Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TGS1 (trimethylguanosine synthase 1)

Identity

Alias (NCBI)NCOA6IP
PIMT
PIPMT
HGNC (Hugo) TGS1
HGNC Alias symbPIMT
HGNC Previous nameNCOA6IP
HGNC Previous namenuclear receptor coactivator 6 interacting protein
 trimethylguanosine synthase homolog (S. cerevisiae)
LocusID (NCBI) 96764
Atlas_Id 52236
Location 8q12.1  [Link to chromosome band 8q12]
Location_base_pair Starts at 55773446 and ends at 55826445 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LYN (8q12.1) / TGS1 (8q12.1)TGS1 (8q12.1) / SNTG2 (2p25.3)TGS1 (8q12.1) / TGS1 (8q12.1)
TNRC18 (7p22.1) / TGS1 (8q12.1)LYN 8q12.1 / TGS1 8q12.1TNRC18 7p22.1 / TGS1 8q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TGS1   17843
Cards
Entrez_Gene (NCBI)TGS1    trimethylguanosine synthase 1
AliasesNCOA6IP; PIMT; PIPMT
GeneCards (Weizmann)TGS1
Ensembl hg19 (Hinxton)ENSG00000137574 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137574 [Gene_View]  ENSG00000137574 [Sequence]  chr8:55773446-55826445 [Contig_View]  TGS1 [Vega]
ICGC DataPortalENSG00000137574
TCGA cBioPortalTGS1
AceView (NCBI)TGS1
Genatlas (Paris)TGS1
SOURCE (Princeton)TGS1
Genetics Home Reference (NIH)TGS1
Genomic and cartography
GoldenPath hg38 (UCSC)TGS1  -     chr8:55773446-55826445 +  8q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TGS1  -     8q12.1   [Description]    (hg19-Feb_2009)
GoldenPathTGS1 - 8q12.1 [CytoView hg19]  TGS1 - 8q12.1 [CytoView hg38]
ImmunoBaseENSG00000137574
Genome Data Viewer NCBITGS1 [Mapview hg19]  
OMIM606461   
Gene and transcription
Genbank (Entrez)AF286340 AF432215 AK026648 AK055178 AK314693
RefSeq transcript (Entrez)NM_001317902 NM_001363184 NM_024831
Consensus coding sequences : CCDS (NCBI)TGS1
Gene ExpressionTGS1 [ NCBI-GEO ]   TGS1 [ EBI - ARRAY_EXPRESS ]   TGS1 [ SEEK ]   TGS1 [ MEM ]
Gene Expression Viewer (FireBrowse)TGS1 [ Firebrowse - Broad ]
GenevisibleExpression of TGS1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)96764
GTEX Portal (Tissue expression)TGS1
Human Protein AtlasENSG00000137574-TGS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RS0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RS0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RS0
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ96RS0
Domains : Interpro (EBI)RNA_cap_Gua-N2-MeTrfase    SAM-dependent_MTases   
Domain families : Pfam (Sanger)Methyltransf_15 (PF09445)   
Domain families : Pfam (NCBI)pfam09445   
Conserved Domain (NCBI)TGS1
PDB (RSDB)3EGI    3GDH   
PDB Europe3EGI    3GDH   
PDB (PDBSum)3EGI    3GDH   
PDB (IMB)3EGI    3GDH   
Structural Biology KnowledgeBase3EGI    3GDH   
SCOP (Structural Classification of Proteins)3EGI    3GDH   
CATH (Classification of proteins structures)3EGI    3GDH   
SuperfamilyQ96RS0
AlphaFold pdb e-kbQ96RS0   
Human Protein Atlas [tissue]ENSG00000137574-TGS1 [tissue]
HPRD07567
Protein Interaction databases
DIP (DOE-UCLA)Q96RS0
IntAct (EBI)Q96RS0
BioGRIDTGS1
STRING (EMBL)TGS1
ZODIACTGS1
Ontologies - Pathways
QuickGOQ96RS0
Ontology : AmiGOspliceosomal snRNP assembly  protein binding  extracellular space  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  7-methylguanosine RNA capping  Cajal body  regulation of lipid metabolic process  ribonucleoprotein complex biogenesis  small nuclear ribonucleoprotein complex  7-methylguanosine cap hypermethylation  7-methylguanosine cap hypermethylation  RNA trimethylguanosine synthase activity  RNA trimethylguanosine synthase activity  
Ontology : EGO-EBIspliceosomal snRNP assembly  protein binding  extracellular space  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  7-methylguanosine RNA capping  Cajal body  regulation of lipid metabolic process  ribonucleoprotein complex biogenesis  small nuclear ribonucleoprotein complex  7-methylguanosine cap hypermethylation  7-methylguanosine cap hypermethylation  RNA trimethylguanosine synthase activity  RNA trimethylguanosine synthase activity  
Pathways : KEGGRNA transport   
NDEx NetworkTGS1
Atlas of Cancer Signalling NetworkTGS1
Wikipedia pathwaysTGS1
Orthology - Evolution
OrthoDB96764
GeneTree (enSembl)ENSG00000137574
Phylogenetic Trees/Animal Genes : TreeFamTGS1
Homologs : HomoloGeneTGS1
Homology/Alignments : Family Browser (UCSC)TGS1
Gene fusions - Rearrangements
Fusion : MitelmanLYN/TGS1 [8q12.1/8q12.1]  
Fusion : MitelmanTNRC18/TGS1 [7p22.1/8q12.1]  
Fusion : QuiverTGS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTGS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TGS1
dbVarTGS1
ClinVarTGS1
MonarchTGS1
1000_GenomesTGS1 
Exome Variant ServerTGS1
GNOMAD BrowserENSG00000137574
Varsome BrowserTGS1
ACMGTGS1 variants
VarityQ96RS0
Genomic Variants (DGV)TGS1 [DGVbeta]
DECIPHERTGS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTGS1 
Mutations
ICGC Data PortalTGS1 
TCGA Data PortalTGS1 
Broad Tumor PortalTGS1
OASIS PortalTGS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTGS1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTGS1
Mutations and Diseases : HGMDTGS1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTGS1
DgiDB (Drug Gene Interaction Database)TGS1
DoCM (Curated mutations)TGS1
CIViC (Clinical Interpretations of Variants in Cancer)TGS1
Cancer3DTGS1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606461   
Orphanet
DisGeNETTGS1
MedgenTGS1
Genetic Testing Registry TGS1
NextProtQ96RS0 [Medical]
GENETestsTGS1
Target ValidationTGS1
Huge Navigator TGS1 [HugePedia]
ClinGenTGS1
Clinical trials, drugs, therapy
MyCancerGenomeTGS1
Protein Interactions : CTDTGS1
Pharm GKB GenePA162405660
PharosQ96RS0
Clinical trialTGS1
Miscellaneous
canSAR (ICR)TGS1
HarmonizomeTGS1
DataMed IndexTGS1
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTGS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:34:58 CEST 2021

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