THAP11 (THAP domain containing 11)

2012-07-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
CTG-B43a,CTG-B45d,HRIHFB2206,RONIN

Other Information

Locus ID:

NCBI: 57215
MIM: 609119
HGNC: 23194
Ensembl: ENSG00000168286

Variants:

dbSNP: 57215
ClinVar: 57215
TCGA: ENSG00000168286
COSMIC: THAP11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168286ENST00000303596Q96EK4

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
235391392013HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy.28
223714842012A transcriptional regulatory role of the THAP11-HCF-1 complex in colon cancer cell function.25
190089242009Cell growth suppression by thanatos-associated protein 11(THAP11) is mediated by transcriptional downregulation of c-Myc.15
292693922018Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy.14
254375532014Host cell factor-1 recruitment to E2F-bound and cell-cycle-control genes is mediated by THAP11 and ZNF143.12
226735072012THAP11, a novel binding protein of PCBP1, negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line.11
214005152012Down-regulation of Thanatos-associated protein 11 by BCR-ABL promotes CML cell proliferation through c-Myc expression.9
284491192017Mutations in THAP11 cause an inborn error of cobalamin metabolism and developmental abnormalities.7
269752122016The C-terminal region of the transcriptional regulator THAP11 forms a parallel coiled-coil domain involved in protein dimerization.3
246377162014Effects of THAP11 on erythroid differentiation and megakaryocytic differentiation of K562 cells.2

Citation

Dessen P

THAP11 (THAP domain containing 11)

Atlas Genet Cytogenet Oncol Haematol. 2012-07-01

Online version: http://atlasgeneticsoncology.org/gene/52767/thap11