2.13
266380072015Down-Regulation of miR-148a Promotes Metastasis by DNA Methylation and is Associated with Prognosis of Skin Cancer by Targeting TGIF2.13
274483002016MiR-541-3p reverses cancer progression by directly targeting TGIF2 in non-small cell lung cancer.13
263307482015Role of 5'TG3'-interacting factors (TGIFs) in Vorinostat (HDAC inhibitor)-mediated Corneal Fibrosis Inhibition.10
294312692018MiR-129-5p inhibits glioma cell progression in vitro and in vivo by targeting TGIF2.8
279567042017Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.7
277125922016Suppressive Role of MicroRNA-148a in Cell Proliferation and Invasion in Ovarian Cancer Through Targeting Transforming Growth Factor-β-Induced 2.5
298957192018miR-34 inhibits growth and promotes apoptosis of osteosarcoma in nude mice through targetly regulating TGIF2 expression.4
306327032019Three inflammation-related genes could predict risk in prognosis and metastasis of patients with breast cancer.3

Citation

Dessen P

TGIF2 (TGFB induced factor homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42544/tgif2