Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TGM3 (transglutaminase 3)

Identity

Alias (NCBI)TGE
UHS2
HGNC (Hugo) TGM3
HGNC Alias symbTGE
HGNC Alias nameE polypeptide, protein-glutamine-gamma-glutamyltransferase
HGNC Previous nametransglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
LocusID (NCBI) 7053
Atlas_Id 46285
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 2296001 and ends at 2341079 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EPB41L1 (20q11.23) / TGM3 (20p13)VPS72 (1q21.3) / TGM3 (20p13)EPB41L1 20q11.23 / TGM3 20p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TGM3   11779
Cards
Entrez_Gene (NCBI)TGM3    transglutaminase 3
AliasesTGE; UHS2
GeneCards (Weizmann)TGM3
Ensembl hg19 (Hinxton)ENSG00000125780 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125780 [Gene_View]  ENSG00000125780 [Sequence]  chr20:2296001-2341079 [Contig_View]  TGM3 [Vega]
ICGC DataPortalENSG00000125780
TCGA cBioPortalTGM3
AceView (NCBI)TGM3
Genatlas (Paris)TGM3
SOURCE (Princeton)TGM3
Genetics Home Reference (NIH)TGM3
Genomic and cartography
GoldenPath hg38 (UCSC)TGM3  -     chr20:2296001-2341079 +  20p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TGM3  -     20p13   [Description]    (hg19-Feb_2009)
GoldenPathTGM3 - 20p13 [CytoView hg19]  TGM3 - 20p13 [CytoView hg38]
ImmunoBaseENSG00000125780
Genome Data Viewer NCBITGM3 [Mapview hg19]  
OMIM600238   617251   
Gene and transcription
Genbank (Entrez)AI216028 AK290324 AK291351 AK298637 AK299447
RefSeq transcript (Entrez)NM_003245
Consensus coding sequences : CCDS (NCBI)TGM3
Gene ExpressionTGM3 [ NCBI-GEO ]   TGM3 [ EBI - ARRAY_EXPRESS ]   TGM3 [ SEEK ]   TGM3 [ MEM ]
Gene Expression Viewer (FireBrowse)TGM3 [ Firebrowse - Broad ]
GenevisibleExpression of TGM3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7053
GTEX Portal (Tissue expression)TGM3
Human Protein AtlasENSG00000125780-TGM3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08188   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08188  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08188
PhosPhoSitePlusQ08188
Domaine pattern : Prosite (Expaxy)TRANSGLUTAMINASES (PS00547)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    Papain-like_cys_pep_sf    Transglutaminase-like    Transglutaminase-like_sf    Transglutaminase_animal    Transglutaminase_AS    Transglutaminase_C    Transglutaminase_C_sf    Transglutaminase_N   
Domain families : Pfam (Sanger)Transglut_C (PF00927)    Transglut_core (PF01841)    Transglut_N (PF00868)   
Domain families : Pfam (NCBI)pfam00927    pfam01841    pfam00868   
Domain families : Smart (EMBL)TGc (SM00460)  
Conserved Domain (NCBI)TGM3
PDB (RSDB)1L9M    1L9N    1NUD    1NUF    1NUG   
PDB Europe1L9M    1L9N    1NUD    1NUF    1NUG   
PDB (PDBSum)1L9M    1L9N    1NUD    1NUF    1NUG   
PDB (IMB)1L9M    1L9N    1NUD    1NUF    1NUG   
Structural Biology KnowledgeBase1L9M    1L9N    1NUD    1NUF    1NUG   
SCOP (Structural Classification of Proteins)1L9M    1L9N    1NUD    1NUF    1NUG   
CATH (Classification of proteins structures)1L9M    1L9N    1NUD    1NUF    1NUG   
SuperfamilyQ08188
AlphaFold pdb e-kbQ08188   
Human Protein Atlas [tissue]ENSG00000125780-TGM3 [tissue]
HPRD02584
Protein Interaction databases
DIP (DOE-UCLA)Q08188
IntAct (EBI)Q08188
BioGRIDTGM3
STRING (EMBL)TGM3
ZODIACTGM3
Ontologies - Pathways
QuickGOQ08188
Ontology : AmiGOprotein-glutamine gamma-glutamyltransferase activity  protein-glutamine gamma-glutamyltransferase activity  catalytic activity  structural molecule activity  calcium ion binding  cytoplasm  cellular protein modification process  acyltransferase activity  peptide cross-linking  peptide cross-linking  keratinocyte differentiation  keratinocyte differentiation  hair follicle morphogenesis  extrinsic component of cytoplasmic side of plasma membrane  keratinization  protein-containing complex  cell envelope organization  extracellular exosome  
Ontology : EGO-EBIprotein-glutamine gamma-glutamyltransferase activity  protein-glutamine gamma-glutamyltransferase activity  catalytic activity  structural molecule activity  calcium ion binding  cytoplasm  cellular protein modification process  acyltransferase activity  peptide cross-linking  peptide cross-linking  keratinocyte differentiation  keratinocyte differentiation  hair follicle morphogenesis  extrinsic component of cytoplasmic side of plasma membrane  keratinization  protein-containing complex  cell envelope organization  extracellular exosome  
NDEx NetworkTGM3
Atlas of Cancer Signalling NetworkTGM3
Wikipedia pathwaysTGM3
Orthology - Evolution
OrthoDB7053
GeneTree (enSembl)ENSG00000125780
Phylogenetic Trees/Animal Genes : TreeFamTGM3
Homologs : HomoloGeneTGM3
Homology/Alignments : Family Browser (UCSC)TGM3
Gene fusions - Rearrangements
Fusion : MitelmanEPB41L1/TGM3 [20q11.23/20p13]  
Fusion : QuiverTGM3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTGM3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TGM3
dbVarTGM3
ClinVarTGM3
MonarchTGM3
1000_GenomesTGM3 
Exome Variant ServerTGM3
GNOMAD BrowserENSG00000125780
Varsome BrowserTGM3
ACMGTGM3 variants
VarityQ08188
Genomic Variants (DGV)TGM3 [DGVbeta]
DECIPHERTGM3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTGM3 
Mutations
ICGC Data PortalTGM3 
TCGA Data PortalTGM3 
Broad Tumor PortalTGM3
OASIS PortalTGM3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTGM3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTGM3
Mutations and Diseases : HGMDTGM3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTGM3
DgiDB (Drug Gene Interaction Database)TGM3
DoCM (Curated mutations)TGM3
CIViC (Clinical Interpretations of Variants in Cancer)TGM3
Cancer3DTGM3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600238    617251   
Orphanet
DisGeNETTGM3
MedgenTGM3
Genetic Testing Registry TGM3
NextProtQ08188 [Medical]
GENETestsTGM3
Target ValidationTGM3
Huge Navigator TGM3 [HugePedia]
ClinGenTGM3
Clinical trials, drugs, therapy
MyCancerGenomeTGM3
Protein Interactions : CTDTGM3
Pharm GKB GenePA36492
PharosQ08188
Clinical trialTGM3
Miscellaneous
canSAR (ICR)TGM3
HarmonizomeTGM3
DataMed IndexTGM3
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTGM3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:34:57 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.