Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TGS1 (trimethylguanosine synthase 1)

Identity

Alias_namesNCOA6IP
nuclear receptor coactivator 6 interacting protein
trimethylguanosine synthase homolog (S. cerevisiae)
Alias_symbol (synonym)PIMT
Other aliasPIPMT
HGNC (Hugo) TGS1
LocusID (NCBI) 96764
Atlas_Id 52236
Location 8q12.1  [Link to chromosome band 8q12]
Location_base_pair Starts at 55773232 and ends at 55826445 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LYN (8q12.1) / TGS1 (8q12.1)TGS1 (8q12.1) / SNTG2 (2p25.3)TGS1 (8q12.1) / TGS1 (8q12.1)
TNRC18 (7p22.1) / TGS1 (8q12.1)LYN 8q12.1 / TGS1 8q12.1TNRC18 7p22.1 / TGS1 8q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TGS1   17843
Cards
Entrez_Gene (NCBI)TGS1  96764  trimethylguanosine synthase 1
AliasesNCOA6IP; PIMT; PIPMT
GeneCards (Weizmann)TGS1
Ensembl hg19 (Hinxton)ENSG00000137574 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137574 [Gene_View]  chr8:55773232-55826445 [Contig_View]  TGS1 [Vega]
ICGC DataPortalENSG00000137574
TCGA cBioPortalTGS1
AceView (NCBI)TGS1
Genatlas (Paris)TGS1
WikiGenes96764
SOURCE (Princeton)TGS1
Genetics Home Reference (NIH)TGS1
Genomic and cartography
GoldenPath hg38 (UCSC)TGS1  -     chr8:55773232-55826445 +  8q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TGS1  -     8q12.1   [Description]    (hg19-Feb_2009)
EnsemblTGS1 - 8q12.1 [CytoView hg19]  TGS1 - 8q12.1 [CytoView hg38]
Mapping of homologs : NCBITGS1 [Mapview hg19]  TGS1 [Mapview hg38]
OMIM606461   
Gene and transcription
Genbank (Entrez)AF286340 AF432215 AK026648 AK055178 AK314693
RefSeq transcript (Entrez)NM_001317902 NM_024831
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TGS1
Cluster EST : UnigeneHs.335068 [ NCBI ]
CGAP (NCI)Hs.335068
Alternative Splicing GalleryENSG00000137574
Gene ExpressionTGS1 [ NCBI-GEO ]   TGS1 [ EBI - ARRAY_EXPRESS ]   TGS1 [ SEEK ]   TGS1 [ MEM ]
Gene Expression Viewer (FireBrowse)TGS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)96764
GTEX Portal (Tissue expression)TGS1
Human Protein AtlasENSG00000137574-TGS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RS0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RS0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RS0
Splice isoforms : SwissVarQ96RS0
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
PhosPhoSitePlusQ96RS0
Domains : Interpro (EBI)RNA_cap_Gua-N2-MeTrfase    SAM-dependent_MTases   
Domain families : Pfam (Sanger)Methyltransf_15 (PF09445)   
Domain families : Pfam (NCBI)pfam09445   
Conserved Domain (NCBI)TGS1
DMDM Disease mutations96764
Blocks (Seattle)TGS1
PDB (SRS)3EGI    3GDH   
PDB (PDBSum)3EGI    3GDH   
PDB (IMB)3EGI    3GDH   
PDB (RSDB)3EGI    3GDH   
Structural Biology KnowledgeBase3EGI    3GDH   
SCOP (Structural Classification of Proteins)3EGI    3GDH   
CATH (Classification of proteins structures)3EGI    3GDH   
SuperfamilyQ96RS0
Human Protein Atlas [tissue]ENSG00000137574-TGS1 [tissue]
Peptide AtlasQ96RS0
HPRD07567
IPIIPI00291376   IPI00974052   
Protein Interaction databases
DIP (DOE-UCLA)Q96RS0
IntAct (EBI)Q96RS0
FunCoupENSG00000137574
BioGRIDTGS1
STRING (EMBL)TGS1
ZODIACTGS1
Ontologies - Pathways
QuickGOQ96RS0
Ontology : AmiGOspliceosomal snRNP assembly  protein binding  extracellular space  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  RNA methyltransferase activity  7-methylguanosine RNA capping  Cajal body  ribonucleoprotein complex biogenesis  small nuclear ribonucleoprotein complex  7-methylguanosine cap hypermethylation  cellular lipid metabolic process  RNA trimethylguanosine synthase activity  ribonucleoprotein complex import into nucleus  
Ontology : EGO-EBIspliceosomal snRNP assembly  protein binding  extracellular space  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  RNA methyltransferase activity  7-methylguanosine RNA capping  Cajal body  ribonucleoprotein complex biogenesis  small nuclear ribonucleoprotein complex  7-methylguanosine cap hypermethylation  cellular lipid metabolic process  RNA trimethylguanosine synthase activity  ribonucleoprotein complex import into nucleus  
Pathways : KEGGRNA transport   
NDEx NetworkTGS1
Atlas of Cancer Signalling NetworkTGS1
Wikipedia pathwaysTGS1
Orthology - Evolution
OrthoDB96764
GeneTree (enSembl)ENSG00000137574
Phylogenetic Trees/Animal Genes : TreeFamTGS1
HOVERGENQ96RS0
HOGENOMQ96RS0
Homologs : HomoloGeneTGS1
Homology/Alignments : Family Browser (UCSC)TGS1
Gene fusions - Rearrangements
Fusion : MitelmanLYN/TGS1 [8q12.1/8q12.1]  [t(8;8)(q12;q12)]  
Fusion : MitelmanTNRC18/TGS1 [7p22.1/8q12.1]  [t(7;8)(p22;q12)]  
Fusion: TCGA_MDACCLYN 8q12.1 TGS1 8q12.1 HNSC LGG
Fusion: TCGA_MDACCTNRC18 7p22.1 TGS1 8q12.1 LUAD
Tumor Fusion PortalTGS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTGS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TGS1
dbVarTGS1
ClinVarTGS1
1000_GenomesTGS1 
Exome Variant ServerTGS1
ExAC (Exome Aggregation Consortium)ENSG00000137574
GNOMAD BrowserENSG00000137574
Genetic variants : HAPMAP96764
Genomic Variants (DGV)TGS1 [DGVbeta]
DECIPHERTGS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTGS1 
Mutations
ICGC Data PortalTGS1 
TCGA Data PortalTGS1 
Broad Tumor PortalTGS1
OASIS PortalTGS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTGS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTGS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TGS1
DgiDB (Drug Gene Interaction Database)TGS1
DoCM (Curated mutations)TGS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TGS1 (select a term)
intoGenTGS1
Cancer3DTGS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606461   
Orphanet
DisGeNETTGS1
MedgenTGS1
Genetic Testing Registry TGS1
NextProtQ96RS0 [Medical]
TSGene96764
GENETestsTGS1
Target ValidationTGS1
Huge Navigator TGS1 [HugePedia]
snp3D : Map Gene to Disease96764
BioCentury BCIQTGS1
ClinGenTGS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD96764
Chemical/Pharm GKB GenePA162405660
Clinical trialTGS1
Miscellaneous
canSAR (ICR)TGS1 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTGS1
EVEXTGS1
GoPubMedTGS1
iHOPTGS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:38:19 CET 2017

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