Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TGM3 (transglutaminase 3)

Identity

Alias_namesprotein-glutamine-gamma-glutamyltransferase
Alias_symbol (synonym)TGE
Other aliasUHS2
HGNC (Hugo) TGM3
LocusID (NCBI) 7053
Atlas_Id 46285
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 2295967 and ends at 2341079 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EPB41L1 (20q11.23) / TGM3 (20p13)VPS72 (1q21.3) / TGM3 (20p13)EPB41L1 20q11.23 / TGM3 20p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(20;20)(p13;q11) EPB41L1/TGM3


External links

Nomenclature
HGNC (Hugo)TGM3   11779
Cards
Entrez_Gene (NCBI)TGM3  7053  transglutaminase 3
AliasesTGE; UHS2
GeneCards (Weizmann)TGM3
Ensembl hg19 (Hinxton)ENSG00000125780 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125780 [Gene_View]  ENSG00000125780 [Sequence]  chr20:2295967-2341079 [Contig_View]  TGM3 [Vega]
ICGC DataPortalENSG00000125780
TCGA cBioPortalTGM3
AceView (NCBI)TGM3
Genatlas (Paris)TGM3
WikiGenes7053
SOURCE (Princeton)TGM3
Genetics Home Reference (NIH)TGM3
Genomic and cartography
GoldenPath hg38 (UCSC)TGM3  -     chr20:2295967-2341079 +  20p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TGM3  -     20p13   [Description]    (hg19-Feb_2009)
EnsemblTGM3 - 20p13 [CytoView hg19]  TGM3 - 20p13 [CytoView hg38]
Mapping of homologs : NCBITGM3 [Mapview hg19]  TGM3 [Mapview hg38]
OMIM600238   617251   
Gene and transcription
Genbank (Entrez)AI216028 AK290324 AK291351 AK298637 AK299447
RefSeq transcript (Entrez)NM_003245
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TGM3
Cluster EST : UnigeneHs.2022 [ NCBI ]
CGAP (NCI)Hs.2022
Alternative Splicing GalleryENSG00000125780
Gene ExpressionTGM3 [ NCBI-GEO ]   TGM3 [ EBI - ARRAY_EXPRESS ]   TGM3 [ SEEK ]   TGM3 [ MEM ]
Gene Expression Viewer (FireBrowse)TGM3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7053
GTEX Portal (Tissue expression)TGM3
Human Protein AtlasENSG00000125780-TGM3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08188   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08188  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08188
Splice isoforms : SwissVarQ08188
PhosPhoSitePlusQ08188
Domaine pattern : Prosite (Expaxy)TRANSGLUTAMINASES (PS00547)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    Transglutaminase-like    Transglutaminase-like_sf    Transglutaminase_animal    Transglutaminase_AS    Transglutaminase_C    Transglutaminase_C_sf    Transglutaminase_N   
Domain families : Pfam (Sanger)Transglut_C (PF00927)    Transglut_core (PF01841)    Transglut_N (PF00868)   
Domain families : Pfam (NCBI)pfam00927    pfam01841    pfam00868   
Domain families : Smart (EMBL)TGc (SM00460)  
Conserved Domain (NCBI)TGM3
DMDM Disease mutations7053
Blocks (Seattle)TGM3
PDB (SRS)1L9M    1L9N    1NUD    1NUF    1NUG   
PDB (PDBSum)1L9M    1L9N    1NUD    1NUF    1NUG   
PDB (IMB)1L9M    1L9N    1NUD    1NUF    1NUG   
PDB (RSDB)1L9M    1L9N    1NUD    1NUF    1NUG   
Structural Biology KnowledgeBase1L9M    1L9N    1NUD    1NUF    1NUG   
SCOP (Structural Classification of Proteins)1L9M    1L9N    1NUD    1NUF    1NUG   
CATH (Classification of proteins structures)1L9M    1L9N    1NUD    1NUF    1NUG   
SuperfamilyQ08188
Human Protein Atlas [tissue]ENSG00000125780-TGM3 [tissue]
Peptide AtlasQ08188
HPRD02584
IPIIPI00300376   IPI00910597   IPI00909882   
Protein Interaction databases
DIP (DOE-UCLA)Q08188
IntAct (EBI)Q08188
FunCoupENSG00000125780
BioGRIDTGM3
STRING (EMBL)TGM3
ZODIACTGM3
Ontologies - Pathways
QuickGOQ08188
Ontology : AmiGOprotein-glutamine gamma-glutamyltransferase activity  catalytic activity  calcium ion binding  cytoplasm  cellular protein modification process  transferase activity, transferring acyl groups  peptide cross-linking  keratinocyte differentiation  keratinocyte differentiation  hair follicle morphogenesis  extrinsic component of cytoplasmic side of plasma membrane  keratinization  cell envelope organization  protein tetramerization  extracellular exosome  
Ontology : EGO-EBIprotein-glutamine gamma-glutamyltransferase activity  catalytic activity  calcium ion binding  cytoplasm  cellular protein modification process  transferase activity, transferring acyl groups  peptide cross-linking  keratinocyte differentiation  keratinocyte differentiation  hair follicle morphogenesis  extrinsic component of cytoplasmic side of plasma membrane  keratinization  cell envelope organization  protein tetramerization  extracellular exosome  
NDEx NetworkTGM3
Atlas of Cancer Signalling NetworkTGM3
Wikipedia pathwaysTGM3
Orthology - Evolution
OrthoDB7053
GeneTree (enSembl)ENSG00000125780
Phylogenetic Trees/Animal Genes : TreeFamTGM3
HOVERGENQ08188
HOGENOMQ08188
Homologs : HomoloGeneTGM3
Homology/Alignments : Family Browser (UCSC)TGM3
Gene fusions - Rearrangements
Fusion : MitelmanEPB41L1/TGM3 [20q11.23/20p13]  [t(20;20)(p13;q11)]  
Fusion PortalEPB41L1 20q11.23 TGM3 20p13 HNSC
Fusion : QuiverTGM3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTGM3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TGM3
dbVarTGM3
ClinVarTGM3
1000_GenomesTGM3 
Exome Variant ServerTGM3
ExAC (Exome Aggregation Consortium)ENSG00000125780
GNOMAD BrowserENSG00000125780
Varsome BrowserTGM3
Genetic variants : HAPMAP7053
Genomic Variants (DGV)TGM3 [DGVbeta]
DECIPHERTGM3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTGM3 
Mutations
ICGC Data PortalTGM3 
TCGA Data PortalTGM3 
Broad Tumor PortalTGM3
OASIS PortalTGM3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTGM3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTGM3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TGM3
DgiDB (Drug Gene Interaction Database)TGM3
DoCM (Curated mutations)TGM3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TGM3 (select a term)
intoGenTGM3
Cancer3DTGM3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600238    617251   
Orphanet
DisGeNETTGM3
MedgenTGM3
Genetic Testing Registry TGM3
NextProtQ08188 [Medical]
TSGene7053
GENETestsTGM3
Target ValidationTGM3
Huge Navigator TGM3 [HugePedia]
snp3D : Map Gene to Disease7053
BioCentury BCIQTGM3
ClinGenTGM3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7053
Chemical/Pharm GKB GenePA36492
Clinical trialTGM3
Miscellaneous
canSAR (ICR)TGM3 (select the gene name)
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTGM3
EVEXTGM3
GoPubMedTGM3
iHOPTGM3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:44:48 CET 2018

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