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TGM6 (transglutaminase 6)

Identity

Alias (NCBI)SCA35
TG6
TGM3L
TGY
dJ734P14.3
HGNC (Hugo) TGM6
HGNC Alias symbdJ734P14.3
TGY
SCA35
HGNC Alias namespinocerebellar ataxia 35
HGNC Previous nameTGM3L
HGNC Previous nametransglutaminase 3-like
LocusID (NCBI) 343641
Atlas_Id 74661
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 2380901 and ends at 2432753 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TGM6   16255
Cards
Entrez_Gene (NCBI)TGM6    transglutaminase 6
AliasesSCA35; TG6; TGM3L; TGY; 
dJ734P14.3
GeneCards (Weizmann)TGM6
Ensembl hg19 (Hinxton)ENSG00000166948 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166948 [Gene_View]  ENSG00000166948 [Sequence]  chr20:2380901-2432753 [Contig_View]  TGM6 [Vega]
ICGC DataPortalENSG00000166948
TCGA cBioPortalTGM6
AceView (NCBI)TGM6
Genatlas (Paris)TGM6
SOURCE (Princeton)TGM6
Genetics Home Reference (NIH)TGM6
Genomic and cartography
GoldenPath hg38 (UCSC)TGM6  -     chr20:2380901-2432753 +  20p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TGM6  -     20p13   [Description]    (hg19-Feb_2009)
GoldenPathTGM6 - 20p13 [CytoView hg19]  TGM6 - 20p13 [CytoView hg38]
ImmunoBaseENSG00000166948
Genome Data Viewer NCBITGM6 [Mapview hg19]  
OMIM613900   613908   
Gene and transcription
Genbank (Entrez)AF540969 AF540970
RefSeq transcript (Entrez)NM_001254734 NM_198994
Consensus coding sequences : CCDS (NCBI)TGM6
Gene ExpressionTGM6 [ NCBI-GEO ]   TGM6 [ EBI - ARRAY_EXPRESS ]   TGM6 [ SEEK ]   TGM6 [ MEM ]
Gene Expression Viewer (FireBrowse)TGM6 [ Firebrowse - Broad ]
GenevisibleExpression of TGM6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)343641
GTEX Portal (Tissue expression)TGM6
Human Protein AtlasENSG00000166948-TGM6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95932   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95932  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95932
Catalytic activity : Enzyme2.3.2.13 [ Enzyme-Expasy ]   2.3.2.132.3.2.13 [ IntEnz-EBI ]   2.3.2.13 [ BRENDA ]   2.3.2.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO95932
Domaine pattern : Prosite (Expaxy)TRANSGLUTAMINASES (PS00547)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    Papain-like_cys_pep_sf    Transglutaminase-like    Transglutaminase-like_sf    Transglutaminase_animal    Transglutaminase_AS    Transglutaminase_C    Transglutaminase_C_sf    Transglutaminase_N   
Domain families : Pfam (Sanger)Transglut_C (PF00927)    Transglut_core (PF01841)    Transglut_N (PF00868)   
Domain families : Pfam (NCBI)pfam00927    pfam01841    pfam00868   
Domain families : Smart (EMBL)TGc (SM00460)  
Conserved Domain (NCBI)TGM6
SuperfamilyO95932
AlphaFold pdb e-kbO95932   
Human Protein Atlas [tissue]ENSG00000166948-TGM6 [tissue]
HPRD15495
Protein Interaction databases
DIP (DOE-UCLA)O95932
IntAct (EBI)O95932
BioGRIDTGM6
STRING (EMBL)TGM6
ZODIACTGM6
Ontologies - Pathways
QuickGOO95932
Ontology : AmiGOprotein-glutamine gamma-glutamyltransferase activity  protein-glutamine gamma-glutamyltransferase activity  cytoplasm  cytoplasm  peptide cross-linking  metal ion binding  
Ontology : EGO-EBIprotein-glutamine gamma-glutamyltransferase activity  protein-glutamine gamma-glutamyltransferase activity  cytoplasm  cytoplasm  peptide cross-linking  metal ion binding  
NDEx NetworkTGM6
Atlas of Cancer Signalling NetworkTGM6
Wikipedia pathwaysTGM6
Orthology - Evolution
OrthoDB343641
GeneTree (enSembl)ENSG00000166948
Phylogenetic Trees/Animal Genes : TreeFamTGM6
Homologs : HomoloGeneTGM6
Homology/Alignments : Family Browser (UCSC)TGM6
Gene fusions - Rearrangements
Fusion : QuiverTGM6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTGM6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TGM6
dbVarTGM6
ClinVarTGM6
MonarchTGM6
1000_GenomesTGM6 
Exome Variant ServerTGM6
GNOMAD BrowserENSG00000166948
Varsome BrowserTGM6
ACMGTGM6 variants
VarityO95932
Genomic Variants (DGV)TGM6 [DGVbeta]
DECIPHERTGM6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTGM6 
Mutations
ICGC Data PortalTGM6 
TCGA Data PortalTGM6 
Broad Tumor PortalTGM6
OASIS PortalTGM6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTGM6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTGM6
Mutations and Diseases : HGMDTGM6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTGM6
DgiDB (Drug Gene Interaction Database)TGM6
DoCM (Curated mutations)TGM6
CIViC (Clinical Interpretations of Variants in Cancer)TGM6
Cancer3DTGM6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613900    613908   
Orphanet20354    21659   
DisGeNETTGM6
MedgenTGM6
Genetic Testing Registry TGM6
NextProtO95932 [Medical]
GENETestsTGM6
Target ValidationTGM6
Huge Navigator TGM6 [HugePedia]
ClinGenTGM6
Clinical trials, drugs, therapy
MyCancerGenomeTGM6
Protein Interactions : CTDTGM6
Pharm GKB GenePA38098
PharosO95932
Clinical trialTGM6
Miscellaneous
canSAR (ICR)TGM6
HarmonizomeTGM6
DataMed IndexTGM6
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTGM6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:25:24 CEST 2021

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